University of Groningen

Genetics of celiac disease and its diagnostic valueRomanos, Jihane

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CURRICULUM VITAE

C.V.JIHANE ROMANOS

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Curriculum Vitae

Jihane Romanos was born on 23rd January 1982 in Haret-Sakhr, Lebanon. She lived in Sao Paulo, Brazil,

for two years before moving back to Lebanon where she grew up and went to school at the Soeur des Saint

Coeur college in Kfarhbab. After taking the French baccalaureate in 2000, she went to the American University

of Beirut where she majored in Biology (BSc). In 2003 Jihane moved back to Brazil, where she followed a

three-month training course at the genetics department of the University of Sao Paulo. In 2004, she started

her MSc degree in that department, working on the screening of mutations in the OTOF gene in patients with

hearing impairment and its relation with auditory neuropathy, under the supervision of Prof. Regina Celia

Mingronino-Netto, PhD. She graduated in 2006 with an MSc in Biology, specializing in genetics. In 2007, she

started her PhD work at the Department of Genetics, University Medical Center Groningen, the Netherlands,

under the supervision of Prof. Cisca Wijmenga, PhD. Her main topic has been the genetics of celiac disease

and assessing its diagnostic value. As someone holding both the Brazilian and Lebanese nationalities, Jihane

has excellent language skills. She is fluent in Arabic, French, English and Portuguese, and has also learned

some basic Dutch.

207

Publications (H-index in Sept 2011 = 8)

*Both authors contributed equally to the manuscript

1. Trynka G, Hunt KA, Bockett NA, Romanos J, Mistry V, Szperl A, Bakker SF, Bardella MT, Bhaw-

Rosun L, Castillejo G, de la Concha EG, Almeida RC, Dias KM, van Diemen CC, Dubois PCA,

Duerr RH, Edkins S, Franke L, Fransen K, Gutierrez J, Heap GAR, Hrdlickova B, Hunt S, Plaza

Izurieta L, Izzo V, Joosten LAB, Langford C, Mazzilli MC, Mein CA, Midah V, Mitrovic M, Mora

B, Morelli M, Nutland S, Núñez C, Onengut-Gumuscu S, Pearce K, Platteel M, Polanco I, Potter

S, Ribes-Koninckx C, Ricaño-Ponce I, Rich SS, Rybak A, Santiago JL, Senapati S, Sood A,

Szajewska H, Troncone R, Varadé J, Wallace C, Wolters VM, Zhernakova A, CEGEC (Spanish

Consortium on the Genetics of Coeliac Disease), PreventCD Study Group, Wellcome Trust Case

Control Consortium, Thelma B.K., Cukrowska B, Urcelay E, Bilbao JR, Mearin ML, Barisani D,

Barrett JC, Plagnol V, Deloukas P, Wijmenga C, van Heel DA. Dense genotyping reveals and

localises multiple common and rare variant association signals in celiac disease. Nat. Genet.

2011; in press

2. Sperandeo MP, Tosco A, Izzo V, Tucci F, Troncone R, Auricchio R, Romanos J, Trynka G,

Auricchio S, Jabri B, Greco L. Potential celiac patients: a model of celiac disease pathogenesis.

PLoS One. 2011; 6(7):e21281.

3. Zhernakova A, Stahl EA, Trynka G, Raychaudhuri S, Festen EA, Franke L, Westra HJ, Fehrmann

RS, Kurreeman FA, Thomson B, Gupta N, Romanos J, McManus R, Ryan AW, Turner G,

Brouwer E, Posthumus MD, Remmers EF, Tucci F, Toes R, Grandone E, Mazzilli MC, Rybak

A, Cukrowska B, Coenen MJ, Radstake TR, van Riel PL, Li Y, de Bakker PI, Gregersen PK,

Worthington J, Siminovitch KA, Klareskog L, Huizinga TW, Wijmenga C, Plenge RM. Meta-

analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies

fourteen non-HLA shared loci. PLoS Genet. 2011; 7(2):e1002004.

4. Romanos J and Wijmenga C. Predicting susceptibility to celiac disease by genetic risk profiling.

Annals of Gastroenterology and Hepatology. 2010; 1(1):11-18.

5. Hogen Esch CE, Rosén A, Auricchio R, Romanos J, Chmielewska A, Putter H, Ivarsson A,

Szajewska H, Koning F, Wijmenga C, Troncone R, Mearin ML. The PreventCD Study design:

towards new strategies for the prevention of coeliac disease. Eur J Gastroenterol Hepatol. 2010;

22(12):1424-1430.

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6. Zhernakova A, Elbers CC, Ferwerda B, Romanos J, Trynka G, Dubois PC, de Kovel CG, Franke

L, Oosting M, Barisani D, Bardella MT; Finnish Celiac Disease Study Group, Joosten LA,

Saavalainen P, van Heel DA, Catassi C, Netea MG, Wijmenga C. Evolutionary and functional

analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection. Am J

Hum Genet. 2010; 86(6):970-7.

7. Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA,

Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B,

Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R,

Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P,

Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley

KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M,

Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek

WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R,

Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA. Multiple common

variants for celiac disease influencing immune gene expression. Nat Genet. 2010; 42(4):295-

302.

8. Romanos J*, van Diemen CC*, Nolte IM, Trynka G, Zhernakova A, Fu J, Bardella MT, Barisani

D, McManus R, van Heel DA, Wijmenga C. Analysis of HLA and non-HLA alleles can identify

individuals at high risk for celiac disease. Gastroenterology 2009; 137(3):834-40, 840.e1-3.

9. Romanos J, Kimura L, Fávero ML, Izarra FA, de Mello Auricchio MT, Batissoco AC, Lezirovitz K,

Abreu-Silva RS, Mingroni-Netto RC. Novel OTOF mutations in Brazilian patients with auditory

neuropathy. J. Hum. Genet. 2009; 54(7):382-5.

10. Romanos J*, Koskinen L*, Kaukinen K, Mustalahti K, Korponay-Szabo K, Barisani D, Bardella

M.T, Ziberna F, Vatta S, Széles G, Pocsai Z, Karell K, Haimila K, Ádány R, Not T, Ventura

A, Mäki M, Partanen J, Wijmenga C, Saavalainen P. Cost-effective HLA-typing with tagging

SNPs predicts celiac disease risk haplotypes in Finnish, Hungarian and Italian populations.

Immunogenetics 2009; 61(4):247-56.

11. Romanos J and Wijemenga C. Letter to the editor in response to the article “Two single nucleotide

polymorphisms identify highest-risk diabetes human leukocyte antigen genotype: potential for

rapid screening” by Barker et al. Diabetes 2009; 58(1):e1; author reply e2.

12. Romanos J, Barisani D, Trynka G, Zhernakova A, Bardella MT, Wijmenga C. Six new celiac

209

disease loci replicated in an Italian population confirming association to celiac disease. J Med

Genet. 2009; 46(1):60-3.

13. Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA,

Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ,

Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus

R, van Heel DA, Wijmenga C. Coeliac disease associated risk variants in TNFAIP3 and REL

implicate altered NF-κB signalling. Gut 2009; 58(8):1078-83.

14. Monsuur AJ, de Bakker PI, Zhernakova A, Pinto D, Verduijn W, Romanos J, Auricchio R, Lopez A,

van Heel DA, Crusius JB, Wijmenga C. Effective detection of human leukocyte antigen risk alleles

in celiac disease using tag single nucleotide polymorphisms. PLoS One 2008; 28;3(5):e2270.

15. Hunt KA, Zhernakova A, Turner G, Heap GAR, Franke L, Bruinenberg M, Romanos J, Dinesen

LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GKT, Howdle PD,

Walters JRF, Sanders DS, Playford RJ, Trynka G, Mulder CJJ, Mearin ML, Verbeek WHM,

Trimble V, Stevens FM, O’Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP,

McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C,

van Heel DA. Newly identified genetic risk variants for celiac disease related to the immune

response. Nat Genetics 2008; 40:395-402.

16. Romanos J*, Rybak A*, Wijmenga C, Wapenaar MC. Molecular diagnosis of celiac disease: Are

we there yet? Expert Opin. Med. Diagn. 2008; 2(4):399-416.

17. Abreu-Silva RS, Batissoco AC, Lezirovitz K, Romanos J, Rincon D, Auricchio MT, Otto PA,

Mingroni-Netto RC. Correspondence regarding Ballana et al., “Mitochondrial 12S rRNA gene

mutations affect RNA secondary structure and lead to variable penetrance in hearing impairment”.

Biochem Biophys Res Commun. 2006; 343(3):675-6.

18. Fávero ML, Romanos J, Mingroni-Netto RC, Balieiro CR, Donini TS, Spinelli M. Auditory

neuropathy due to mutations in OTOF gene. Arq. Otorrino laringol. 2005; 9(4):325-30.

19. Viana-Morgante AM (The Human Cytogenetics Study Group including Romanos J). The ratio of

maternal to paternal UPD associated with recessive diseases. Hum Genet. 2005; 117(2-3):288-

90.

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