March 2008

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

CURRICULUM VITAE Name: Mark A. Rosen, M.D. Position: Professor of Clinical Anesthesia and Perioperative Care, Step VI School of Medicine Professor of Clinical Obstetrics, Gynecology and Reproductive Sciences (secondary) Address: S-436, Box 0427 University of California San Francisco 513 Parnassus Avenue San Francisco, California 94143-0427 Telephone (415) 476-3234 Facsimile: (415) 514-0185 Email: RosenM@anesthesia.ucsf.edu Web Sites: Residency Director: www.ucsf.anesthesia.edu/external Fetal Surgery: http://www.fetus.ucsf.edu/our_team/anesthesiologists.html Medical School: http://medschool.ucsf.edu/faculty/profile.asp?PersonID=14487 EDUCATION 1968-72 University of California Davis

Davis, California

B.A. Magna Cum Laude, Zoology

1968-72 University of California Davis Davis, California

B.S. Magna Cum Laude, Genetics

1973-77 University of California San Francisco San Francisco, California

M.D.

1977-78 University of California San Francisco, California

Intern Medicine

1978-80 University of California San Francisco San Francisco, California

Resident Anesthesia

1980-81 University of California San Francisco San Francisco, California

Fellow Obstetrical Anesthesia

Mark A. Rosen, M.D.

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LICENSURE, CERTIFICATION 1978 Diplomat, National Board of Medical Examiners

1978 Medical licensure, California

California State Medical Board License Number G39350

1982 American Board of Anesthesiology

2003 Recertification: American Board of Anesthesiology PRINCIPAL POSITIONS HELD 1981-89 University of California San Francisco

Assistant Professor

Anesthesia

1986-89 University of California San Francisco

Assistant Professor

Obstetrics, Gynecology, and Reproductive Sciences

1989-93 University of California San Francisco

Associate Professor

Anesthesia

1989-93 University of California San Francisco

Associate Professor

Obstetrics, Gynecology, and Reproductive Sciences

1993-now University of California San Francisco

Professor Anesthesia and Perioperative Care

1993-now University of California San Francisco

Professor Obstetrics, Gynecology, and Reproductive Sciences

OTHER POSITIONS HELD CONCURRENTLY University of California San Francisco 1983-84

Department of Anesthesia

Acting Vice-Chairman

1984-85

Long Hospital Recovery Room

Medical Director

1991-now Department of Anesthesia

Director, Anesthesia Training Programs

1992-now Department of Anesthesia

Vice Chairman

1994-now Department of Anesthesia Moffitt-Long Hospital

Obstetrical Anesthesia Division Chief (Director)

Mark A. Rosen, M.D.

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HONORS AND AWARDS 1973 Magna Cum Laude & Valedictorian, University of California Davis

1973 Phi Beta Kappa, University of California Davis

1977 Alpha Omega Alpha, University of California San Francisco

1993 Nomination, UCSF Kaiser Award (Excellence in Teaching)

2005 Teacher of the Year, Moffitt-Long Hospital; Department of Anesthesia

PROFESSIONAL ACTIVITIES CLINICAL Director, Obstetrical Anesthesia, Moffitt-Long (Children’s) Hospital Birthing Center: I provide clinical care and faculty supervision for anesthesia residents and medical students in the UCSF Birthing Center about 3 days per week. My academic career has been focused on anesthetic care for pregnant women; I have authored many chapters and co-edited a textbook about anesthesia for obstetrics. I am the primary teacher of obstetrical anesthesia at UCSF; all anesthesia residents spend at least one month on my clinical service and I am responsible for their education in this important clinical subspecialty of anesthesiology. Fetal Treatment Center: I have been a member of the world-renowned UCSF fetal surgery enterprise since its inception, and a charter member of the UCSF Fetal Treatment Center. I pioneered methods to provide anesthesia for both mother and fetus undergoing these bold, complex procedures, demonstrating success in non-human, primate animal models before the UCSF team considered operating on pregnant women. I pioneered and provided anesthesia for the first human fetal surgical procedure to correct a simple, congenital anatomical fetal malformation that, if untreated, would have resulted in fetal or neonatal death. For the past 25 years, I have provided anesthesia for the vast majority of the hundreds of fetal procedures performed at UCSF for a broad diversity of fetal conditions. I have taught anesthesia for fetal procedures to faculty colleagues and residents at UCSF, as well as nationally and internationally through chapters in many textbooks, invited review articles, invited public lectures, clinical consultation and teaching visitors. The techniques I pioneered have become utilized worldwide.

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Moffitt-Long Hospital Operating Room & Post-Anesthesia Care Unit (PACU): I provide clinical care and faculty supervision for anesthesia residents in the operating rooms and numerous other places in which anesthesia care is required for late running and emergency procedures during in-hospital, 24-hour clinical shifts about 1.5 days per month. During these shifts, I also supervise patient care in the PACU and provide emergent care for patients in the intensive care units and those who suffer cardiac or respiratory arrest (‘code blue’’). Mt. Zion Hospital Operating Room & Intensive Care Unit (ICU): I provide faculty supervision for anesthesia residents in the operating room, clinical care in the ICU and emergent care for patients who suffer cardiac or respiratory arrest (‘code blue’') during in-hospital overnight shifts about 1-2 days per month. SUMMARY OF CLINICAL ACTIVITIES My clinical activities are focused on anesthetic care for pregnant women undergoing labor, vaginal or operative delivery, fetal surgery or other surgical procedures during pregnancy. I specialize in anesthetic care for high-risk pregnancies, pregnancies complicated by co-existing diseases and anesthetic care for fetal surgeries. I have been the primary teacher of obstetrical anesthesia at the University for more than a decade. I also provide clinical care in the operating rooms, post anesthesia care units, intensive care units numerous other places in which anesthesia care is required in Moffitt-Long and Mt. Zion hospitals.

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PROFESSIONAL ORGANIZATIONS Memberships State: 1978-now California Society of Anesthesiologists National: 1978-now American Society of Anesthesiologists (ASA)

1980-now Society for Obstetric Anesthesia and Perinatology (SOAP)

1983-now Fetal Medical and Surgical Society, Charter member

1988-now Association of University Anesthetists (AUA)

2003-now Society for Education in Anesthesia (SEA)

International: 1982-now International Anesthesia Research Society (IARS) Service to Professional Organizations 1992-1993 American Society of Anesthesiologists Subcommittee on Obstetric

Anesthesia & Perinatology

1993-1996 Association of University Anesthetists, Educational Advisory Board

SERVICE TO PROFESSIONAL PUBLICATIONS Editorial Services (ad hoc referee) Number of papers reviewed

in past five years

1983-now Consultant, Anesthesiology

8

1991-now Consultant, Anesthesia and Analgesia

5

1996-now Consultant, International Journal of Obstetrical Anesthesia

4

2000-now Consultant, Gynecologic and Obstetric Investigation

3

2002-now Consultant, American Family Physician

1

2003-now Consultant, Fetal Diagnosis and Therapy 2

2006 Journal of the American Medical Association (JAMA) 1

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INVITED PRESENTATIONS INTERNATIONAL PRESENTATIONS International Conference on the Unborn; Santa Ynez Valley, California 1982 International Anesthesia Research Society; San Francisco, California, 1982 German Society of Anesthesiologists; Mannheim, Germany 1988 Obstetric Anaesthetists Association Oxford Meeting; Oxford, England, 1988 Janssen Pharmaceutica Symposium; Lisbon, Portugal, 1989 European Society of Regional Anesthesia; Lisbon, Portugal, 1989 MAPAR; Department d'Anesthesiologie Hopital Bicetre; Paris, France, 1989 F.I.G.O. Study Group on Assessment of New Technologies in Obstetrics and Gynaecology; University Hospital, Nottingham, England, 1990 (Panel Chair) International Anesthesia Research Society; San Francisco, California, 1997 (poster) European Society of Regional Anesthesia Winter Forum; Davos, Switzerland, 2003 Anesthesia Case Conferences; Cancun, Mexico, 2003 Obstetric Anaesthetists Association; Dublin, Ireland, 2006

PRESENTATIONS AT NATIONAL MEETINGS Society for Obstetric Anesthesia and Perinatology; San Diego, California, 1982 American Society of Anesthesiologists; Los Vegas, Nevada, 1982 American Osteopathic College of Anesthesiologists; San Francisco, California, 1982 National Abortion Federation; San Francisco, California, 1986 The Organization for Obstetric, Gynecologic and Neonatal Nurses; San Francisco, California, 1986 American Society for Psychoprophylaxis in Obstetrics; San Francisco, California, 1988 American Society of Anesthesiologists; San Francisco, California, 1994 American Society of Anesthesiologists; San Francisco, California, 2005

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PRESENTATIONS AT NATIONAL CONTINUING EDUCATION MEETINGS, STATE SOCIETIES AND VISITING PROFESSORSHIPS University of Chicago; Chicago, Illinois, 1987 (Visiting Professor) California Society of Anesthesiologists; Anaheim, California, 1988 Department of Anesthesiology Grand Rounds, University of California Davis; Sacramento, California, 1989 (Visiting Professor) Department of Anesthesiology and Critical Care Medicine Grand Rounds, University of Chicago; Chicago, Illinois, 1990 Oregon Health Sciences University; Portland, Oregon 1990 (Visiting Professor) California Society of Anesthesiologists; Anaheim, California, 1991 University of Chicago; Chicago, Illinois, 1991 (Visiting Professor) Aspen Anesthesia 1992; Snowmass, Colorado, 1992 Oregon State Society of Anesthesia; Eugene, Oregon, 1992 Aspen Anesthesia 1993; Snowmass, Colorado, 1993 Arizona Society of Anesthesiologists; Scottsdale, Arizona, 1993 Refresher Course in Anesthesiology, Department of Anesthesiology, University of Texas; Lubbock, Texas, 1993 Swanman Lectures; Portland, Oregon, 1993 Aspen Anesthesia 1995; Snowmass, Colorado, 1995 Penrose-St. Francis Hospital Grand Rounds, Colorado Springs, Colorado, 1995 Anesthesia Symposium, Colorado Medical Society; Colorado Springs, Colorado, 1995 Oregon Society of Anesthesiologists; Gleneden Beach, Oregon, 1995 California Society of Anesthesiologists; Monterey, California, 1995 Annual Hawaiian Seminar; The Anesthesiologist as the Perioperative Physician, California Society of Anesthesiologists; Kauai, Hawaii, 1995 Anesthesiology Update, Department of Anesthesiology, University of California San Diego; San Diego, California, 1996

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Women and Pain Conference, Nursing Pain Association; San Francisco, California, 1996 Walter Reed Medical Center Department of Anesthesiology Grand Rounds; Washington, DC, 1997 (Visiting Professor) California Society of Anesthesiologists; Monterey, California, 1997 Anesthesia Update; Colorado Society of Anesthesiologists; Vail, Colorado, 1997 Annual Hawaiian Seminar; California Society of Anesthesiologists; Kauai, Hawaii, 1997 Southern California Permanente Medical Group Anesthesia Symposium; Irvine, California, 1997 Oregon Society of Anesthesiologists; Gleneden Beach, Oregon, 1998 California Society of Anesthesiologists; San Francisco, California, 1998 23rd Annual Perinatal Conference, Rogue Valley Medical Center; Medford, Oregon, 1998 Panel Chair: Obstetrical Anesthesia Update, California Society of Anesthesiologists; San Francisco, California, 2000 Idaho Society of Anesthesiologists; Sun Valley, Idaho, 2000 California Society of Anesthesiologists Hawaiian Seminar; Honolulu, Hawaii, 2001 Virginia Mason Clinic; Seattle, Washington, 2001 (Visiting Professor) New York Academy of Medicine; New York, New York University of California Los Angeles; Los Angeles, California, 2003 (Visiting Professor) University of Chicago; Chicago, Illinois, 2003 (Visiting Professor) Texas Anesthesia Conference for Obstetrics, Baylor College of Medicine; Houston, Texas, 2003 49th Annual Postgraduate Course in Anesthesiology, Department of Anesthesiology University of Utah School of Medicine; Park City, Utah, 2004 Anesthesia Symposium, Southern California Permanente Medical Group; Anaheim, California, 2004 Panel Chair: Obstetrical Anesthesia California Society of Anesthesiologists / University of California San Diego, Annual Meeting and Anesthesiology Review Course; San Francisco, California 2005 California Society of Anesthesiologists Hawaiian Seminar; Poipu Beach, Kuai, Hawaii, 2005 Stanford Annual Review; Copper Mountain, Colorado, 2006

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33rd Annual Bert and Judith Hershenson Memorial Lecture, Department of Anesthesiology, Perioperative and Pain Medicine and Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard University, Boston, Massachusetts, 2006 (Visiting Professor) 53rd Annual Postgraduate Course in Anesthesiology, Department of Anesthesiology University of Utah School of Medicine; Park City, Utah, 2008 UNIVERSITY OF CALIFORNIA SAN FRANCISCO SPONSORED CONTINUING EDUCATION MEETINGS AND LOCAL (NORTHERN CALIFORNIA) PRESENTATIONS Mt. Diablo Hospital Department of Anesthesiology Grand Rounds; Concord, California, 1981 Second Symposium on Anesthesiology; Obstetrical Anesthesia: State of the Art 1982; Department of Anesthesia, University of California San Francisco, San Francisco, California Nursing In-service: Moffitt Hospital Recovery Room Nurses; San Francisco, California, 1982 Third Anesthesiology Symposium: 1983; Anesthesia for the High Risk Mother, Fetus, and Newborn, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1983 Merritt Hospital Department of Anesthesiology Grand Rounds; Oakland, California, 1983 St. Rose Hospital Department of Anesthesiology Grand Rounds; Hayward, California, 1983 School of Nursing, University of California San Francisco; San Francisco, California, 1983 Fourth Symposium on Anesthesiology; Anesthesia for Obstetrics: 1984; Department of Anesthesia, University of California San Francisco, San Francisco, California, 1984 School of Nursing; University of California San Francisco, San Francisco, California, 1984 Department of Neurosurgery Grand Rounds, University of California San Francisco; San Francisco, California, 1984 Inhalation Analgesia: State of the Art 1985, California Association of Nurse Anesthetists; San Francisco, California, 1985 School of Nursing, University of California San Francisco; San Francisco, California; 1985 Antepartum and Intrapartum Management, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; San Francisco, California, 1986 Preoperative Evaluation of the Surgical Patient, Departments of Anesthesia and Medicine, University of California San Francisco; San Francisco, California, 1986 The Life Cycle: Anesthetic Implications, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1986 School of Nursing; University of California San Francisco, San Francisco, California, 1986

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Advances in Maternal and Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; Vail, Colorado, 1987 School of Nursing; University of California San Francisco, San Francisco, California, 1987 Comprehensive Review and Annual Postgraduate Course, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; San Francisco, California, 1987 School of Nursing; University of California San Francisco, San Francisco, California, 1988 School of Nursing; University of California San Francisco, San Francisco, California, 1988 Community Hospital of Santa Rosa Department of Anesthesiology Grand Rounds; Santa Rosa, California, 1988 Department of Obstetrics, Gynecology and Reproductive Sciences Grand Rounds; University of California San Francisco; San Francisco, California, 1988 Letterman Army Hospital Department of Anesthesia Grand Rounds; San Francisco, California, 1989 Annual Conference: Focus 1989; North Coast Perinatal Access System; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; San Francisco, California, 1989 Letterman Army Hospital Department of Anesthesia Grand Rounds; San Francisco, California, 1989 Sequoia Hospital Department of Anesthesiology Grand Rounds; Redwood City, California, 1989 Changing Practice of Anesthesia, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1989 School of Nursing, University of California San Francisco; San Francisco, California, 1989 Advances in Maternal and Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; Vail, Colorado, 1989 Oak Knoll Naval Hospital Department of Anesthesiology Grand Rounds; Oakland, California, 1990 Great Expectations Programs for Parents, Medical Center at the University of California San Francisco & Mount Zion Hospital; San Francisco, California, 1990 Changing Practice of Anesthesia, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1990 Fall Postgraduate Course, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; San Francisco, California, 1990 School of Nursing, University of California San Francisco; San Francisco, California, 1990

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Great Expectations Programs for Parents, Medical Center at the University of California San Francisco & Mount Zion Hospital; San Francisco, California, 1991 School of Nursing, University of California San Francisco; San Francisco, California, 1991 Advances in Maternal and Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; Snowmass, Colorado, 1991 Great Expectations Programs for Parents, Medical Center at the University of California San Francisco & Mount Zion Hospital; San Francisco, California, 1992 First Annual Anesthesia Senior Resident's Retreat, Department of Anesthesia, University of California San Francisco; Tahoe City, California, 1992 Antepartum & Intrapartum Management, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; San Francisco, California, 1992 The Changing Practice of Anesthesia, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1992 School of Nursing, University of California San Francisco; San Francisco, California, 1992 Oak Knoll Naval Hospital Department of Anesthesia Grand Rounds; Oakland, California, 1992 School of Nursing, University of California San Francisco; San Francisco, California, 1993 Great Expectations Programs for Parents, Medical Center at the University of California San Francisco & Mount Zion Hospital; San Francisco, California, 1993 (given multiple times each year) Advances in Maternal and Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; Snowmass, Colorado, 1994 Senior Resident's Retreat, Department of Anesthesia, University of California, San Francisco; Lake Tahoe, California, 1994 Great Expectations Programs for Parents, Medical Center at the University of California San Francisco & Mount Zion Hospital; San Francisco, California, 1994 (given multiple times each year) Senior Resident's Retreat, Department of Anesthesia, University of California San Francisco; Lake Tahoe, California, 1995 Department of Obstetrics, Gynecology and Reproductive Sciences Grand Rounds, University of California San Francisco; San Francisco, California, 1995 Great Expectations Programs for Parents, Medical Center at the University of California San Francisco & Mount Zion Hospital; San Francisco, California, 1995 (given multiple times each year) Obstetric Resident Seminar, Kaiser Hospital Oakland; Oakland, California, 1995

Mark A. Rosen, M.D.

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Kaiser Hospital Hayward Department of Anesthesiology Grand Rounds; Hayward, California, 1995 School of Nursing, University of California San Francisco; San Francisco, California, 1995 The Changing Practice of Anesthesia, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1995 Advances in Maternal and Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; Vail, Colorado, 1996 Washington Hospital Department of Anesthesiology Grand Rounds; Fremont, California, 1996 Great Expectations Programs for Parents, Medical Center at the University of California San Francisco & Mount Zion Hospital; San Francisco, California, 1996 (given multiple times each year) Senior Resident Educational Conference, Department of Anesthesia, University of California San Francisco, Lake Tahoe, California, 1997 Great Expectations Programs for Parents, Medical Center at the University of California San Francisco & Mount Zion Hospital; San Francisco, California, 1997 (given multiple times each year) John Muir - Mt. Diablo Health System Hospitals Department of Anesthesiology Grand Rounds; Walnut Creek, California, 1997 Sonoma Valley Hospital Grand Rounds; Sonoma, California, 1998 Continuing Medical Education Program, Summit Medical Center; Oakland, California, 1998 Great Expectations Programs for Parents, Medical Center at the University of California San Francisco & Mount Zion Hospital; San Francisco, California, 1998 (given multiple times each year) The Changing Practice of Anesthesia: 1998, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1998 Advances in Maternal and Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; Breckenridge, Colorado, 1999 Kaiser Permanente Medical Center Department of Anesthesiology Grand Rounds; San Francisco, California, 1999 The Changing Practice of Anesthesia: 1999, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1999 Great Expectations Programs for Parents, Medical Center at the University of California San Francisco & Mount Zion Hospital; San Francisco, California, 1999 (given multiple times each year) Moderator, Community Grand Rounds: “Obstetrical Anesthesia,” Department of Anesthesia and Perioperative Care, University of California San Francisco; San Francisco, California, 1999

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Salinas Valley Memorial Hospital Grand Rounds; Salinas, California, 1999 Great Expectations Programs for Parents, Medical Center at the University of California San Francisco & Mount Zion Hospital; San Francisco, California, 2000 (given multiple times each year) Great Expectations Programs for Parents, Medical Center at the University of California San Francisco & Mount Zion Hospital; San Francisco, California, 2001 (given multiple times each year) Antepartum & Intrapartum Management, Department of Obstetrics, Gynecology and Reproductive Sciences University of California San Francisco; San Francisco, California, 2001 Advances in Maternal and Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; Telluride, Colorado, 2001 Great Expectations Programs for Parents, Medical Center at the University of California San Francisco & Mount Zion Hospital; San Francisco, California, 2002 (given multiple times each year) Antepartum & Intrapartum Management, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; San Francisco, California, 2002 Santa Rosa Anesthesiologists' Meeting; Santa Rosa, California, 2003 Great Expectations Programs for Parents, Medical Center at the University of California San Francisco & Mount Zion Hospital; San Francisco, California, 2002 (given multiple times each year) What’s Hot in Obstetrics and Gynecology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; Squaw Valley, California, 2004 Antepartum & Intrapartum Management, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; San Francisco, California, 2004 The Changing Practice of Anesthesia, Department of Anesthesia and Perioperative Care, University of California San Francisco; San Francisco, California, 2004 Obstetrics and Gynecology Update: What Does the Evidence Tell Us? Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; San Francisco, California, 2004 Nursing In-Service, Birthing Center, Children’s Hospital of the University of California San Francisco; San Francisco, California, 2005 Antepartum & Intrapartum Management, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; San Francisco, California, 2005 Obstetrics and Gynecology Update: What Does the Evidence Tell Us? Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; SF, CA, 2005

Mark A. Rosen, M.D.

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Antepartum & Intrapartum Management, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco; San Francisco, California, 2006 53rd Annual Postgraduate Course in Anesthesiology and TEE. University of Utah. Park City, Utah 2008 CONFERENCES DIRECTED / CO-DIRECTED / CHAIRED (PRESENTATIONS ALSO GIVEN)

Fifth Symposium on Anesthesiology: Changing Practice of Obstetrical Anesthesia for Normal and High Risk Pregnancy, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1985 Obstetric Anesthesia Update: State of the Art 1986, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1986 Obstetrical Anesthesia: 1987, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1987 Obstetrical Anesthesia 1989, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1989 Obstetrical Anesthesia 1990, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1990 Obstetrical Anesthesia 1991, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1991 Obstetrical Anesthesia 1992, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1992 Obstetrical Anesthesia 1993, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1993 Obstetrical Anesthesia 1994, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1994 Obstetrical Anesthesia 1995, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1995 The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; Obstetrical Anesthesia 1996, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1996 The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; Obstetrical Anesthesia 1997, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1997 The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; Obstetrical Anesthesia 1998, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1998 The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; Obstetrical Anesthesia 1999, Department of Anesthesia, University of California San Francisco; San Francisco, California, 1999

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The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; Obstetrical Anesthesia 2000, Department of Anesthesia, University of California San Francisco; San Francisco, California, 2000 The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; Obstetrical Anesthesia 2001, Department of Anesthesia, University of California San Francisco; San Francisco, California, 2001 The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; Obstetrical Anesthesia 2002, Department of Anesthesia, University of California San Francisco; San Francisco, California, 2002 The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; Obstetrical Anesthesia 2003, Department of Anesthesia, University of California San Francisco; San Francisco, California, 2003 The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; Obstetrical Anesthesia 2004, Department of Anesthesia, University of California San Francisco; San Francisco, California, 2004 The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; Obstetrical Anesthesia 2005, Department of Anesthesia, University of California San Francisco; San Francisco, California, 2005 The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; Obstetrical Anesthesia 2006, Department of Anesthesia, University of California San Francisco; San Francisco, California, 2006 The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; Obstetrical Anesthesia 2007, Department of Anesthesia, University of California San Francisco; San Francisco, California, 2007 CME COURSES ATTENDED (past 5 years)

2003, Joint Council on In-Training Examinations; Chicago, Illinois 2003, Texas Anesthesia Conference for Obstetrics; Houston, Texas, 2003 2003, American Society of Anesthesiologists Annual Meeting; San Francisco, California 2003, UCSF Anesthesia Department Grand Rounds; San Francisco, California 2003, European Society of Regional Anesthesia; Davos, Switzerland 2003, Anesthesia Case Conferences; Cancun, Mexico, 2003 2004, Association of University Anesthesiologists; Davis, California 2004, UCSF Anesthesia Department Grand Rounds; San Francisco, California 2004, Society for Education in Anesthesia; Hershey, Pennsylvania 2004, Joint Council on In-Training Examinations; Chicago, Illinois

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2004, Antepartum & Intrapartum Management; San Francisco, California 2004, Joint Council on In-Training Examinations; Chicago, Illinois 2004, The Changing Practice of Anesthesia; San Francisco, California 2004, Obstetrics and Gynecology Update: What Does the Evidence Tell Us? SF, CA 2004, The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; San Francisco, California 2004, 49th Annual Postgraduate Course in Anesthesiology; Park City, Utah 2004, Anesthesia Symposium, Permanente Medical Group; Anaheim, California 2005, California Society of Anesthesiologists / UCSD Review Course; San Francisco, California

2005, California Society of Anesthesiologists Hawaiian Seminar; Poipu Beach, Kuai, Hawaii 2005, UCSF Anesthesia Department Grand Rounds; San Francisco, California 2005, Joint Council on In-Training Examinations; Chicago, Illinois 2005, The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; San Francisco, California 2005, Antepartum & Intrapartum Management; San Francisco, California 2005, Obstetrics and Gynecology Update: What Does the Evidence Tell Us? SF, CA 2005, Society for Education in Anesthesia; Washington, D.C. 2005, American Society of Anesthesiologists Annual Meeting; New Orleans, Louisiana 2006, The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; San Francisco, California 2006, The Stanford Annual Update 2006, Antepartum & Intrapartum Management; San Francisco, California 2006, Society of Obstetric Anesthesia and Perinatology and the Obstetric Anaesthetist Association

Joint Meeting, Dublin, Ireland 2007, The Sol Shnider, M.D. Obstetrical Anesthesia Meeting; San Francisco, California 2007, Society for Obstetrical Anesthesia and Perinatology, Banff Springs, Alberta, Canada 2008, 53rd Annual Postgraduate Course in Anesthesiology; Park City, Utah

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GOVERNMENT and OTHER PROFESSIONAL SERVICE American Board of Anesthesiology (ABA) 1983-86 Question writer, Joint Council on In-training Written Examinations

1986-94 Editorial Board, Joint Council on In-training Written Examinations

1994-2005 Council Member: Joint Council on In-Training Examination

1986-90 Junior Associate Examiner. Oral Examinations

1990-now Senior Associate Examiner. Oral Examinations

2004-2006 Review Panel, ABA Candidate Conflicts & Protests

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UNIVERSITY and PUBLIC SERVICE

UNIVERSITY SERVICE University of California San Francisco 1991-94 Board of Directors

Marilyn Reed Lucia Child Care Study Center

Moffitt/Long and Children’s Hospitals of UCSF 1983-85 Ad Hoc Committee for Come-and-Stay Surgery

1983-95 Code Blue Committee of the Medical Staff

1985-87 Operating Room Quality Assurance Committee

1988-90 Ad Hoc Labor and Delivery Suite Design Committee

1990-now Educator, Great Expectations Program for Parents

2005 Mission Bay Hospital User Group Planning Committee School of Medicine 1982-now Fetal Treatment Program

1983-84

Admissions Committee

1992-now Dean's Advisory Committee on Postdoctoral Education (Postdoctoral Affairs; Graduate Medical Education)

1989-now Ad Hoc Faculty Promotion Review Committees (including Chair)

1991-92 Steering Committee, William K. Hamilton, M.D. Distinguished Professorship Committee

1994 Ad Hoc Housestaff Grievance Committee Office of the Dean, Postdoctoral Affairs

1999 Chair and Chief Hearing Officer, Ad Hoc Housestaff Grievance Committee Office of the Dean, Graduate Medical Education {4 months of meetings with attorneys at the Office of the President, conducting pre-hearing meetings with attorneys, writing opinions about admissible evidence, serving as hearing officer for >30 hours of oral testimony (generating >1000 pages of court reporter transcription), preparation and writing final decision}

1992-2005 Academic Standards Committee

1995-99 Admissions Committee

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1996-2000

Chair, Sol M. Shnider M.D. Endowed Chair in Obstetrical Anesthesia

2003-04 Governing Board for Continuing Medical Education

2003-now Medical Student Career Advisor

2005-now Chair, Academic Standards Committee Department of Anesthesia and Perioperative Care 1982-1985 Coordinator, Moffitt-Long Hospital Operating Room Scheduling

1983-1984 Merits and Promotions Committee

1983-1985 Chairman, Resident Clinical Competence Committee 1984-now Chairman, Resident Selection Committee 1984-1990 Clinical Faculty Management Committee 1984-now Chair, Resident Rotation Committee

1984-85 Moffitt-Long Operating Room Strategy Committee

1985-now Chair, Resident Education Committee

1985-90 Counseling and Evaluation Committee

1985-90 Chairman, Fellowship Selection Committee

1985-94 Co-Chair, Subcommittee on Obstetric Anesthesia Training Program

1985 Epidural Morphine Committee

1987 Chair, Obstetric Anesthesia Refresher Course

1986-now Co-Chair, Obstetric Anesthesia Refresher Course

1990-now Executive Committee

1990-now Resident Evaluation and Advising Committee

1990-now Resident Practice Oral Exam Committee

1991-92 Merits and Promotions Committee

1991-92 Ad Hoc Committee, Faculty Evaluations

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1994-95 Ad Hoc Committee, Faculty Evaluations

2001-02

Chair, Promotions Committee

2004

Organized & Arranged Faculty Retreat; Chaired major session

PUBLIC SERVICE 1983 Ad Hoc Investigative Committee, Medical Staff Affairs, Los Medanos Hospital

1986 Ad Hoc Investigative Committee, Medical Staff Affairs, Santa Rosa Memorial Hospital

1986-88 Ad Hoc Investigative Committee, Medical Staff Affairs, San Jose Hospital

1986-90 Ad Hoc Investigative Committee, Medical Staff Affairs,

Community Hospital Santa Rosa

1989 Ad Hoc Investigative Committee, Medical Staff Affairs Los Medanos Hospital

1989 Ad Hoc Investigative Committee, Board of Medical Quality Assurance State of California

1998, 2003 Obstetric Anesthesia, Quality Improvement Meetings Marin General Hospital

2004 Epidural Use in Smaller Facilities, Quality Improvement Meeting North Coast Perinatal Access System

2004 Consultant to Sonoma Valley Hospital

2005 Consultant to the American Civil Liberties Union, American College of Obstetricians and Gynecologists, Association of Reproductive Health Professionals, Center for Reproductive Rights, National Abortion Federation, Planned Parenthood Federation of America, Reproductive Health Technologies Project and the Society for Maternal-Fetal Medicine

Mark A. Rosen, M.D.

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SUMMARY OF SERVICE ACTIVITIES I have been engaged in many University and Public service activities throughout my career at UCSF. Currently I serve as a Medical Student Career Advisor and Chair the Academic Standards Committee for the School of Medicine. Medical Student Career Advisors assist medical students with choices of specialization and the applications process for residency training. The Academic Standards Committee assesses medical students whose academic progress falls short of established standards, reviews the details of their progress and problems, and explores potential confounding personal problems or other problems that can contribute to impairment of academic progress. The Committee meets with the referred student and makes recommendations to the Dean about whether to offer special assistance, special leniency, some interventional therapy, or whether to proceed to dismissal. I also serve on the Dean’s Advisory Committee on Postdoctoral Education and have served on the admissions committee, ad hoc promotions committees and special grievance committees for the School of Medicine. At the Departmental level, I serve in a leadership role by directing the residency-training program, participating as a member of the Chairman’s Executive Committee and recently having organized a faculty retreat, at which I led a major session to educate the Department’s faculty about new teaching mandates for residency training from the Accreditation Council for Graduate Medical Education (ACGME), and now oversee a major re-engineering of our residency training program. As the residency director, I serve on numerous committees related to resident education and training. Serving in the primary role for the Department’s resident selection and recruitment process alone occupies the majority of my time about two months per year. I have given freely of my time to teach at local Bay Area and Northern California hospitals, speaking at their Grand Rounds, participating in their quality assurance program reviews and serving as a consultant, both formally and informally. I also participate with the UCSF Perinatal Outreach program to provide education at facilities that refer their complicated patients to the University and I teach for the Great Expectations Program for Parents about four times a year. I have provided substantial professional service to the American Board of Anesthesiology in its examination process for certification since 1983, for both the written and oral examinations. I served as a question writer, member of the editorial board, and council member for the examination as well as an examiner for the oral examinations, which occupies one week per year.

Mark A. Rosen, M.D.

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TEACHING and MENTORING MEDICAL STUDENTS and RESIDENTS

Course Title Hours Anesthesia 110 Anesthesia Core Clerkship

(Medical Students) 40

Anesthesia 140.07 Advanced Anesthesia (Course Director)

(Medical Students) 10

Anesthesia 140.08 Obstetrical Anesthesia (Course Director)

(Medical Students) 20

Anesthesia 400 Anesthesia Staff Conferences

(Residents) >150

Anesthesia 450 Anesthesia Clinical Work

(Residents) >800

Ob-Gyn 400 Ob-Gyn Staff Conferences

(Residents and Fellows) 100

Total hours of teaching previous fiscal year:

>1120 hours

Total hours of teaching current fiscal year:

>1120 hours

Total hours of teaching next fiscal year: >1120 hours Teaching Description Anesthesia 110 – Two-week Core Clerkship in anesthesia for all medical students in their 3rd or 4th year of medical school. This is an introductory course in anesthesia, focused on preoperative evaluation, intraoperative and postoperative management. Students spend the majority of the two weeks in the surgical operating rooms and spend one day in various anesthesia subspecialty venues. I teach the students who elect to spend their day in obstetrical anesthesia at Moffitt-Long Hospital (Children’s Hospital of UCSF). Anesthesia 140.07 - Twelve-week Advanced Clerkship in general anesthesia for medical students who are in the last three months of the medical school phase of the integrated training program in Oral and Maxillofacial Surgery. During this three-month period, students become familiar with administration of general anesthesia for basic surgical procedures. Anesthesia 140.08 - Four-week, advanced elective in obstetrical anesthesia for medical students. The objectives for this course include learning physiologic and anatomic changes that take place during pregnancy, placental physiology and transfer of drugs, their effects on the fetus and newborn, newborn assessment and resuscitation, management of labor analgesia, cesarean section and management of high risk and emergency obstetric patients.

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Anesthesia 400 - Didactic lectures in sciences basic to the specialty of anesthesia, as well as case reviews, clinical discussions, and seminars on current medical literature. These are conducted in small group seminars on a, nearly daily basis with residents on my clinical service. Anesthesia 450 - Direct supervision of residents in the management of clinical anesthesia care of patients in the labor and delivery suites (UCSF Birthing Center), operating rooms, recovery rooms and other locations in which anesthesia is provided (cardiac catheter lab, neuroradiology suite, interventional radiology suite, MRI and CT scanners, in vitro fertilization lab, etc.) Obstetrics and Gynecology 400 - Daily teaching rounds with residents in obstetrics, gynecology and reproductive sciences and anesthesia residents on their obstetrical anesthesia rotation. Weekly one-hour participation in perinatal morbidity and mortality conferences attended by faculty, fellows and residents in pediatrics (neonatalogy), obstetrics (perinatology) and anesthesia (obstetrics). ADDITIONAL TEACHING FORMAL TEACHING POSTGRADUATE AND OTHER COURSES I co-organize and direct an annual continuing medical education conference and teach at numerous other continuing education courses offered by the Department of Anesthesia and Perioperative Care, the Department of Obstetrics, Gynecology and Reproductive Sciences, as well as by invitation at many other national conferences. This has been an important avenue for my teaching and updating the practice of anesthesia for fetal surgery, obstetrics, and surgery during pregnancy, newborn resuscitation and many related topics. By teaching in venues that have large audiences, as well as by writing for textbooks, I fulfill an important personal commitment to teaching and widespread dissemination of information. INFORMAL TEACHING CONSULTANT ACTIVITY International, national and local consultation for clinical care -- I am frequently contacted for assistance by clinicians confronted with complex issues pertaining to anesthetic management of pregnant women for labor and delivery, surgery during pregnancy, fetal surgery or other fetal procedures. RESIDENT & MEDICAL STUDENT TEACHING Attending rounds, Obstetrical Anesthesia Service, 1-1.5 hours, 3 days per week

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POSTDOCTORAL FELLOWS DIRECTLY SUPERVISED OR MENTORED

Dates Name Faculty Role Current Position 1982 Patricia Dailey, M.D. Clinical and

Research Training Private Practice

1982 Curtis Baysinger, M.D. (US Army) Clinical and Research Training

Univ S. Carolina

1982 Dennis Kotelko, M.D. (Canada) Clinical and Research Training

Private Practice

1982 Ray Brizgys, M.D. 1982 (US Army) Clinical and Research Training

Private Practice

1982 Stan Fouts, M.D. (US Army) Clinical and Research Training

Private Practice

1982 Jarman Thigpen, M.D. Clinical and Research Training

Deceased

1983 Bobby Dallas, M.D. (US Army) Clinical and Research Training

Private Practice

1983 David Shapiro, M.D. (US Army) Clinical and Research Training

Private Practice

1983 Edward Eisler, M.D. Clinical and Research Training

Private Practice

1983 Steve Halpern, M.D. (Canada) Clinical and Research Training

Private Practice

1983 Kevin Healy, M.D. (US Army) Clinical and Research Training

Private Practice

1983 Judith Holmgren, M.D. (US Navy) Clinical and Research Training

Private Practice

1983 Lee Brookshire, M.D. (US Army) Clinical and Research Training

Private Practice

1984 Sol Pytka, M.D. (Canada) Clinical and Research Training

Univ Halifax

1984 David Cheek, M.D. Clinical and Research Training

Private Practice

1985 Wycke Baker, M.D. Clinical and Research Training

Baylor University

1985 Dayle O'Connor, M.D. Clinical and Research Training

Private Practice

1985-1986 Craig Leicht, M.D. Clinical and Research Training

Private Practice

1986 Brian Ross, M.D. Clinical and Research Training

Univ. Washington

1986-1987 Beth Glosten, M.D. Clinical and Research Training

Univ. Chicago (retired)

1986-1987 Paul Preston, M.D. Clinical and Research Training

Kaiser Hospital

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1987 Steve Carlton, M.D. (US Army) Clinical and Research Training

Private Practice

1987-1988 Daniel Murphy, M.D. Clinical Training Private Practice

1987 William Hughes, M.D. (US Army) Clinical Training Private Practice

1987 Allen Lavee, M.D. Clinical Training Private Practice

1988 Gary Glaze, D.O. (US Army) Clinical Training Private Practice

1988 Gordon Curry, M.D. Clinical Training Private Practice

1988 Ann Valerie Thirion, M.D. (France) Clinical Training France NHS

1989 Jan Vertommen, M.D. (Belgium) Research Training Univ. Leuven

1989 Katherine Limanek, M.D. Clinical Training Private Practice

1989 Cheryl Messer, M.D. (England) Clinical and Research Training

England NHS

1990-1991 Mark Gillie, M.D. Clinical Training Private Practice

1991-1992 Lawrence Caldwell, M.D. Clinical Training Private Practice

1992 Craig Fong, M.D. Clinical Training Private Practice

1994-1995 Charlize Kessin M.D. (Brazil) Clinical Training Brazil NHS

1994-1995 Randall Kan M.D. Clinical and Research Training

Private Practice

1996-1997 Susan Gorman M.D. Clinical and Research Training

UCSF, then Private Practice

2000-2001 Rhonda Arnette, M.D. Clinical and Research Training

Univ. N. Carolina

Clinical Visitors Gabriela Dumitru (Romania) (World Bank award: RO-3409) 1995-96

Mona Gherman (Romania) (World Bank award: RO-3409) 1995-96

Cristina Gutierrez (Columbia) 2003

Jariya Santatianant (Thailand) 2003-04

Peter Liang, MD (University of California Los Angeles) 2 weeks 2005

Sanjeev Tanwar (India) 2005

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FACULTY MENTORING A majority of the Anesthesia Department’s faculty are former UCSF residents. For many, as their Program Director during residency training, I spent considerable time as a mentor, and it has been a natural evolution that I informally mentor and counsel many of the faculty members of our Department for professional, as well as personal, issues. (20 hours / year) RESIDENT MENTORING I spend a considerable amount of time mentoring residents. As the Residency Director, I have 72 trainees under my supervision, 24 residents per year for a three-year program and I mentor the majority of our residents for a variety of matters, including educational and academic assistance to help improve their overall academic achievement, career mentoring and/or assistance with securing employment after residency training, as well as personal development mentoring to support residents during times of personal and academic stress or pressure, or for guidance in decision making about career and life issues. I approach mentoring as a guide to residents through a productive thinking, learning, and problem-solving process. Our Residency has a well-established program of planned mentoring that occurs through a structured program in which mentors and participants are selected and matched through a formal process in which a formalized faculty mentor is identified for each resident to facilitate closer faculty-resident relationships and individual counsel for each resident. For the most part, my involvement with residents can be characterized as a more natural mentoring that occurs through friendship, collegiality, teaching, coaching, and counseling. My role as the Residency Director positions me as a contact for many private practices across the country, and therefore as an established and knowledgeable career advisor. Additionally, as the Residency Director I have counseled residents in academic difficulty, residents with attitude or behavioral problems, confronted residents with concern for substance abuse and I’ve counseled residents with personal issues or problems ranging from pregnancy to dying, death of family member, marital discord, depression, angst about career choice, and for numerous other reasons. (80 hours / year) MEDICAL STUDENT MENTORING Each year, about a dozen UCSF senior medical students are interested in applying for anesthesia residency-training programs. Through the Department’s Medical Student Anesthesia Interest Group, I meet with a group of these interested medical students twice per year to discuss a career in anesthesia and guide them about the application process. Further, I meet with most of the students individually to help them assess their qualifications as an applicant, assist them in preparing an application, and guide them in selecting suitable places for them to apply, based on their academic and professional achievements, goals as well as the many other personal factors involved in such a decision, such as location. I spend about an hour with each student. I directly assist most of the students plan and write their personal statements (I edit many of them), and help them select appropriate faculty for letters of reference. I also see many students from other medical schools that come to UCSF for student externships, counseling them about applications in a similar, but more abbreviated fashion. (20 hours / year)

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TEACHING AIDS Numerous slide-enhanced lectures for residents Textbook of Obstetrical Anesthesia published in 2002, which is widely used by many other Universities for teaching obstetrical anesthesia at their institutions. Four chapters in: The Manual of Anesthesia Practice. PocketMedicine.com, Inc. 2004 Pain relief during childbirth: Obstetrical anesthesia at UCSF (patient information brochure). 1992 Obstetrical Anesthesia Syllabus (for residents rotating on the service) (updated 2005) Obstetrical Anesthesia Syllabus for medical students rotating on the service in course 140.08 (updated 2005) TEACHING AWARDS AND NOMINATIONS 1993, Kaiser Teaching Award Nomination 2005, Outstanding Teacher of the Year at Moffitt-Long by the graduating senior class 2007, Excellence in Teaching Award, UCSF Academy of Medical Educators SUMMARY OF TEACHING HOURS 2003-2004 > 1200 teaching hours, including informal teaching and mentoring 2004-2005 > 1200 teaching hours, including informal teaching and mentoring 2005-2006 > 1200 teaching hours, including informal teaching and mentoring (anticipated) TEACHING NARRATIVE My career has been devoted to clinical care and teaching, primarily at the resident and postdoctoral (continuing medical education) levels. I teach residents about 170 days per year in daily attending rounds, daily informal lecture/seminars, and by clinical supervision. I teach medical students in courses pertaining to obstetrical anesthesia. I also teach in numerous continuing medical education courses, courses for future parents, and by consultation to clinical practitioners and hospital medical staffs. In addition, I annually plan and direct one of the nation’s largest and most highly regarded obstetrical anesthesia continuing medical education conferences, which is the most highly rated, large-attendance, continuing medical education conference sponsored by the University of California San Francisco.

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RESEARCH AND OTHER CREATIVE ACTIVITY Keywords / Areas of Interest Anesthesia, obstetrical anesthesia, anesthesia for fetal surgery, anesthesia for surgery during pregnancy, anesthetic agent teratology, fetal assessment, neonatal resuscitation, medical education, Anesthesia for Clinical Fetal Surgery: The Fetal Treatment Center at UCSF performed the first surgery on a human fetus in 1981, a fetus with bilateral urinary tract obstruction due to a posterior urethral valve. I have collaborated with Dr. Michael Harrison (UCSF Department of Surgery) in this innovational UCSF program since its inception. We demonstrated the crucial importance of skillful and inventive management of anesthesia and intra-operative uterine muscle relaxation for fetal survival in non-human primates, before embarking on our first human clinical fetal surgery. I've provided creative solutions for clinical problems of adequate intra-operative fetal monitoring and intense uterine muscle relaxation (atony; tocolysis) that has been necessary for surgical success. I have been principal in providing anesthesia care to mothers and their unborn fetuses for a variety of congenital abnormalities, many undergoing procedures in a variety of NIH funded trials, including congenital diaphragmatic hernia (CDH) repair, tracheal occlusion for CDH, and presently for myelomeningocele repair and late-gestation tracheal occlusion for CDH. I'm internationally recognized as the pioneer in anesthesia for fetal surgical procedures. Commercial fetal pulse oximetry, recently introduced in the United States resulted from my early work with the Nellcor Company (early 1980's) and my designs of reflectance (rather than transmittance) pulse oximeters. My work has involved significant refinement of anesthetic and intraoperative tocolytic techniques for treatment of congenital diaphragmatic hernia (CDH) in utero, and development of maternal and fetal anesthetic techniques to accommodate EX-utero Intrapartum Treatment (EXIT procedures) for fetuses that undergo in utero tracheal occlusion. Success of the tracheal occlusive procedures required successful modifications of conventional anesthetic techniques for cesarean delivery to maintain the fetal-placental circulation for as long as two hours after 'birth' to ensure the fetal airway is surgically established and secured. Harrison MR, Adzick NS, Flake AW, VanderWall KJ, Bealer JF, Howell LJ, Farrell JA. Filly RA, Rosen MA, Sola A: Correction of congenital diaphragmatic hernia in utero VIII: Response of the hypoplastic lung to tracheal occlusion. J Ped Surg 1996; 31:1339-48

Mychaliska GB, Bealer JF, Graf JL, Rosen MA, Adzick N. Harrison MR: Operating on placental support: The ex utero intrapartum treatment procedure. J Ped Surg 1997; 32:1-6

Harrison MR, Adzick NS, Bullard KM, Farrell JA, Howell LJ, Rosen MA, Sola A. Goldberg J, Filly RA: Correction of congenital diaphragmatic hernia in utero VII: A prospective trial. J Ped Surg 1997; 32:1637-1642 Ball R, Golombeck K, Jacobs V, Lee H, Farrel J, Farmer D, Filly R, Rosen M, Harrison M. Maternal morbidity after fetal surgery. Am J Obstet Gynecol 2004; 191:S10

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Funded Research Participant in NIH funded fetal surgery trials for myelomeningocele repair and management of twin-twin transfusion syndrome. Most Recent Publications Rosen MA: Anesthesia for fetal procedures and surgery. Yonsei Med J 2001; 42:669-680 This invited review article allowed me to summarize the anesthetic achievements for fetal surgery, including techniques developed to provide sufficient time for surgical establishment of a neonatal airway while oxygenation for the 'newborn' is maintained by umbilical blood flow and gas exchange in the placenta. This required anesthetic techniques to prevent the uterus from contracting (which is the normal response to delivery), yet avoiding excessive bleeding from uterine atony associated with halogenated anesthetic agent administration. Techniques for fetal monitoring and anesthetic management of the mother are summarized. Rosen MA. Nitrous oxide for relief of labor pain: A systematic review. Am J Obstet Gynecol 2002; 186:S110-26 This was a Cochrane style review of the world’s literature about use of nitrous oxide for labor analgesia, a technique widely utilized in the United Kingdom, Scandinavia, Canada, and Australia but not in the United States. The author uses nitrous oxide in his practice at UCSF. Rosen MA. Paracervical block for labor analgesia: A brief historic review. Am J Obstet Gynecol 2002; 186:S27-30 This was a review of the use, efficacy and side effects of paracervical block techniques for labor analgesia, a technique that is rarely used in the United States, but much more popular in other parts of the world. By invitation, these two articles were prepared in a Cochrane review format for oral presentation at the New York Academy of Medicine in a symposium co-sponsored by the Maternity Association of America. Since publication, these systematic literature reviews have generated considerable national discussion, consultation and media attention (print, radio and television). Lee SJ, Ralston HJP, Drey EA, Partridge JC, Rosen MA. Fetal Pain: A Multidisciplinary Review of the Evidence. JAMA 2005; 294:947-54 Proposed federal and state legislation would require physicians to inform women seeking abortions at 20 or more weeks after fertilization that the fetus feels pain and to offer anesthesia directly to the fetus. We assembled a multidisciplinary team to examine the evidence about whether a fetus feels pain and if so, whether safe and effective techniques exist for providing direct fetal anesthesia or analgesia in the context of abortion. This paper has generated widespread, international media attention and has contributed to a national political debate about abortion. This paper represents an area of interest I’ve long held and addresses clinical questions I’ve long considered. I have consulted to numerous national organizations about the issues discussed in this paper, and presently I am being sought to testify before many state legislatures, and possibly the US Congress about issues addressed in this paper.

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Golombeck K, Ball RH, Lee H, Farrell JA, Farmer DL, Jacobs VR, Rosen MA, Filly RA, Harrison MR. Maternal morbidity after maternal-fetal surgery. Am J Obstet Gynecol 2006;194:834-9. There is a paucity of published data on the maternal risks of fetal surgical interventions. We analyzed maternal morbidity and mortality that were associated with different types of fetal intervention (open hysterotomy, various endoscopic procedures and percutaneous techniques) to quantify this risk. Short-term morbidities include increased rates of cesarean birth, treatment in intensive care, prolonged hospitalization, and blood transfusion, all of which were more common with hysterotomy compared with other techniques. Maternal-fetal surgery can be performed without maternal death. Results from this study provide helpful data for counseling prospective patients.

Educational Administration: Program Director, Anesthesia Residency Training Program The program director is responsible for the program and accountable for the operation of the program, general administration of the program, and for the establishment and maintenance of a stable educational environment. The program director must possess faculty experience, leadership, organizational and administrative qualifications, and the ability to function effectively within the institutional governance. The program director must have significant academic achievements in anesthesiology, such as publications, the development of educational programs, or the conduct of research. The program director must oversee and organize the activities of the educational program in all institutions that participate in the program. This includes selecting and supervising the faculty and other program personnel at each participating institution, appointing a local site director, and monitoring appropriate resident supervision at all participating institutions. The program director is responsible for preparing an accurate statistical and narrative description of the program as requested by the RRC, as well as updating annually both program and resident records through the ACGME's Accreditation Data System. The program director must ensure the implementation of fair policies, grievance procedures, and due process, as established by the sponsoring institution and in compliance with the Institutional Requirements. The program director must seek the prior approval of the RRC for any changes in the program that may significantly alter the educational experience of the residents. In the past several years, with increasing educational mandates and the institution of competency-based assessments by the Accreditation Committee on Graduate Medical Education (ACGME), much more of my time has been focused on restructuring and reorganization of the Department’s residency training program. I have been developing educational goals and objectives for our residency training program, as well as competency-based criteria for measuring outcomes to define more specifically our success in clinical training, and the desirable volume and distribution of clinical work. This has resulted in less productivity in creative activities in other areas of my career. Since 1983, I have been directly responsible for resident selection and residency co-ordination in the Department of Anesthesia, and for more than 15 years I have formally served as the Director of the Residency Training Program in the Department of Anesthesia and Perioperative Care at UCSF. This involves overseeing the selection, employment and education of residents, overall program design and organization of all clinical and didactic activities of the educational program, including clinical rotation development, resident clinical assignments, and the logistic organization of 72 residents at 5 institutions (UCSF, SFGH, SFVAH, Mt. Zion Medical Center,

Mark A. Rosen, M.D.

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Oakland Children’s Hospital), in thirty different clinical rotations over a three-year training period. I oversee all the requisite institutional affiliation agreements, resident contracts, resident employment duty hour compliance and resident welfare, required reporting to the ACGME, RRC and American Board of Anesthesiology, and the logistics and supervision of a non-academic staff of three full-time administrative assistants. I also oversee other faculty members who have primary responsibilities for chairing committees for resident didactic education, evaluation and welfare. Program Design & Leadership in Residency Teaching and Evaluation: Most recently, I organized a faculty retreat (Fall 2004) and led a full, half-day session to educate and update faculty regarding the Accreditation Council for Graduate Medical Education (ACGME) Clinical Competencies and new teaching mandates. I assigned faculty to committees to address these mandates and I have sustained an overall leadership role in their implementation and a major restructuring of the residency-training program. I have attended national conferences devoted to these topics for the past two years. Resident Selection: I read about 600 applications per year for our residency program and select about 100 applicants to invite for personal interviews. I coordinate all applicant interview-day activities and personally interview every invited applicant (about 14 full-days of interviewing per year). At the conclusion of the interview season, I create the final rank order list submitted to the National Resident Matching Program. Resident Training Rotations: I oversee thirty different resident rotations and coordinate their sequencing and the logistics of resident scheduling for each resident at each rotation over their three-year residency. I create an annual resident rotation schedule and meet with rotation directors to create and modify teaching goals and objectives, orientation guides and resident evaluation in clinical competency areas of patient care, medical knowledge, practice-based learning and improvement, professionalism, interpersonal and communication skills, and systems-based practice. Resident Logistics: I create and oversee an annual rotation assignment schedule and a monthly resident call schedule for each of the four teaching institutions and coordinate all resident vacations, meetings and absences. Resident Mentoring: described in the Mentoring section Resident Assessment: I serve as an ex officio member of the resident advising and evaluation committee. Prior to ACGME guidelines prohibitions, I served as the Chair of this committee. ACGME Re-Accreditation: The Accreditation Council for Graduate Medical Education (ACGME) is an organization responsible for the accreditation of residency education programs. Completion of an accredited residency program is a prerequisite for primary board certification and for certification in the majority of subspecialty boards. To maintain accreditation, residency programs are expected to comply substantially with the Program Requirements for their specialty, and the institutions sponsoring them are expected to comply with a set of Institutional Requirements. Compliance is measured through periodic review. The formal periodic review of programs involves an on-site inspection. It is based on a Program Information Form (PIF), a comprehensive self-study document prepared by the program being reviewed. The PIF and the site visitor’s report form the basis of the RRC’s review and accreditation decision. The site visit

Mark A. Rosen, M.D.

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consists of interviews with the program director, members of the teaching faculty, resident physicians, and often administrators and other key personnel. In preparation for site visitation by a representative of the Residency Review Committee (RRC) of the ACGME and re-accreditation, I oversee the massive undertaking of comprehensively chronicling our residency-training program in a program information form. The writing, data collection and collation involved in this task now occupy a major portion of my non-clinical time. Additionally, as the site visit date approaches, faculty and residents will need to be educated and prepared for meeting with the site visitor. Although these activities have not resulted in peer-reviewed publications, my experience and expertise have resulted in many consultations from colleagues across the country, counterparts at UCSF, one formal invited lecture in England, and widespread national recognition. I’m proud of the contributions I’ve made to the UCSF anesthesia residency program, which has sustained its international reputation as one of the finest training programs in the world. UCSF is one of the most highly sought and highly regarded residency training programs in the United States.

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Bibliography Journal Articles 1. Farnden KJF, Rosen MA, Lelgegren DR: Aldoximes and nitriles as intermediates in the

biosynthesis of cyanogenic glucosides. Phytochemistry 1973;12:2673-7 2. Rosen MA, Farnden KJF, Conn EE, Hanson KR: Steriochemical aspects of the

biosynthesis of the epimeric cyanogenic glucosides dhurrin and taxiphyllin. J Bio Chem 1975; 250:8302-8

3. Harrison MR, Anderson J, Rosen MA, Ross NA, Hendrickx AG: Fetal surgery in the

primate. I. Anesthetic, surgical, and tocolytic management to maximize fetal-neonatal survival. J Pediatr Surg 1982; 17:115-22

4. Harrison MR, Golbus MS, Filly RA, Callen PW, Katz M, deLorimier AA, Rosen M,

Jonsen AR: Fetal surgery for congenital hydronephrosis. 1982; N Engl J Med 306:591-3 5. Rosen MA, Hughes SC, Shnider SM, Abboud TK, Norton M, Dailey PA, Curtis JD:

Epidural morphine for the relief of postoperative pain after cesarean delivery. Anesth Analg 1983; 62:666-72

6. Rosen MA, Baysinger CL, Shnider SM, Dailey PA, Norton M, Curtis JD, Collins M, Davis

RL: Evaluation of neurotoxicity after subarachnoid injection of large volumes of local anesthetic solutions. Anesth Analg 1983; 62:802-8

7. Hughes SC, Rosen MA, Shnider SM, Abboud TK, Stefani SJ, Norton M: Maternal and

neonatal effects of epidural morphine for labor and delivery. Anesth Analg 1984; 63:319-24

8. Kotelko DM, Shnider SM, Dailey PA, Brizgys RV, Levinson G, Shapiro WA, Koike M,

Rosen MA: Bupivacaine-induced cardiac arrhythmia’s in sheep. Anesthesiology 1984; 60:10-18

9. Kotelko DM, Dailey PA, Shnider SM, Rosen MA, Hughes SC, Brizgys RV: Epidural

morphine analgesia after cesarean delivery. Obstet Gynecol 1984; 63:409-13 10. Rosen MA, Thigpen JW, Shnider SM, Foutz SE, Levinson G, Koike M: Bupivacaine-

induced cardiotoxicity in hypoxic and acidotic sheep. Anesth Analg 1985; 64:1089-96 11. Rosen MA, Roizen MF, Eger EI II, Glass RH, Martin M, Dandekar PV, Dailey PA, Litt L:

The effect of nitrous oxide on in vitro fertilization success rate. Anesthesiology1987; 67:42-4

12. Cheek DBC, Hughes SC, Dailey PA, Field DR, Pytka S, Rosen MA, Parer JT, Shnider

SM: Effect of halothane on regional cerebral blood flow and cerebral metabolic oxygen consumption in the fetal lamb in utero. Anesthesiology 1987; 67:361-6

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13. Harrison MR, Golbus MS, Filly RA, deLorimier AA, Anderson RL, Flake AW, Huff RW, Rosen MA: Fetal hydronephrosis: Selection and surgical repair. J Pediatr Surg 1987; 22:556-8

14. Rosen MA, Dailey PA, Hughes SC, Leicht CH, Shnider SM, Jackson CE, Baker BW,

Cheek DB, O'Connor DE: Epidural sufentanil for postoperative analgesia after cesarean section. Anesthesiology 1988; 68:448-54

15. Preston PG, Rosen MA, Hughes SC, Glosten B, Ross BK, Daniels D, Shnider

SM,Dailey PA: Epidural anesthesia with fentanyl and lidocaine for cesarean section: Maternal effects and neonatal outcome. Anesthesiology 1988; 68:938-43

16. Glosten BG, Dailey PA, Preston PG, Shnider SM, Ross BK, Rosen MA, Hughes SC: pH

adjusted 2-chloroprocaine for epidural anesthesia in patients undergoing postpartum tubal ligation. Anesthesiology 1988; 68:948-50

17. Inturrisi M, Camenga CF, Rosen MA: Epidural morphine for relief of postpartum,

postsurgical pain. JOGNN 1988; 17:238-43 18. Dailey PA, Hughes SC, Rosen MA, Healy K, Cheek DBC, Shnider SM: Effect of

cimetidine and ranitidine on lidocaine concentrations during epidural anesthesia for cesarean section. Anesthesiology 1988; 69:1013-7

19. Baker BW, Hughes SC, Shnider SM, Field DR, Rosen MA: Maternal anesthesia and the

stressed fetus: Effect of isoflurane on the asphyxiated fetal lamb. Anesthesiology 1990; 72:65-70

20. Harrison MR, Adzick NS, Jennings RW, Duncan BW, Rosen MA, Filly RA, Goldberg JD, deLorimier AA, Golbus MS: Antenatal intervention for congenital cystic adenomatoid malformation. Lancet 1990; 336:965-7

21. Harrison MR, Langer JC, Adzick NS, Golbus MS, Filly RA, Anderson RL, Rosen MA

Callen PW, Goldstein RB, deLorimier AA: Correction of congenital diaphragmatic hernia in utero, V. Initial clinical experience. J Pediatr Surg 1990; 25:47-57

22. Harrison MR, Adzick NS, Longaker MT, Goldberg JD, Rosen MA, Filly RA, Evans MI

Golbus MS: Successful repair in utero of a fetal diaphragmatic hernia after removal of herniated viscera from the left thorax. N Engl J Med 1990; 322:1582-4

23. Harrison MR, Adzick NS, Jennings RW, Duncan BW, Rosen MA, Filly RA, Goldberg JD,

deLorimier AA, Golbus MS: Antenatal intervention for congenital cystic adenomatoid malformation. Lancet 1990; 336:965-7

24. Longaker MT, Harrison MR, Filly RA, Rosen MA, Chang SW, Golbus MS: Maternal

outcome after fetal surgery: a review of the first 17 human cases. JAMA 1991; 265:737-41

25. Rosen MA: Anesthesia for procedures involving the fetus. Sem Perinatol 1991; 15:410-7

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26. Vertommen JD, Hughes SC, Rosen MA, Shnider SM, Espinoza MI, Messer CP, Johnson JL, Parer JT: Hydralazine does not restore uterine blood flow during cocaine-induced hypertension in the pregnant ewe. Anesthesiology, 1992; 76:580-7

27. Alon E, Ball RH, Gillie MH, Parer JT, Rosen MA, Shnider SM: Effects of propofol and

thiopental on maternal and fetal cardiovascular and acid-base variables in the pregnant ewe. Anesthesiology 1993; 78:562-76

28. Harrison MR, Adzick NS, Flake AW, Jennings RW, Estes JM, MacGillivray TE, Chueh

JT, Goldberg JD, Filly RA, Goldstein RB, Rosen MA, Cauldwell C, Levine AH, Howell LJ: Correction of congenital diaphragmatic hernia in utero: VI. Hard-earned lessons. J Pediatr Surg 1993; 28:1411-8

29. Caldwell LE, Rosen MA, Shnider SM: Subarachnoid morphine and fentanyl for labor

analgesia. Regional Anesthesia 1994; 19:2-8 30. Hughes SC, Rosen MA: Obstetric anesthesia and analgesia; editorial comment. Current

Opinion in Anaesthesiology 1995; 8:193-5 31. Harrison MR, Adzick NS, Flake AW, VanderWall KJ, Bealer JF, Howell LJ, Farrell JA.

Filly RA, Rosen MA, Sola A: Correction of congenital diaphragmatic hernia in utero VIII: Response of the hypoplastic lung to tracheal occlusion. J Ped Surg 1996; 31:1339-48

32. Mychaliska GB, Bealer JF, Graf JL, Rosen MA, Adzick N. Harrsion MR: Operating on

placental support: The ex utero intrapartum treatment procedure. J Ped Surg 1997; 32:1-6

33. Harrison MR, Adzick NS, Bullard KM, Farrell JA, Howell LJ, Rosen MA, Sola A.

Goldberg J, Filly RA: Correction of congenital diaphragmatic hernia in utero VII: A prospective trial. J Ped Surg 1997; 32:1637-43

34. Cammarano WB, Gray AT, Rosen MA, Lim K-H: Anesthesia for combined cesarean

section and extra-adrenal pheochromocytoma resection: a case report and literature review. Int J Obstet Anesth 1997; 6:112-7

35. King S, Rosen MA: Prophylactic ephedrine and hypotension associated with spinal

anesthesia for cesarean delivery. Int J Obstet Anesth 1998; 7:18-22 36. Kan RE, Hughes SC, Rosen MA, Kessin C, Preston PG, Lobo EP: Intravenous

remifentanil; placental transfer, maternal and neonatal effects. Anesthesiology 1998; 88:1467-74

37. Rosen MA: Management of Anesthesia for the Pregnant Surgical Patient.

Anesthesiology 1999; 91:1159-63 38. Gorman SR, Rosen MA: Anesthetic implications of maternal physiological changes with

pregnancy. Seminars in Anesthesia, Perioperative Medicine and Pain 2000; 19:1-9

Mark A. Rosen, M.D.

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39. Rosen MA: Papillary Thyroid cancer in pregnancy: Therapeutic consideration of thyroid surgery under local anesthesia. Asian J Surg 2001; 24:314-5

40. Rosen MA: Anesthesia for fetal procedures and surgery. Yonsei Med J 2001; 42:669-80 41. Rosen MA: Nitrous oxide for relief of labor pain: A systematic review. Am J Obstet

Gynecol 2002; 186:S110-26 42. Rosen MA: Paracervical block for labor analgesia: A brief historic review. Am J Obstet

Gynecol 2002; 186:S27-30 43. Rosen MA, Andreae MH, Cameron AG: Nitroglycerin for fetal surgery: fetoscopy and ex

utero intrapartum treatment procedure with malignant hyperthermia precautions. Anesth Analg 2003; 96:698-700

44. Rosen MA: Waiting Too Long (Case & Commentary) Agency for Healthcare Research

and Quality, Morbidity & Mortality Rounds on the Web, http://www.webmm.ahrq.gov/case.aspx?caseID=38 November 2003

45. Lee SJ, Ralston HJP, Drey EA, Partridge JC, Rosen MA. Fetal Pain: A Multidisciplinary

Review of the Evidence. JAMA 2005; 294:947-54 46. Golombeck K, Ball RH, Lee H, Farrell JA, Farmer DL, Jacobs VR, Rosen MA, Filly RA,

Harrison MR. Maternal morbidity after maternal-fetal surgery. Am J Obstet Gynecol 2006;194:834-9.

Books & Book Chapters 1. Rosen MA: Cerebrovascular lesions and tumors in the pregnant patient. In Handbook of

Neuroanesthesia: Clinical and Physiologic Essentials. Newfield P, Cottrell JE, eds. Boston; Little, Brown and Company, 1983:226-244

2. Rosen MA: Anesthesia and tocolysis for fetal intervention. In The Unborn Patient::

Prenatal Diagnosis and Treatment. Harrison MR, Golbus MS, Filly RA, eds. Orlando; Grune and Stratton, Inc., 1984:417-433

3. Rosen MA: Anesthesia for fetal surgery. In Anesthesia for Obstetrics, 2nd Edition.

Shnider SM, Levinson G, eds. Baltimore; Williams and Wilkins, 1987:206-216 4. Rosen MA: Anesthesia for neurosurgery during pregnancy. In Anesthesia for Obstetrics,

2nd Edition. Shnider SM, Levinson G, eds. Baltimore; Williams and Wilkins, 1987: 403-413

5. Glosten B, Rosen MA: Obstetrical Anesthesia: Alternatives to epidural analgesia for

labor. In Antepartum and Intrapartum Management. Parer JT, ed. Philadelphia; Lea and Febiger, 1989:184-206

Mark A. Rosen, M.D.

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6. Rosen MA: Anesthesia for fetal intervention. In The Unborn Patient:: Prenatal Diagnosis and Treatment, 2nd Edition. Harrison MR, Golbus MS, Filly RA, eds. Philadelphia; W.B. Saunders Company, 1991:172-181

7. Vertommen JD, Rosen MA: Analgésie du post-partum. In La Douleur en Milieu

Chirugical. Bonnet F, ed. Paris; Arnette, 1991: 291-310 8. Rosen MA: Cerebrovascular lesions and tumors in the pregnant patient. In Handbook of

Neuroanesthesia: Clinical and Physiologic Essentials, 2nd Edition. Newfield P, Cottrell JE, eds. Boston; Little, Brown and Company, 1991:230-248

9. Vertommen JD, Rosen MA: Postpartum Analgesia, in Pain in the Perioperative Period.

Bonnet F, ed. Paris; Blackwell, Inc., 1992:291-310 10. Rosen MA: Neonatal resuscitation. In Common Problems in Pediatric Anesthesia, 2nd

Edition. Stehling L, ed. St. Louis; Mosby Year Book, Inc., 1992:1-6 11. Rosen MA: Anesthesia for fetal procedures and surgery. In Anesthesia for Obstetrics,

3rd Edition. Shnider SM, Levinson G, eds. Baltimore; Williams and Wilkins, 1993:281-298

12. Rosen MA: Anesthesia for neurosurgery during pregnancy. In Anesthesia for Obstetrics,

3rd Edition. Shnider SM, Levinson G, eds. Baltimore; Williams and Wilkins, 1993:551-562

13. Rosen MA: Fetal surgery. In Obstetric Anesthesia, Principles and Practice. Chestnut

DH, ed. Chicago; Mosby Year Book, Inc., 1994:110-121 14. Rosen MA. Obstetric analgesia and anesthesia. In Neonatology, Pathophysiology &

Management of the Newborn, 5th edition. Avery GB, Fletcher MA, MacDonald MG, eds. Philadelphia; Lippincot Williams & Wilkins, 1999:237-253

15. Rosen MA: Fetal surgery. In Obstetric Anesthesia, Principles and Practice, 2nd edition.

Chestnut DH, ed. St. Louis; Mosby, 1999:110-121 16. Rosen MA: Fetal surgery. In Decision Making in Anesthesiology, An Algorithmic

Approach 3rd edition. Bready LL, Smith RB, Mullins R, Norrily S, eds. Chicago; Mosby, 2000: 450-451

17. Cauldwell CB, Rosen MA, Jennings RW. Anesthesia and monitoring for fetal

intervention. In The Unborn Patient: The Art and Science of Fetal Therapy, 3rd Edition. Harrison MR, Evans MI, Adzick NS, Holzgreve W, eds. Philadelphia; W.B. Saunders Company, 2001:149-170

18. Telleria AM (translator), Rosen MA. Anestesia en terapia y cirugia fetal. In Manual de

Anestesiologia Pediatricia para medicos residents. Moreno MC, ed. Madrid; Ediciones Ergon, SA 2001:297-303

Mark A. Rosen, M.D.

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19. TEXTBOOK: Hughes SC, Levinson G, Rosen MA, eds., Shnider & Levinson's Anesthesia for Obstetrics, 4th Edition. Philadelphia; Lippincott, Williams & Wilkins 2002

20. Parer JT, Rosen MA, Levinson G. Uteroplacental circulation and respiratory gas

exchange. In Shnider & Levinson's Anesthesia for Obstetrics, 4th Edition. Hughes SC, Levinson G, Rosen MA, eds. Philadelphia; Lippincott, Williams & Wilkins 2002:19-40

21. Rosen MA, Hughes SC, Levinson G. Regional anesthesia for labor and delivery. In

Shnider & Levinson's Anesthesia for Obstetrics, 4th Edition. Hughes SC, Levinson G, Rosen MA, eds. Philadelphia; Lippincott, Williams & Wilkins 2002:123-148

22. Hughes SC, Levinson G, Rosen MA. Anesthesia for cesarean section. In Shnider &

Levinson's Anesthesia for Obstetrics, 4th Edition. Hughes SC, Levinson G, Rosen MA, eds. Philadelphia; Lippincott, Williams & Wilkins 2002:201-236

23. Rosen MA. Anesthesia for fetal procedures. In Shnider & Levinson's Anesthesia for

Obstetrics, 4th Edition. Hughes SC, Levinson G, Rosen MA, eds. Philadelphia; Lippincott, Williams & Wilkins 2002:267-285

24. Dodson BA, Rosen MA. Anesthesia for neurosurgery during pregnancy. In Shnider &

Levinson's Anesthesia for Obstetrics, 4th Edition. Hughes SC, Levinson G, Rosen MA, eds. Philadelphia; Lippincott, Williams & Wilkins 2002:509-527

25. Levinson G, Hughes SC, Rosen MA. Evaluation of the neonate. In Shnider & Levinson's Anesthesia for Obstetrics, 4th Edition. Hughes SC, Levinson G, Rosen MA, eds. Philadelphia; Lippincott, Williams & Wilkins 2002:639-655

26. TEXTBOOK (Chinese translation): Hughes SC, Levinson G, Rosen MA, eds., Shnider

& Levinson's Anesthesia for Obstetrics, 4th Edition. Shandong Science & Technology, Beijing; 2004

27. Rosen MA: Fetal surgery. In Obstetric Anesthesia, Principles and Practice, 3rd Edition.

Chestnut DH, ed. Philadelphia; Elsevier Mosby 2004:96-109 28. Rosen MA, Hughes SC. Maternal and fetal anesthesia and analgesia. In Avery's

Diseases of the Newborn, 8th Edition. Taeusch WH, Ballard RA eds. Philadelphia; Elsevier Saunders 2005:159-170

29. Rosen MA, Hughes SC. Obstetrics. In Basics of Anesthesia, 5th Edition. Stoelting RK,

Miller RD, ed. Philadelphia; Churchill Livingstone Elsevier 2007:475-503. 30. Rosen MA: Fetal surgery. In Decision Making in Anesthesiology, An Algorithmic

Apporach 4th Edition. Bready LL, Dillman D, Norrily S, eds. Chicago; Mosby, (in press)

Mark A. Rosen, M.D.

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Miscellaneous 1. Rosen MA: Chloroprocaine not absolved of neurotoxicity (in reply). Anesth Analg

63:545-546, 1984 2. Daniels D, Rosen MA: A method for monitoring pulse rate changes during test doses of

epidural anesthetic solutions in obstetrics (letter to the editor). Anesth Analg 65:1089, 1986

3. Rosen MA: Bupivacaine toxicity (epitome). West J Med 144:598-599, 1986 4. Rosen MA: Pain relief during childbirth: Obstetrical anesthesia at UCSF (patient

information brochure). 1987 5. Rosen MA: Effects of epidural sufentanil and morphine on postsurgical pain.

Therapeutics Today, 1989 6. Rosen MA: Pain relief during childbirth: Obstetrical anesthesia at UCSF (patient

information brochure). 1992 7. Waldman JD, Chilton L, Golmes G, Plowden J, Wernly J. Placenta-dependent systemic

oxygenation; a case report of transposition with no septal defects. Prenat Neonat Med 2:152-155, 1997 (acknowledged “for expertise and willing collaboration”)

8. Cammarano WB, Gray AT, Rosen MA, Lim KH. Magnesium and pheochromocytoma (in

reply). Int J Obstet Anesth 7:62-63, 1998 9. King S, Rosen MA: Prophylactic ephedrine and hypotension associated with spinal

anesthesia (in reply). Int J Obstet Anesth 7:278-279,1998 10. Rosen MA: Carbon dioxide for obstetric pneumoperitoneum (in reply). Anesthesiology

93:270-271, 2000 11. Rosen MA: Another choice for Queen Victoria? (Editorial) Int J Obstet Anesth 12:71-73,

2003 12. Rosen MA: Pain relief during childbirth: Obstetrical anesthesia at UCSF (patient

information brochure). 2004 13. Lee JP, Hughes S, Rosen M. Labor & Vaginal Delivery, in The Manual of Anesthesia

Practice, PocketMedicine.com, 2004 14. Lee JP, Hughes S, Rosen M. Cesarean-Hysterectomy, in The Manual of Anesthesia

Practice, PocketMedicine.com, 2004 15. Lee JP, Hughes S, Rosen M. Cesarean Section, Non-emergent, in The Manual of

Anesthesia Practice, PocketMedicine.com, 2004

Mark A. Rosen, M.D.

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16. Lee JP, Hughes S, Rosen M. Cesarean Section, Emergent, in The Manual of Anesthesia Practice, PocketMedicine.com, 2004

17. Lee SJ, Ralston HJP, Drey EA, Partridge JC, Rosen MA. Fetal Pain (in reply), JAMA

2006; 295:160-1 18. Rosen, MA. Obstetrical Anesthesia Continuing Medical Education Program (4 modules).

Editor. California Society of Anesthesiologists Newsletter, 2007-2008 Abstracts 1. Farnden KJF, Rosen MA, Conn EE: In vivo and in vitro studies on aldoximes as

intermediates in the biosynthesis of cyanogenic glucosides in higher plants. Plant Physiol 1972; 49:S38

2. Rosen MA, Baysinger CL, Shnider SM, Dailey PA, Norton M, Levinson G, Curtis JD,

Collins W, Davis RL: Evaluation of neurotoxicity of local anesthetics following subarachnoid injection. Anesthesiology 1982; 57:A196

3. Rosen MA, Hughes SC, Curtis JD, Norton M, Levinson G, Shnider SM: Effects of

epidural morphine on uterine blood flow and acid-base status in the pregnant ewe. Anesthesiology 1982; 57:A383

4. Woods WA, Stanski DR, Curtis J, Rosen M, Shnider SM: The role of the fetal liver in the

distribution of thiopental from mother to fetus. Anesthesiology 1982; 57:A390 5. Hughes SC, Rosen MA, Shnider SM, Norton M, Curtis JD: Epidural morphine for the

relief of postoperative pain after cesarean section. Anesth Analg 1982; 61:190 6. Thigpen JW, Kotelko DM, Shnider SM, Foutz SE, Levinson G, Koike M, Rosen MA:

Bupivacaine cardiotoxicity in hypoxic-acidotic sheep. Anesthesiology 1983; 58:A204 7. Kotelko DM, Thigpen JW, Shnider SM, Foutz SE, Rosen MA, Hughes SC: Postoperative

epidural morphine analgesia after various local anesthetics. Anesthesiology 1983; 59:A413

8. Foutz SE, Kotelko DM, Shnider SM, Thigpen JW, Rosen MA, Brookshire GL Koike M,

Levinson G, Elias-Baker B: Placental transfer and effects of cocaine on uterine blood flow and the fetus. Anesthesiology 1983; 59:A422

9. Hughes SC, Shnider SM, Rosen MA: Neurologic and adaptive capacity scoring system

(scientific exhibit). American Society of Anesthesiologists Annual Meeting, Atlanta, Georgia, 1983, and 1983 New York Postgraduate Assembly, New York City

10. Hughes SC, Kotelko DM, Rosen MA: Epidural morphine: A clinical reality for analgesia

after cesarean section. Abstract of the 8th World Congress of Anesthesiologists, Manila, The Philippines, 1984

Mark A. Rosen, M.D.

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11. Halpern SH, Eisler EA, Shnider SM, Shapiro DA, Levinson G, Rosen MA, Johnson J, Jones MJ: Myocardial tissue uptake of bupivacaine and lidocaine after intravenous injection in normal and acidotic rabbits. Anesthesiology 1984; 61:A208

12. Eisler EA, Shapiro DA, Shnider SM, Halpern SH, Levinson G, Rosen MA, Johnson J,

Jones MJ: The lethal dose of intravenous bupivacaine with and without epinephrine in rabbits. Anesth Analg 1985; 64:209

13. Roizen MF, Dandekar PV, Cahalan MK, Cronnelly R, Dailey PA, Litt L, Eger EI II,

Rosen MA, Sohn YJ, Glass RH, MacKenzie NL: Effect of nitrous oxide on in vitro fertilization success rate. Anesth Analg 1985; 64:274

14. Cheek DBC, Pytka S, Shnider SM, Dailey PA, Rosen MA, Hughes SC, Levinson G,

Johnson J, Jones MA: Successful resuscitation after massive intravenous bupivacaine overdose in the acidotic rabbit. Anesthesiology 1985; 63:A246

15. Cheek DBC, Pytka S, Shnider SM, Parer ST, Field R, Dailey PA, Hughes SC,

Rosen MA, Levinson G, Johnson J, Jones MJ: The effect of halothane anesthesia on the asphyxiated fetal lamb. Anesthesiology 1985; 63:A356

16. Dailey PA, Hughes SC, Rosen MA, Healy K, Cheek DBC, Pytka S, Fisher DM, Shnider

SM: Lidocaine levels during cesarean section after pretreatment with ranitidine or cimetidine. Anesthesiology 1985; 63:A444

17. Baker W, Eisler EA, Shnider SM, Halpern SH, Levinson G, Dailey PA, Hughes SC,

Rosen MA, Johnson J and Jones MJ: The lethal dose of intravenous bupivacaine in pregnant and nonpregnant rabbits. Anesthesiology 1985; 63:A447

18. Leicht CH, Rosen MA, Dailey PA, Hughes SC, Shnider SM, Baker BW, Cheek DBC,

O'Connor DE: Evaluation and comparison of epidural sufentanil citrate and morphine sulfate for analgesia after cesarean section. Anesthesiology 1986; 65:A365

19. Leicht CH, Hughes SC, Dailey PA, Shnider SM, Rosen MA: Epidural morphine sulfate

for analgesia after cesarean section: A prospective report of 1000 patients. Anesthesiology 1986; 65:A366

20. Leicht CH, Baker BW, Rosen MA, Field DR, Dailey PA, Hughes SC, Shnider SM, Parer

JT, Ross BK, Auslender R: The effect of ketamine or sodium thiopental rapid sequence induction on the asphyxiated fetal lamb. Anesthesiology 1986; 65:A387

21. Preston P, Rosen MA, Daniels D, Glosten B, Shnider S, Ross B, Dailey P, Hughes S:

Epidural fentanyl with lidocaine for cesarean section. Anesthesiology 1987; 67:A442 22. Ross BK, Hughes S, Glosten B, Shnider S, Preston P, Rosen MA, Dailey P: Evaluation

of epidural pH-adjusted 2%-chloroprocaine for labor analgesia. Anesthesiology 1987; 67:A629

Mark A. Rosen, M.D.

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23. Glosten B, Dailey P, Preston P, Shnider S, Ross B, Rosen MA, Hughes S: Epidural anesthesia with pH-adjusted 3% 2-chloroprocaine for postpartum tubal ligation. Anesthesiology 1987; 67:A630

24. Wright RG, Shnider SM, Thirion A-V, Messer CP, Rosen MA: Regional anesthesia for

preterm labor and vaginal delivery: Effects on the fetus and neonate. Anesthesiology 1988; 69:A654

25. Preston P, Hughes S, Dailey P, Ross B, Glosten B, Rosen MA, Shnider S: Fetal effects

of induction agents in the hemorrhaged maternal ewe. Anesth Analg 1988; 67:S175 26. Hughes SC, Wright RG, Murphy D, Preston P, Hughes W, Rosen MA, Shnider S: The

effect of pH adjusting 3% 2-chloroprocaine on the quality of post-cesarean section analgesia with epidural morphine. Anesthesiology 1988; 69:A689

27. Thirion A-V, Wright RG, Messer CP, Rosen MA, Shnider SM: Maternal blood loss

associated with low dose halothane administration for cesarean section. Anesthesiology 1988; 69:A693

28. Hughes SC, Thirion AV, Messer CP, Hassanzadeh MK, Gambertoglio JG, Rosen MA,

Shnider SM: Placental transfer and acute maternal and fetal effects of AZT in the pregnant ewe. Society of Obstetric Anesthesia and Perinatology 1989, 9th Annual Meeting, New Orleans, Louisiana

29. Rosen MA, Hughes SC, Shnider SM, Curry GR, Glaze GM, Thirion AV, Vertommen JD:

Continuous infusion epidural sufentanil for postoperative analgesia. Anesth Analg 1990; 70:S331

30. Vertommen JD, Hughes SC, Shnider SM, Rosen MA, Espinoza MI, Messer CP:

Hydralazine does not improve decreased uterine blood flow during cocaine induced hypertension in the pregnant ewe. Anesthesiology 1990; 73:A928

31. Hughes SC, Vertommen JD, Rosen MA, Messer CP, Espinoza MI, Parer JT, Shnider

SM: Cocaine induced hypertension in the ewe and response to treatment with labetalol. Anesthesiology 1991; 75:A1076

32. Alon E, Rosen MA, Shnider SM, Ball RH, Parer JT: Maternal and fetal effects of propofol

anesthesia in the ewe. Anesthesiology 1991; 75:A1077 33. Caldwell LE, Rosen MA, Shnider SM: Intrathecal morphine and fentanyl for labor

analgesia: efficacy and adverse effects. Reg Anesth 1993; 18:S51 34. Kessin C, Hughes S, Rosen MA, Kan R, Parer J, Johnson J: Cocaine-induced

hypertension and response to treatment with nitroglycerin in the pregnant ewe. Society for Obstetric Anesthesia and Perinatology 1995, 27th Annual Meeting, Montreal, Canada; Anesthesiology 1995; 83:A937

35. Cauldwell C, Rosen MA, Harrison MR: The use of niroglycerin for uterine relaxation

during fetal surgery. Anesthesiology 1995; 83:A929

Mark A. Rosen, M.D.

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36. Hughes S, Kan R, Rosen MA, Kessin C, Preston PG, Lobo EP, Johnson LR, Johnson J:

Remifentanil: ultra-short acting opioid for obstetric anesthesia. Anesthesiology 1996; 84:A894

37. Maloney SR, Johnson JL, Hughes SC, Rosen MA. Epidural bupivacaine decreases

pushing strength. Anesthesiology 2001; 94:A61 38. Ball R, Golombeck K, Jacobs V, Lee H, Farrel J, Farmer D, Filly R, Rosen M, Harrison

M. Maternal morbidity after fetal surgery. Am J Obstet Gynecol 2005; 191:S10