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NAME: Saeed R. Khan ADDRESS: Department of Pathology College of Medicine, Box 100275 University of Florida Gainesville, Florida 32610 UNIVERSITY EDUCATION: B.Sc. 1962 Agra University, Agra, India M.Sc. 1964 Peshawar University, Peshawar, Pakistan Ph.D. 1973 University of Florida, Gainesville, Florida CONTINUING EDUCATION: 5. American Urological Association Summer Research Conference, Houston, Texas, August 10-

12, 2001 4. Workshop on Molecular Approaches to Kidney and Urologic Problems, Sponsored by

NIH/NIDDK, October 19-21, 1990 3. Workshop on Scanning Tunnelling Microscopy, given by Dr. Phillip E. Russell of

Materials Science and Engineering Department Center, North Carolina State University, during VIth Annual Meeting of the Florida Society for Electron Microscopy, 1988.

2. Scanning Electron Microscopy and X-ray Microanalysis: Theory and Practice in Biology

and Medicine, State University of New York, New Paltz, New York, 1982. 1. Vertebrate Cell and Organ Culture, The W. Alton Jones Cell Science Center, Lake Placid,

New York, 1980.

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PROFESSIONAL EXPERIENCE:

2013 Co-Director, University of Florida Training Program in Urology Research

2012 Finlayson Professor of Urological Research, Department of Urology

2011 Professor (Adjunct), Department of Pathology 1997-2010 Professor

Department of Pathology, 1991 Associate Professor Department of Pathology 1987 Assistant Professor Department of Pathology 1985 Associate Research Scientist Department of Pathology, 1982 Assistant Research Scientist Department of Surgery/Urology, 1979 Assistant in Surgery Department of Surgery/Urology 1978 Postdoctoral Fellow Department of Pathology 1976 Assistant Professor Biology Department King Abdulaziz University Jeddah, Saudi Arabia 1974 University Research Fellow Plant Pathology Department University of Adelaide, Adelaide, Australia 1973 Assistant Professor Institute of Biological Sciences Islamabad University, Islamabad, Pakistan 1964 Lecturer in Biology, Directorate of Education, NWFP Region, Peshawar, Pakistan

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TEACHING EXPERIENCE: 2006-2010 Lecturer, Special Topics in Pathology, Cellular and Molecular Basis of

Kidney Diseases 2004, 06 Coordinator, Special Topics in Pathology, Cellular and Molecular Basis of

Kidney Diseases

1991-02 Mechanisms of Disease Coordinator and Lecturer Graduate Course 1989-95 Systemic Pathology III,

(Medical Students) 1989 Special Topics in Pathology, Graduate Course 1989 Workshop on "Biological X-ray Microanalysis" to Members of Florida Society for Electron Microscopy, 1988 Biology and Taxonomy of Ascomycetes & Their Imperfect Stages, and Lichens, Graduate Course 1973,74 Cell Biology Graduate Course 1973,74 Mycology Graduate Course 1972 Electron Microscopy and Cytochemistry, Teaching Assistant 1964-70 Undergraduate General Biology Undergraduate Botany GRADUATE COMMITTEE ACTIVITIES Department of Pathology and Laboratory Medicine Doctoral Dissertation Chairman Jayashree A. Gokhale, 1995 Joanne Johnson-Tardieu, 1998

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Member Liliana Guedez 1995 Ying Yu 1995 Christy Myrick 1995 Brian E. Szente 1993 Michael Ambrose 1993 Lucia Fernandes Aleixo 1996 Masters Thesis: Chairman Suzanne A. Maslamani 1998 Julie M. Norton-Fasano 1999 Marie E. Buie 2001 Member Monique Y. Huggins, 1995 Xin (Cindy) Zhang, 1995 Xianggao Ye, 1994 Department of Pharmaceutics Member Vikram Arya, 2003 Sassiporn Sarawek 2007 Kai Wu 2006 Pattaraporn Vanachayangkul 2008 Karin Haug Current Wan, Sun Current Department of Plant Pathology Doctoral Dissertation Member Li-Tzu Li, 1994 Chi-Guang Wu, 1994 Department of Materials Science and Engineering Doctoral Dissertation Member Richard V. Linhart, 1994 Kimberly G. Christmas, 2001 Fairland Amos 2005 Saijit Daosukho 2007 Farid Vaghefi 2012 Archana Chidambaram current

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Masters Thesis Jin-Hwan Jeon, 2002 Charley Malpass, 2001

Department of Chemistry

Doctoral Dissertation Member Scott Whipps 1996 Isa Benitez 2004 Denise Sharbaugh 2010 RESEARCH FELLOWS: Dr. Chung-Jen Su, M.d., Ph.D. Dr. D. Ackermann, M.D.

Dr. D.J. Kok, Ph.D. Dr. Fouad Atmani, Ph.D. Dr. Sivagnanan Thamilselvan, Ph.D. Dr. Shizuka Iida, M.D., Ph.D. Dr. Manbu Moriyama, M.D., Ph.D. Dr. Tohru Umekawa, M.D., Ph.D. Dr. J. Y. Tsai, M.D., Ph.D. Dr. Kinue Aihara, M.D., Ph.D. Dr. Pouran Habibzadegah-Tari, Ph.D. Dr. Carla Escobar, Ph.D. Dr. Hassan Khaskhali, Ph.D. Dr. Jian Zou Ph.D. Dr. Benjamin K. Canales, M.S., M.D., current Dr. Sunil Joshi, Ph.D., current Dr. Hidenori Tsuji, M.D., Ph.D. Dr. Paul Ramon Gutierrez Dominguez, Ph.D.

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DEPARTMENTAL, COLLEGE AND UNIVERSITY ADMINISTRATION AND COMMITTEES: 2010 Member, Senate Infrastructure Policy Council 2009 Member, COM Mentoring Selection Committee 2007-08 Member, IDP M.S. Curriculum Committee 2007-10 Member, Faculty Senate 2007-08 Member, Senate Steering Committee 2007-08 Member, Research Policy Committee 2007-10 Member, Senate Academic Policy Council 2007-08 Chair, Senate Research and Scholarship Policy Council 2006-07 Chair, Senate Honorary Degrees, Distinguished Alumnus Awards and Memorial

Committee 2006-07 Member, Senate Research and Scholarship Policy Council 2006-07 Member, Senate Academic Policy Council 2005 Member, Animal Resources and Research Advisory Group 2005 Member, University of Florida Teacher/Scholar of the Year Award Committee 2005 Member, Medical Student Research Program Committee 2004-07 Member, Senate Honorary Degrees Distinguished Alumnus Awards and

Memorial Committee 2004-08 Member, Senate Research and Scholarship Policy Council 2004-05 Chair, Senate Research and Scholarship Policy Council 2004-05 Member, UF Research Policy Council 2004-06 Member, University of Florida Faculty Senate 2004 Member, Medical Student Research Program Committee 2004 Member, Selection Comm for Doctoral Dissertation Advisor/Mentoring

Committee 2004 Member, Panel of Judges for Medical Student’s Research Presentations

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2004 Member, Selection Comm Research & Graduate Programs Opportunity Fund 2003-05 Member, Graduate Coordinators Advisory Council 2003-06 Member, Faculty Senate Steering Committee 2000-2002 Member, University of Florida Faculty Senate 2000- Member, Departmental Clinical Research Committee 1986- Laboratory Host and Mentor, Annual Student Science Training Program

(SSTP), Center for Precollegiate Education and Training, University of Florida 1996- Director, Center for the Study of Lithiasis and

Pathological Calcification

2000-02 Director, Research and Academic Affairs, Division of Experimental Pathology, Department of Pathology

1998-02 Chief, Division of Experimental Pathology, Department of Pathology 2001 Member, Medical Student Research Committee

2001 Member, Oversight Committee, Medical Education Week

2000-01 Chairman, College Investment Fund (CIF) Grant Review Committee 2000-01 Member, UF Faculty Advisory Committee to Animal Care Services

1999- Member, College of Medicine, Electron Microscopy Committee

1998-02 Member, University of Florida Senate

1997- Member, Department of Pathology Variable Compensation Plan

1997- Member, Advisory Committee to the College of Medicine Associate Dean for Graduate Education

1994-2000 Alternate Member, Institutional Review Board 2000 Member, Ad Hoc Committee, Professor’s Salary Increase 1998-01 Chairman, Immunology Faculty Search Committees 1999 Chairman, Selection Committee for College of Medicine

Faculty Council Excellence in Basic Science Research Awards

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1999 Chairman, Medical Guild Graduate Student Research Competition Committee

1999 Chairman, Selection Committee for University Scholar’s Program

1998-99 Member, Research Committee, Howard Hughes Medical Research Institute Research Resources Program

1998-99 Chairman, Computer Operations Committee, Department of Pathology 1998 Member, Selection Committee for College of Medicine

Professional Excellence Program (PEP) Awards

1998 Member, Selection Committee for College of Medicine Teaching Incentive Program (TIP) Awards 1998 Member, Surgical Pathology Faculty Search Committees

1997 Member, The PhD/MBA subcommittee

1997 Chairman, Selection Committee for College of Medicine Faculty Council Excellence in Research Awards 1995 Member, College of Medicine Diversity Group 1994-98 Pathology Representative, College of Medicine Faculty Council 1993-94 Director, Center for the Study of Inflammatory Host Defense & Tissue Injury 1992-94 Director, Graduate Program, Department of Pathology 1992-94 Member, Department of Pathology Section Chief's Committee 1991-94 Departmental Representative, Pathology Comparative Pathology Joint Electron Microscopy Facility 1990-99 Member, Department of Pathology Graduate Committee 1989-90 Member, Advisory Committee to the Center for International Student and Scholar Services 1989-90 Member, Shand’s Hospital Kidney Stone Center Committee 1989-90 Member, University of Florida Task Force on International Students and Visiting Scholar

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NATIONAL & INTERNATIONAL RESEARCH GRANT AND PROGRAM REVIEW AND ADVISORY COMMITTEES:

2014 Member, CSR Special Emphasis Panel, RFA: Digestive and Kidney feasibility y

Clinical Study, ZRG1 DKUS-A (56), June 24, 2014 2014 Member, NIDDK Special Emphasis Panel, 2014/05 ZDK1 GRB-G (M2) M,

February5, 2014 2013 Member, Special Emphasis Panel/Scientific Review Group 2013/05 ZDK1

GRB-9 (M2), George M. O'Brien Urology Cooperative Research Centers (U54) April 16-17, 2013

2012 Member, National Institute Of Diabetes And Digestive And Kidney Diseases,

Member Conflict Telephone SEP, ZDK1 GRB-G (M2) 2009-Current Member, National Institutes Of Health, National Institute Of Diabetes And

Digestive And Kidney Diseases, Special Emphasis Panel, ZDK1 GRB-G M1 1, The NIDDK-KUH Fellowship Review Committee

2009 Reviewer, NIDDK, Challenge Grants, RFA-OD-09-003 2008 Reviewer, Joint Research Grant under National Research Foundation South

Africa/Japan Society for the Promotion of Science 2008 Member, NIDDK Special Emphasis Panel, ZDK1 GRB-6 01 1, George M.

O'Brien Urology Research Centers (P50), July 21-22 2008 Member, Urology Overflow Group, ZRG1 RUS-F (02) S, June 17, 2008 2008 Member, Dallas Kidney Stone Program Project Grant Review, ZDK1 GRB-7

(M2), April 10, 2008 2007 Member, Fellowship: Physiology and Pathobiology of Organ System, F10-H

20L, Study Section, March 2007 2006-10 Member, Urologic and Kidney Development and Genitourinary Diseases

(UKGD) Study Section 2006 Member, ZRG1 RUS-A 51 1, NIDDK PAR 06 113, October 26-31 2006 Reviewer, Research Grant Management, South African Medical Research

Council, Cape Town, South Africa 2006 Member, NIH Center for Scientific Review, ZRG1 EMNR-E (10),

Endocrinology, Metabolism, Nutrition and Reproductive Sciences, March 9-10, 2006

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2006 External Referee, Innovational Research Incentives Scheme, Netherlands Organization for Health Research and Development, Netherlands

2006 Consultant Reviewer, Health Research Board, Ireland 2005 Chair, NIDDK ZDK1 GRB-9 (J1), Special Emphasis Panel, Nephrolithiasis,

November 21, 2005 2004 Member, National Center for Complementary and Alternative Medicine Special

Emphasis Panel, ZAT1 DB15, Basic and Preclinal Research, June 7-8. 2003-05 Member, Scientific Review Board, Oxalosis and Hyperoxaluria Foundation,

St Louis, Missouri 2003 Consultant Reviewer, Reviewer, VA Merit Review Application, R. Tyler Miller,

Cleveland, Ohio

2002 Member, Center for Scientific Review Special Emphasis Panel, ZRG1 UROL (01), July 9-10

2002 Member, Center for Scientific Review Special Emphasis Panel, ZRG1 UROL

(17), Small Business: Urology, July 10 2002 Assessor (Reviewer), Grant PolyU 5265/02M, Research Grants Council,

University Grants Committee, Hong Kong, China 2001 Member, Special Emphasis Panel CSR/NIH SSS-T-10B Study Section,

Endocrine and Reproductive Sciences and Nutritional and Metabolic Sciences Integrated Review Groups, November 8

2001 Reviewer, Masters of Science Program in the Department of Pathology, College

of Medicine, Kuwait University, Kuwait, May 18-22rd 2001 2001 Reviewer, VA Merit Review Application, Dr. Neil S. Mandel, Professor of

Medicine, Biophysics, Biochemistry, Orthopedic Surgery, Medical College of Wisconsin, Associate Dean for VA Research and Associate Chief of Staff for research, Zablocki VA Medical Center, Milwaukee, Wisconsin.

2001 Reviewer, VA Merit Review Application, Dr. Jeff A. Wesson, Department of

Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 2001 Assessor (Reviewer), Grant PolyU 5280/01M, Research Grants Council,

University Grants Committee, Hong Kong, China

2000 Reviewer, Travelling Research Fellowship Application, The Wellcome Trust London, England

2000-04 Consultant, Program Project on Kidney Stones, University of Chicago,

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Chicago 1999 Reviewer, Stone Grant, St. Peters Trust, London, England 1999 Member, Review Comm, National Institute of Diabetes and Digestive and

Kidney Diseases, RFA: DK-98-018 “Urology Research Centers”, March 25-26, Baltimore, Maryland

1998 Reviewer, Kidney Stone Grant, The Division of Biology and Medicine,

Swiss National Science Foundation, Berne, Switzerland 1998 Member, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Special Emphasis Panel Review Committee, University of Texas

Southwestern Medical Center Program Project Application, Formulation of Rational Therapy of Nephrolithiasis (Dr. Charles Y.C. Pak, PI)

1996-1999 Member, National Institutes of Health (NIH)

Urology Special Emphasis Panel Study Section

1996-00 Member, Scientific Review Board, Oxalosis and Hyperoxaluria Foundation, St Louis, Missouri

1995-97 Member, National Institutes of Health (NIH) General Medicine - B Study

Section 1995-1999 Member, Advisory Group, O’Brien Center on Kidney Stones, University of

Chicago, Chicago 1990-95 NIH, Ad-hoc Reviewer on Urinary Stone Grants 1990-91 Veteran’s Administration, Reviewer on Urinary Stone Grants 1990-92 Member, NIDDK Special Grants Review Committees, University of Chicago

Program Project Application, Pathogenesis and Treatment of Calcium Nephrolithiasis (Dr. Frederic L. Coe, PI).

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ORGANIZATIONAL EXPERIENCE: 2014 Member, Advisory Committee, Expert in Stone Disease, December 10-13, 2014,

Cape Town, South Africa.

2008-2012 Member, Scientific Advisory Board, 12th International Symposium on Urolithiasis, May 9-12, 20012, Ouro Preto, Brazil.

2007-08 Member, International Scientific Committee, World Congress of Nephrology

Satellite symposium, Bone, Stone and Kidney, April 26-28, Rio de Janeiro, Brazil

2008-09 Member, Scientific Committee, 12thEuropean Symposium on Urolithiasis, October 15-17, Lake Como, Italy.

2006-7 Member, Scientific Committee, 12thEuropean Symposium on Urolithiasis,

July 4-7, 2007, Lisbon, Portugal.

2004-08 Member, International Organizing Committee, International Symposium on Urolithiasis, Niece, France, to be held 2008.

2004 Member, International Advisory Committee, 7th International Workshop on

Primary Hyperoxaluria, October 8-10, Mayo Clinic, Rochester 2006 Chair, Nominating Committee, Society for Leukocyte Biology

2004-7 Member, Nominating Committee, Society for Leukocyte Biology

2004 Member, International Organizing Committee, International

Symposium on Urolithiasis, Hong Kong, May 24-28, 2004

2003-04 Member, Graduate Coordinators Advisory Council 2004-05 Chair, Faculty Senate Research and Scholarship Policy Council 2002-03 Chair, Faculty Senate Nominating Committee 2002-03 Chair, Faculty Academic Advisory Council

2000-2001 Past President, Faculty Council, College of Medicine

1999-00 President, Faculty Council, College of Medicine 1997-00 Member, International Organizing Committee, International

Symposium on Urolithiasis held February 13-17, 2000; Cape Town, South Africa

1999 Organizer, 2nd Finlayson Colloquium on Urolithiasis, January 28-31st, Gainesville, Florida

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1998-99 President-elect, Faculty Council, College of Medicine 1997-99 President, Society for Research on Calculus Kinetics (The ROCK society) 1997-98 Vice President, Faculty Council, College of Medicine 1993-95 Secretary-Treasurer, The ROCK society 1993-94 President, Florida Society for Microscopy 1992-93 President Elect, Florida Society for Microscopy

1989-90 Director-at-Large, Biological Sciences, Florida Society for Electron Microscopy

1991 Member, Organizing Committee, Joint Meeting of Florida Society for

Electron Microscopy, Alabama Society for Electron Microscopy and Southeastern Electron Microscopy Society Gainesville, April 1st - April 4th.

1990 Member, Organizing Committee, Finlayson Colloquium on Urolithiasis,

Held at University of Florida April 22-24 1985 Member, Local Arrangements Committee, Annual Meeting of the

Mycological Society of America.

1988-89 President, Florida Society for Electron Microscopy 1987-88 President Elect, Florida Society for Electron Microscopy 1986-87 Vice President, Florida Society for Electron Microscopy 1986 Vice-Chairman, Gordon Conference on Calcium Oxalate

1984-86,89-90,93 Faculty Advisor, Muslim Students Association, University of Florida 1984-1994 Member Organizing Committee, Symposium on Stones and Crystals

in Disease, Annual Meetings of the Scanning Microscopy International

1973 Chairman, Council of International Organizations, University of

Florida 1972 President, International Club, University of Florida 1971 Secretary, International Club, University of Florida

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1964-66 Coach, Cricket Team, Government College, D.I. Khan, Pakistan 1961 Secretary, Biological Association, Reza Degree College, Rampur, India

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EDITORIAL AND JOURNAL REVIEW EXPERIENCE:

2013 Associate Editor, Urolithiasis 2004-20012 Associate Editor, Urological Research 2010- Member, International Advisory Board, Kuwait Journal of Science and

Engineering, Academic Publication Council, University of Kuwait, Kuwait

2004- Member, American Urological Association Urolithiasis Abstract Review Team

2008 Member, American Society of Nephrology Mineral Metabolism

Abstract Review Team

2007- Member, Editorial Board, Nephron Experimental Nephrology

2003-04 Member, Editorial Board, Urological Research 2002-04 Managing Editor, Frontiers in Bioscience 2000 Co-Editor, Proceedings of the 9th International Symposium on Urolithiasis,

University of Cape Town, Rondebosch, Cape Town, South Africa 1999 Co-Guest Editor, Kidney Stones: Recent Research and Management

Concepts, J Eondourology 13 (9) 1999 Guest Editor, J Am Soc Nephrol Supplement 10, Proceedings of The 2nd Finlayson Symposium 1997-2000 Member, Editorial Board Journal of Urology, Investigative Urology Section, 1996 Guest Editor, Stones and Crystals, Scanning Microscopy 10 (2), 303-612 1995 Member, American Society of Nephrology Mineral Metabolism

Abstract Review Team 1984-98 Member, Editorial Board, Scanning Microscopy 1994- Member, Editorial Board, Italian Journal of Mineral and Electrolyte Metabolism 1991 Guest Editor, Proceedings of Finlayson Colloquium Urolithiasis, Journal of Kidney Diseases, Vol. 17, April 1991

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1982- Ad-hoc Reviewer 1. Journal of Urology, 2. Scanning Microscopy 3. Cell and Materials 4. Kidney International 5. American Journal of Physiology 6. Clinical Chemistry 7. J. Clinical Chemistry 8. J. Clinical Investigation 9. J. Crystal Growth 10. J. Nutritional Biochemistry 11. J. Endourology 12. J. Bone and Min Research 13. Protein Science 14. Urology 15. Nephrol, Dialysis, Transplantation 16. Am J Kid Diseases 17. J Am Soc Nephrol 18. Clin Chem & Lab Med 19. Planta Medica 20. Experimental Biology and Medicine 21. African Journal of Biotechnology

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INVITED STATE OF THE ART AND PLENARY LECTURES: 83. September 6, 2013, Role of calcium phosphate in calcium oxalate crystallization, 2nd Meeting of

the EAU Section of Urolithiasis (EULIS), Copenhagen, Denmark. 82. September 5, 2013, Genetic basis of macromolecular modifications and their role in stone

formation, 2nd Meeting of the EAU Section of Urolithiasis (EULIS), Copenhagen, Denmark. 81. September 5, 2013, Experimental models in urolithiasis, 2nd Meeting of the EAU Section of

Urolithiasis (EULIS), Copenhagen, Denmark. 80. September 5, 2013, Formation of Randall’s plaques and their involvement in stone formation,

2nd Meeting of the EAU Section of Urolithiasis (EULIS), Copenhagen, Denmark. 79. April 26, 2013, Oxidative Stress as the basis of association between Nephrolithiasis and other

Chronic Kidney Diseases, 101 Annual Meeting of Japanese Urological Association, Sapporo, Japan.

78. December 13, 2012, Oxidative Stress, nephrolithiasis and chronic kidney disease, 1st

Conference, Expert on Stone Disease, Dubai, United Arab Emirate 77. May 12, 2012, Stress Oxidative: Urolithiasis and Chronic Kidney Disease, 12th International

Symposium on Urolithiasis, Ouro Preto, Brazil 76. May 11, 2012, Crystal and cells, a Review. 12th International Symposium on Urolithiasis, Ouro

Preto, Brazil 75. May 9, 2012. Plenary Debate, Basic Science Research of the Past 25 years: Prognosis for Stone

Treatment - Promising, 12th International Symposium on Urolithiasis, Ouro Preto, Brazil 74. February 24-28, 2012, 27th Annual Meeting of the European Association of Urology, Paris,

France, Meeting of the EAU Section of Urolithiasis (EULIS): Urolithiasis - new insights in pathophysiology - challenges in education - trends in treatment

73. September 8, 2011, The association of stone disease with chronic kidney disease, diabetes and

hypertension, is oxidative stress a common link? 1st Metting of European Association of Urology Section of Urolithiasis (EULIS), London, United Kingdom.

72. September 7, 2011, Of Mice and men, what do animal model studies reveal about pathogenesis

of kidney stones? 1st Metting of European Association of Urology Section of Urolithiasis (EULIS), London, United Kingdom.

71. September 12, 2010, Hypertension and nephrolithiasis. 25th Brazilian Nephrology Meeting,

Vitorai, Brazil. 70. September 14, 2010, Reactive Oxygen species (oxidative stress) and calcium oxalate

nephrolithiasis. 25th Brazilian Nephrology Meeting, Vitorai, Brazil.

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69. July 21, 2010, Renal oxidative stress in stone disease, evidence from animal model and tissue culture studies. Nephrology Research Conference, Medical College of Wisconsin, Milwaukee, Wisconsin

68. February 14, 2010, Genetic Basis of Renal Cellular Dysfunction and the Formation of Kidney

Stones, University of Florida Department of Urology, CME Seminar, Ponte Vedra, Florida 67. December 3, 2009, Nephrocalcinosis in Animal Models with or without Stones, 3rd

International Urolithiasis Symposium and Indiana University School of Medicine, Continuing Medical Education Seminar, Indianapolis, Indiana

66. October 16, 2009, Crystal/Cell Interaction : Oxidative Stress and Nephrolithiasis, 6th

Eurolithiasis Society Symposium and 16th European Symposium on Urolithiasis, Como, Italy 65. June 12, 2009, Herbal Medicines in the Management of Urolithiasis: Alternative or

Complementary? 7th Symposium, New Developments in Clinical Pharmacy and Clinical Pharmacology; Stresa, Italy

64. October 25, 2008, Cellular Dysfunction and kidney stones, SIUT 6th International Symposium

of Urology, Nephrology and Transplantation, Karachi, Pakistan 63. October 24, 2008, Alternative medicine for kidney stones, SIUT 6th International Symposium of

Urology, Nephrology and Transplantation, Karachi, Pakistan 62. September 4, 2008, Crystal-Cell interaction: Reactive oxygen species, oxidative stress and

nephrolithiasis, 11th International Symposium on Urolithiasis, Nice, France 61. April 26, 2008, Crystal Induced Inflammation, 2nd Annual Urology Research Retreat, Urology

Department, College of Medicine, UF 60. November 7, 2007, Calcium Oxalate Nephrolithiasis: Animal Models, Urology Grand

Rounds, Urology Department, College of Medicine, UF. 59. October 5, 2007, Investigations of Nephrolithiasis: Animal Model Studies, Urology Grand

Rounds, University of Colorado Health Sciences Center, Denver, Colorado. 58. Aug 25th, 2007, Calcium Oxalate/Calcium Phosphate Association in Kidney Stones, Results of

Experimental Studies, State of the Art Lecture, 17th Annual Meeting of the Japanese Society on Urolithiasis Research, Kurume , Japan

57. Aug 21st, 2007, Hypercalciuric Mice, Special Lecture, Urolithiasis Mini-Forum, Kanazawa

Medical University, Uchinada, Ishikawa, Japan 56. July 6th, 2007, What did we learn yesterday? Highlights of Presentations, 5th eUlis Symposium,

Lisbon, Portugal 55. July 6th, 2007, Research Methods on Stone Disease, Round Table on Research Methods, 5th

eUlis Symposium, Lisbon, Portugal

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54. April 28, 2007, Invited Lecture, Crystal Attachment and Stone Formation, Bone, Stone and

the Kidney, World Congress of Nephrology Satellite Symposium, Rio de Janeiro, Brazil. 53. May 26, 2006, Invited Lecture, Role of Injury and Inflammation in Urolithiasis, ROCK

Society Meeting at the Annual American Urological Association Meeting IN Atlanta. 52. April 12, 2006, Surgical Grand Rounds, Agha Khan University Medical College, Karachi,

Pakistan 51. April 10, 2006, Guest Lecture, Cell Injury/Dysfunction Critical for Stone Formation, Sindh

Institute of Urology and Transplantation, Dow Medical College, Karachi, Pakistan 50. April 6, 2006, Visiting Professor, Renal Tubular Damage/Dysfunction Key to the Formation

of Kidney Stones, International Center for Chemical Scineces, University of Karachi, Pakistan 49. April 1, 2006, Seminar, Kidney Stone Microstructure, Studies of Biological Sciences, University

of the Punjab, Lahore, Pakistan 48. March 28, 2006, Visiting Professor, Micromorphology of Kidney Stones, International Center

for Chemical Scineces, University of Karachi, Pakistan 47. July 19th, 2005, State of the Art Lecture, Tissue injury induced by oxalate. FASEB Summer

Research Conference, Calcium Oxalate in Biological Systems, Tucson, Arizona 46. June 16th, 2005, Discussant, Debate: The key to Stone formation is, Renal tubular dysfunction.

11th European Urolithiasis Symposium, Coburg, Germany. 45. February 25, 2005, Keynote Address, Urolithiasis Research – Past, Present and Future. SIUT

(Sind Institute of Urology and Transplantation) Urolithiasis Symposium, Karachi University, Pakistan

44. February 25, 2005, Plenary Lecture, Crystal-induced renal inflammation. SIUT Urolithiasis

Symposium, Karachi University, Pakistan 43. February 26, 2005, Plenary Lecture, Animal Models of CaOx nephrolithiasis. SIUT Urolithiasis

Symposium, Karachi University, Pakistan 42. October 8, 2004, State of the Art Lecture, Oxalate-induced oxidative stress in the kidneys, 7th

International Workshop on Primary Hyperoxaluria, Mayo Clinic, Rochester, MN 41. July 8, 2004, State of the Art Lecture Animal Models Calcium Oxalate Nephrolithiasis. I xion Biotechnology, Alachua, Florida 40. May 28, 2004, State of the Art Lecture, Animal Models of the Calcium Oxalate Nephrolithiasis.

10th International Symposium on Urolithiasis, Hong Kong, May 25-28, 39. December 1-15, 2003, Visiting Professor, Sindh Institute of Urology and Transplantation,

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Dow Medical College, Karachi, Pakistan 38. November 20, 2003, Plenary Lecture, Mediators of Oxalate Induced Tissue Injury, Oxalosis

and Hyperoxaluria Meeting sponsored by National Institutes of Health, Annapolis, Maryland 37. October 24, 2003, Invited Lecture, Crystal Cell Interaction: Cellular Involvement in Stone

Disease, Department of Urology, Nagoya City University, Nagoya, Japan 36. October 24, 2003, Keynote Address Special Lecture, Crystal-Induced Inflammation of the

Kidneys: Results from Tissue Culture and Animal Model Studies, 33rd Western Regional Meeting of the Japanese Society of Nephrology, Nagoya, Japan.

35. June 11, 2003, State of the Art Lecture, Organic Matrix of Kidney Stones: Its role in the

pathogenesis of urolithiasis, 10th European Symposium on Urolithiasis, Istanbul, June 11-14 34. June 11, 2003, State of the Art Lecture, Crystal Cell Interaction: Cellular involvement in stone

disease, 10th European Symposium on Urolithiasis, Istanbul, June 11-14 33. June 12, 2003, State of the Art Lecture, Stone research on the bench: where we are and where

we are going?, 10th European Symposium on Urolithiasis, Istanbul, June 11-14 32. June 14, 2003, Take Home Message, Pathophysiology / Etiology, 10th European

Symposium on Urolithiasis, Istanbul, June 11-14 31. May 28, 2002, First Annual Birdwell Finalyson Memorial Lecture, ROCK Society meeting

at the annual meeting of the American Urological Association, Orlando, Florida, , Stone Research on the Bench: where we are and where we are going”

30. April 5-6, 2002, Invited Lecture, 6th European Workshop on Hyperoxaluria, Hannover,

Germany. 29. July 3-5, 2001, Member, Biochemistry of Stone Disease Committee, 1st International

Consultation on Stone Disease, Organized by Am Urol Assoc, Con Am Urol, Eur Assoc Urol, Urol Asssc Asia, Soc Endourol, WHO, Intl Consul Urol Dis, Intl Soc Urol, Palais des Congress, Paris, France.

28. April 28th-29th , 2001, 4th Biennial Conference of Pakistan Society of Nephrology, Avari Hotel,

Lahore, Pakistan. State of the Art Lecture: New Trends in Renal Stone Research 27. April 10th -14th , 2001, 1st International and 11th National Chemistry Conference, Peshawar

University, Peshawar, Pakistan Plenary Lecture: Nucleation of Calcium Oxalate 26. November 16-17, 2000, Oxalosis and Calcium Oxalate Stone Disease, Workshop organized by

National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH.

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State of the Art Invited Presentation: Animal Model of Hyperoxaluria, Experimental Induction

25. February 17, 2000, Invited Overview lecture, Crystal-cell Interaction,

The backbone of stone formation, Urolithiasis 2000, 9th International Symposium on Urolithiasis, Cape Town, South Africa.

24. November 30, 1999, Symposium on Mineralization in Natural and Synthetic Biomaterials,

Fall Meeting of the Materials Research Society, Boston, Mass. Invited Lecture: Involvement of Cellular Membranes and Their Lipids in Nucleation of

Stone Forming Crystals. 23. November 29, 1999, Department of Physiology, University of Massachusetts College of

Medicine, Worcester, Mass. Seminar: Renal Epithelial Injury and Nephrolithiasis 22. August 18, 1999, FASEB Summer Research Conference, Calcium Oxalate in

Biological Systems, Copper Mountain, Colorado Invited Lecture: Cell culture and animal models in the study of nephrolithiasis 21. June 9-12, 1999, 8th European Symposium on Urolithiasis, Parma, Italy State of the Art Lecture: Calcium Oxalate Stone Formation as an Example of

Biomineralization 20. May 28-29, 1999, 1st Istanbul Urolithiasis Symposium, Istanbul, Turkey State of the Art Lectures 1. Inhibitors and Promoters of Stone Growth

2. Calcium Oxalate Crystals are Injurious to renal Epithelial Cells: Results of Studies in Rat Model of Hyperoxaluria

19. April 12-15, 1999, Keynote Address, 87th Annual Meeting of the Japanese Urological

Association, Osaka, Japan Pathogenesis of Urolithiasis: Results of Experimental Studies 18. March 12-13, 1999, 5th Workshop on Primary Hyperoxaluria, Kappel, Switzerland

Renal Epithelial Cells are Provoked by Exposure to both Oxalate and Calcium Oxalate Crystals: Results of studies in a rat model of nephrolithiasis

17. December 8-9, 1998, Workshop on New Horizons in the Pathogenesis,

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Treatment & Cure of Hyperoxaluria, Oxalosis & Oxalate Stone Diseases, Sponsored by The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland

State of the Art Lecture, Oxalate and Calcium Oxalate Crystals Provoke Renal Epithelial Cells: Results of Studies in rat Models

16. August 29, 1998, Keynote Address Special Lecture, Annual Meeting of the Urological

Association of the Republic of China, Taipei, Taiwan Oxalate Induced Responses of Renal Epithelial Cells 15. April 13, 1998, Hospital For Special Surgery, New York,

Metabolic Bone Disease Conference Seminar: Crystal Cell Interaction and Calcium Oxalate Nephrolithiasis 14. January 27, 1997, MARC/MBRS Guest Lecture Series,

School of Natural and Health Sciences, Barry University, Barry University,Miami Seminar: “Kidney Stone Formation” 13. November 21, 1996. NIDDK, The Division of Kidney, Urologic and Hematologic Diseases, NIH Campus, Bethesda, Maryland

Seminar: Calcium Oxalate Crystal-Renal Epithelial Cell Interaction and Kidney Stone Formation

12. June 8-10, 1995. Sixth European Symposium on Urolithiasis, Stockholm, Sweden Invited Speaker Round Table Discussion “What happens in the nephron in calcium oxalate stone disease” 11. August 21-26, 1994, Mineral Scale Formation and Inhibition, Symposium in honor of

Prof. George H. Nancollas, American Chemical Society Meeting, Washington, D.C. Invited Speaker, “Role of Calcium Phosphate in Calcium Oxalate Crystallization in vivo” 10. April 21st-23rd, 1994, 5th European Urolithiasis Symposium, Manchester, England Invited Speaker Round Table Discussions on: 1. Methods of Crystallization Studies 2. Site and Mechanism of Stone Initiation 9. October 4-5, 1993, Urolithiasis: State of the art and future research needs, Sponsored by

the Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland

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State of the Art: Basic research

8. December 27-29, 1993, 7th National Conference of Urolithiasis Society of India,

Madras, India Keynote Address Oration Lecture: "Nephrolithiasis: A free or fixed particle disease." 7. April 14, 1993, Symposium on hydroxyapatite and related materials, Spring meeting of

Materials Research Society, San Francisco Title: Pathological Crystallization of calcium oxalate and calcium phosphate." 6. April 1-3, 1993, 4th European Symposium on Urolithiasis, Tubingen, Germany Title: "Cellular membranes as heterogeneous nucleator of calcium oxalate crystals." 5. April 5, 1993, University Hospital, Marburg, Germany Title: "Formation and retention of calcium oxalate crystals in the renal tubules." 4. March 31, 1993, Faculty of Medicine and University Policlinic, Inselspital, Berne,

Switzerland Title: "Formation and retention of calcium oxalate crystals in the renal tubules." 3. August 23-27, 1992, 7th International Symposium on Urolithiasis, Cairns, Australia Co-chairperson, Theme Poster Session on "Stone Composition: Matrix and Membranes." Plenary Lecture: "Renal epithelial injury: a risk factor in urolithiasis." 2. April 30th, 1992, Symposium on Pathogenesis, diagnosis and therapy of nephrolithiasis,

Ospedale S. Maria della Misericordia, Udine, Italy Title: "Ultrastructural morphology of calcium oxalate crystal deposition in kidneys." 1. October 18, 1991, Department of Nephrology, Institute of Internal Medicine and

Institute of Urology, University of Padova, Italy Title: "Renal epithelial injury, cell membrane and crystallization of calcium oxalate."

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SESSION CHAIRMANSHIPS: May 20, 2014, Moderator, Stone Disease: Evaluation III (Moderated Poster), AUA Annual Meeting,

May 16-21, Orlando, Fl December 15, 2012, Chairman, Un-moderated Poster Session 6: Stones Non-Surgical II –

Epidemiology, 1st Conference, Expert on Stone Disease, Dubai, United Arab Emirate December 15, 2012, Co-Chairman, Moderated Poster Session 4, Non-Surgical Stone Disease, 1st

Conference, Expert on Stone Disease, Dubai, United Arab Emirate May 11, 2012, Moderator, Mini-Conferences, 12th International Symposium on Urolithiasis, Ouro

Preto, Brazil May 10, 2012, Moderator, Oral Presentations-Pediatric Stones, 12th International Symposium on

Urolithiasis, Ouro Preto, Brazil September 9, 2011, Co-Chair, Stones in animals/ Clinical Therapy in humans. Ist Meeting of European Association of Urology Section of Urolithiasis (EULIS), London, United Kingdom April 29, 2009, Moderator, Poster Session, Stone Disease: Research/New Technology (1), Annual Meeting of American Urological Association, Chicago October 24, 2008, Session Chair, Urology, SIUT 6th International Symposium of Urology, Nephrology and Transplantation, Karachi, Pakistan September 4, 2008, Session Chair, Crystal and cells, 11th International Symposium on Urolithiasis, Nice, France July 10, 2007, Session Chair, 5th European Urolithiasis Symposium, Lisbon, Portugal July 19th, 2005, Session Chair, Oxalate Chemistry and Biology, FASEB Summer Research Conference, Calcium Oxalate in Biological Systems, Tucson, Arizona June 17th, 2005, Chair, Session on Crystallization, Renal Tubules, 11th European Urolithiasis Symposium, Coburg, Germany. April 30th, 2005, Moderator, Session 4, Annual Meeting of the ROCK (Research on Calculus Kinetics) Society, Chicago, IL. June 11, 2003, Session Chair, Hyperoxaluria and Related Disorders, 10th European Symposium on Urolithiasis, Istanbul, Turkey. August 6, 2002, Session Chair, Crystal-Cell Interactions, 2002 FASEB Summer Research Conferences, Calcium Oxalate in Biological Systems, August 3-8, Vermont Academy, Saxtons river, Vermont. February 16, 2000, Co-Chair, Crystallization Modulators and Macromolecules, Urolithiasis 2000, 9th International Symposium on Urolithiasis, Cape Town, South Africa.

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June 9-12, 1999, Co-Chair: Session on Inhibitors and Promoters, 8th European Symposium on Urolithiasis, Parma, Italy. March 12-13, 1999, Co-Chair: Session on Diagnostic Approaches, 5th Workshop on Primary Hyperoxaluria, Kappel, Switzerland. May 22, 1997, Chairperson, Crystallization Processes, 7th European Symposium on Urolithiasis, Paris, France. April 12, 1997, Moderator, Basic Research, Annual Meeting of American Urological Association, Special Session on Stone Disease sponsored by the R.O.C.K. Society, San Antonio, Texas. December 27-29, 1993, Co-Chair, Pathogenesis of renal calculi, 7th National Conference of Urolithiasis Society of India, Madras, India. April 1-3, 1993, Co-Chair, Session on Calcium metabolism and related problems, 4th European Symposium on Urolithiasis, Tubingen, Germany

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HONORS & AWARDS: 2011 MARQUIS Who's Who in America, 66th Edition

2010 Fellow of the American Society of Nephrology

2006 Fellow of the American Society of Nephrology

2001 University of Florida Research Foundation Professor

1997 University of Florida College of Medicine, Award for Excellence in Research, Faculty Research Prize in Basic Science

1997 Best Poster in Basic Science Research, 97th Annual Meeting of

The American Urological Association, New Orleans, April 16, 1997. 1993 MARQUIS Who's Who in Science and Engineering 1993 Oration Lecture, 7th National Meeting of the Urolithiasis Society of India,

Madras, India 1993 Invited Speaker, State of the Art: Basic Research.

Urolithiasis: State of the Art and Future Needs, Sponsored by the Division of Kidney, Urologic and Hematologic Diseases, NIDDK, NIH

1992 University of Florida Research Achievement Award 1974- University Research Fellowship, 1976, University of Adelaide, Australia 1973 Admitted to Academic Honorary Society, Phi Kappa Phi 1972 Admitted to Leadership Honorary Society, Omicron Delta Kappa 1972 Admitted to Scientific Honorary Society, Sigma Xi 1970-73 Fulbright-Hays Scholar, University of Florida, Gainesville 1964 Graduated with Honors from University of Peshawar, Pakistan 1963 Highest Grade in M.Sc. Part I. University of Peshawar, Pakistan

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CURRENT AND PAST MEMBERSHIP IN PROFESSIONAL SOCIETIES: Society for Free Radical Biology and Medicine American Physiological Society American Society for Investigative Pathology American Society of Nephrology American Urological Association The American Society for Bone and Mineral Research The Society for Basic Urologic Research New York Academy of Sciences Society for Biomaterials Florida Society for Microscopy Microscopy Society of America Histochemical Society

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RESEARCH GRANTS: Active: 2012-2016 Principal Investigator with Dr. Laurie Gower (contact) NIH, RO1DK092311-01A1

An in vitro model for studying the role of acidic proteins in Randall’s Plaque and Stone Formation

2009-014 Principal Investigator NIH, RO1

Crystal Associated Renal Inflammation and Treatment Options

2013-2018 Co-Principal Investigator and co-Director with Dr. Johannes W.G. Vieweg, NIH, T32 DK 094789

Training Program in Urologic Research Completed:

2005-2010 Principal Investigator NIH, RO1

Calcium Phosphate crystals responsible for idiopathic nephrolithiasis 2005-2007 Co-Principal Investigator

NIH, R21 Oxalobacter as a therapy in IBD-associated urolithiasis

2001-2005 Co-Principal Investigator, Bioengineering Research Partnership with College of Engineering NIH RO1 DK59765 Role of Bioplymer and Lipids in Kidney Stone Formation

2000-2005 Principal Investigator

NIH RO1DK 53962 Tissue-Crystal Interaction in Calcium Oxalate Neophrolithiasis

1997-2001 Co-Principal Investigator NIH RO1 DK53556 Regulation of Enteric Hyperoxaluria by Oxalobacter

2000-2003 Co-Principal Investigator, NIH RO1DK56249 Urolithiasis and Peroxidative Injury

1996-2001 Principal Investigator,

NIH RO1 DK 41434 Role of Lipids in Urolithiasis 1999 Principal Investigator, NIH R13 DK 54761

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2nd Finlayson Colloquium on Urolithiasis

1996-97 Director, Program Project on Biophysics of Urolithiasis,

NIH 5PO1 DK 20586 1997-00 Pathology Core Laboratory NIH #A1-37281 Malaria-Associated Lactic Acidosis/DCA Trial in Africa (P.W. Stacpoole, PI) 1992-97 Principal Investigator, Project 2 Program Project on Urolithiasis NIH 5PO1 DK 20586

1992-97 Principal Investigator, Analytical Core Program Project NIH 5PO1 DK 20586 Urolithiasis 1991-95 Principal Investigator NIH #RO1 DK 41434 Role of Lipids in Urolithiasis 1990 Principal Investigator University of Florida Division of Sponsored Research Development Award 1990 Co-Principal Investigator with Dr. Woodard Kingston Technologies, Catheter Calcification 1987-1992 Co-Principal Investigator with Dr. Hackett NIH program project grant # 5 PO1 DK20586 Urolithiasis 1978-1987 Co-Investigator with Drs. Hackett and Finlayson, NIH program project grant # AM20586 Urolithiasis 1974-1973 University Research Fellowship University of Adelaide, Adelaide, Australia 1970-1973 Fulbright-Hay's Scholarship University of Florida