university of groningen chemistry-based enzyme detection ... · thesis marilena ourailidou.indb 218...
TRANSCRIPT
![Page 1: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/1.jpg)
University of Groningen
Chemistry-based enzyme detection and inhibition in epigeneticsOurailidou, Maria-Eleni
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.
Document VersionPublisher's PDF, also known as Version of record
Publication date:2016
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):Ourailidou, M-E. (2016). Chemistry-based enzyme detection and inhibition in epigenetics. [Groningen]:University of Groningen.
CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.
Download date: 03-09-2020
![Page 2: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/2.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Thesis Marilena Ourailidou.indb 215 29-08-16 20:12
![Page 3: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/3.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
216
7
via
Thesis Marilena Ourailidou.indb 216 29-08-16 20:12
![Page 4: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/4.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Activity-based probes for detection of LSD1 activity
217
7
via
Thesis Marilena Ourailidou.indb 217 29-08-16 20:12
![Page 5: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/5.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
218
7
via
Figure 1.
Thesis Marilena Ourailidou.indb 218 29-08-16 20:12
![Page 6: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/6.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Activity-based probes for detection of LSD1 activity
219
7
via8
via8
13 14
15 16via
viain vitro
in vitrovia
Figure 2.
Thesis Marilena Ourailidou.indb 219 29-08-16 20:12
![Page 7: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/7.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
220
7
via
13 14
i
i
i
via 14 16 via
13 15
814 16
8
via
Thesis Marilena Ourailidou.indb 220 29-08-16 20:12
![Page 8: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/8.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Activity-based probes for detection of LSD1 activity
221
7
8
8
2
2
13
8
via
13
Figure 3.8
Thesis Marilena Ourailidou.indb 221 29-08-16 20:12
![Page 9: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/9.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
222
7
16
8
8
Figure 4. 138 16 .
Figure 5. 8
Thesis Marilena Ourailidou.indb 222 29-08-16 20:12
![Page 10: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/10.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Activity-based probes for detection of LSD1 activity
223
7
via
8
8
Thesis Marilena Ourailidou.indb 223 29-08-16 20:12
![Page 11: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/11.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
224
7
Thesis Marilena Ourailidou.indb 224 29-08-16 20:12
![Page 12: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/12.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Activity-based probes for detection of LSD1 activity
225
7
Thesis Marilena Ourailidou.indb 225 29-08-16 20:12
![Page 13: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/13.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
226
7�
Thesis Marilena Ourailidou.indb 226 29-08-16 20:12
![Page 14: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/14.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Activity-based probes for detection of LSD1 activity
227
7
Thesis Marilena Ourailidou.indb 227 29-08-16 20:12
![Page 15: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/15.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
228
7
Thesis Marilena Ourailidou.indb 228 29-08-16 20:12
![Page 16: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/16.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Activity-based probes for detection of LSD1 activity
229
7
General
R
8
Thesis Marilena Ourailidou.indb 229 29-08-16 20:12
![Page 17: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/17.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
230
7
1
R
N N
1
2 J J
J JJ
2
3J J
J J
trans
Thesis Marilena Ourailidou.indb 230 29-08-16 20:12
![Page 18: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/18.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Activity-based probes for detection of LSD1 activity
231
7
4 J J
tert trans
4
5J J
tert trans
5
6J J
tert trans -
36
Thesis Marilena Ourailidou.indb 231 29-08-16 20:12
![Page 19: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/19.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
232
7
7J
J J JJ J J
N trans
7
8J
J J J J
+
tert transtert trans
tert trans
10
6
Thesis Marilena Ourailidou.indb 232 29-08-16 20:12
![Page 20: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/20.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Activity-based probes for detection of LSD1 activity
233
7
10J
J J J
tert trans
6
9J
N trans N trans -
N transN trans
8
Thesis Marilena Ourailidou.indb 233 29-08-16 20:12
![Page 21: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/21.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
234
7
13: J J J
J J J J J
14: J J J
J
15: J J J
J
16:J J J
J J
Thesis Marilena Ourailidou.indb 234 29-08-16 20:12
![Page 22: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/22.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Activity-based probes for detection of LSD1 activity
235
7
Figure S1.
Thesis Marilena Ourailidou.indb 235 29-08-16 20:12
![Page 23: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/23.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
236
7
Figure S2.
Thesis Marilena Ourailidou.indb 236 29-08-16 20:12
![Page 24: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/24.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Activity-based probes for detection of LSD1 activity
237
7
Figure S3.
Thesis Marilena Ourailidou.indb 237 29-08-16 20:12
![Page 25: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/25.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
238
7
i i
i i
i i
8
Thesis Marilena Ourailidou.indb 238 29-08-16 20:12
![Page 26: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/26.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Activity-based probes for detection of LSD1 activity
239
7
C +
2+
14 +
16 +
8
via
Thesis Marilena Ourailidou.indb 239 29-08-16 20:12
![Page 27: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/27.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
240
7
Figure S4.
14 16 8
8
2
Thesis Marilena Ourailidou.indb 240 29-08-16 20:12
![Page 28: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/28.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Activity-based probes for detection of LSD1 activity
241
7
138
16
Figure S5. 82
Figure S6. 1313
8 16
Thesis Marilena Ourailidou.indb 241 29-08-16 20:12
![Page 29: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/29.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
242
7
8
2 8
Thesis Marilena Ourailidou.indb 242 29-08-16 20:12
![Page 30: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/30.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Activity-based probes for detection of LSD1 activity
243
7
Figure S7. 82
Thesis Marilena Ourailidou.indb 243 29-08-16 20:12
![Page 31: University of Groningen Chemistry-based enzyme detection ... · Thesis Marilena Ourailidou.indb 218 29-08-16 20:12. Processed on: 30-8-2016 504765-L-sub01-bw-Ourailidou Activity-based](https://reader033.vdocuments.site/reader033/viewer/2022050120/5f503cdabff770598a5a377a/html5/thumbnails/31.jpg)
Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016Processed on: 30-8-2016
504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou504765-L-sub01-bw-Ourailidou
Chapter 7
244
7
Thesis Marilena Ourailidou.indb 244 29-08-16 20:12