University of North Carolina Department of Obstetrics & Gynecology

Maternal Fetal Medicine 2020-2021 Fellowship Training Program

University of North Carolina School of Medicine Department of Obstetrics & Gynecology Division of Maternal Fetal Medicine

3010 Old Clinic Building, CB 7516 Chapel Hill, NC 27599

Alison Stuebe, MD, MSc Interim Director, Division of Maternal Fetal Medicine

Robert Strauss, MD Director, Maternal Fetal Medicine Fellowship

Department of Obstetrics & Gynecology

University of North Carolina

MATERNAL FETAL MEDICINE

Faculty

Interim Div Dir,

General OBGyn

Alice Chuang

Fellowship Director,

MFM

Robert Strauss

Director

UNC Fetal Care

Program

William Goodnight

Interim Div Dir.

MFM

Alison Stuebe

Professor

M. Kathryn Menard

Neeta Vora

Director Genetic

Counseling

Tracy Manuck

Director, Prematurity

Prevention

Director Perinatal

Research

Karen Dorman

University of North Carolina

MATERNAL FETAL MEDICINE

Faculty

Professor

Elizabeth Stringer

Assistant Professor

Elizabeth Coviello

Assistant Professor

Christina Herrera

Assistant Professor

Julie Johnson

Nancy Chescheir

Professor

Editor, Green Journal

Kim Boggess

Professor

Assistant Professor

Angelica Glover

University of North Carolina

MATERNAL FETAL MEDIC INE

Fellows and Administration 2020-2021

3rdYear

Graduating 2021

2nd Year

Graduating 2022

Divya Mallampati

2nd Year

Graduating 2022

Asha Talati

Fellowship

Coordinator

919-966-4103

Qiana Davis

3rd Year

Graduating 2021

Anne West Honart Jasmine Johnson

Kathleen Drexler

1st Year

Graduating 2023

Nicole Teal

1st Year

Graduating 2023

Emily Richbourg

Assoc. Fellowship

Coordinator

919-966-1998

University of North Carolina

MATERNAL FETAL MEDICINE

Genetic Counselors

Genetic Counselor

Elysia Davis

Genetic Counselor

Kelly Gilmore

Genetic Counselor

Diane Vargo

Genetic Counselor

Rachel Veazey

Coordinator, Genetic

Counselor

Emily Hardisty

Genetic Counselor

Ginger Hocutt

Introduction Since its beginning in 1978, the fellowship training program in Maternal Fetal Medicine at the University of North Carolina in Chapel Hill has enjoyed the reputation of being one of the finest in the country. This is reflected in the quality of both faculty and fellows who are attracted to Chapel Hill, and the number of UNC-trained clinicians and researchers who are known locally and nationally for their clinical and research accomplishments.

Our mission is to prepare highly skilled subspecialists dedicated to the care of pregnant women and their fetuses, spanning the depth and breadth of the specialty. To achieve this, the educational experiences are tailored to the fellow’s interests and needs. Acquisition and development of research skills is an important component of the educational process and critical and analytic

thinking are an expectation for completion of the fellowship. The faculty of the Division of Maternal Fetal Medicine supports the clinical and research missions of the fellowship training program by mentoring fellows to achieve future successes as clinicians, academicians and as national leaders in Maternal Fetal Medicine. Fellows are assigned 17 months of core Maternal Fetal Medicine clinical rotations, 18 months of dedicated research time (at which time fellows in MPH track complete their coursework), and one month of elective. During the second and third year of training, fellows have the option of pursuing a master’s degree in Public Health in Maternal Child Health, Epidemiology, Health Behavior, Health Policy and Administration, or Biostatistics, through the UNC School of Public Health. Fellows can also pursue a master’s in Science and Clinical Research (MSCR). The University of North Carolina Hospitals UNC Hospitals and the School of Medicine of the University of North Carolina at Chapel Hill comprise North Carolina’s most comprehensive public center for medical care, health careers education and biomedical research. UNC is one of only 4 medical centers that rank in the top 20 in both research funding and clinical care. Each year over 500,000 people from North Carolina and the Southeast come for the comprehensive medical services offered at UNC. Obstetrical Care Facilities

The Women’s Hospital includes Labor and Delivery, an Obstetric Inpatient Unit, the Newborn Nursery, and Women’s Outpatient Services and represents the state of the art in facilities. The L and D unit (20,000 sq. feet) consists of five triage rooms, four LDRPs, 10 LDRs, and three operating rooms. Located one floor above L and D is the combined postpartum unit with 28 private rooms, and the

newborn nursery with 14 bassinets. Located one floor below L&D is a 13-bed antepartum unit, dedicated to high-risk obstetrical patients. Outpatient obstetrical care is practiced within the Women’s Clinic (~23,000 sq. feet), located within the Women’s Hospital. Fellows attend their continuity clinic, consultation clinic, and High Risk Clinic under the direct supervision of a member of the Maternal Fetal Medicine faculty. The OB high-risk clinic has 4 physician modules, with a total of 8 exam rooms. The University of North Carolina Obstetric Ultrasound Unit maintains American Institute of Ultrasound in Medicine certification and is located within the Women’s Clinic at the North Carolina Women’s Hospital. The unit is staffed by nine American Registry for Diagnostic Medical Sonography certified sonographers. There is a full time genetic counselor to assist in counseling of obstetric patients with fetal anomalies. Current equipment includes seven General Electric Voluson 730 with color and pulsed Doppler capability, and 3-D and 4-D capability (including STIC technology). Maternal Fetal Medicine faculty directly supervises fellows during their ultrasound rotation. Educational Curriculum High-Risk Obstetrics and Maternal Physiology Skill in caring for the in-patient high-risk pregnancy is acquired during the Antepartum and Labor and Delivery coverage. During the Labor and Delivery coverage, the fellow manages the high-risk in-patient service, under supervision of the Maternal Fetal Medicine faculty. Also during the Labor and Delivery coverage, the fellow is responsible for coordination and execution of clinical care for all in-patient obstetrical transports, under the supervision of the faculty as back-up. The fellow acquires outpatient management skills during participation in their own weekly continuity of care clinic, and by participating in once weekly High Risk Pregnancy Clinic and once weekly High Risk Consultation Clinic, all of which are supervised by a member of the Maternal Fetal Medicine faculty

A unique opportunity for educational experience is through the Center for Maternal Infant Health. (https://www.mombaby.org/) The Center for Maternal Infant Health provides a variety of services to patients and referring providers who are in need of perinatal care coordination. There is an established special program for pregnant women who have a medical emergency and need transport to UNC.

The Maternal Transport Program is designed to provide pregnant women with individualized and personalized services while they are at UNC. In addition to referral services, care coordination, and multidisciplinary clinical care, the Center for Maternal Infant Health offers perinatal hospice services to those families whose infant is not expected to survive. Fellows actively participate in the services

provided by the Center, including presentation of ongoing and new cases at the weekly Perinatal Care Conference. Genetics The Reproductive Genetics Division has five Board Certified/Eligible Genetic Counselors who provide over 2,000 preconceptional or prenatal counseling visits each year. Dr. Neeta Vora, who is board certified in both Genetics and Maternal Fetal Medicine, helps to oversee this division. During two four-week Genetics rotations, the fellow observes and then performs genetic counseling during eight half day sessions for such conditions as advanced maternal age, abnormal serum screening, personal or family history of genetic disorder, and current pregnancy with anomalous fetus, supervised by one of the genetic counselors. The fellow attends the Multidisciplinary Patient Care Conference, and two weekly clinical genetics conferences, one of which is dedicated to the discussion of perinatal patients. Time is spent rotating through the Cytogenetics Laboratory. During the second or third year the fellow completes the Society for Maternal Fetal Medicine Nuchal Translucency Certification. A didactic series specifically dedicated to Reproductive Genetics is conducted by our genetic counselors and Dr. Vora. Ultrasound

The fellow is assigned to seven months of specialized ultrasound training, under the direct supervision of the Maternal Fetal Medicine faculty, where responsibilities are acquired with a graduated level of experience and skill. Over 12,000 ultrasound examinations, 200 amniocenteses, and 50 CVS procedures are

performed annually. The first month is spent observing targeted ultrasounds and faculty assigned to the ultrasound unit directly supervises fellows as they gain proficiency in the ultrasound equipment and basic hands-on ultrasound experience. During the second through fifth months the fellow completes basic and targeted ultrasounds, which are then reviewed by the sonographer and the attending faculty. Fellows also perform ultrasounds on suspected anomalies, present their findings to the attending in the unit and then participate in a confirmatory ultrasound. During the last two months, the fellow interprets ultrasounds independently, and then reviews images with the faculty member for feedback. Fellows are expected to interpret ultrasound images, develop a differential diagnosis of the findings, recommend further evaluation if appropriate, and develop a management plan for the patient. During the ultrasound rotation the fellow presents fetal anomaly patients at the weekly Multidisciplinary Perinatal Care Conference, and facilitates discussion of the obstetrical and neonatal management plan. Other – Clinical Rotations During the first year, the fellow completes rotations in the following disciplines: NICU, Medical ICU, and Obstetrical Anesthesia. During these rotations the fellow acts as a member of the clinical care team, under the supervision of the faculty of

that discipline. During the third year, the fellow completes a rotation in Pediatric Cardiology, under the supervision of a Pediatric Cardiologist. Departmental/Divisional Educational Conferences There are several departmental and divisional educational conferences available to fellows. Fellows are expected to attend Departmental Grand Rounds, Morbidity and Mortality Conference, as well as the Fellow’s Journal Club, Fellow’s Research meetings, and Fellow’s Didactic Series. In addition, all fellows attend the clinical conferences, including the High Risk Obstetrical Conference, the Multidisciplinary Perinatal Care Conference, and the In-Patient Care Conference. The third year fellow is expected to present at the Departmental Grand Rounds Conference. Research Curriculum Eighteen months of dedicated research time is allotted to each fellow. Typically 4 months are scheduled during the first year of fellowship, 9 months during the second year, and 5 during the third year. Research time during the first year is used to develop research ideas, identify research project(s) and appropriate mentor(s) to perform the research. Research meetings occur on a regular basis throughout the year. Progress is then monitored on a regular basis by the primary mentor and program director on a quarterly basis. It is expected the fellow will complete at least one primary research project during the fellowship; many of our fellows complete several projects. Fellows are encouraged to explore clinical, basic, or translation science research, and there are many resources available to achieve this objective. Fellows present their research every 6 months at “Work In Progress” meetings held with division members and invited guests. Departmental Resources Members of the Department of Ob/Gyn have approximately 2000 sq. feet of dedicated laboratory space. The laboratories are fully equipped for basic and molecular laboratory analyses, and cell and tissue culture (four -80 °C freezers, four thermocyclers, a Stratagene real-time thermocycler, three CO2 incubators for cell culture, two biosafety cabinets for tissue culture, an isolation hood for RNA, and blot equipment). The laboratories are staffed by two full-time research specialists, one full-time post doctural scientist, and one PhD scientist. Fellows have access to all of the laboratory resources. As members of the Maternal Fetal Medicine Network (MFMU), the fellows have available to them a group of obstetrical research nurses who are experienced in conducting clinical research. Ms. Karen Dorman, the Director of Perinatal Research, coordinates all clinical obstetrical research at UNC, and is available to assist fellows with the planning and conduct of clinical research projects. Fellows are also encouraged to submit ideas for secondary analyses and ancillary projects to on-going Network research. School of Medicine Resources Numerous campus-wide research resources are available to the fellow. The division employs a full-time research assistant, Karen Dorman, to aid in the execution of

clinical research. She is available to help with IRB submissions, recruitment, collection of data or samples, and subject follow up. The North Carolina Translational and Clinical Sciences (NC TraCS) Institute is one of 60 medical research institutions working together as a national consortium to improve the way biomedical research is conducted across the country. The consortium, funded through the NIH Clinical and Translational Science Awards (CTSA), shares a common vision to facilitate laboratory discoveries and clinical research (http://tracs.unc.edu/). There are a number of resources available to all UNC investigators, including fellows. These resources include a Biostatistical/Epidemiology Consultation Service, an Informatics Core, and the Bioanalytic Core Laboratory and Mass Spectrometry Facility. There is an Investigational Drug Service (IDS), which provides comprehensive drug distribution and patient care pharmacy services for clinical trials at UNC Hospitals. IDS services include study drug randomization, blinding and protocol development for drug administration. Many state-of-the-art core laboratory facilities are available on campus, which provide efficient use of technical staff, equipment, and facilities. Core labs have combinations of state, federal, and institutional funding support for sharing, and a mandate to assist in the career development of new investigators, which would include fellows. Core facilities are numerous and range from Animal Facilities, to Molecular Genetics, to Pathology and Microscopy. In addition to the above resources, faculty in maternal fetal medicine collaborate across campus with numerous other investigators, which allows fellows to participate in multidisciplinary research. Professional Development The program directors meet regularly with the fellows to discuss issues germane to the fellowship. Research ideas and progress, questions and ideas to improve the fellowship, and overall progress are some of the topics covered at this meeting. All fellows attend the annual meeting of the Society for Maternal Fetal Medicine. Attendance at other scientific meetings is encouraged. Many of the fellows attend several scientific meetings a year to present their research. Fellows are also invited to attend the NICHD Perinatal-Neonatal Fellow Conference, and the Molecular Biology Workshop, both offered annually. Fellows Schedule Fellows call schedule is 3 nights/month (1 weekend and 2 weekdays). Fellows do not round on weekends they are not on call. During 2 months each year each fellow does not take call.

Standard Fellowship Track

Year 1 of 3 Year 2 of 3 Year 3 of 3 Rotation / #Months Rotation / #Months Rotation / #Months Antepartum/2 Research/9 Research/5 L&D/1 Ultrasound/2 Ultrasound/2 Ultrasound/2 Antepartum/1 Antepartum/1 Research/4 L&D/1 Genetics/1 Elective/1 NICU/Anesth/1 Fetal Echo/1 MICU/1 Genetics/1

2020-21 GME Pay and Benefits Salary Vacation 1st Year $64,168 21 days 2nd Year $66,622 21days 3rd Year $67,017 21 days

Fringe Benefits Health Insurance Yes Disability Insurance Yes Life Insurance Yes Dental Yes Malpractice Insurance Yes Freedom Pay for Meals Monthly Allotment Uniforms (white coats) Yes Administrative Assistant Support Yes Discretionary Fund $1875/year Maternity/Paternity Leave Yes

1-2018

GRADUATE LEVEL COURSE Requirements for UNC MFM Fellowship Fellows are required to take a minimum of two graduate level courses, typically during the 2nd year. Unless prior graduate training, should consider taking one Epi and one Stats course. Recommended courses include: • PUBH 741: Quantitative Methods for Health Care Professionals: Offered in the fall (J

Garrett or K Faurot). Learn Stata. Designed for health care professionals needing to appraise the design and analysis of health care studies and intending to pursue academic research careers. The emphasis of the course is on applied data analysis of major health-related studies. Must E-mail the course director for permission if you are not in a degree program.

And then one of the following courses: • EPI 711: Clinical Measurement/Evaluation: Only offered in the fall (Dr. Narpravnik)

Prerequisite, epidemiology or health care and prevention major. An introduction to the fundamental concepts of epidemiology, including clinical epidemiology, for clinicians. Emphasis is to applications in clinical research and practice. This course is a lot of work.

• PUBH 742: Advanced Quantitative Methods for Health Care Professionals: Offered

in the spring (J Garrett). Continuation of PUBH 741 with understanding of exploratory data analysis, logistic regression, and survival analysis.

.

Fellow Publications & Presentations

Year 1 Fellows: (Graduating 2023) Kathleen Drexler Davidson C, Bellows P, Shah U, Hawley L, Drexler K, et al. Outcomes associated with trial of labor after cesarean in women with one versus two prior cesarean deliveries after a change in clinical practice guidelines in an academic hospital. J Matern Fetal Neonatal Med. 2019;1–6. Shah U, Bellows P, Drexler K, et al. Comparison of induction of labor methods for unfavorable cervices in trial of labor after cesarean delivery. J Matern Fetal Neonatal Med. 2017;30(9):1010–1015. Elizabeth Nicole Teal Teal EN, Lewkowitz AK, Koser SLP, Tran CBN, Gaw SL. Quantifying the Risks and Benefits of Continuing Labor Induction: Data for Shared Decision-Making [published online ahead of print, 2020 Feb 3]. Am J Perinatol. 2020;10.1055/s-0039-1701025.

Year 2 Fellows: (Graduating 2022)

Divya Mallampati Mei JY, Mallampati D, Pluym ID, Han CS, Afshar Y. Twin vaginal deliveries in labor rooms: A cost-effective analysis Poster, SMFM Conference, Grapevine, TX, 2020. Copel JA, Platt LD, Hobbins JC, Afshar Y, Grechukhina O, Mallampati D, et al. Gottesfeld-Hohler Memorial Foundation Risk Assessment for Early-Onset Preeclampsia in the United States: Think Tank Summary. Obstet Gynecol. 2020;135(1):36–45. Mallampati D, Grobman W, Rouse DJ, Werner EF. Strategies for Prescribing Aspirin to Prevent Preeclampsia: A Cost-Effectiveness Analysis. Obstet Gynecol. 2019;134(3):537–544. Asha Talati Talati AN, Gilmore KL, Hardisty E, Lyerly A, Rini C, Vora NL. Impact of prenatal exome-sequencing (ES) for fetal diagnosis on maternal psychological outcomes: a prospective cohort. Poster, SMFM Conference, Grapevine, TX, 2020. Talati AN, Webster CM, Vora NL. Prenatal genetic considerations of congenital anomalies of the kidney and urinary tract (CAKUT). Prenat Diagn. 2019;39(9):679–692.

Year 3 Fellows: (Graduating 2021) Anne West Honart Honart A, Pfister A, Battarbee AN, Manuck T. Time to delivery after cervical cerclage removal. Poster presented at: SMFM Conference, Grapevine, TX, 2020. West Honart A, Talati AN, Johnson JD, Vladutiu C, Goodnight W, Manuck TA. Spontaneous preterm birth phenotype and initial neonatal and early childhood outcomes Poster, February 2019, Society for Maternal-Fetal Medicine Annual Meeting, Las Vegas, NV Jasmine Johnson Johnson J, Green C, Vladutiu C, Manuck T. Racial disparities in preeclampsia and growth restriction persist among women of high socioeconomic status (SES). Poster presented at: SMFM Conference, Grapevine, TX, 2020. Johnson J, Robinson S, Smeester L, Fry R, Boggess K, Vora N. Ubiquitous identification of inorganic arsenic in a cohort of second trimester amniotic fluid in women with preterm and term births. Reprod Toxicol. 2019;87:97–99.

Johnson, JD, Stuebe, A, Asiodu, I. Using the Electronic Medical Record to Identify Racial Disparities in Post-partum Pain Management. Poster presented at: The Minority Health Conference; Chapel, Hill, NC, USA. 2019. Johnson, JD, Vuletich, H., Stuebe, A. Associations Between Racial Bias and Adverse Perinatal Outcomes. Poster presented at: ACOG Clinical and Scientific Meeting. May 2019 Johnson, JD, Talati, A, West-Honart, A,Vladutiu, C., Goodnight, WH, Manuck, TA. Recurrent Preterm Birth Phenotype by Gestational Age. Poster presented at: The Society for Maternal Fetal Medicine National Meeting; Las Vegas, NV, USA; February 2019

Past Fellow Theses

Year Fellow Thesis Title

2014 Beamon Is the type of neuraxial anesthesia associated with adverse neonatal outcomes among patients with preeclampsia?

2014 Smith Risk of uterine rupture among women attempting vaginal birth after cesarean with an unknown scar

2015 Wiegand Buprenorphine/Naloxone versus Methadone Treatment in Pregnancy: A Comparison of Neonatal Abstinence Syndrome

2015 Stringer Coverage of 17-Hydroxyprogesterone Caproate (17P) Among Eligible Women Delivering at two North Carolina Hospitals in 2012 and 2013

2016 McPherson Association of duration of neuroprotective magnesium sulfate on neonatal and maternal outcomes

2016 Smid Positive feedback between soluble fms-like tyrosine kinase-1 (sFlt-1) and endothelin-1 (ET-1) in mouse endothelial and human trophoblast cells

2017 Dotters-Katz The Effect of Blood Loss on Cefazolin Levels in Women Undergoing Cesarean Delivery

2017 Grace Effect of high fat diet and metformin on pup weight and placental mTOR signaling in mice

2018 Carlson Use of a Novel Decision Aid for Aneuploidy Screening: A randomized controlled trial

2018 Grant Early Pregnancy HgbA1c Screening for Overt Type 2 Diabetes in At Risk Women

2019 Battarbee Maternal and neonatal outcomes associated with timing of amniotomy with term labor induction

2019 Glover Elevated mid-trimester serum cytokines are associated with PTB in women undergoing cerclage placement

Faculty Bio-Summaries Kim Boggess, MD, Professor__________________________________________________________________ Dr. Boggess is a Professor with the Division of Maternal Fetal Medicine with specialized training in Infectious Diseases and a Certificate in Health Disparities Research. She has a special interest and expertise in oral infections and pregnancy outcomes, and was the first investigator to report an association between maternal periodontal infection and preeclampsia. She currently is conducting studies on improving maternal oral health to benefit both mother and child. In addition she is a co-investigator of a study on optimal antibiotic use at time of cesarean section to reduce infectious morbidity. As the alternate PI for the Maternal Fetal Medicine Units Network she is also the Co-PI for a proposal on optimal treatment of type 2 Diabetes in pregnancy. Positions & Honors

Professor, Department of Obstetrics and Gynecology 2011–present Program Director, Training Epidemiology and Clinical Trials (TECT) Fellowship UNC 2012–present Program Director, Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) 2012–present

Other Experience & Professional Memberships Pregnancy and Neonatology Study Section, NICHD 2005–present

Biomedical Institutional Review Board, University of North Carolina 2008–present

Most Recent Peer-Reviewed Publications Battarbee AN, Venkatesh KK, Aliaga S, Boggess KA. The association of pregestational and gestational diabetes with severe neonatal morbidity and mortality. J Perinatol. 2020;40(2):232–239. Glover AV, Battarbee AN, Gyamfi-Bannerman C, Boggess KA, et al. Association Between Features of Spontaneous Late Preterm Labor and Late Preterm Birth [published online ahead of print, 2019 Sep 17]. Am J Perinatol. 2019;10.1055/s-0039-1696641. Battarbee AN, Cavallini M, Keller C, Boggess KA. Missed Opportunities for Early Diabetes Screening in Pregnancy [published online ahead of print, 2019 Aug 17]. Am J Perinatol. 2019;10.1055/s-0039-1694727. Ausbeck EB, Jauk VC, Boggess KA, et al. Impact of Azithromycin-Based Extended-Spectrum Antibiotic Prophylaxis on Noninfectious Cesarean Wound Complications. Am J Perinatol. 2019;36(9):886–890. Battarbee AN, Aliaga S, Boggess KA. Management of diabetic women with threatened preterm birth: a survey of Maternal-Fetal Medicine providers [published online ahead of print, 2019 Jan 24]. J Matern Fetal Neonatal Med. 2019;1–9. Battarbee AN, Clapp MA, Boggess KA, et al. Practice Variation in Antenatal Steroid Administration for Anticipated Late Preterm Birth: A Physician Survey. Am J Perinatol. 2019;36(2):200–204. Becker-Dreps S, Butler AM, McGrath LJ, Boggess KA, et al. Effectiveness of Prenatal Tetanus, Diphtheria, Acellular Pertussis Vaccination in the Prevention of Infant Pertussis in the U.S. Am J Prev Med. 2018;55(2):159–166. Boggess KA, Baker JB, Murtha AP, et al. Pharmacokinetics of Hydroxyprogesterone Caproate and its Primary Metabolites during Pregnancy. AJP Rep. 2018;8(2):e106–e112. Zerden ML, Castellano T, Doll KM, Stuart GS, Munoz MC, Boggess KA. Risk-Reducing Salpingectomy Versus Standard Tubal Sterilization: Lessons From Offering Women Options for Interval Sterilization. South Med J. 2018;111(3):173–177. Berggren EK, Boggess KA, Mathew L, Culhane J. First Trimester Maternal Glycated Hemoglobin and Sex Hormone-Binding Globulin Do Not Predict Third Trimester Glucose Intolerance of Pregnancy. Reprod Sci. 2017;24(4):613–618. Ongoing Research Support 2018-2020 Fetal metabolic consequences of late preterm steroid exposure NIH Role: Co-Primary Investigator 2014-2020 Chronic Hypertension and Pregnancy NIH Role: Co-Invesigator 2019-2024

Childhood Neurodevelopment and Obesity: C/SOAP Follow-up Study I NIH Role: Co-Invesigator 2019-2021 Comparative safety of ondansetron versus alternative antiemetics in pregnancy NIH Role: Co-Invesigator 2020-2025 Lifestyle behaviors and cardiometabolic disease risk in college-based young adults NIH Role: Co-Invesigator 2019-2024 Mechanisms of altered drug metabolism in pregnancy NIH Role: Co-Invesigator 2015-2020 UNC BIRCWH NIH Role: Primary Investigator 2016-2021 MOMPOD NIH Role: Co-Primary Investigator 2019-2024 North Carolina Collaborative to Prevent Diabets in Pregnancy NIH Role: Co-Primary Investigator 2020-2022 Diagnosis and monitoring of gestational diabetes by quantitative detection of acetone in breath NIH Role: Primary Investigator

Nancy Chescheir, MD, Professor_______________________________________________________ Dr. Nancy Chescheir is a professor of obstetrics and gynecology and a maternal-fetal medicine specialist. Her primary interests are in global women's health, fetal disorders, and high order multiple gestations. She has served in multiple administrative roles, including the chair of obstetrics and gynecology at Vanderbilt University School of Medicine, acting chair at UNC School of Medicine, Associate Dean for the Curriculum at UNC, Chief of Staff at Bokamoso Private Hospital in Botswana and scientific program director for the NICHD Randomized Controlled Trial of in utero v standard repair of fetal myelomeningocele. Currently she is serving as the Director of Prenatal Diagnosis with clinical and research interest in advanced obstetrical ultrasound and fetal therapy, clinical informatics, quality improvement and patient safety. Dr. Chescheir was recently appointed Editor in Chief of our specialty’s leading journal, Obstetrics and Gynecology. Positions & Honors

University of North Carolina, Chapel Hill Chief of Staff; Director, Women’s and Children’s Services

2008–present

Editor in Chief, Obstetrics and Gynecology 2013-present Consultant, MED-CPU OB Program 2015–present Academy of Educators elected member, UNC 2009–present

Other Experience & Professional Memberships

University Health system Consortium Obstetrical Steering Committee 2007–present ACOG, Committee on Obstetrics 2008–present ACOPG, Committee to write ―Pregnancy, Birth and Beyond‖ 2nd (1995), 3rd (1998 – 1999), 4th (2003 – 2004), 5th editions

2008–present

ACOG Precis 2008–present Most Recent Peer-Reviewed Publications Abbasi A, Watters J, Kim T, Chescheir NC. Connect the Dots-February 2020. Obstet Gynecol. 2020;135(2):479–480. Devin KM, Stowers PN, Wasickanin ME, Chescheir NC. Connect the Dots-January 2020. Obstet Gynecol. 2020;135(1):215–216. Chescheir NC. We Don't Practice in a Vacuum. Obstet Gynecol. 2020;135(1):1–3. Aksel S, Wannamaker LR, Lesser HT, Chescheir NC. Connect the Dots-December 2019. Obstet Gynecol. 2019;134(6):1361–1362. Wong ML, Dolan SM, Wright S, Chescheir NC. Connect the Dots-November 2019. Obstet Gynecol. 2019;134(5):1112–1113. Hollenbach SJ, Slocum B, Kailasam A, Chescheir NC. Connect the Dots-October 2019. Obstet Gynecol. 2019;134(4):878–879. Chescheir NC. Serum Uric Acid Measurement in Women With Hypertensive Disorders of Pregnancy. Obstet Gynecol. 2019;134(3):636–638. Fee EK, Cutler A, Nicasio E, Chescheir NC. Connect the Dots-September 2019. Obstet Gynecol. 2019;134(3):646–647. Saiz AM, Thomas MC, Sax M, Chescheir NC. Connect the Dots-August 2019. Obstet Gynecol. 2019;134(2):416–417. Pace ND, Siega-Riz AM, Olshan AF, Chescheir NC, et al. Survival of infants with spina bifida and the role of maternal prepregnancy body mass index. Birth Defects Res. 2019;111(16):1205–1216.

Elizabeth Coviello, DO, Assistant Professor_________________________________________________ Dr. Coviello earned her Bachelor of Arts in Broadcast Journalism from Pennsylvania State University in 2007 and her Doctor of Osteopathic Medicine from the University of New England in 2012. She completed her Obstetrics and Gynecology residency in 2016 at MedStar Washington Hospital Center and MedStar Georgetown University Medical Center in Washington, DC, where she was elected by her peers to serve as Administrative Chief Resident and received multiple teaching awards. Throughout her career, Dr. Coviello has been actively involved in obstetric quality improvement initiatives and committees. She has extensive experience with postpartum hemorrhage and quantifying blood loss. She serves on UNCH’s postpartum hemorrhage task force. In the clinical arena she works with management of medically complicated pregnancies, labor and delivery, and prenatal diagnosis. Her clinical interests include maternal health, preeclampsia, lupus and autoimmune diseases. Dr. Coviello’s research interests include preeclampsia, obstetrical hemorrhage and clinical blood loss. Professional Memberships

Most Recent Peer-Reviewed Publications Adams AD, Coviello EM, Drassinower D. The Effect of Maternal Obesity on Oxytocin Requirements to Achieve Vaginal Delivery [published online ahead of print, 2019 Aug 20]. Am J Perinatol. 2019;10.1055/s-0039-1694982. Coviello EM, Grantz KL, Huang CC, Kelly TE, Landy HJ. Risk factors for retained placenta. Am J Obstet Gynecol. 2015;213(6):864.e1–864.e11. Kawakita T, Bowers K, Coviello E, et al. Prepregnancy Weight in Women with Type I Diabetes Mellitus: Effect on Pregnancy Outcomes. Am J Perinatol. 2016;33(13):1300–1305. Drassinower D, Coviello E, Landy HJ, Gyamfi-Bannerman C, Perez-Delboy A, Friedman AM. Outcomes after periviable ultrasound-indicated cerclage. J Matern Fetal Neonatal Med. 2019;32(6):932–938. Coviello EM, Iqbal SN, Grantz KL, Huang CC, Landy HJ, Reddy UM. Early preterm preeclampsia outcomes by intended mode of delivery. Am J Obstet Gynecol. 2019;220(1):100.e1–100.e9. Coviello E, Iqbal S, Kawakita T, et al. Effect of Implementing Quantitative Blood Loss Assessment at the Time of Delivery. Am J Perinatol. 2019;36(13):1332–1336. Starikov RS, Inman K, Has P, Iqbal SN, Coviello E, He M. Correlation of placental pathology and perinatal outcomes with Hemoglobin A1c in early pregnancy in gravidas with pregestational diabetes mellitus. Placenta. 2017;52:94–99. Starikov R, Inman K, Chen K, Lopes V, Coviello E, et al. Comparison of placental findings in type 1 and type 2 diabetic pregnancies. Placenta. 2014;35(12):1001–1006. Richter LA, Coviello E, Loftus K, Gutman RE. Uretero-Uterine Fistula: Delayed Presentation After Ureteral Reimplantation for Vesicoureteral Reflux. Female Pelvic Med Reconstr Surg. 2015;21(4):e36–e38.

Communications Committee, Member Society for Maternal-Fetal Medicine

2019-present

American College of Obstetrics and Gynecology 2012-present Director, Fourth year student Maternal-Fetal Medicine Elective 2019–present

Angelica Glover, MD, Assistant Professor__________________________________________________ Dr. Glover received her Bachelor of Science in Chemistry from Texas A&M University in 2006 and her M.D. from the University of Texas Medical Branch at Galveston in 2012. She completed her Obstetrics and Gynecology residency at the University of Alabama at Birmingham in 2016 and her Maternal-Fetal Medicine fellowship at UNC in 2019. Her clinical interests include hypertensive disorders of pregnancy, maternal cardiac disease, placenta accreta spectrum, obstetric surgical complications. and postpartum care (the “4th trimester”). Dr. Glover is actively involved in obstetric quality improvement initiatives within UNC and through the Perinatal Quality Collaborative of North Carolina. She is engaged in advocacy efforts at the state level through the Society for Maternal-Fetal Medicine State Liaison Network and the National Hispanic Medical Association. Professional Memberships

National Hispanic Medical Association 2019-Present

North Carolina Obstetrical and Gynecological Society 2016-Present

Society for Maternal-Fetal Medicine 2014-Present

American College of Obstetricians and Gynecologists 2012-Present

Most Recent Peer-Reviewed Publications Glover AV, Battarbee AN, Heine RP, Dotters-Katz S. Association of Treatment of Chorioamnionitis with Non-Beta Lactam Antibiotics and Postcesarean Infectious Morbidity [published online ahead of print, 2019 Oct 10]. Am J Perinatol. 2019;10.1055/s-0039-1697675. Glover AV, Battarbee AN, Gyamfi-Bannerman C, et al. Association Between Features of Spontaneous Late Preterm Labor and Late Preterm Birth [published online ahead of print, 2019 Sep 17]. Am J Perinatol. 2019;10.1055/s-0039-1696641. Battarbee AN, Glover AV, Stamilio DM. Association between early amniotomy in labour induction and severe maternal and neonatal morbidity [published online ahead of print, 2019 Jul 10]. Aust N Z J Obstet Gynaecol. 2019;10.1111/ajo.13031. Battarbee AN, Glover AV, Vladutiu CJ, et al. Risk factors associated with prolonged neonatal intensive care unit stay after threatened late preterm birth [published online ahead of print, 2019 Jun 6]. J Matern Fetal Neonatal Med. 2019;1–6. Battarbee AN, Glover AV, Vladutiu CJ, et al. Sex-Specific Differences in Late Preterm Neonatal Outcomes. Am J Perinatol. 2019;36(12):1223–1228. Venkatesh KK, Glover AV, Vladutiu CJ, Stamilio DM. Association of chorioamnionitis and its duration with adverse maternal outcomes by mode of delivery: a cohort study. BJOG. 2019;126(6):719–727. Glover AV, Tita A, Biggio JR, Anderson SB, Harper LM. Incidence and Risk Factors for Postpartum Severe Hypertension in Women with Underlying Chronic Hypertension. Am J Perinatol. 2019;36(7):737–741. Glover AV, Berry DC, Schwartz TA, Stuebe AM. The Association of Metabolic Dysfunction with Breastfeeding Outcomes in Gestational Diabetes. Am J Perinatol. 2018;35(14):1339–1345. Glover AV, Manuck TA. Screening for spontaneous preterm birth and resultant therapies to reduce neonatal morbidity and mortality: A review. Semin Fetal Neonatal Med. 2018;23(2):126–132. Harper LM, Glover AV, Biggio JR, Tita A. Predicting failure of glyburide therapy in gestational diabetes. J Perinatol. 2016;36(5):347–351.

William Goodnight III, MD, MSCR, Associate Professor___________________________________ William Goodnight, MD, MSCR is an Associate Professor whose current research interests include prenatal diagnosis and ultrasound with projects including evaluating the natural history of ventriculomegaly in fetuses with open neural tube defects, long term neurological outcomes of newborns following PPROM compared to PTB for other indications, creation of a database for NAFTNET for twins complicated by TTTS, and establishing a biobank at UNC for fetus with fetal anomalies. Dr. Goodnight is also interested in decision analyses, and is collaborating with the school of public health on a decision analysis evaluating the cost effectiveness of Amnisure for the diagnosis of PPROM. His current clinical activities include prenatal diagnosis and management of medical complications of pregnancy.

Positions & Honors

Associate Professor, Division of Maternal Fetal Medicine 2014-present

Medical Director, UNC Fetal Care Program, UNC Chapel Hill NC

2012–present

American Journal of Perinatology editorial board member

Most Recent Peer-Reviewed Publications Kessler BA, Catalino MP, Quinsey C, Goodnight W, Elton S. Cost of prenatal versus postnatal myelomeningocele closure for both mother and child at 1 year of life. Neurosurg Focus. 2019;47(4):E15. Cools M, Northam W, Goodnight W, Mulvaney G, Elton S, Quinsey C. Thirty-day medical and surgical readmission following prenatal versus postnatal myelomeningocele repair. Neurosurg Focus. 2019;47(4):E14. Goodnight WH, Bahtiyar O, Bennett KA, et al. Subsequent pregnancy outcomes after open maternal-fetal surgery for myelomeningocele. Am J Obstet Gynecol. 2019;220(5):494.e1–494.e7. Brancazio S, Saramago I, Goodnight W, McGinty K. Cesarean scar ectopic pregnancy: Case report☆. Radiol Case Rep. 2019;14(3):354–359. Published 2019 Feb 2. Ning A, Vladutiu CJ, Dotters-Katz SK, Goodnight WH, Manuck TA. Gestational age at initiation of 17-alpha hydroxyprogesterone caproate and recurrent preterm birth. Am J Obstet Gynecol. 2017;217(3):371.e1–371.e7. Dotters-Katz SK, Myrick O, Smid M, Manuck TA, Boggess KA, Goodnight W. Use of prophylactic antibiotics in women with previable prelabor rupture of membranes. J Neonatal Perinatal Med. 2017;10(4):431–437. Myrick O, Dotters-Katz S, Grace M, Manuck T, Boggess K, Goodnight W. Prophylactic Antibiotics in Twin Pregnancies Complicated by Previable Preterm Premature Rupture of Membranes. AJP Rep. 2016;6(3):e277–e282. Moise, K. J., Jr, Moldenhauer, J. S., Bennett, K. A., Goodnight, W., Luks, F. I., Emery, S. P., … Wetjen, N. M. (2016). Current Selection Criteria and Perioperative Therapy Used for Fetal Myelomeningocele Surgery. Obstetrics and gynecology, 127(3), 593–597. Smid MC, Waltner-Toews R, Goodnight W. Spontaneous Posterior Uterine Rupture in Twin-Twin Transfusion Syndrome. AJP Rep. 2016 Mar;6(1):e68-70. PMID: 26929874 Goodnight W. Clinical Application of Progesterone for the Prevention of Preterm Birth, 2016. Am J Perinatol. 2016;33(3):253–257. Ongoing Research Support 2015 – present MORe AHEC NC AHEC Innovation Grant Role: PI 2012 – present Randomized trial to prevent congenital Cytomegalovirus Infection. NICHD – Maternal Fetal Medicine Network Units. Role: UNC Site PI August 2011 – present Early Brain Development in Twins National Institutes of Health (NIH) PI: John Gilmore

Christina Herrera, MD, MSCI, Assistant Professor__________________________________________ Dr. Herrera is the resident OB rotation director and the OB service line leader. She also runs an obstetric emergencies simulation program. She completed her OBGYN residency at UNC and her MFM fellowship at University of Utah, where she also obtained a Masters of Science in Clinical Investigation (MSCI). She is most passionate about maternal care, medical disorders and complications of pregnancy. Dr. Herrera currently runs a combined chronic kidney disease in pregnancy clinic with Dr. Monica Reynolds, a UNC nephrologist with a passion for obstetrics. She loves to teach; working with residents and fellows is one of the things that keeps her going and makes her love academic medicine. Most Recent Peer-Reviewed Publications Heuser CC, Gibbins KJ, Herrera CA, Theilen LH, Holmgren CM. Moms in medicine: Job satisfaction among physician-mothers in obstetrics and gynecology. Work. 2018;60(2):201–207. Herrera CA, Manuck TA, Stoddard GJ, et al. Perinatal outcomes associated with intrahepatic cholestasis of pregnancy. J Matern Fetal Neonatal Med. 2018;31(14):1913–1920. Herrera CA, Stoerker J, Carlquist J, et al. Cell-free DNA, inflammation, and the initiation of spontaneous term labor. Am J Obstet Gynecol. 2017;217(5):583.e1–583.e8. Herrera CA, Silver RM. Perinatal Asphyxia from the Obstetric Standpoint: Diagnosis and Interventions. Clin Perinatol. 2016;43(3):423–438. Manuck TA, Herrera CA, Korgenski EK, et al. Tocolysis for Women With Early Spontaneous Preterm Labor and Advanced Cervical Dilation. Obstet Gynecol. 2015;126(5):954–961.

Julie M. Johnson, MD, Clinical Assistant Professor________________________________________ A graduate of the University of North Carolina at Chapel Hill with a B.S. in biology, Dr. Johnson earned her medical degree from the Wake Forest University School of Medicine. She completed a residency in obstetrics and gynecology at Palmetto-Richland Memorial Hospital/University of South Carolina School of Medicine and a fellowship in maternal-fetal medicine at Women & Infants Hospital of Rhode Island/the Warren Alpert School of Medicine at Brown University. Board certified in obstetrics & gynecology, she was previously a member of the active medical staff at Women & Infants Hospital and at Rhode Island Hospital, both in Providence, R.I., and a consulting physician for four hospitals in Massachusetts and Rhode Island. Dr. Johnson expects that most of her practice at Moore Regional will involve patients in the following three categories: women who have complicated medical problems that are not related to their pregnancy, women who have problems that are directly related to their pregnancy, and healthy women who are carrying a fetus with a medical problem or problems. Most Recent Peer-Reviewed Publications Johnson J, Anderson B. Screening, prevention, and treatment of congenital cytomegalovirus. Obstet Gynecol Clin North Am. 2014;41(4):593–599. Johnson J, Clifton RG, Roberts JM, et al. Pregnancy outcomes with weight gain above or below the 2009 Institute of Medicine guidelines. Obstet Gynecol. 2013;121(5):969–975. Johnson JM, Anderson BL. Cytomegalovirus: should we screen pregnant women for primary infection?. Am J Perinatol. 2013;30(2):121–124. Johnson J, Anderson B, Pass RF. Prevention of maternal and congenital cytomegalovirus infection. Clin Obstet Gynecol. 2012;55(2):521–530. Johnson JM, Chauhan SP, Lopes V, Sibai B, Abuhamad AZ. Society of Maternal-Fetal Medicine annual meeting and a continuing medical education course: results of pre- and postcourse survey. Am J Perinatol. 2012;29(10):833–841.

Tracy Manuck, MD, Assistant Professor___________________________________________________ Dr. Manuck is an Associate Professor in the Department of Obstetrics and Gynecology in the Division of Maternal Fetal Medicine and is the Perinatal Section Head of the Institute for Environmental Health Solutions. Dr. Manuck has been at UNC for over 5 years and is committed to improving the lives of women and children through a combination of clinical care and high-quality patient-oriented research. Her research and clinical interests and expertise include preterm labor (including cervical insufficiency and preterm premature rupture of membranes), multiple gestations (including complicated twin, triplet, and higher order multiples), and caring for pregnancies complicated by fetal chromosomal or structural anomalies. She is the founder and Medical Director of the UNC Prematurity Prevention Program, which complements her ongoing research efforts. This program cares for women with the most severe, highest risk SPTB phenotypes. Dr. Manuck co-directs the MFM fellowship research education program and is privileged to advise dozens of young investigators in patient-oriented research, including students, MDs, and PhDs. Most Recent Peer-Reviewed Publications Mogos MF, Liese KL, Thornton PD, Manuck TA, OʼBrien WD Jr, McFarlin BL. Inpatient Maternal Mortality in the United States, 2002-2014. Nurs Res. 2020;69(1):42–50. Venkatesh KK, Manuck TA. Maternal body mass index and cervical length among women with a history of spontaneous preterm birth†. J Matern Fetal Neonatal Med. 2020;33(5):825–830. Sun SV, Manuck TA. Alcohol in pregnancy: not recommended at any gestational age. BJOG. 2019;126(12):1455. Battarbee AN, Glover AV, Vladutiu CJ, Gyamfi-Bannerman C, Aliaga S, Manuck TA, Boggess KA. Risk factors associated with prolonged neonatal intensive care unit stay after threatened late preterm birth [published online ahead of print, 2019 Jun 6]. J Matern Fetal Neonatal Med. 2019;1–6. Battarbee AN, Ellis JS, Manuck TA. Beyond Cervical Length: Association between Postcerclage Transvaginal Ultrasound Parameters and Preterm Birth. Am J Perinatol. 2019;36(13):1317–1324. Battarbee AN, Glover AV, Vladutiu CJ, Gyamfi-Bannerman C, Aliaga S, Manuck TA, Boggess KA. Sex-Specific Differences in Late Preterm Neonatal Outcomes. Am J Perinatol. 2019;36(12):1223–1228. Panzer A, Dotters-Katz S, Smid M, Boggess K, Manuck T. Factors Associated with Previable Delivery following Second Trimester Rupture of Membranes. Am J Perinatol. 2019;36(8):812–817. Smid MC, Stuebe AM, Manuck TA, Sen S. Maternal obesity, fish intake, and recurrent spontaneous preterm birth. J Matern Fetal Neonatal Med. 2019;32(15):2486–2492. Guintivano J, Manuck T, Meltzer-Brody S. Predictors of Postpartum Depression: A Comprehensive Review of the Last Decade of Evidence. Clin Obstet Gynecol. 2018;61(3):591–603. Manuck TA, Fry RC, McFarlin BL. Quality Improvement in Perinatal Medicine and Translation of Preterm Birth Research Findings into Clinical Care. Clin Perinatol. 2018;45(2):155–163. Ongoing Research Support 8/8/17– 3/31/2022 The Pharmacogenomics of Spontaneous Preterm Birth Prevention and Treatment University of Utah Personalized Healthcare DNA Sequencing Grant Award Role: Principal Investigator 12/1/2018– 11/30/2022 Perinatal PFAS Exposure and Placental Toxicity in NC NC PFAST Network Role: Co-PI 12/1/18 – 11/30/20 Children’s Environmental Solutions Study RTI IMPACT Seed Fund Role: Co-PI 6/1/2019– 5/31/2020 The Placental Exposome: a Driver of Epigenetic Regulation and Preeclampsia Center for Environmental Health and Susceptibility Pilot Grant Program Role: Co-PI Ongoing Prevention of Preeclampsia by Targeting Pro-inflammatory Exposures (the P3IE Study)

Role: Co-PI Ongoing Combined Environmental and Psychosocial Stress, Hurricane Florence, and Preterm Birth Role: Co-PI

M. Kathryn Menard, MD, MPH, Professor_________________________________________________ Dr. Menard serves as an Upjohn Distinguished Professor. She is interested in the study of maternal health services delivery, preconception and interconception care, strategies to prevent preterm birth. Throughout her career, Dr. Menard has worked at the intersect between public health and the everyday challenges and joys of clinical obstetric care. In addition to her duties at UNC, she currently serves as Medical Director of the Pregnancy Medical Home model through Community Care of North Carolina. This is a state wide program designed to enhance access to high quality prenatal care and improve birth outcomes for pregnant women with Medicaid coverage. Positions & Honors

Professor, Obstetrics and Gynecology 2006–present

American Board of Obstetrics and Gynecology, Obstetrics and Gynecology Examiner Maternal Fetal Medicine Subspecialty Examiner (2007 – present)

1999–present

North Carolina Health and Human Services, Physician Advisory Council 2006–present The Best Doctors in America: Maternal - Fetal Medicine, Marfeh S and Smith GW (eds)

Woodard and White 1994–present

Most Recent Peer-Reviewed Publications Kimple KS, Rouse L, Karim-Rhoades W, Menard MK. The State of North Carolina's Perinatal Health. N C Med J. 2020;81(1):24–27. Vladutiu CJ, Minnaert JJ, Sosa S, Menard MK. Levels of Maternal Care in the United States: An Assessment of Publicly Available State Guidelines [published online ahead of print, 2019 Oct 21]. J Womens Health (Larchmt). 2019;10.1089/jwh.2019.7743. Easter SR, Robinson JN, Menard MK, et al. Potential Effects of Regionalized Maternity Care on U.S. Hospitals. Obstet Gynecol. 2019;134(3):545–552. Menard MK. Toward Achieving Risk-Appropriate Maternity Care: Maternal Morbidity Prediction. Obstet Gynecol. 2019;134(2):213–215. Vladutiu CJ, Stringer EM, Kandasamy V, Ruppenkamp J, Menard MK. Emergency Care Utilization Among Pregnant Medicaid Recipients in North Carolina: An Analysis Using Linked Claims and Birth Records. Matern Child Health J. 2019;23(2):265–276. Zahn CM, Remick A, Catalano A, Goodman D, Kilpatrick SJ, Menard MK. Levels of Maternal Care Verification Pilot: Translating Guidance Into Practice [published correction appears in Obstet Gynecol. 2019 Sep;134(3):655]. Obstet Gynecol. 2018;132(6):1401–1406. Vladutiu CJ, Ahrens KA, Verbiest S, Menard MK, Stuebe AM. Cardiovascular Health of Mothers in the United States: National Health and Nutrition Examination Survey 2007-2014. J Womens Health (Larchmt). 2019;28(9):1227–1236. Stringer EM, Vladutiu CJ, Batra P, Stringer JS, Menard MK. Operationalizing 17α-Hydroxyprogesterone Caproate to Prevent Recurrent Preterm Birth: Definitions, Barriers, and Next Steps. Obstet Gynecol. 2016;128(6):1397–1402. Austin AE, Vladutiu CJ, Jones-Vessey KA, Norwood TS, Proescholdbell SK, Menard MK. Improved Ascertainment of Pregnancy-Associated Suicides and Homicides in North Carolina. Am J Prev Med. 2016;51(5 Suppl 3):S234–S240. Verbiest S, McClain E, Stuebe A, Menard MK. Postpartum Health Services Requested by Mothers with Newborns Receiving Intensive Care. Matern Child Health J. 2016;20(Suppl 1):125–131. Ongoing Research Support 4/2018-6/2020 Regional Perinatal Outreach to Assess Hospital Levels of Maternal Care and Increase Capacity for use of Immediate Postpartum LARC North Carolina Department of Public Health Role: Principle Investigator 10/2017-present ECHO model to build capacity for treatment of substance use disorder among primary care providers AHRQ Role: Consultant

Robert Strauss, MD, Director of Maternal Fetal Medicine Fellowship Program___________________ Robert Strauss, MD is a Professor in Obstetrics and Gynecology, and also serves as the Director of the Maternal-Fetal Medicine Fellowship and is a beloved teacher and mentor. His greatest interests are in medical education and clinical care. He has won numerous departmental teaching awards, including a 5-time recipient of the CREOG National Faculty award for Excellence in Resident Education. Dr. Strauss served as the Ob/Gyn Residency Program Associate Director and then Director from 2000-2008. He also served as the Director of Labor and Delivery and the OB Physician Service Line Leader for 14 years. This past year, the UNC Health Care Board of Directors awarded him the prestigious H. Fleming Fuller Award, given to the member of the medical staff who demonstrates lifelong dedication to the highest standards of patient care, teaching and community. His research interests are focused on clinical obstetrics, including preterm birth, placental abruption, gestational diabetes, and fetal lung maturity studies. He has also received grant funding for research in prevention of preterm birth, as well as having mentored several resident and fellow research projects resulting in publication. Positions & Honors

Director, MFM Fellowship 2019–present Professor, Department of Obstetrics & Gynecology 2011–present Journal Reviewer, Obstetrics and Gynecology 1999–present

Most Recent Peer-Reviewed Publications Beamon CJ, Stuebe AM, Edwards LJ, Mayer DC, Strauss RA. Is the type of neuraxial anesthesia associated with adverse neonatal outcomes among patients with preeclampsia? [published online ahead of print, 2019 Nov 16]. J Neonatal Perinatal Med. 2019;10.3233/NPM-180183. Beamon C, Carlson L, Rambally B, Berchuck S, Gearhart M, Hammett-Stabler C, Strauss R. Predicting neonatal respiratory morbidity by lamellar body count and gestational age. J Perinat Med. 2016;44(6):677–683. Dotters-Katz SK, Carlson LM, Johnson J, Patterson J, Grace MR, Price W, Vladutiu CJ, Manuck TA, Strauss RA. Management of Pregnancy and Survival of Infants with Trisomy 13 or Trisomy 18. Am J Perinatol. 2016;33(12):1121–1127. Dotters-Katz SK, Kuller JA, Grace MR, Laifer SA, Strauss RA. Management Considerations for Ongoing Pregnancies Complicated by Trisomy 13 and 18. Obstet Gynecol Surv. 2016;71(5):295–300. Eichelberger KY, Baker AM, Woodham PC, Haeri S, Strauss RA, Stuebe AM. Second-Trimester Maternal Serum Paraxanthine, CYP1A2 Activity, and the Risk of Severe Preeclampsia. Obstet Gynecol. 2015;126(4):725–730. Dotters-Katz SK, Grace MR, Strauss RA, Chescheir N, Kuller JA. Chikungunya Fever: Obstetric Considerations on an Emerging Virus. Obstet Gynecol Surv. 2015;70(7):453–457. Smith D, Stringer E, Vladutiu CJ, Zink AH, Strauss R. Risk of uterine rupture among women attempting vaginal birth after cesarean with an unknown uterine scar. Am J Obstet Gynecol. 2015;213(1):80.e1–80.e5. McPherson JA, Strauss RA, Stamilio DM. Nonreassuring fetal status during trial of labor after cesarean. Am J Obstet Gynecol. 2014;211(4):408.e1–408.e4088. O'Connell RV, Dotters-Katz SK, Kuller JA, Strauss RA. Gastroschisis: A Review of Management and Outcomes.Obstet Gynecol Surv. 2016 Sep;71(9):537-44. Dotters-Katz SK, Carlson LM, Johnson J, Patterson J, Grace MR, Price W, Vladutiu CJ, Manuck TA, Strauss A. Management of Pregnancy and Survival of Infants with Trisomy 13 or Trisomy 18. Am J Perinatol. 2016 Oct;33(12):1121-7.

Elizabeth M Stringer, MD, MSc, Professor_________________________________________________ Throughout her career, Dr. Stringer has conducted research at the intersection of obstetrics and public health. While in Zambia, she worked with local public health officials to implement a program to prevent mother-to-child HIV transmission which had served over 1.6 million women at the time of her return to the U.S. She also conducted clinical trials in contraception, AIDS therapeutics in women, and neonatal circumcision. Although Dr. Stringer now lives in North Carolina, she maintains strong ties to her colleagues at the University of Zambia and its affiliated University Teaching Hospital. She practices clinical Maternal-Fetal Medicine at UNC and has multiple NIH grants for studies being conducted in Zambia and Nicaragua. Dr. Stringer is the head of the Society for Maternal Fetal Medicine’s Global Health Committee and is an associate editor of the International Journal of Gynecology and Obstetrics. She also serves on the combined board of American International Schools of Tangier and Marrakesh, Morocco. Positions & Honors

Professor, Department of OBGYN 2019–present

Lecturer (Honorary), University of Zambia School of Medicine 2001–present

Other Experience and Professional Memberships Board Member of the American School of Tangier, Morocco 2013–present

Member, Global Health Committee, Society for Maternal Fetal Medicine 2012–present

American College of Obstetrics and Gynecology 2003–present

Zambian Society of Obstetrican Gynecologists 2001–present

Most Recent Peer-Reviewed Publications Becker-Dreps S, Stringer EM, Bucardo F, Bowman NM, Boivin MJ. Is there a silver lining to the Zika virus epidemic in the Americas?. Lancet Infect Dis. 2020;20(1):14–15. Hopkins AM, Desravines N, Stringer EM, et al. Capnocytophaga bacteremia precipitating severe thrombocytopenia and preterm labor in an asplenic host. Infect Dis Rep. 2019;11(3):8272. Published 2019 Dec 5. Price JT, Vwalika B, Hobbs M, Nelson J, Stringer EM, et al. Highly diverse anaerobe-predominant vaginal microbiota among HIV-infected pregnant women in Zambia. PLoS One. 2019;14(10):e0223128. Published 2019 Oct 2. Kalmin MM, Gower EW, Stringer EM, Bowman NM, Rogawski McQuade ET, Westreich D. Misclassification in defining and diagnosing microcephaly. Paediatr Perinat Epidemiol. 2019;33(4):286–290. Khorrami N, Stone J, Small MJ, Stringer EM, Ahmadzia HK. An overview of advances in global maternal health: From broad to specific improvements. Int J Gynaecol Obstet. 2019;146(1):126–131. Vladutiu CJ, Stringer EM, Kandasamy V, Ruppenkamp J, Menard MK. Emergency Care Utilization Among Pregnant Medicaid Recipients in North Carolina: An Analysis Using Linked Claims and Birth Records. Matern Child Health J. 2019;23(2):265–276. Stringer EM, Kendall MA, Lockman S, et al. Pregnancy outcomes among HIV-infected women who conceived on antiretroviral therapy. PLoS One. 2018;13(7):e0199555. Published 2018 Jul 18. Stringer EM. Ending preventable stillbirth: A gift for all women. Int J Gynaecol Obstet. 2017;138(3):237–238. Staley SA, Smid MC, Dotters-Katz SK, Stringer EM. Epstein-Barr Virus-Induced Mononucleosis as an Imitator of Severe Preeclampsia. AJP Rep. 2017;7(1):e5–e7. Stringer EM, Vladutiu CJ, Batra P, Stringer JS, Menard MK. Operationalizing 17α-Hydroxyprogesterone Caproate to Prevent Recurrent Preterm Birth: Definitions, Barriers, and Next Steps. Obstet Gynecol. 2016;128(6):1397–1402. Ongoing Research Support 9/2019 – 8/2020 A pilot trial of perinatal depression treatment in Zambia NIMH Role: PI 6/2019-5/2024 Understanding Maternal-Fetal Zika Virus Transmission and its Complications in Nicaragua NICHD Role: PI

Ongoing Understanding the relationship between antiretrovirals and preterm birth among HIV infected women in Zambia NICHD / NIAID Role: Co-PI

Alison Stuebe, MD, MSc, Professor, Interim Director of the Division of Maternal-Fetal Medicine Dr. Stuebe serves as Interim Director and professor of the division of Maternal Fetal Medicine and Distinguished Professor of Infant and Young Child Feeding at the Gillings School of Global Public Health. She has published more than 150 peer-reviewed articles. She is Medical Director of Lactation Services at UNC Health Care, and she works with an interdisciplinary team of faculty and staff to enable women to achieve their infant feeding goals. Her current research focuses on developing models for holistic and equitable care of families during the 4th Trimester. Dr. Stuebe is a member of the Steering Committee for Moms Rising North Carolina, as well as being president of the Academy of Breastfeeding Medicine. At the Society for Maternal-Fetal Medicine, she is a member of the SMFM Health Policy and Advocacy Committee. At the American College of Obstetricians and Gynecologists, she is a member of both the Breastfeeding Expert Work Group and the Maternal Mental Health Expert Work Group, and she chaired the Task Force on Reinventing Postpartum Care. Positions & Honors

Professor, Department of Obstetrics and Gynecology 2019–present

Assistant Professor, Department of Maternal and Child Health Gillings School of Global Public Health, University of North Carolina

2010–present

Most Recent Peer-Reviewed Publications Stuebe A. Go Red for Breastfeeding [published online ahead of print, 2020 Jan 6]. Breastfeed Med. 2020;10.1089/bfm.2019.29145.ams. Stuebe A. Putting the "M" in Breastfeeding Medicine. Breastfeed Med. 2020;15(1):63–64. Beamon CJ, Stuebe AM, Edwards LJ, Mayer DC, Strauss RA. Is the type of neuraxial anesthesia associated with adverse neonatal outcomes among patients with preeclampsia? [published online ahead of print, 2019 Nov 16]. J Neonatal Perinatal Med. 2019;10.3233/NPM-180183. Stuebe AM, Meltzer-Brody S, Propper C, et al. The Mood, Mother, and Infant Study: Associations Between Maternal Mood in Pregnancy and Breastfeeding Outcome. Breastfeed Med. 2019;14(8):551–559. Fryer KE, Vines AI, Stuebe AM. A Multisite Examination of Everyday Discrimination and the Prevalence of Spontaneous Preterm Birth in African American and Latina Women in the United States [published online ahead of print, 2019 Jul 31]. Am J Perinatol. 2019;10.1055/s-0039-1693696. Maldonado LY, Fryer KE, Tucker CM, Stuebe AM. The Association between Travel Time and Prenatal Care Attendance [published online ahead of print, 2019 Jun 12]. Am J Perinatol. 2019;10.1055/s-0039-1692455. Chetwynd EM, Stuebe AM, Rosenberg L, Troester MA, Palmer JR. Prepregnancy Diabetes and Breastfeeding Cessation Among Black Women in the United States. Breastfeed Med. 2019;14(4):249–255. Stuebe A. Does breastfeeding prevent metabolic disease or does metabolic disease prevent breastfeeding?. BJOG. 2019;126(4):535. Oliver-Williams C, Vladutiu CJ, Loehr LR, Rosamond WD, Stuebe AM. The Association Between Parity and Subsequent Cardiovascular Disease in Women: The Atherosclerosis Risk in Communities Study. J Womens Health (Larchmt). 2019;28(5):721–727. Vladutiu CJ, Ahrens KA, Verbiest S, Menard MK, Stuebe AM. Cardiovascular Health of Mothers in the United States: National Health and Nutrition Examination Survey 2007-2014. J Womens Health (Larchmt). 2019;28(9):1227–1236. Ongoing Research Support 2020-2023 First Mile to Health: Using Data Analytics to Identify and Address Transport Barriers to Care HRSA Role: Co-I 2019-2024 Implementing Shared Decision Making Toolkit to Improve Birth Outcomes HRSA Role: Co-I 2019-2023 Reengineering Postnatal Unit Care to Reduce Perinatal Morbidity and Mortality ARHRQ Role: PI

2019-2023 Safeguarding Two Lives: Expanding Early Identification & Access to Perinatal Mental Health & Substance Abuse Treatment Health Resources and Services Administration/U.S. Department of Health and Human Services Role: Co-Investigator PI: Mary Kimmel, UNC Psychiatry 2018-2023 Mood, Mother and Child: The Psychobiology of Dyadic Resilience NICHD Role: Co-PI; Roger Mills-Koonce, Frank Porter Graham Child Development Institute 2018-2023 Scaling up psychological treatments for perinatal depression and anxiety symptoms via telemedicine PCORI Role: Co-investigator Co-PIs: Samantha Meltzer-Brody, UNC Psychiatry and Daisy Singla, University of Toronto 2018-2022 Preconceptional health of Latinas and its association with child adiposity Co-PI Siega-Riz/Stores, UNC Departments of Epidemiology and Biostatistics Role: Co-I 2016-2021 Cocaine and Maternal Behavior: Effects on Trajectory of Infant Brain Development Role: Co-I PI: Karen Grewen, UNC Department of Psychiatry

Neeta L. Vora, MD, Director of the Reproductive Genetics, Associate Professor___________________ Dr. Vora is triple boarded in Obstetrics and Gynecology, Maternal Fetal Medicine, and Clinical Genetics. Dr. Vora has authored more than 50 articles on prenatal genetics, ranging from cell free DNA to whole exome and genome sequencing. She has a K23 from the NICHD to study use of new genomic technologies in obstetrics and an R21 to study novel genes critical to human brain development in a zebrafish model. She is a co-investigator on a multicenter prenatal whole genome sequencing grant and co-investigator on a grant which aims to understand how parents prepare for a prenatal diagnosis of a genetic condition. Dr. Vora’s research has focused on cell free fetal DNA in the maternal circulation. She is interested in obesity and has investigated the levels of cell free fetal DNA in obese versus lean patients. She also has an interest in the differences in fetal gene expression in obese versus lean mothers using cell free fetal nucleic acids in amniotic fluid. Positions and Honors

Associate Professor, Department of Genetics 2019-present Associate Professor, Division of Maternal Fetal Medicine 2017-present Director of Reproductive Genetics, Department of Ob/Gyn, Division Maternal Fetal Medicine 2012-present

Most Recent Peer-reviewed Publications Vora NL, Gilmore K, Brandt A, et al. An approach to integrating exome sequencing for fetal structural anomalies into clinical practice [published online ahead of print, 2020 Jan 24]. Genet Med. 2020;10.1038/s41436-020-0750-4. Talati AN, Webster CM, Vora NL. Prenatal genetic considerations of congenital anomalies of the kidney and urinary tract (CAKUT). Prenat Diagn. 2019;39(9):679–692. Gray KJ, Wilkins-Haug LE, Herrig NJ, Vora NL. Fetal phenotypes emerge as genetic technologies become robust. Prenat Diagn. 2019;39(9):811–817. Vora NL, Parker JS, Mieckowski PA, Smeester L, Fry RC, Boggess KA. RNA-Sequencing of Umbilical Cord Blood to Investigate Spontaneous Preterm Birth: A Pilot Study. AJP Rep. 2019;9(1):e60–e66. Harris S, Gilmore K, Hardisty E, Lyerly AD, Vora NL. Ethical and counseling challenges in prenatal exome sequencing. Prenat Diagn. 2018;38(12):897–903. Vora NL, Wapner RJ. Introducing new and emerging genetic tests into prenatal care. Semin Perinatol. 2018;42(5):283–286. Vora NL, Hui L. Next-generation sequencing and prenatal 'omics: advanced diagnostics and new insights into human development. Genet Med. 2018;20(8):791–799. Vora NL, Grace MR, Smeester L, et al. Targeted Multiplex Gene Expression Profiling to Measure High-Fat Diet and Metformin Effects on Fetal Gene Expression in a Mouse Model. Reprod Sci. 2019;26(5):683–689. Harris S, Vora NL. Maternal Genetic Disorders in Pregnancy. Obstet Gynecol Clin North Am. 2018;45(2):249–265. Vora NL, Hui L. Prenatal screening for fetal and obstetric complications: New opportunities and challenges. Semin Fetal Neonatal Med. 2018;23(2):77. Ongoing Research Support 09/01/2018-08/31/2023 Prenatal Genetic Diagnosis by Genomic Sequencing: A Prospective Evaluation Role: Site PI (Ronald Wapner, Columbia University Department of OB/GYN) 7/6/2017-6/30/2021 Early Genomic Diagnosis Role: PI, Trainee. Mentors: Dr Cynthia Powell (UNC Department of Pediatrics-Genetics and Metabolism), Dr Jonathan Berg (UNC Department of Genetics), Dr Kim Boggess (UNC Department of OB/GYN) 04/01/2019-03/31/2021 Genetic and Functional Dissection of Congenital Anomalies of the Brain Role: Co-PI

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UNC HOSPITALS 44. N.C. Clinical Cancer Center 41. N.C. Memorial Hospital 43. N.C. Neurosciences Hospital42. N.C. Women's and Children's Hospitals40. Old Clinic

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We here at the Division of Maternal Fetal Medicine hope that you enjoyed your visit. Please let us know if you have any questions about your visit, the fellowship program or the department. Qiana Davis, Fellowship Coordinator qiana_davis@med.unc.edu Emily Richbourg, Associate Fellowship Coordinator emily_richbourg@med.unc.edu Robert Strauss, Fellowship Director robert_strauss@med.unc.edu 919.966.1601 – MFM Front Desk https://www.med.unc.edu/obgyn/mfm/copy_of_fellowship/

Department of Obstetrics and Gynecology Division of Maternal-Fetal Medicine