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University: Alexandria

Faculty: Medicine

Program Specifications

(Academic year: 2015/2016)

A. Basic Information:

1. Program title: Doctor degree of Medical Parasitology

2. Type of program: single

3. Department(s) offering the program: Department of Medical

Parasitology

4. Program Coordinator: Prof. Dr. Mona El-Temsahy - Prof. Dr.

Lobna El Zawawy

5. External Evaluator(s): Prof. Dr. Stéfane Picot; Prof. of

Parasitology and Tropical Medicine, Malaria Research Unit,

University Lyon 1, France.

6. Date of program specifications approval: 29/3/2016

B. Professional Information

1- Program Aims are to

1.1 Recognize recent advances in the field of Medical Parasitology.

1.2 Provide professionals with a broad training to be able to

examine and diagnose parasitological specimens.

1.3 Prepare the candidate to participate in senior

management teams that develop, implement, monitor,

evaluate and redevelop polices and strategies to improve

diagnosis of parasitic diseases.

1.4 Develop research skills applicable to a wide range of

problems in parasitic diseases.

1.5 Prepare the candidate to be an efficient staff member to

perform teaching tasks, plan and modify curricula, assess and

appraise junior staff.

2. Academic Standards: Academic reference standards of Doctor Degree in Medical

Parasitology designed and approved by the Medical

Parasitology Department, Faculty of Medicine, Alexandria

University.

Based on:

Generic Academic Reference Standards (ARS): Postgraduate

Medical Education, Egypt (2009). Published by National

Authority for Quality Assurance and Accreditation of

Education (NAQAAE) National

[http;//naqaae.org/main/php/book/index.php]

Adapted from: (Bench marks)

1. School of Public Health and Tropical Medicine – Tulane

University.

http://www.sph.tulane.edu/tropmed/programs/phd.htm

2. London School of Hygiene and Tropical Medicine, University of

London.

http://www.Ishtm.ac.uk/prospectus/masters/msmp.html

3. Liverpool School of Tropical Medicine.

http://www.liv.ac.uk/lstm

Domain

Academic reference standards by

area

ILOs

Knowledge &

Understanding

Graduate must have fluent deep

knowledge & understanding of:

- Review of basic informations

studied in the master degree in the

field of helminths, protozoa and

medically important arthropods.

- The updates on morphology and

classification of helminths,

protozoa and vectors transmitting

parasitic infections, with special

emphasis on emerging parasitic

diseases.

_____________________________

-

Mechanisms of pathogenesis of

parasitic diseases (helminthic and

protozoal).

_____________________________

- Classical and recent antiparasitic

drugs.

_____________________________

- Modern approaches in the

diagnosis of parasitic infections.

_____________________________

- The principles of prevention

and control of parasitic

infections.

By the end of the program the

PG students will be able to:

a1- Revise the diagnostic morphology, life

cycles, clinical manifestations, diagnosis and

treatment of the studied parasites.

a2- Recognize updates in morphology, biology

and life cycles of parasites and their relevance

for human health.

a3- Describe the mode of infection of different

parasites among humans.

a4- Identify the role played by intermediate

hosts and vectors in disease transmission.

_______________________________________

a5- Define terms used in describing aspects of

parasitic pathogenesis.

a6- Recognize the pathogenic characters of

parasites and how they produce tissue damage.

a7- Explain at the cellular and molecular levels

the concept of pathogenesis and the host-

parasite interactions.

_______________________________________

a8- Explain the basis for therapeutic effects of

antiparasitic drugs and their mode of action.

a9- Identify pitfalls and resistance of current

therapy regimens and the role of recently

discovered antiparasitic drugs.

_______________________________________

a10- Identify recent methods for laboratory

diagnosis of parasitic infections with special

emphasis on molecular techniques.

_______________________________________

a11- Discuss the prevention strategies for

control of vectors and intermediate hosts

transmitting human parasites especially newly

emerging and re-emerging parasites.

a12- Recognize the hazards of various customs

and habits applied by people which contribute to

the spread of parasitic infections.

- Advanced research techniques

used in the field of medical

parasitology and immunology of

parasitic infections.

a13- Trace recent advances in the field of

medical parasitology and apply this knowledge

in the diagnosis of parasitic infections.

a14- Describe the nature of parasitic infections

in the immunocompromized host (opportunistic

parasites).

a15- Select laboratory techniques for assessment

of humoral and cellular immunity.

a16- Identify the recent approaches in vaccine

development.

Intellectual

skills

Graduate must be able to:

- Choose appropriate laboratory tests

and interpret their results.

_____________________________

- Organize and direct laboratory

personnel working in a

parasitology laboratory.

_____________________________

- Contribute to the development of

the curriculum through applied

study or research to add to the

existing specialty knowledge.

b1- Interpret the results of direct parasitological

techniques.

b2- Interpret the results of serologic techniques.

_______________________________________

b3- Employ personnel management principles

and apply workload assessment.

_______________________________________

b4- Plan, undertake and evaluate medical

research in the field of medical parasitology.

Professional &

Practical skills

- Use techniques of medical

informatics to acquire and manage

data and translate them to clinically

useful information.

_____________________________

- Implement standard precautions

in all phases of sample collection

and handling.

_____________________________

- Employ techniques for specimen

preparation for routine and

reference procedures to recover

c1- Use a systematic approach for data

collection and recording.

c2- Analyze the statistical methods needed to

evaluate diagnostic tests; including sensitivity,

specificity, positive and negative predictive

values.

_______________________________________

c3- Perform competently sample handling

including: specimen collection and transport,

sample handling and storage in the laboratory

and disposal of high risk samples and

containment.

_______________________________________

c4- Examine different clinical specimens (stool,

urine, blood, aspirate and tissues) to detect and

identify diagnostic stages of parasites.

parasites in clinical specimens.

_____________________________

- Apply procedures for the indirect


_____________________________

- Direct a parasitic disease

diagnostic laboratory in a hospital,

clinic or local, regional or national

governmental health agency.

_____________________________

- Select and utilize appropriate

computer software in presenting

scientific data.

_____________________________

- Report results of different

techniques performed.

_____________________________

- Conduct research studies on

various aspects of parasitic diseases

in the community.

c5. Evaluate and improve methods and tools

used in specialty.

_______________________________________

c6- Perform indirect tests for detection of:

•Antigens and antibodies using serological

methods such as indirect haemagglutination test,

immunofluorescence test and enzyme linked

immuno-sorbent assay.

•Nucleic acid using molecular amplification

methods.

c7- Develop new skills or procedures for new

situations such as emerging and re-emerging

parasitic diseases.

_______________________________________

c8- Train laboratory personnel in the detection

and identification of parasites in clinical

specimens (stool, urine, blood, aspirate, and

tissues) and the methodology employed.

_______________________________________

c9- Apply computerized information systems for

recording, analyzing, and reporting data.

c10- Use computer and software which provide

management, quality control, safety and

infection control data.

_______________________________________

c11- Write and appraise comprehendible reports

related to the examined clinical specimens

(stool, urine, blood, aspirate and tissues)

_______________________________________

c12- Design and employ research relevant to

medical and public health problems in parasitic

diseases.

c13- Prepare scientific articles related to

specialty and use appropriate media for their

presentation.

c14- Employ research studies that add to the

existing specialty knowledge.

General &

transferable

skills

- Apply generic communication

skills.

d1- Conduct individual presentations at scientific

conferences that are focused, clear, and concise

and appropriately utilize time.

d2- Communicate effectively with patients and

_____________________________

- Carry out research management

and apply team working skills.

_____________________________

- Use self learning methods in

practice information gathering and

information technology.

colleagues giving advice, instructions and

professional opinions.

d3- Employ skills to be an efficient staff member

to perform teaching tasks, plan and modify

curricula, assess and appraise junior staff.

_______________________________________

d4- Design appropriate time scales for different

stages of the research with clear starting and

finishing dates.

d5- Present a clear statement of the purposes and

expected results of the research.

d6- Develop appropriate means of estimating

and monitoring resources and the use of time.

d7- Demonstrate skills in educating colleagues,

students or other health care professionals.

_______________________________________

d8- Communicate information clearly both in

written and oral format.

d9- Competently and indepently undertake and

interpret innovative research.

d10- Retrieve information from all sources (

printed, electronic, communications etc…).

d11- Verify the accuracy of scientific material

on basis of best evidence in medicine and in

practice.

d12- Perform self appraisal and seek continuous

learning.

d13- Demonstrate an ability to use methods of

inquiry to collect and interpret data in order to

provide information that would reform or benefit

practice.

d14- Use effectively and efficiently information

and communication technology to improve

his/her professional research ability and to

collect data.

Ethics &

Attitudes:

- Adopt to ethical principles in

dealing with patients, colleagues

and subordinates.

e1- Demonstrate compassion and be

understanding and respectful to patients and

their families.

e2- Interact with others without discrimination

based on religious, ethnic, sexual, or educational

differences.

e3- Deal effectively with students, colleagues

whether juniors or seniors and subordinates.

e4- Demonstrate positive work habits, including

punctuality, dependability, and professional

appearance.

e5- Appraise principles of confidentiality with

_____________________________

- Apply medical research ethics.

all information transmitted both during and

outside a patient encounter.

_______________________________________

e6- Apply ethical principles to the collection of

samples from patients (consent) in

epidemiologic and community intervention

research.

e7- Identify and apply the main principles of

research ethics while using experimental

animals.

e8- Satisfy the requirements of ethics review

committees.

Program courses ILOs Matrix

A

16

A

15

A

14

A

13

A

12

A

11

A

10

A9 A8 A7 A6 A5 A4 A3 A2 A1 ILOs course title

x x x x x x x Advanced medical

Helminthology

x x x X x x x x x x Gastrointestinal & urogenital

protozoa

X x x x x x X x x x x x x x Blood & tissue protozoa

x Laboratory diagnosis of

parasitic diseases III

X x x x x x x x x Medical entomology II

x x X x x Immuno- parasitology

X x Laboratory diagnosis of

parasitic diseases IV

x x Molecular parasitologyII

x x x Vaccine trials in parasitic

diseases

X x Seminar I (special topics)

x x x x Seminar II (special topics)

x x X x Integrated parasitology

course

C

14

C

13

C

12

C

11

C

10

C

9

C

8

C

7

C

6

C

5

C

4

C

3

C

2

C

1

B

4

B

3

B

2

B

1 ILOs course title

x x x x Advanced medical

Helminthology

x x Gastrointestinal &

urogenital protozoa

x x Blood & tissue protozoa

x x x X x x x x x x Laboratory diagnosis of


x x x x Medical entomology II

x x x x Immuno-parasitology

x x x x X x x x x x Laboratory diagnosis of


x x x x x x Molecular parasitologyII

X x Vaccine trials in

parasitic diseases

x X x x Seminar I

(special topics)

X x x Seminar II

(special topics)

x x x x x x Integrated parasitology

course

x x x x x x x x x Thesis

E

8

E

7

E

6

E

5

E

4

E

3

E

2

E

1

D

14

D

13

D

12

D

11

D

10

D

9

D

8

D

7

D

6

D

5

D

4

D

3

D

2

D

1 ILOs course title

x x Advanced medical

Helminthology

x x Gastrointestinal &

urogenital protozoa

x x Blood & tissue

protozoa

x x x x x x Laboratory diagnosis

of parasitic diseases III

x x x x x Medical entomology II

x x Immuno-

parasitology

x X x x x x x Laboratory diagnosis

of parasitic diseases

IV

X x x Molecular parasitology

x x x x x Vaccine trials in

parasitic diseases

x x x x x x Seminar I (special

topics)

x x x x x Seminar II

(special topics)

x x x x Integrated parasitology

course

x x x X x x x x x x x x x x x x x Thesis

Curriculum Structure:

- Students should fulfill at least 52 credit hours in not less than three years

with a maximum of seven years (semesters & thesis)

- Program structure:

1. Obligatory courses: 30 credit hours.

2. Thesis: 20 credit hours.

3. Elective courses: 2 credit hours.

Program content:

A. Obligatory courses:

Code Course Credit

hours

Credit hours Prerequisites Lectures Practical

1 05190901

Advanced medical

Helminthology

3 2 1

2 05190902

Gastrointestinal &

urogenital protozoa

3 2 1

3 05190903 Blood & tissue

protozoa

3 2 1

4 05190904 Laboratory

diagnosis of


3 2 1 Courses from

05190901 to

05190903

5 05190905 Medical entomology

II

3 2 1

6 05190906 Immunoparasitology 3 3

7 05190907 Molecular

parasitology II

2 2 Courses from

05190902-

05190903

8 05190908 Laboratory

diagnosis of


2 2

9 05190909 Vaccine trials in

parasitic diseases

2 2 Courses from

05190901 to

05190903

10 05190910 Seminar I (special

topics)

2 2

11 05190911 Seminar II (special

topics)

2 2

12 05190912 Integrated

parasitology course

2 2 Courses from

05190901 to

05190911

B. Elective courses:

Students can choose two elective courses either from the parasitology

department or any other departments.

Program admission requirements:

According to the regulations of the credit hours bylaws of the Faculty of

Medicine, Alexandria University (annex).

Regulations for Progression and Program Completion: According to the regulations of the credit hours bylaws of the Faculty of

Medicine, Alexandria University (annex).

Methods of student assessment:

Methods Intended learning outcomes to be

assessed 1. Written exam a1-a16

2. Practical exam b1, b2, c4, c6, c11.

3. Assignments c9,c10, c13, c14, d1, d3, d6, d7, d8,d9,d11-15, e2-4.

4. Oral exam -----------------------------------------------------------

5. Thesis b3, b4, c1-3, c5, c7- 12, d2, d4-6, d10-14, e1, e5-8. .

Methods of student assessment may be modified in some courses (Laboratory

diagnosis of parasitic diseases III & IV and seminars I & II) to include continuous

assessment.

Methods of program evaluation:

Evaluator Tool Sample

1. Students enrolled in the program Questionnaires

2. Alumni -------------------

3. Stakeholders (Employers) Focus group

4. External Evaluator (s) yes

5. Others:

Course description

1 Code Course

Credit hours

3

Prerequisites

05190901 Advanced medical

Helminthology

Lecture 2

Practical 1

A course in advanced medical Helminthology discussing Phylum

Platyhelminthes and Phylum Nematoda, regarding all advanced subjects and

parasites.

2 Code Course

Credit hours

3

Prerequisites

05190902 Gastrointestinal &

urogenital protozoa

Lecture 2

Practical 1

A course in gastrointestinal and urogenital protozoa discusses the different

protozoa affecting gastrointestinal and urogenital tracts including

Sarcomastigophora, Ciliophora, Coccidia and free living parasites ( protozoa)

their geographical distribution , morphology, life cycle, physiology (

reproduction, nutrition etc….), pathogenesis, diagnosis, prevention and control.

All newly emerging protozoa in this subject.

3 Code Course

Credit hours

3

Prerequisites

05190903 Blood and tissue protozoa Lecture 2

Practical 1

A course in blood and tissue protozoa discusses the different protozoa affecting

the tissue and the blood including mastigophora ,coccidian, sporozoa as regards

their geographical distribution, morphology, life cycle, clinical picture,

complications, impact on human health and means of control. All newly

emerging protozoa in this subject.

4 Code Course Credit hours Prerequisites

3

05190904 Laboratory diagnosis of


Lecture 2

Practical 1

Courses from

05190901 to

05190903

A three credit hours course of laboratory diagnosis III which include different

methodology of stool, urine and blood examinations. Identification of the parasites

present in the previous specimens. Preparation of permanent mounted slides.

5 Code Course

Credit hours

3

Prerequisites

05190905 Medical entomology II Lecture 2

Practical 1

A three credit hours course on Entomology includes the knowledge about

different types, behavior, diseases, transmitted or caused by them, their

importance in relation to human health and control.

6 Code Course

Credit hours

3

Prerequisites

05190906 Immunoparasitology

Lecture 3

Practical -

A three credit hours course on immunoparasitology includes:

-Basic immunology in details

-Host parasite relationships

-Immune response against different parasites

7 Code Course

Credit hours

2

Prerequisites

05190908 Laboratory diagnosis of


Lecture 1

Practical 1

A two credit hours course of laboratory diagnosis IV which include serological and

immunological techniques. Propagation of parasites in culture and experimental

animals. Different means of quality control.

8 Code Course Credit hours

2

Prerequisites

05190907 Molecular parasitology II Lecture 2

Practical -

Courses from

05190902-

05190903

A two credit hours course of Molecular parasitology II includes: molecular biology

of parasites (parasite genomics & RNA processing in parasites transcription…etc),

biochemistry and cell biology of protozoa (energy metabolism & parasite

glycobiology….etc), some advanced topics in molecular parasitology and the related

medical application.


2

Prerequisites

05190909 Vaccine trials in parasitic

diseases

Lecture 2

Practical -

Courses from

05190901 to

05190903

A two credit hours course of vaccination trials in parasitic diseases include new

approaches against different parasitic diseases.

10 Code Course

Credit hours

2

Prerequisites

05190910 Seminar I ( Special topics) Lecture 2

Practical -

A seminar which is carried out by the students under supervision, in any chosen

topic in relation to their studies to help them enforce their power of information

collection and presentation.

11 Code Course

Credit hours

2

Prerequisites

05190911 Seminar II ( Special topics) Lecture 2

Practical -

A seminar which is carried out by the students under supervision in any chosen

topic in relation to their studies to help them to increase their knowledge,

information and presentation.


2

Prerequisites

05190912 Integrated parasitology

course

Lecture 2

Practical -

Courses from

05190901 to

05190911

A two credit hours course includes discussion in details of some case problems

related to parasitic infections regarding the clinical manifestations, differential

diagnosis, recent methods in diagnosis, and treatment of each studied case.

Program Coordinator:

Name Prof. Dr. Mona El-Temsahy

Signature:

Name: Prof. Dr. Lobna El Zawawy

Signature:

Program Director (Head of Department)

Name: Prof. Dr. Iman Abou El Naga

Signature

Course Specifications


Faculty: Medicine

Department: Medical Parasitology

Course Information

Course Code: 05190902 Course Name: Gastrointestinal &urogenital

protozoa

Program in which the Course is Given: Doctor of Medical Parasitology

Number of Credit Hours: 3 Theoretical Clinical/Practical

Course Aims:

The course of gastrointestinal and urogenital protozoa discusses the different protozoa affecting

gastrointestinal and urogenital tracts including Sarcomastigophora, Ciliophora, Coccidia and free living

protozoa as regards their geographical distribution , morphology, life cycle, physiology ( reproduction,

nutrition etc….), pathogenesis, diagnosis, prevention and control. All newly emerging protozoa in this field

are also studied.

Intended Learning Outcomes (ILOs)

Program ILO (refer to program

matrix) Course ILOs

A. Knowledge and

Understanding

By the end of the course

graduate must :

a1- Revise the diagnostic

morphology, life cycles, clinical

manifestations, diagnosis and

treatment of the studied

parasites.

a2- Recognize updates in

morphology, biology and life

cycles of parasites and their

relevance for human health.

By the end of the gastrointestinal

& urogenital course the student

will be able to:

A1- Revise the diagnostic


manifestations, routine diagnostic

techniques and drug of choice of

the studied protozoa.

A2- Describe updates in the

morphology to differentiate between

pathogenic & nonpathogenic

intestinal protozoa in the studied

1 2

a3- Describe the mode of

infection of different parasites

among humans.

a5- Define terms used in

describing aspects of parasitic

pathogenesis.

a6- Recognize the pathogenic

characters of parasites and how

they produce tissue damage.

a7- Explain at the cellular and

molecular levels the concept of

pathogenesis and the host-

parasite interactions.

phyla.

A3-Select the morphology of the

studied protozoa by the electron

microscope.

A.4- Describe updates in the

biology and life cycle of the

studied protozoa in the human

body& environment.

A5-Identify updates in the methods

of disease transmission of the

studied protozoa and their

relevance for human health.

A6-Recognize modes of infection

of newly emerging intestinal

protozoa (e.g. Cyclospora).

A7-Distinguish reservoir hosts

which have a role transmission of

infection.

A8- Describe the pathological

lesions caused by gastrointestinal

protozoa and the host immune

response towards them.

A9-Record the pathological lesions

produced by urogenital protozoa in

both male & female patients.

A10-Recognize the pathogenic

characters of gastrointestinal

protozoa & factors that contribute

to their pathogenicity.

A11-Explain the pathogenic

characters of urogenital protozoa

how they produce tissue damage in

relation to both sexes.

A12-Distinguish the pathogenesis

of the studied protozoa at the

cellular or molecular levels.

A13-Associate the pathogenesis

with the host immune response in

relation to the studied protozoa.

A14- Relate the pathogenesis with

the clinical manifestations of cases

infected with the studied protozoa.

a8- Explain the basis for

therapeutic effects of

antiparasitic drugs and their

mode of action.

a9- Identify pitfalls and

resistance of current therapy

regimens and the role of

recently discovered antiparasitic

drugs.

a10- Identify recent methods for

laboratory diagnosis of parasitic

infections with special emphasis

on molecular techniques.

a12- Recognize the hazards of

various customs and habits

applied by people which

contribute to the spread of

parasitic infections

A15-Report the modes of action of

recent drugs used in the treatment

of the gastrointestinal & urogenital

protozoa.

A16-Select the drug of choice for

each studied parasite.

A17-Point the adverse effects &

mechanisms of resistance to

currently used drugs.

A18-Identify recently discovered

antiparasitic drugs & their role in

treatment of resistant strains.

A19—Describe recent diagnostic

techniques whether direct or

indirect for intestinal and tissue

stages of the studied protozoa.

A20-Select the most sensitive &

specific technique for each

condition.

A21-Indicate recent molecular

techniques of value in the

diagnosis of gastrointestinal &

urogenital protozoa.

A22- Define the health problems

related to infection with

gastrointestinal & urogenital

protozoa in the community.

A23-Relate between customs of

people & how they lead to

infection with gastrointestinal

protozoa.

A24-Point out habits of some

individuals that may contribute to

the spread of urogenital protozoa.

B. Intellectual skills

b1- Interpret the results of direct

parasitological techniques.

B1-Determine & evaluate the most

diagnostic direct test suitable for

each studied gastrointestinal &

urogenital protozoal infection.

B2- Interpret the results of the

direct test chosen in relation to

b2- Interpret the results of

serologic techniques.

each case.

B3-Select & evaluate the most

diagnostic serological test suitable

for each studied gastrointestinal &

urogenital protozoal infection.

B4- Interpret the results of the

serological test chosen in relation

to each case.

D. General & transferable

Skills

d8- Communicate information

clearly both in written and oral

format.

d10- Retrieve information from

all sources (printed, electronic

communications etc.)

D1- Use effectively and efficiently

information and communication

technology to improve his/her

ability to write a review article in

relation to gastointestinal &

urogenital protozoa

D2-Conduct an oral presentation

that is focused, clear, and concise

using effectively & efficiently

different methods of presentations

e.g. data show, videos.

D3- Manage time effectively.

D 4- Acquire updated knowledge

from various sources, appraise and

systematize this knowledge

D5-Summarize scientific data

retrieved verify their accuracy and

present it to peers in a professional

manner.

Course Content (Units/Topics)

Teaching/Learning Methods

Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

1- Sarcomastigophora

a)Sarcodina

b)Gastrointestinal

flagellates

c)Urogenital flagellates

✓ ✓ √

2- Ciliophora ✓ ✓ ✓

3-Coccidia (Intestinal members)

✓ ✓ ✓

4- Intestinal Microsporidia ✓ ✓ ✓

Please check (✓) the appropriate method.

Student Assessment

Methods of Assessment

Essay Objective questions

Case OSCE/OSPE

Assignment Logbook fulfillment

Others

Schedule of Assessment

Mid-term - %

End of term 100 %

Distribution of Marks

Written Exam 70 %

Practical/Clinical Exam 30 %

Others

✓ ✓

✓

✓ ✓

List of Textbooks and References

Lecture Notes

Ash and Orihel, Atlas of human Parasitology

Course Text Books

- Beaver & Jung, Clinical Parasitology

- Garcia, Diagnostic Medical Parasitology

- Manson Bahr, Manson's Tropical Diseases

Suggested Extra Reading

Links of Parasitology from the internet

www. Dpd.cdc.gov/dpdx. Parasites and health

Journals and Periodicals, others

- American Journal of Tropical Medicine

& Hygiene

- Journal of protpzoology

- Parasitology Today

Course Instructor

Name: Prof. Dr. Mona Mohamed El-Temsahy Signature:

Program Coordinator

Name: Prof. Dr. Mona Mohamed El-Temsahy Signature:

Prof. Dr. Lobna El- Zawawy Signature:


Name: Prof. Dr. Iman Abo El Naga Signature:



Faculty: Medicine


Course Information

Course Code: 05190904

Course Name: Laboratory Diagnosis of


Program in which the Course is Given: Doctor of Medical parasitology


Course Aims: A three credit hours course of laboratory diagnosis of parasitic diseases III

include different methodology of stool, urine and blood examinations. Identification of the

parasites present in the previous specimens. Preparation of permanent mounted slides for

the previous parasites in addition to arthropods. Methods of snail examination and snail

infection.

Intended Learning Outcomes (ILOs) Program ILO (refer to

program matrix) Course ILOs


graduate must :

a.10- Identify recent methods

for laboratory diagnosis of

parasitic infections with

special emphasis on molecular

techniques.

By the end of the course the student

will be able to:

A.1. Recognize recent advances in the

field of the direct diagnosis of parasitic

infections.

A.2. Define recent approaches in the

indirect serodiagnosis of parasitic

infections.

1 2

A.3. Trace recent techniques that

depending on molecular biology in


B. Intellectual

skills

b.1- Interpret the results of

direct parasitological

techniques.

b.3- Employ personnel

management principles and

apply workload assessment.

B.1. Undertake skills in examination of

stool, urine and blood and other

specimens for helminthes and protozoa.

B.2. Develop skills in identification of

different helminths and protozoa in

different clinical samples.

B.3. Determine the most direct test

suitable for examination and

identification of each studied parasite

and evaluate and interpret its result.

B.4. Correlate the results with the

clinical picture and line of treatment.

B.5. Organize and direct laboratory

personnel working in a parasitology

laboratory.

C.

Professional

and Practical

Skills

c.3- Perform competently

sample handling including:

specimen collection and

transport, sample handling and

storage in the laboratory and

disposal of high risk samples

and containment.

C.1. Collect and process different

parasitological samples.

C.2. Implement standard precautions in

all phases of sample collection and

handling.

C.3. Perform safe disposal of high risk

samples and containment.

c.4- Examine different clinical

specimens (stool, urine, blood,

aspirate and tissues) to detect

and identify diagnostic stages

of parasites.

c.5- Evaluate and improve

methods and tools used in

specialty.

C.4. Process stool, urine, blood

samples and other specimens for

helminths and protozoa.

C.5. Examine different parasitological

samples with the appropriate technique.

C.6. Employ the use of microscope

(low power high power and oil

immersion lens) for identification of

diagnostic stages of helminths and

protozoa in different specimens.

C.7. Develop new skills or procedures

for identify helminths and protozoa and

artifacts that confused with these

parasites in stool, blood and other

samples.

C.8. Employ the different staining

techniques for worms, protozoa and

arthropods.

C.9.Employ methods of snail

examination and snail infection.

C.10. Develop and evaluate new

methods for diagnosis of emerging and

re-emerging helminthic and parasitic

infections and comparing them with the

gold standard methods used for

c.7- Develop new skills or

procedures for new situations

such as emerging and re-

emerging parasitic diseases.

c.8- Train laboratory

personnel in the detection and

identification of parasites in

clinical specimens (stool,

urine, blood, aspirate, and

tissues) and the methodology

employed.

c.9- Apply computerized

information systems for

recording, analyzing, and

reporting data.

c.10- Use computer and

diagnosis.

C.11. Carry out specialized skills in

advanced molecular techniques for

diagnosis of helminthic infections.

C.12. Develop skills to train junior staff

and technicians in the collection,

processing and examination of different

clinical specimens (stool, urine, blood,

aspirate, and tissues) for helminthes

and protozoa.

C.13. Train junior staff and technicians

and other laboratory personnel in the

detection and identification of

helminthes and protozoa in different

samples.

C.14. Train personnel in snail infection

and examination.

C.15. Apply team working skills and

manage time effectively.

C.16. Use information technologies to

collect analyze record and report data.

C.17. Utilize appropriate computer

software which provide

management, quality control,

safety and infection control

data.

c.11- Write and appraise

comprehendible reports

related to the examined


urine, blood, aspirate and

tissues).

software to analyze, deduce and

evaluate data and information.

C.18. Prepare and interpret a report

with sufficient data for different

techniques used in the diagnosis of

helminthes and protozoa in different

clinical samples.

D. General

Skills

d.13- Demonstrate an ability

to use methods of inquiry to

collect and interpret data in

order to provide information

that would reform or benefit

practice.

d.14- Use effectively and

efficiently information and

communication technology to

improve his/her professional

research ability and to collect

data.

D.1. Use sufficient and effective

methods in collection and interpretation

of data.

D.2. Be able to infer the beneficial

information from the collected data.

D.3. Use information and

communication technology to collect,

evaluate and interpret scientific data.

D.4. Use updated information to


knowledge and research ability.

D.5. Demonstrate competence in

transferable skills (information and

communication technologies and

communication skills).

Ethics & e.1- Demonstrate compassion E.1. Use ethical principles in dealing

Attitudes:

and be understanding and

respectful to patients and their

families.

e.2- Interact with others

without discrimination based

on religious, ethnic, sexual, or

educational differences.

e.4- Appraise principles of

confidentiality with all

information transmitted both

during and outside a patient

encounter.

e.8- Satisfy the requirements

of ethics review committees.

with patients and their families.

E.2. Take consent from patients before

collection of samples.

E.3. Respect the patients and their

families.

E.4. Collect data confidentiality and

apply all medical research ethics.

E.5. Show honesty and integrity in

collection of data from patients.

E.6. Obey the instructions of ethics

review committees.

Course Content

(Units/Topics)


Lectures self

learning

Practical

/

Clinical

Small

group

discussion

Others

1- Examination of stool and

urine for helminthes,

protozoa and arthropods

(larva of higher Diptera and

Phthirus pubis).

✓ ✓ √

2- Examination of blood for

helminthes and protozoa.

✓ ✓ ✓

3- Other diagnostic

techniques for helminths

protozoa and arthropods

✓ ✓

(larva of higher diptera and

Phthirus pubis).

4- Artifacts that be confused

with helminths protozoa and

arthropods ( larva of higher

diptera and Phthirus pubis).

in stool, urine, blood and

other samples.

✓ ✓ √

Please check (✓) the appropriate method

Student Assessment



Case OSCE/OSPE


Others


Mid-term

End of term 100 %


Written Exam 70 %


Others


Lecture Notes

- Ash and Orihel, Atlas of human Parasitology

Course Text Books



- Monica Cheesbrough, District laboratory

practice in tropical countries part I.


Links of Parasitology from the net:



- J. Clinical Microbiology

- American J. Tropical Medicine and Hygiene

✓ ✓

√

✓

- International J. Parasitology

Course Instructor

Name: Prof. Dr. Lobna abdel Aziz El Zawawy

Signature

Program Coordinator

Name: Prof. Dr. Mona El-Temsahy Signature

Name: Prof. Dr. Lobna abdel Aziz El Zawawy Signature


Name: Prof. Dr. Iman Abo El Naga Signature



Faculty: Medicine


Course Information

Course Code: 05190908 Course Name: Laboratory diagnosis of




Course Aims: A two credit hours course of laboratory diagnosis of parasitic diseases IV

which include serological and immunological techniques. Propagation of parasites in

culture and experimental animals. Different means of quality control.

Intended Learning Outcomes (ILOs) Program ILO (refer to

program matrix) Course ILOs

A. Knowledge

and

Understanding:


graduate must:

a.10- Identify recent methods

for laboratory diagnosis of

parasitic infections with

special emphasis on molecular

techniques.

By the end of the course the student

will be able to:

A.1. Describe recent direct diagnostic

techniques for diagnosis of parasitic

infections.

A.2. Define modern approaches in the

indirect serodiagnosis of parasitic

infections.

1 1

a.15- Select laboratory

techniques for assessment of

humoral and cellular

immunity.

A.3. Trace recent molecular techniques

for diagnosis of parasitic infections.

A.4. Determine immunological

techniques for measurement of humoral

immunity to diagnose parasitic

infections especially those caused by

helminths.

A.5. Describe immunological

techniques measuring cellular

immunity for diagnosis of different

parasitic diseases especially those

caused by protozoa.

B. Intellectual

skills


direct parasitological

techniques.



B.1. Determine the most direct test

suitable for each studied parasite.

B.2. Evaluate and interpret the results

of different direct techniques for

examination and identification of

parasites.

B.3. Determine, perform and interpret

the most serological test and/or

molecular technique suitable to

diagnose each parasitic infection.

B.4. Correlate the results of serological

techniques with the clinical picture.

B.5. Correlate the results of serological

techniques with the line of treatment.

C.

Professional

and Practical

Skills

c.2- Analyze the statistical

methods needed to evaluate

diagnostic tests; including

sensitivity, specificity,

positive and negative

predictive values.

c.3- Perform competently

sample handling including:

specimen collection and

transport, sample handling

and storage in the laboratory

and disposal of high risk


c.5- Evaluate and improve

methods and tools used in

specialty.

C.1. Utilize statistical methods to

assess whether direct or indirect, as

regards sensitivity, specificity, positive

and negative predictive values, percent

of agreement and accuracy.

C.2. Use statistical methods to compare

between different diagnostic tests.

C.3. Collect and process different

parasitological samples used in

different serological tests.

C.4. Implement standard precautions in

all phases of sample collection and

handling.

C.5. Perform safe disposal of high risk


C.6. Develop new skills or procedures

for identification of parasites and

artifacts that confused with parasites in

different samples.

C.7. Perform parasitological cultures

methods for different parasites.

C.8. Maintain life cycle of parasites in

c.6- Perform indirect tests for

detection of:

•Antigens and antibodies

using serological methods

such as indirect

haemagglutination test,

immunofluorescence test and

enzyme linked immuno-

sorbent assay.

•Nucleic acid using molecular

amplification methods.

c.7- Develop new skills or

procedures for new situations

such as emerging and re-

experimental animals for research and

antigen preparation.

C.9. Conduct skills in specialized

diagnostic tests including serologic

tests.

C.10. Perform indirect tests for

diagnosis of parasitic infections by

detection of antigen or antibodies as

indirect haemagglutination test

(IHAT), immunofluorescence test

(IFT) and enzyme linked immuno-

sorbent assay (ELISA)

C.11. Predict indirect tests for

detection of nucleic acid of the

parasites as DNA probe and

polymerase chain reaction techniques

(PCR).

C.12. Utilize properly different

laboratory equipments used in

serological and molecular diagnosis of

parasitic infections.

C.13. Develop and evaluate new

methods or procedures for diagnosis of

parasitic infections and comparing

them with the gold standard methods


c.9- Apply computerized

information systems for

recording, analyzing, and

reporting data.

c.10- Use computer and

software which provide

management, quality control,

safety and infection control

data.

c.11- Write and appraise

comprehendible reports

related to the examined


urine, blood, aspirate and

tissues).

used for diagnosis.

C.14. Carry out specialized skills in:

advanced diagnostic molecular and

immunological aspects of parasitic

infections.

C.15. Use information technology to

collect, analyze, record and report data

C.16. Utilize appropriate computer

software in recording, analyzing, and

reporting scientific data in a

parasitology lab.

C.17. Use a wide range of software to

support and enhance work and specify

software requirements if needed.

C.18. Select computer software in

writing and presenting scientific data.

C.19. Prepare and interpret reports with

sufficient data for different serological

and immunological techniques used in

the diagnosis of parasites.

C.20. Prepare and interpret reports with

sufficient data for direct tests used to

diagnose parasitic infections in

different samples as stool, urine, blood,

other human excreta.

D. General

Skills

d.13- Demonstrate an ability

to use methods of inquiry to

collect and interpret data in

order to provide information

that would reform or benefit

practice.

d.14- Use effectively and





data.

D.1. Use sufficient and efficient

methods in collection and interpretation

of data.

D.2. Use information and

communication technology to collect,


D.3. Demonstrate competence in




Ethics &

Attitudes:

e.1- Demonstrate compassion

and be understanding and

respectful to patients and their

families.

e.2- Interact with others

without discrimination based

on religious, ethnic, sexual, or

educational differences.

E.1. Identify and apply ethical

principles in dealing with patients and

their families.

E.2. Apply ethical principles during

collection of samples from patients

(consent).

E.3. Respect the patients and their

families.

E.4. Recognize and respect the views

e.5- Appraise principles of

confidentiality with all

information transmitted both

during and outside a patient

encounter.

e.7- Identify and apply the

main principles of research

ethics while using

experimental animals.

e.8- Satisfy the requirements

of ethics review committees.

and opinions of others.

E.5. Collect data confidentiality and

apply all medical research ethics.

E.6. Apply ethical principles when

using experimental animals.

E.7. Follow the instructions of ethics

review committees.

Course Content

(Units/Topics)


Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

1- Antibody detection

techniques.

✓ ✓ √

2- Antigen detection

techniques.

✓ ✓ √

3- Nucleic acid detection

techniques.

✓ ✓

4- Propagation of parasites

in culture and

experimental animals.

✓ ✓ √


Student Assessment



Case OSCE/OSPE


Others


Mid-term

End of term 100 %


Written Exam 70 %


Others 10%

✓ ✓

√

✓ ✓


Lecture Notes

Ash and Orihel, Atlas of human Parasitology

Course Text Books



- Monica Cheesbrough, District laboratory

practice in tropical countries part I.


Links of Parasitology from the net:



- J. Clinical Microbiology

- American J. Tropical Medicine and Hygiene

- International J. Parasitology

Course Instructor

Name: Prof. Dr. Maha Eissa

Signature:

Program Coordinator

Name: Prof. Dr. Mona El-Temsahy

Signature:


Signature:


Name: Prof. Dr. Iman Abo El Naga

Signature:



Faculty: Medicine


Course Information


Course Name: Immunoparasitology

Program in which the Course is Given: Doctor degree of Medical Parasitology


Course Aims: The course of Immunoparasitology aims at studying the specific immune response

against important parasites as Schistosoma, Filarial worms, Leishmania, Plasmodium, and

Toxoplasma and how can the immunological reactions occurring in the host affect the clinical

picture of the diseases. It also aims at studying the parasites frequently affecting

immunocompromised patients and the difference in clinical manifestations and diagnosis in these

patients than normal ones. The course also aims at revising the general immune reactions directed

against parasites, and the interaction between the host and the parasites.


Program ILO (refer to program matrix) Course ILOs

A. Knowledge

and

Understanding

By the end of the course the graduate

must be

a7- Explain at the cellular and molecular

levels the concept of pathogenesis and the

host-parasite interactions.



emphasis on molecular techniques.

By the end of

Immunoparasitology course the

student will be able to:

A1. Recognize how the host can

interact with the parasite.

A2. Determine the mediators

generated from this reaction and

their effect on the pathogenesis of

the disease.

A3. Recognize the immunological

tests used in the diagnosis of

parasitic diseases.

A4. Identify the recent

immunological tests used

specially at the molecular and

genetic levels.

A5. Describe the type of immune

- 3

a14- Describe the nature of parasitic

infections in the immunocompromized host

(opportunistic parasites).

a15- Select laboratory techniques for

assessment of humoral and cellular

immunity.

a16-Identify the recent approaches in

vaccine development.

deficiency in the

immunocompromized host.

A6. Determine the opportunistic

parasites that are usually affect

these patients.

A7. Determine the clinical

manifestations of the parasitic

infection in immunocompromized

patients.

A8. Select immunological tests for

diagnosis of parasitic infection

according to the type of immune

response it evokes.

A9. Determine the molecular

elements concerned with

immunological responses.

A10. Describe how the vaccine

can be generated using these

molecules or antagonize them.

B. Intellectual

skills

b2- Interpret the results of serologic

techniques.

B1. Determine the most diagnostic

test suitable for a certain clinical

presentation.

B2. Correlate the results of

serological techniques with the

clinical picture.

B3. Correlate the results of

serological techniques with the

line of treatment.

C.

Professional

and Practical

Skills

c2- Analyze the statistical methods needed

to evaluate diagnostic tests; including

sensitivity, specificity, positive and

negative predictive values.

c3- Perform competently sample handling

including: specimen collection and

transport, sample handling and storage in

the laboratory and disposal of high risk


C1. Determine the statistical tests

needed for evaluation of different

immunological tests.

C2. Interpret the results of

statistics.

C3. Recognize the risk factors that

may occur during collection of

different specimens.

C4. Choose the appropriate

method for transport.

C5. Decide the safe method in

c7- Develop new skills or procedures for

new situations such as emerging and re-


disposal of the samples not

needed.

C6. Evaluate the risks imposed

during professional laboratory

work

C7. Determine the immune

response against the emerging and

re-emerging parasites.

C8. Select suitable diagnostic tests

for these parasites.

D. General

Skills

d1- Conduct individual presentations at

scientific conferences that are focused, clear,

and concise and appropriately utilize time.

d13- Demonstrate an ability to use methods

of inquiry to collect and interpret data in

order to provide information that would

reform or benefit practice.

D1. Participate in seminars,

conferences and workshops for

further development of specialty.

D2.Employ skills to be concise in his

presentation and appropriately

utilize time. D3. Able to get use of different

methods of presentations e.g data

show ,videos

D4. Retrieve information from all

sources (printed, electronic,

communications etc…) to know

recent methods in diagnosis. D5. Acquire updated knowledge from

various sources, appraise and

systematize this knowledge and

present it to peers in a professional

manner.

D6. Use self learning methods in

practice information gathering and

information technology.



Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Revision of the general immune

response against parasites.

✓ ✓

Escape mechanisms of the parasites. ✓ ✓

Specific immune response against

trematodes (Schistosoma).

✓ ✓


nematodes (larva of Toxocara canis,

filaria).

✓ ✓


protozoa (Leishmania, Toxoplasma

gondii, trypanosomes, malarial

parasites)

✓ ✓

Immune response against parasites in

immunocompromized hosts.

✓ ✓

Helminths as immuno-modulators ✓ ✓


Student Assessment



Case OSCE/OSPE


Others

Mid term

End of term 100 %


Written Exam 70 %

Practical/Clinical Exam - %

Others: 30 %

Assignment 15 %

Oral exam 15 %

✓ ✓

✓ ✓

Oral exam


Lecture Notes

Course Text Books Mal;e, Brosto, Roth & Roitt, Immunology.


Links of Parasitology from the net



- Infection and immunity.

- Parasite immunology.

Course Instructor

Name: Prof. Dr. Iman Fathy Abo El Naga

Signature:

Program Coordinator

Name: Prof. Dr. Mona El Temsahy

Signature:

Namer: Prof. Dr. Lobna El Zawawy

Signature:



Signature:



Faculty: Medicine


Course Information

Course Code: 05190912 Course Name: Integrated parasitology course



Course aims: Integrated parasitology course focusing on how to develop clinical case study, the

clinical presentations of case, writing the objectives, analyzing data, differential parasitic diagnosis,

the most possible parasitic cause and the treatment of case.



matrix) Course ILOs

A. Knowledge

and

Understanding


graduate must :





By the end of integrated parasitology

course the student will be able to:

A1- Define the parasitological causes of

different health issues as fever, diarrheas,

pain, neurological symptoms, skin and

subcutaneous tissue manifestations, and

lymphadenopathy.

A2- Describe the different clinical

manifestations of each case.

A3- Define the newly emerging parasites as

causative agents for the different health

issues related to parasitic diseases.

A4- Describe the different clinical picture

for each newly emerging parasite.

A5-Identify the differential diagnosis of

2


therapeutic effects of antiparasitic

drugs and their mode of action.





a13- Trace recent advances in the

field of medical Parasitology and

apply this knowledge in the


each case.

A6- Determine the most reliable diagnosis

to each studied case.

A7- Select the recent and the drug of

choice used to treat each case.

A8- Recognize the adverse effects and

mechanisms of resistance to drugs used in

treatment.

A9-Recognize the different recent

diagnostic techniques whether direct or

indirect for each case studied.

A10- Recognize what is new in medical

parasitology especially re- emerging

parasites and imported ones.

A11- Know the recent convenient

techniques which can be used in diagnosis

of related parasitic diseases.

A12- Recognize the recent methods in

diagnosis of related parasitic infections.

B. Intellectual

skills



b2- Interpret the results of


b3- Employ personnel

management principles and apply

workload assessment.

B1- Determine the most diagnostic direct

test suitable for each studied case.

B2- Interpret the results of the direct test

chosen in relation to each case.

B3- Select the most diagnostic serological

test suitable for each studied case.

B4- Interpret the results of the serological

test chosen in relation to each case.

B5- Estimate the level of basic knowledge

that helps in solving common

parasitological problems.

B6- Evaluate skills in solving cases of

endemic nature.

B7- Realize the public health implications

of each case, and means for control for each

parasitic cause.

C.Professional

and Practical

Skills

c5-Evaluate and improve methods

and tools used in specialty.

C1-Use parasitological evidence to solve

each case problem.

C2- Manage case problem in an integrated

manner.

C3- Solve cases which have implication to

c7- Develop new skills or

procedures for new situations such

as emerging and re-emerging

parasitic diseases.

c9- Apply computerized

information systems for recording,

analyzing, and reporting data.

the community.

C4- Prepare data show preparation for each

studied case.

C5- Interpret commonly used

immunological techniques such as ELISA

and immunodiffusion.

C6- Interpret some advanced molecular

methods such as nucleic acid extraction,

PCR amplification and transformation.

C7- Use information technologies to access,

analyze record and report data.

C8- Retrieve information from various

available sources, appraise and systematize

this knowledge.

C9- Conduct skills in specialized diagnostic

tests, including culture techniques and

antigen/antibody detection tests related to

each studied case.

D. General

Skills

d1- Conduct individual

presentations at scientific

conferences that are focused, clear,

and concise and appropriately

utilize time.



D1- Communicate effectively using written

and oral format to show the results of

investigations related to each case studied.

D2- Use appropriate media for their

presentation.

D3- Co-operate in discussion groups to

solve scientific problems.

D4- Communicate effectively as a director

format.

d10- Retrieve information from all


communications etc…).

d13- Demonstrate an ability to use

methods of inquiry to collect and

interpret data in order to provide

information that would reform or

benefit practice.

to show the results of investigations related

to each case studied.

D5- Explain parasitological point of view

in certain studied cases.

D6- Able to represent an evidence-based

presentation about the studied case.

D7- Use different sources of knowledge to

solve the case problem.

D8-Use information technology to solve

the case problem.

D9- Demonstrate decision making skills in

solving endemic parasitic case problems.

D10- Demonstrate skills in collecting data

that help in solving problem.

D11- Demonstrate decision making skills in

unpredictable situations.



Lectures self-

learning

Practical

/

Clinical

Small

group

discussion

Others

1- Fever in parasitic diseases

2- Diarrhea/ dysentry in parasitic

diseases

3- Nervous system affection in

parasitic diseases

4- Skin and subcutaneous tissue

lesions in parasitic diseases

5- Lymphadenopathy in parasitic

diseases

6- Hepatosplenomegaly in parasitic

diseases

7- Occular lesions in parasitic diseases

8- Anaemia in parasitic diseases

9- Eosinophilia in parasitic diseases

10- Parasitic diseases in children

11- Parasitic diseases in immuno-

compromised patients

12- Nosocomial and laboratory

acquired parasitic infections.

√

√

√

√

√

√

√

√

√

√

√

√

√

√

√

√

√

√

√

√

√

√

√

√

Discussion

Discussion

Discussion

Discussion

Discussion

Discussion

Discussion

Discussion

Discussion

Discussion

Discussion

Discussion

Presentation

Presentation

Presentation

Presentation

Presentation

Presentation

Presentation

Presentation

Presentation

Presentation

Presentation

Presentation


Student Assessment



Case OSCE/OSPE


Others


Mid-term %

End of term 100 %


Group discussion 20 %

Steps for creating the case 30 %

Analysis of data 30 %

Data show presentation 20 %


Lecture Notes

Parasitology notes

Coulored Atlas of Parasitology

Course Text Books

-Beaver & Jung, Clinical Parasitology,






- American Journal of parasitology

- Lancet

- Parasitology today

- International journal for parasitology

- Experimental parasitology

- PLOS neglected tropical diseases

Course Instructor:

Ass. Prof. Dr. Maha Reda Gaafar Signature

Program Coordinator

Prof. Dr. Mona El-Temsahy Signature

√

√

Name: Prof. Dr. Lobna El Zawawy Signature


Name: Prof. Dr. Iman Abo El Naga Signature



Faculty: Medicine


Course Information


Course Name: Seminar II(special topics)


Number of Credit Hours 2 Theoretical Clinical/Practical

Course Aims: The course of Seminar II: Parasite genomes and proteomes aim at understanding the

scientific means of genomes and proteomes. The course also aims at understanding how

proteomics, the large-scale analysis of proteins, will contribute greatly to understand of gene

function in the post-genomic era. The student will understand how this aspect of proteomic studies

of different parasites is perhaps the area of greatest promise. The aim of the course is also to show

how the integration of the genomic, transcriptomic, and proteomic information, together with

genetic manipulation on individual genes, will provide a global insight into the molecular

architecture of the biology, pathogenesis, and host-parasite interactions of the human and different

parasites. Another aim is to explain how these functional genomics analysis laid a foundation on

which new vaccines develop as well as drug targets and diagnostic markers for treatment and

control of different parasites.



matrix) Course ILOs

A. Knowledge

and

Understanding





pathogenesis and the host-parasite

interactions.

a9- Identify pitfalls and resistance

of current therapy regimens and

the role of recently discovered

antiparasitic drugs.

By the end of the Seminar I the student will

be able to:

A1. Recognize how the host can interact

with the parasite.

A2. Determine the proteins generated from

this reaction and enzymes used and their

effect on the pathogenesis of the disease.

A3. Identify the mode of action of

antiparasitic drugs at the molecular level.

A4. Explain how the resistance against

drugs occurs at the molecular level.

- 2





a11- Discuss the prevention

strategies for control of vectors

and intermediate hosts

transmitting human parasites

especially newly emerging and re-

emerging parasites.

A5. Recognize the use of proteomic

analysis in diagnosis of parasitic diseases.

A6. Determine the role of genomic analysis

of parasites in diagnosis of parasitic

infections and select the appropriate method

of diagnosis for each parasite.

A7. Discuss how the proteomics can be

used in the control strategy against

parasites.

A8.Choose the appropriate strategy for

special cases.

C.

Professional

and Practical

Skills

c2- Analyze the statistical

methods needed to evaluate

diagnostic tests; including

sensitivity, specificity, positive

and negative predictive values.

.

c9- Apply computerized

information systems for recording,

analyzing, and reporting data.

c13- Prepare scientific articles

related to specialty and use

appropriate media for their

presentation.

C1. Determine the statistical tests needed

for evaluation of different tests.

c2. Interpret the results of statistics.

C3. Use information technology to access,

evaluate, report and interpret scientific data.

c4. Prepare scientific articles related to

genomes and proteomes.

c5. Use appropriate media for their

presentation (data show,video,etc……)

D. General &

Transferable

Skills

d3- Employ skills to be an efficient

staff member to perform teaching

tasks, plan and modify curricula,

assess and appraise junior staff.

d7- Demonstrate skills in

educating colleagues, students or

other health care professionals.

D1.Acquire skills to be an efficient staff

member.

d2. Acquire skills to perform teaching tasks.

D3.Plan and modify curricula.

D4. Assess and appraise junior staff.

D5. Practice educating colleagues, students

or other health care professionals while

presenting the seminar.

D6.Recognize and respect the views and

opinions of others.



format.


sources ( printed, electronic,






benefit practice.

d7.Co-operate in discussion groups to solve

scientific problems d8.Employ an evidence-based presentation

D8. Use different sources of information to

obtain data.

D9. Show competence in communicating

scientific findings.

D10. Acquire updated knowledge from various

sources.

d11. Appraise and systematize aquired

knowledge and present it to peers in a

professional manner.



Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

1. General Introduction to genomics.

√

2. Contributions of proteomics in

parasitology.

√

3. The role of functional genomics

analysis in development of vaccines.

√

4- Impact of genomic analysis in


√


Student Assessment



Case OSCE/OSPE


Others

Midterm

End of term 100 %




√

Presentation


Continuous assessment 30 %


Lecture Notes

Course Text Books

-Genome Transcriptome and Proteome

Analysis by Alain Bernot

1. –Microbial Proteomics:Functionl

Biology of Whole Organisms by Ian

Humphery-Smith and Michael Hecker





- BMC Genomics

- Molecular and Biochemical

Parasitology.

Course Instructor

Name: Prof. Dr. Shereen Farouk Mosalam

Signature:

Program Coordinator

Name: Prof. Dr. Mona El Temsahy

Signature:

Name: Prof. Dr. Lobna Abdel Aziz El Zawawy

Signature:



Signature:



Faculty: Medicine


Course Information


Course Name: Seminar I( special topics)



Course Aims: Seminar I includes a special topic: Electron microscopic studies of important

parasites such as Schistosoma spp., Leishmania spp., Toxoplasma gondii, Trichomanas vaginalis

and Giardia lamblia. It is carried by the students under supervision, to help them enforce their

power of information collection and presentation.



matrix) Course ILOs

A. Knowledge

and

Understanding


graduate must:






therapeutic effects of antiparasitic

drugs and their mode of action.

By the end of course: electron

microscopic studies of different parasites,

the student will be able to:

A1- Describe the ultrastructural features of

different important parasites such as,

Schistosoma spp., and leishmania

spp.,…etc.

A2- Define the internal and external

morphological details of such parasites

through transmission and scanning electron

microscopic studies.

A3- Recognize the value of electron

microscopic studies of parasites to explain

the basic role of anti-parasitic drugs on their

- 2

morphology.

A4- Identify the mode of action of anti-

parasitic drugs on the external cuticle and

the internal structure of the studied

parasites.

B. Intellectual

skills

b4- Plan, undertake and evaluate

medical research in the field of

medical parasitology.

B1- Recognize the efficacy of chemicals,

drugs, vaccine, and different environmental

factors in disfiguring the parasitic structure

and loosing their function.

B2- Select the recent drug used to treat

different parasitic infections.

C. Professional

and Practical

Skills

c12- Design and employ research

relevant to medical and public

health problems in parasitic

diseases.

c13-Prepare scientific articles



presentation.

c14- Employ research studies that

add to the existing specialty

knowledge.

C1- Plan and prepare research studies about

the effect of recent advanced therapeutic

agents on ultrastructure of resistant

parasites to the ordinary effective drugs.

C2- Prepare scientific articles related to the

chosen topic (electron microscopic study of

different species of Leishmania, Schistosoma,

……etc).

C3- Select an appropriate media to facilitate

articles presentations.

C4- Plan and prepare research studies about

recent updates in ultra-structure morphology of

chosen parasites.

C5- Design and conduct a research project

and apply relevant research skills to

estimate the ultrastructure changes of

different parasites under the effect of drugs

or vaccines.

General &

transferable

skills

d1- Conduct individual

presentations at scientific

D1- Able to represent an evidence-based

presentation about the chosen topics.

conferences that are focused,

clear, and concise and

appropriately utilize time.








benefit practice.

d14- Use effectively and





data.

D2- Able to get use of different methods of

presentations e.g data show, videos.

D3- Mange time effectively.

D4- Acquire updated knowledge from various

sources, appraise and systematize this

knowledge and present it to peers in a

professional manner.

D5- Use sufficient and efficient methods in

collection and interpretation of data.

D6- Use information and communication

technology to collect evaluate and interpret

scientific data.

D7- Demonstrate competence in




D. Ethics &

Attitudes

e3- Deal effectively with students,

colleagues whether juniors or

seniors and subordinates.

e4- Demonstrate positive work

habits, including punctuality,

dependability, and professional

appearance.

E1- Adopt to ethical principles in dealing

with colleagues and subordinates.

E2- Point to certain important positive work

habits including punctuality of the selected

and presenting items.

E3- Recognize the value of dependability in

data collection, and article presentation.



Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Electron microscopic studies of

Schistosoma spp.

✓


Leishmania spp.

✓


Toxoplasma gondii

✓

Electron microscopic studies of Giardia

lamblia

✓


Trichomonas vaginalis

✓


Student Assessment



Case OSCE/OSPE


Others


Mid-term

End of term 100 %





Continuous assessment 30 %


Lecture Notes

Course Text Books

Roberts & Janovy, Foundations of Parasitology

Mullers & Baker, Medical Parasitology

Markell & Voge's, Medical Parasitology


Links of Parasitology :



International journals for parasitology.

Journal of Parasitology.

√ Presentation

Course Instructor

Name: Prof. Dr. Iman Helmy

Signature:

Program Coordinator

Name: Prof. Dr. Mona Mohamed El-Temsahy

Signature:

Name: Prof. Dr. Lobna abdel Aziz El zawawy

Signature:



Signature:



Faculty: Medicine


Course Information

Course Code: 05190909 Course Name: Vaccine trials in parasitic diseases

Program in which the Course is Given: Doctor Degree of Medical Parasitology

Number of Credit Hours Theoretical Clinical/Practical

Course Aims This course focusing on vaccine trials in parasitic diseases of global health importance such as schistosomiasis, leishmaniasis, trypanosomiasis, toxoplasmosis and malaria. It aims at studying the specific pathogenic characters and pathogenesis of parasites, immunological host response to parasites, different types and recent approaches of vaccines tried against parasites in addition to their applicability, advantage and disadvantages.



matrix) Course ILOs

A. Knowledge

and

Understanding

Graduate must have sufficient

knowledge & understanding of:


characters of parasites and how they

produce tissue damage.




interactions.

By the end of course: vaccination trials in

parasitic disease, the student will be able

to: A1- Recognize the pathogenic characters of

parasites of global heath importance such as,

Schistosoma, Leishmania, Trypanosoma,

Toxoplasma gondii and Plasmodium species

and how they produce tissue damage.

A2- Describe the immunological host response

to parasites of global heath importance such as,


Toxoplasma gondii and Plasmodium species.

A3- Defines the main immunological

mechanism responsible for host protection

against parasites of global heath importance

such as, Schistosoma, Leishmania,

Trypanosoma, Toxoplasma gondii and

2

a16- Identify the recent approaches

in vaccine development.

Plasmodium species.

A4- Identify the different types and recent

approaches of vaccines tried against parasites

of global heath importance such as,


Toxoplasma gondii and Plasmodium species.

A5-Recognize the advantage and disadvantages

of different vaccines tried against parasites of

global heath importance such as, Schistosoma,

Leishmania, Trypanosoma, Toxoplasma gondii

and Plasmodium species.

A6- Describe the state of the art for vaccination

trials for parasites of global heath importance

such as, Schistosoma, Leishmania,


Plasmodium species.

C.Professional

and Practical

Skills

c1- Use a systematic approach for

data collection and recording.

C13-Prepare scientific articles



presentation.

C1-Collect data from different sources about

vaccination trials for parasites of global health

importance such as, Schistosoma, Leishmania,


Plasmodium species.

C 2- Plan and prepare for a review article about

vaccination trials for schistosomiasis.

C3- Plan and prepare for a review article about

vaccination trials for leishmaniasis.


vaccination trials for trypanosomiasis.


vaccination trials for Toxoplasmosis.


vaccination trials for Malaria.

D. General &

Transferable

Skills

d1- Conduct individual presentations

at scientific conferences that are

focused, clear, and concise and a

appropriately utilize time.



format.

D1- Conduct indindividual presentation at

scientific conferences about the state of art of

vaccination in schistosomiasis which should be

clear, concise and appropriately use time.



vaccination in leishmaniasis which should be




vaccination in trypanosomiasis which should be




vaccination in toxoplasmosis which should be




vaccination in malaria which should be clear,

concise and appropriately use time.

D6- Apply effectively & efficiently different

methods of presentations e.g. data show,

videos

D7- shows skills in preparing data show

presentation for the previous topics.

D8- Communicate effectively using written and

oral format to show the various data collected

for the previous topics.

D9- Communicate effectively as a lecturer to

present the state of the art of vaccination trials

for parasites of global heath importance such

as, Schistosoma, Leishmania, Trypanosoma and

Plasmodium.

D10- Demonstrate skills in collecting data about

vaccination trials of vaccination trials for

_____________

E-Ethics &

Attitudes:




d11- Verify the accuracy of scientific

material on basis of best evidence in

medicine and in practice.





benefit practice.

e4- Demonstrate positive work

habits, including, punctuality,

dependability & professional

appearance.

parasites of global health importance such as

Schistosoma, Leishmania, Trypanosoma and

Plasmodium from all sources.

D11-Retrieve relevant parasitological updates

from reliable scientific resources.

D12- Show accuracy in collecting scientific data,

and focusing on the most recent data for the

previous topics

D13- Use sufficient and effective methods in

collection and interpretation of data.

D14-Use information technology to access,


E1- Respect timing required for data collection.

E2- be punctuate in presenting article reviews

and data show presentation

E3-respect the views and opinions of others.



Lectures Self

learning

Practical/

Clinical

Small

group

discussion

Others

Vaccination trials in schistosomiasis √

Vaccination trials in leishmaniasis

√

Vaccination trials in trypanosomiasis √

Vaccination trials in toxoplasmosis √

Vaccination trials in malaria √


Student Assessment



Case OSCE/OSPE


Others


Mid-term

End of term 100 %


Written Exam 100 %

Practical/Clinical Exam

Others


Lecture Notes

Course Text Books



- Bell, Tropical medicine





▪ Vaccine

▪ Journal infectious diseases

▪ Journal immunology

▪ Infection and immunity

√

Course Instructor

Name: Prof. Dr. Maha Eissa

Signature:

Program Coordinator

Name: Prof. Dr. Mona el -Temsahy

Signature:


Signature:



Signature:



Faculty: Medicine

Department: Medical parasitology

Course Information


Course Name: Advanced medical helminthology

Program in which the Course is Given; Doctor degree of Medical Parasitology.


Course Aims; The course of advanced medical helminthology is discussing Phylum Platyhelminthes and Phylum Nematoda, regarding all advanced subjects and parasites.



matrix) Course ILOs

A. Knowledge

and

Understanding



a2- Recognize updates in morphology, biology and life cycles of parasites and their relevance for human health. a7- Explain at the cellular and molecular levels the concept of pathogenesis and the host-parasite

By the end of the advanced medical helminthology course the student will be able to: A1- Outline the new scientific taxonomy for helminthes (Platyhelminthes & Nematodes) if any. A2- Recognize morphological characters of important helminthes and re-emerging parasites. A3- Recognize different reservoirs, intermediate hosts and vectors of helminthes. A4-Describe the biology and interrelationships between worms and their hosts. A5- Describe ultra-structure and morphological identification of different stages of the worms. A6- Recognize the main pathological lesions caused by worms by the usual pathological examination and by application of electron

1 2

interaction. a9- Identify pitfalls and resistance of current therapy regimens and the role of recently discovered antiparasitic drugs. a10- Identify recent methods for laboratory diagnosis of parasitic infections with special emphasis on molecular techniques. a11- Discuss the prevention strategies for control of vectors and intermediate hosts transmitting human parasites especially newly emerging and re-emerging parasites. a13- Trace recent advances in the field of medical parasitology and apply this knowledge in the diagnosis of parasitic infections. a16- Identify the recent approaches in vaccine development.

microscopic studies. A7- Associate the pathogenesis caused by the studied worms with the host immune response. A8- Relate the pathogenesis with the clinical manifestations of the studied helminths. A9- Explain the therapeutic effects of antihelminthic drugs and their mode of action. A10- Define the side effects, contraindications of antihelminthic drugs. A11- Recognize the parasites which develop resistance to common antihelminthic therapy like praziquantel A12- Select laboratory techniques for assessment of humoral and cellular immunity. A13- Recognize new advanced techniques regarding molecular ones in diagnosis of endemic and common infectious helminthic infections. A14- Define the intermediate host and vectors of helminthes and their impact in their transmission. A15- Recognize the hazards of people's habits which contribute to spread of infections caused by helminths. A16- Identify the preventive strategies already applied in the field of control of helminthic infections. A17- Recognize the new strategies for prevention and control of helminthic infections. A18- Identify recent molluscicides and methods of their application. A19- Recognize what is new in medical heminthology specially re- emerging parasite and imported ones. A20- Recognize methods of diagnosis and treatment of re-emerging and imported parasites. A21- Recognize the classical lines in treatment & new drugs developed to overcome resistance strains in schistosoma.

A22- Recognize the development of vaccines to schistosoma and filarial infection. A23- Trace the findings in genome projects of Schistosoma spp. and filarial worms.

B. Intellectual

skills

b4- Plan, undertake and evaluate medical research in the field of medical parasitology.

B1- Recognize the concepts behind research in medical helminthology and the need for continuous development of diagnostic and preventive methods.

B2-Practice planning, undertaking and evaluating medical and clinical research in the field of medical helminthology.

B3- Evaluate new diagnostic techniques and compare them with old ones before introducing them into the lab.

C.Professional

and Practical

Skills

c7- Develop new skills or procedures for new situations such as emerging and re-emerging parasitic diseases. c9- Apply computerized information systems for recording, analyzing, and reporting data. c12- Design and employ research relevant to medical and public health problems in parasitic diseases.

C1- Employ recent staining techniques for different stages of helminthic parasites .

C2- Identify staining patterns, morphologies and arrangements under the microscope. C3- Apply the safety precautions in the lab. C4- Perform and interpret commonly used immunological techniques such as ELISA and immunodiffusion. C5- Employ some advanced molecular methods such as nucleic acid extraction, PCR amplification and transformation.

C6- Use information technologies to access, analyze record and report data. C7- Retrieve information from various available sources, appraise and systematize this knowledge. C8- Employ research studies that add to the existing specialty knowledge. C9- Design research that solve common community problems related to helmintic infections.

D. General

Skills

d1- Conduct individual presentations at scientific conferences that are focused, clear, and concise and appropriately utilize time. d3- Employ skills to be an efficient

D1- Prepare scientific articles related to specialty with clear and concise knowledge. D2- Use appropriate media for their presentation. D3- Develop appropriate means of estimating and monitoring recourses and the use of time. D4- Demonstrate skills in educating colleagues,

staff member to perform teaching tasks, plan and modify curricula, assess and appraise junior staff.

students or other health care professionals. D5- Verify the accuracy of scientific material on basis of best evidence in medicine and in practice. D6- Perform self appraisal and seek continuous learning.



Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

1- Advances in classification,

ultrastructural and diagnosis of

Platyhelminthes.

✓ ✓ √

2- Advances in classification,

ultrastructural and diagnosis of

Nematodes.

✓ ✓ ✓

3- Case reports of rarely infectious

and re-emerging helminthic

infections.

✓ ✓ ✓


Student Assessment



Case OSCE/OSPE


Others


Mid-term

End of term 100 %


Written Exam 70 %


Others 10 %

✓ ✓

✓

✓ ✓


Lecture Notes

Peters & Pasval, Atlas of Tropical Medicine

and Parasitology

Course Text Books

• Beaver & Jung, Clinical parasitology.

• Garcia, Diagnostic parasitology.

• Bell, Tropical Medicine

• Paniker, Text book of Medical

parasitology.


Links of Parasitology from the internet



- American Journal of Parasitology

- Lancet

- Parasitology Today

- Journal of newly emerging infectious diseases.

Course Instructor

Name: Prof. Dr. Eman Dorry Hussein

Signature:

Program Coordinator


Signature:


Signature:



Signature:



Faculty: Medicine


Course Information


Course Name: Medical entomology II

Program in which the Course is Given :Doctorate of Medical Parasitology


Course Aims Medical Entomology II course focuses on the knowledge about different types of Crustaceans, Arachnids

(Scorpionida, Acarina), Insecta (Bugs, Lice, and Fleas, Mosquitoes, Flies), their behavior, diseases,

transmitted or caused by them, their importance in relation to human health and control.



matrix) Course ILOs

A. Knowledge

and

Understanding

By the end of the course graduate

must have sufficient knowledge &

understanding of:

a1- Revise the diagnostic morphology,

life cycles, clinical manifestations,

diagnosis and treatment of the studied

parasites.

By the end of Entomology II course 1;

the student will be able to:

A1- Describe the diagnostic morphology

of different life cycle stages of the

Crustaceans, Arachnids, Insecta of

medical importance and to differentiate

between each order.

A2- Identify the habitat of different stages

of the studied arthropods of medical

importance belonging to these classes.

A3- Understand the biology and life

cycle of the studied arthropods.

A4- Know the different diagnostic

techniques which could allow proper

diagnosis of the diseases caused by the

studied arthropods.

1 2

a2- Recognize updates in morphology,

biology and life cycles of parasites and

their relevance for human health.

a3- Describe the mode of infection of

different organisms transmitted by

parasites among humans.

a4- Identify the role played by

intermediate hosts and vectors in

disease transmission.

a5- Define terms used in describing

aspects of parasitic pathogenesis.

A5- Select the proper therapeutic

regimen for treating diseases caused by

these arthropods.

A6- Identify the updates in the diagnostic

morphology of different Crustaceans,

Arachnids, Insecta of medical

importance.

A7- Recognize the updates in the biology

of different life cycle stages of these

arthropods.

A8- Recognize the updates in the life

cycles of these arthropods.

A9- Correlate between updated

knowledge about these arthropods and

their relevance to human health.

A10- Identify the diseases transmitted

by the medically importance

Crustaceans, Arachnids, Insecta.

A11- Recognize how people get

infection by such diseases.

A12- Comprehend the role played by


medical importance as vectors in disease

transmission whether parasitic,

bacterial, viral or rickettsial diseases.

A13- Identify and classify the diseases

caused by Crustaceans, Arachnids,

Insecta of medical importance: specific

diseases (scabies, tungiasis, pediculosis,

myiasis), allergic reactions or due to

toxin produced by these arthropods.

A14- Recognize the terms used in

describing the main pathological lesions

caused by the various life cycle stages

of Arachnids and Insecta of medical

importance.

a11- Discuss the prevention strategies

for control of vectors and intermediate

hosts transmitting human infectious

agents especially newly emerging and

re-emerging parasites.

a12- Recognize the hazards of various

customs and habits applied by people

which contribute to the spread of

parasites.

a13- Trace recent advances in the field

of medical Parasitology and apply this

knowledge in the diagnosis of parasitic

infections.


infections in the immunocompromized

host (opportunistic parasites).

A15- Discuss the requited preventive

methods against various Crustaceans,

Arachnids, Insecta responsible for

transmitting human infectious agents.

A16- Understand the control measures

that could be used against these

arthropods responsible for transmitting

human infectious agents especially

newly emerging and re-emerging

parasites.

A17- Comprehend the consequences of

different customs and habits applied by

people which contribute to the spread of

diseases caused by or transmitted by


medical importance.

A18- State the recent advances in the

field of medical entomology especially

that related to Crustaceans, Arachnids,

Insecta.

A19- Recognize the recent methods in

diagnosis of various infections

transmitted by these arthropods.

A20- Know the recent convenient

techniques can be used in diagnosis of

various diseases caused by these

arthropods.

A21- Understand the course, hazards

and outcome of infections caused by

Arachnids and Insecta in

immunocompromized host.

B. Intellectual

skills

b1- Interpret the results of diagnostic

techniques.

b4- Plan, undertake and evaluate

medical research in the field of medical

Parasitology.

B1- Infer the interpretations of

diagnostic Sarcoptes scabieii from skin

scrapping and skin sections.

B2- Interpret the results of examination

of different collected samples containing

insects of medical importance.

B3- Recognize the need for continuous

development of effective preventive

measures against Crustaceans,


importance and accomplishes research

about this topic.

B4- Practice planning, undertaking and

evaluating medical research in the field

of medically important Crustaceans,

Arachnids, Insecta.

B5- Evaluate data collected from

research in the field of these arthropods.

C. Professional

and Practical

Skills

c12- Design and employ research

relevant to medical and public health

problems.

c14- Employ research studies that add

to the existing specialty knowledge.

C1- Conduct research studies on the

importance of diseases caused and

transmitted by Crustaceans, Arachnids

and Insecta and clarify their impact on

the community health.

C2- Propose research regarding the

hazard posed by different Crustaceans,

Arachnids and Insecta of medical

importance in transmission and

production of diseases.

C3- Plan further research studies to add

to the knowledge of various preventive

and control measures to Crustaceans,


importance.

D. General

Skills

d1- Conduct individual presentations at

scientific conferences that are focused,

clear, and concise and appropriately

utilize time.

D1- Accomplish individual

presentations about hazards of

Crustaceans, Arachnids and Insecta of

medical importance on the community

with clear and simple knowledge.

D2- Present the prepared topics at

scientific conferences with a clear

concise statement and appropriately

utilize time.

d2- Communicate effectively with

colleagues giving advice, instructions

and professional opinions.

d3- Employ skills to be an efficient

staff member to perform teaching tasks,

plan and modify curricula, assess and


d7- Demonstrate skills in educating

colleagues, students or other health care

professionals.




D3- Communicate effectively with

colleagues from various departments

who could face medical problems posed

by or conveyed by Crustaceans,

Arachnids and Insecta of medical

importance, through giving advice

professional opinions about their

diagnosis, prevention and control.

D4- Update recent skills required to be

an efficient staff member to perform

teaching tasks in the field of


medical importance.

D5- Display recent skills required to be

an efficient staff member to plan and

modify curricula in the field of these

arthropods.

D6- Apply recent skills required to be an

efficient staff member to assess and


D7- Display skills in educating

colleagues in the field of Crustaceans,

Arachnids, and Insecta of medical

importance.

D8- Exhibit skills in educating students

in the field of these arthropods.

D9- Show skills in educating health care

professionals about hazards of these

arthropods.

D10- Gain updated information about


medical importance from all sources

(printed, electronic, communications

etc…).



Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

1- Introduction to Entomology 1 ✓ ✓

2- Crustacea (Cyclops) ✓ ✓ ✓

3- Arachnida:

Order: Scorpionida

Order: Acarina

✓ ✓ ✓

4-Insecta: Class Anoplura ✓ ✓ ✓

5- Insecta: Class Hemiptera ✓ ✓ ✓

6- Insecta: Class siphonaptera ✓ ✓ ✓


Student Assessment



Case OSCE/OSPE


Others


Mid-term

End of term 100 %


Written Exam 70 %


Others


Lecture Notes - Wallace Peters, A colored Atlas of Arthropods in Clinical Medicine

Course Text Books

- Service, Medical Entomology for Students, 2nd ed.2000

- Goddard, Arthropods of Medical Importance2nd ed. 1996

-Beaver & Jung, Clinical Parasitology,9th ed.1984

-Garcia, Diagnostic Medical Parasitology5th ed.2007


Review of Medical and Veterinary Entomology.

http://www.cabipublishing.org/JOURNALS/Abstract/RMVE/Index.asp

Journals and Periodicals,

others

- Journal of Medical Entomology

- Journal of the Entomological Research Society

- Transactions of the American Entomological Society

✓ ✓

✓

✓ ✓

http://www.cabipublishing.org/JOURNALS/Abstract/RMVE/Index.asp

http://www.google.com/url?sa=t&source=web&cd=1&sqi=2&ved=0CBIQFjAA&url=http%3A%2F%2Fwww.entsoc.org%2Fpubs%2Fperiodicals%2Fjme%2Findex.htm&ei=ESC2TO_LCMnIswa_odWbCA&usg=AFQjCNEsETxKcB5HAXV0Ij9GMQ3MK7V7jQ

http://www.google.com/url?sa=t&source=web&cd=1&sqi=2&ved=0CBIQFjAA&url=http%3A%2F%2Fwww.entsoc.org%2Fpubs%2Fperiodicals%2Fjme%2Findex.htm&ei=ESC2TO_LCMnIswa_odWbCA&usg=AFQjCNEsETxKcB5HAXV0Ij9GMQ3MK7V7jQ

http://en.wikipedia.org/wiki/Journal_of_the_Entomological_Research_Society

http://en.wikipedia.org/w/index.php?title=Transactions_of_the_American_Entomological_Society&action=edit&redlink=1

Course Instructor

Name: Prof. Dr. Doaa El Said

Signature:

Program Coordinator

Name Prof. Dr. Mona El-Temsahy

Signature:


Signature:



Signature:



Faculty: Medicine


Course Information

Course Code: 05190907 Course Name: Molecular Parasitology II



Course Aims: The course of Molecular Parasitology II aims at informing students to the

importance of molecular and cellular interactions between different parasites and their hosts. The

course aims to encourage the students to access information from different sources and to

communicate the principles in a well-organized way.


Program ILO (refer to program matrix) Course ILOs

A. Knowledge and Understanding

By the end of the course the graduate must be able to: a7- Explain at the cellular and molecular levels the concept of pathogenesis and the host-parasite interactions.



emphasis on molecular techniques._

By the end of Molecular Parasitology course the student will be able to: A1- Recognize how the host can interact with the parasite. A2- Understand in details the molecular and cell biology of certain protozoan parasites. A3- Understand in details the metabolic novelties in parasites and their potential as novel drug targets. A4- Recognize the molecular tests used in the diagnosis of parasitic diseases. A5- Identify the recent immunological tests used specially at the molecular and genetic levels.

2

B. Intellectual skills

b1- Interpret the results of direct parasitological techniques.

B1- Determine the most suitable diagnostic test for a certain clinical presentation. B2- Correlate the results of molecular techniques with the clinical picture. B3- Correlate the results of molecular techniques with the line of treatment.

C. Professional and Practical Skills

c2- Analyze the statistical methods needed

to evaluate diagnostic tests; including

sensitivity, specificity, positive and

negative predictive values.

c3- Perform competently sample handling including: specimen collection and transport, sample handling and storage in the laboratory and disposal of high risk samples and containment. c6- Perform indirect tests for detection of:

•Nucleic acid using molecular amplification

methods.

c7- Develop new skills or procedures for new situations such as emerging and re-emerging parasitic diseases.

C1- Determine the statistical tests needed for evaluation of different molecular tests. C2- Interpret the results of statistics. C3- Recognize the risk factors that may occur during collection of different specimens. C4- Choose the appropriate method for transport. C5- Decide the safe method in disposal of the samples not needed. C6- Evaluate the risks imposed during professional laboratory work C7- Predict indirect tests for detection of nucleic acid of the parasites as DNA probe and polymerase chain reaction techniques (PCR). C8- Utilize properly different laboratory equipments used in serological and molecular diagnosis of parasitic infections. C9- Develop and evaluate new methods or procedures for diagnosis of parasitic infections and comparing them with the gold standard methods used for diagnosis. C10- Carry out specialized skills in: advanced diagnostic molecular and immunological aspects of parasitic infections. C11- Use information technology to collect, analyze, record and report

c.9- Apply computerized information systems for recording, analyzing, and reporting data.

data C12- Utilize appropriate computer software in recording, analyzing, and reporting scientific data in a parasitology lab.

D. General Skills

d1- Conduct individual presentations at scientific conferences that are focused, clear, and concise and appropriately utilize time. d13- Demonstrate an ability to use methods of inquiry to collect and interpret data in order to provide information that would reform or benefit practice.

D1- Participate in seminars, conferences and workshops for further development of specialty. D2- Employ skills to be concise in his presentation and appropriately utilize time. D3- Able to get use of different methods of presentations e.g data show ,videos D4- Retrieve information from all sources (printed, electronic, communications etc…) to know recent methods in diagnosis. D5- Acquire updated knowledge from various sources, appraise and systematize this knowledge and present it to peers in a professional manner. D6- Use self-learning methods in practice information gathering and information technology.

e5- Appraise principles of confidentiality with all information transmitted both during and outside a patient encounter.

E1- Collect data confidentiality and apply all medical research ethics.



Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Parasite molecular biology:

- Parasite genomics

- RNA processing in parasites

Transcription

- Post-transcriptional regulation

- Antigenic variation

(Trypanosomes)

- Influence of host genetics on

host resistance

- Genetic and genomic

approaches to study virulence

✓

✓

Biochemistry and Cell biology:

Protozoa: -Energy metabolism:

Anaerobic protozoa

Aerobic protists

Apicomplexa

-Amino acid and protein metabolism

-Purine and pyrimidine transport and

metabolism

-Parasite Glycobiology

GPI anchors (Trypanosomes)

Protein glycosylation: Glycans and

virulence

Intracellular signaling I& II

-Cell invasion and intracellular survival

Plasmodium

Toxoplasma gondii

Intestinal coccidians

Leishmania

-Plastids, hydrogenosomes and

mitochondria

✓

✓

Advanced topics in molecular

Parasitology:

-Transposable elements in parasites

✓ ✓

-Remodelling of host erythrocyte by

Plasmodium proteins -Host-paarsite interactions at the site of

the insect vector bite in protozoan

diseases

-Cell division of apicomlexan parasites

-Vesicular traffic in Toxoplasma

infection

Medical applications: -Parasite detection and diagnosis

-Recent molecular diagnostic

techniques for protozoa

-Epidemiology and clinical

manifestations

-Treatment and vaccines

-Drug resistance

✓

✓

✓

Please check (✓) the appropriate method

Student Assessment



Case OSCE/OSPE


Others

Mid term

End of term 100 %


Written Exam 70 %

Practical/Clinical Exam - %

Others: 30 %

Assignment 15 %

Oral exam 15 %

✓ ✓

✓ ✓

Oral exam


Lecture Notes

Parasitology notes

Course Text Books Marr JJ, Nilson TW and Komuniecki RW,

Molecular Medical Parasitology





International Journal of Parasitology

Molecular Microbiology

Molecular cell Biology

Course Instructor

Name: Prof. Dr. Eman Rafaat

Signature:

Program Coordinator


Signature:


Signature:



Signature:



Faculty: Medicine


Course Information


Course Name: Blood and tissue protozoa



Course Aims: A course in blood and tissue protozoa discusses the different protozoa affection the tissue and the blood including mastigophora, coccidian, sporozoa as regards their geographical distribution, morphology, life cycle, clinical picture, complications, impact on human health and means of control. All newly emerging protozoa are in this subject.



matrix) Course ILOs

A. Knowledge

and

Understanding

By the end of the course graduate

must :





a2- Recognize updates in

morphology, biology and life cycles

By the end of course: blood and tissue

protozoa, the student will be able to:

A1- Describe the diagnostic features and life

cycle of different important blood and tissue

protozoa such as, Trypanosoma, leishmania,

plasmodium, and the newly emerging

protozoa.

A2- Recognize the different clinical pictures

and diagnostic approaches and treatment for

each parasite.

A3- Recognize the biological habits of different

important protozoa as their growth

requirement, dealing with the environmental

1 2

of parasites and their relevance for

human health.

a3- Describe the mode of infection of

different parasites among humans.

a4- Identify the role played by

intermediate hosts and vectors in

disease transmission.

a5- Define terms used in describing

aspects of parasitic pathogenesis.


characters of parasites and how they

produce tissue damage.

stresses, and drug susceptibility.

A4- Describe the life cycle of each parasite and

the relevance of each stage for human health.

A5- Recognize how people get infection by

such protozoa.

A6- Name the intermediate hosts of each

parasite.

A7- Identify the numbers of intermediate host

needed for each parasite to complete its life

cycle.

A8- Determine the role of intermediate hosts

or vectors in the development of different

parasite stages.

A9- Define factors affecting the pathogenic

character of parasites which are either related

to the host or to the parasite itself.

A10- Describe different mechanisms by which

parasites cause damage and diseases in the

host.

A11- Recognize the biological habits of

different important parasites which play a role

in their pathogenicity.

A12- Define the main immunological

mechanisms responsible for host protection

against parasites, including immune evasion

mechanisms.

A13- Describe the immunological host

response of different blood and tissue




interactions.

a8- Explain the basis for therapeutic

effects of antiparasitic drugs and

their mode of action.

a9- Identify pitfalls and resistance of

current therapy regimens and the

role of recently discovered

antiparasitic drugs.



infections with special emphasis on

molecular techniques.

a11- Discuss the prevention

strategies for control of vectors and

intermediate hosts transmitting

human parasites especially newly

emerging and re-emerging parasites.

a12- Recognize the hazards of

protozoa.

A14- Describe the effect of antiparasitic drugs

on different parasite stages.

A15- Identify different mechanisms by which

the antiparasitic drugs make their therapeutic

effect.

A16- Describe the mode of action of recent and

most advanced drug therapy.

A17- Define drug resistance and factors causing

it.

A18- Trace a strategy to overcome or limit drug

resistance process.

A19- Identify recent drugs to be used to treat

different parasitic infections.

A20-Describe different diagnostic approaches

applied for diagnosis of blood and tissue

protozoa.

A21- Identify recent and most advanced

molecular techniques for diagnosis of such

important protozoa.

A22- Describe different methods of prevention

and control of the different stages of protozoa.

A23- trace outlines for newly emerging

protozoa prevention and control.

A24- Define the health problems related to

various customs and habits applied

by people which contribute to the

spread of parasitic infections.

a13- Trace recent advances in the

field of medical parasitology and

apply this knowledge in the diagnosis

of parasitic infections.


infections in the

immunocompromized host

(opportunistic parasites).

protozoal infections and their impact in the

community.

A25- Recognize hazards of people's habits

which contribute to spread of such infections

caused by blood and tissue protozoa.

A26- Recognize the value of study of protozoa

that have global heath importance such as,

Leishmania, Trypanosoma and Plamodium spp.

A27- Select the most recent and advanced

approach in the field of medical parasitology to

facilitate the diagnosis of such important

parasites.

A28- Define the opportunistic parasites.

A29- Recognize the behavior of opportunistic

parasite such as Toxoplasma gondii in

immunocompromised host and in pregnancy.

B.

Intellectual

skills



b2- Interpret the results of serologic

techniques

B1- Apply the most simple, reliable, convenient

and cheap test for direct diagnosis of blood and

tissue protozoa of global health importance.

B2-analyze and interpret the findings of each

direct parasitological tests.

B3- Apply the most simple, reliable, convenient

and cheap test for indirect diagnosis of blood

and tissue protozoa of global health

importance.

B4- Analyze and interpret the findings of each

indirect parasitological tests.

D. General

Skills




D1- Acquire updated information from various

sources, appraise and systematize this

d14- Use effectively and efficiently

information and communication

technology to improve his/her

professional research ability and to

collect data.

information.

D2- Summarize the retrieved scientific data and

present it at scientific conferences clearly.

D3- Use information and communication

technology to collect, evaluate, interpret and

present scientific data.



Lectures self

learning

Practical/

Clinical

Small

group

discussion

Others

Mastigophora:

Blood flagellates

Tissue flagellates

✓ ✓ ✓

Coccidia:

Plasmodium spp.

Toxoplasma gondii

✓ ✓ ✓

Tissue Microsporidia ✓ ✓ ✓


Student Assessment



Case OSCE/OSPE


Others


Mid-term

End of term 100 %


Written Exam 70 %


Others

✓ ✓

✓

✓


Lecture Notes

Peters & Pasval, Atlas of Tropical Medicine

and Parasitology

Course Text Books

Beaver & Jung, Clinical parasitology.

Garcia, Diagnostic parasitology.

Bell, Tropical Medicine

Paniker, Text book of Medical parasitology.





International journals for parasitology.

Journal of experimental parasitology.

Journal of clinical microbiological reviews

Course Instructor

Name: Prof. Dr. Merval El Azzouni

Signature:

Program Coordinator


Signature:


Signature:



Signature:

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