uncovering the mechanisms of research capacity development

22
REVIEW Open Access Uncovering the mechanisms of research capacity development in health and social care: a realist synthesis Jo Cooke 1 , Paolo Gardois 2 and Andrew Booth 3* Abstract Background: Research capacity development (RCD) is considered fundamental to closing the evidencepractice gap, thereby contributing to health, wealth and knowledge for practice. Numerous frameworks and models have been proposed for RCD, but there is little evidence of what works for whom and under what circumstances. There is a need to identify mechanisms by which candidate interventions or clusters of interventions might achieve RCD and contribute to societal impact, thereby proving meaningful to stakeholders. Methods: A realist synthesis was used to develop programme theories for RCD. Structured database searches were conducted across seven databases to identify papers examining RCD in a health or social care context (19982013). In addition, citation searches for 10 key articles (citation pearls) were conducted across Google Scholar and Web of Science. Of 214 included articles, 116 reported on specific interventions or initiatives or their evaluation. The remaining 98 articles were discussion papers or explicitly sought to make a theoretical contribution. A core set of 36 RCD theoretical and conceptual papers were selected and analysed to generate mechanisms that map across macro contexts (individual, team, organisational, network). Data were extracted by means of If-Thenstatements into an Excel spreadsheet. Models and frameworks were deconstructed into their original elements. Results: Eight overarching programme theories were identified featuring mechanisms that were triggered across multiple contexts. Three of these fulfilled a symbolic role in signalling the importance of RCD (e.g. positive role models, signal importance, make a difference), whilst the remainder were more functional (e.g. liberate talents, release resource, exceed sum of parts, learning by doing and co-production of knowledge). Outcomes from one mechanism produced changes in context to stimulate mechanisms in other activities. The eight programme theories were validated with findings from 10 systematic reviews (20142017). Conclusions: This realist synthesis is the starting point for constructing an RCD framework shaped by these programme theories. Future work is required to further test and refine these findings against empirical data from intervention studies. Keywords: Research capacity development, Realist synthesis, Evaluation, Leadership, Training * Correspondence: [email protected] 3 School of Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield S1 4DA, United Kingdom Full list of author information is available at the end of the article © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Cooke et al. Health Research Policy and Systems (2018) 16:93 https://doi.org/10.1186/s12961-018-0363-4

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Page 1: Uncovering the mechanisms of research capacity development

REVIEW Open Access

Uncovering the mechanisms of researchcapacity development in health and socialcare: a realist synthesisJo Cooke1, Paolo Gardois2 and Andrew Booth3*

Abstract

Background: Research capacity development (RCD) is considered fundamental to closing the evidence–practicegap, thereby contributing to health, wealth and knowledge for practice. Numerous frameworks and models havebeen proposed for RCD, but there is little evidence of what works for whom and under what circumstances. Thereis a need to identify mechanisms by which candidate interventions or clusters of interventions might achieve RCDand contribute to societal impact, thereby proving meaningful to stakeholders.

Methods: A realist synthesis was used to develop programme theories for RCD. Structured database searches wereconducted across seven databases to identify papers examining RCD in a health or social care context (1998–2013).In addition, citation searches for 10 key articles (citation pearls) were conducted across Google Scholar and Web ofScience. Of 214 included articles, 116 reported on specific interventions or initiatives or their evaluation. Theremaining 98 articles were discussion papers or explicitly sought to make a theoretical contribution. A coreset of 36 RCD theoretical and conceptual papers were selected and analysed to generate mechanisms thatmap across macro contexts (individual, team, organisational, network). Data were extracted by means of ‘If-Then’statements into an Excel spreadsheet. Models and frameworks were deconstructed into their original elements.

Results: Eight overarching programme theories were identified featuring mechanisms that were triggered acrossmultiple contexts. Three of these fulfilled a symbolic role in signalling the importance of RCD (e.g. positive role models,signal importance, make a difference), whilst the remainder were more functional (e.g. liberate talents, release resource,exceed sum of parts, learning by doing and co-production of knowledge). Outcomes from one mechanism producedchanges in context to stimulate mechanisms in other activities. The eight programme theories were validated withfindings from 10 systematic reviews (2014–2017).

Conclusions: This realist synthesis is the starting point for constructing an RCD framework shaped by theseprogramme theories. Future work is required to further test and refine these findings against empirical datafrom intervention studies.

Keywords: Research capacity development, Realist synthesis, Evaluation, Leadership, Training

* Correspondence: [email protected] of Health and Related Research, University of Sheffield, Regent Court,30 Regent Street, Sheffield S1 4DA, United KingdomFull list of author information is available at the end of the article

© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Cooke et al. Health Research Policy and Systems (2018) 16:93 https://doi.org/10.1186/s12961-018-0363-4

Page 2: Uncovering the mechanisms of research capacity development

BackgroundNational policy and financial investment across the globeindicates overwhelming support for building research cap-acity in healthcare systems. Enhanced capacity is believedto promote problem solving [1], reduce the gap betweenevidence and practice [2, 3], and promote health gains [4].It is considered a powerful and cost-effective way of ad-vancing healthcare and development [5] and, if done well,can improve collaboration between high- and low-incomecountries [1] and address health inequalities [6]. UnitedKingdom policy highlights that the ‘best’ health researchpromotes the health and wealth of the nation [7].Despite overwhelming support in the research litera-

ture and policy documents, research capacity develop-ment (RCD) is poorly defined, and conceptually elusive[8]. Undertaking a conceptual review of the literature,Condell and Begley define research capacity-building, acomponent of RCD, as “a funded, dynamic interventionoperationalised through a range of foci and levels to aug-ment ability to carry out research or achieve objectives inthe field of research over the long-term, with aspects ofsocial change as an ultimate outcome” [8]. This defin-ition highlights that RCD is complex and operates at anumber of structural levels, including individual, team,organisational and within networks [9], and includes arange of ‘interventions’ [10] or foci of activity. RCD ac-tivities are often conducted in parallel and can be inter-related. Research training, fellowships and mentorshipschemes, for example, can be planned and evaluatedseparately, but in practice are often linked [11] and addvalue to each other. RCD ‘interventions’ may includeprocesses such as priority-setting [12], but equally canincorporate structural changes in organisations, for ex-ample, developing an information technology infrastruc-ture [13, 14]. Structural and process interventions canlink to outcomes of their own but can also produce afertile environment for other RCD initiatives. Collect-ively and separately, they achieve the common goal ofstimulating ‘more research done well’.The challenge of understanding RCD and how it oper-

ates is compounded by the fact that RCD is often seenas a means to an end [9] rather than an end in itself.From this perspective, means are the skills and structuralenhancements that enable research to be conducted withthe ultimate ‘end’ or goal of RCD in healthcare being tochange practice and systems to improve health [13]. Set-ting the criteria for impact to this level makes it evenmore challenging to understand ‘what works’ in RCD.Although targeting improved health as the goal givesmore value and ‘meaning’ to RCD activity, it necessitateslong and convoluted causal chains, making it even moredifficult to attribute impact. It also requires consider-ation of the nature and quality of how RCD interven-tions are performed, whether they are ‘meaningful’ and

whether they can produce change in practice. Nuyens,for example, suggests that how priority-setting is under-taken influences how meaningful it is, and whether re-search is subsequently used in practice [15].The literature on RCD reflects its elusive and

chameleon-like quality and how difficult it is to measureand attribute impact [16]. Reports and case studies ofRCD interventions in health do exist but evidence oneffectiveness is inconclusive. Many evaluations fall shortof being able to determine the impact on healthcaresystems and thus demonstrate meaningful RCD. Suchlimitations may, in turn, reflect shortcomings in the the-oretical underpinning of RCD interventions [16].Further complexity is added when considering the re-

lationship between RCD and knowledge mobilisation(KM). RCD focuses very much on empowering and en-abling different levels of the health research system toconduct research. KM focuses further downstream –once the capacity is in place, to what extent can the re-search that has been generated change practice? Manyhealth systems display an evolutionary or developmentalaspect to these activities; in the United Kingdom, for ex-ample, antecedent investment in research and develop-ment support units has started to deliver the capacity tomobilise knowledge through networks such as the Col-laborations for Leadership in Applied Health Researchand Care (CLAHRCs). However, typically, RCD and KMco-exist and interact given that new requirements identi-fied from KM will feed into subsequent requirements forspecific reconfigurations of research capacity.In summary, RCD can be categorised as a complex

intervention, what Willis et al. describe as “a set of pur-posefully coordinated components that target multiplelevels and sectors of a system, that operate both inde-pendently and inter-dependently, and that interact in thecontexts in which they are implemented” [17]. Realist ap-proaches offer an ideal methodology for understanding,evaluating and planning such interventions.Numerous models suggest how RCD works [1, 9, 14,

18–21]. However, few models address underlying mecha-nisms for what works, and why, across a range of con-texts, in achieving a meaningful impact on healthservices and systems. No attempt has been undertakento link existing RCD models, nor to develop theories ina systematic way from them.The objective of this realist synthesis is to address

what are the mechanisms that support meaningful RCDthat are triggered across diverse contexts, specifically atindividual, team, organisation or network level, as de-scribed in conceptual and theoretical papers? We aimto isolate mechanisms that are activated across andwithin diverse contexts in order to develop programmetheories that will identify and test causal chains in RCDprogrammes.

Cooke et al. Health Research Policy and Systems (2018) 16:93 Page 2 of 22

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MethodsThis paper reports on a work package within a largerprogramme of work on reviewing the RCD literature inhealth and social care. The wider programme aims to ana-lyse both the conceptual papers and intervention studies.This paper reports on the first stage of this research,namely a realist synthesis of theoretical and conceptualpapers to develop programme theory at a macro level. Arealist synthesis seeks to explain and unpack the mecha-nisms by which an intervention works (or fails to work); itseeks to advance a potential explanation, as opposed to adefinitive judgement, about how interventions (in this caseresearch capacity development activities) achieve theiroutcomes [22]. By mechanisms we mean the responsesthat the ‘active’ components within an intervention stimu-late, either individually or collectively, within participants.We explore these mechanisms by first identifying an ac-cessible explanation of how the intervention is understoodto work, known as a ‘programme theory’, derived from theresearch literature, official documents or stakeholderexplanations.A realist approach recognises that the context within

which an intervention is delivered is “complex, multi-fa-ceted and dynamic” [23]. It challenges the assumption,implicit in conventional systematic review methodology,that the same intervention will work in the same way indifferent contexts. Realist logic seeks to articulate state-ments along the lines of ‘IF Context A includes… THENMechanisms X, Y, Z are activated LEADING TO Out-come O1’ – these statements are technically known as‘CMO Configurations’ or ‘CMO chains’.The work described in this study seeks to identify

mechanisms that are activated across a variety of con-texts operating at different levels (individual, team, or-ganisational, network) within the health research systemto achieve either desirable or unintended outcomes. Sub-sequent work will seek to map evidence from empiricalstudies to the theoretical framework. The realist synthe-sis method was supported by systematic mapping meth-odology. A core set of theoretical and conceptual paperson RCD was analysed in order to generate mechanismsand map these across macro contexts (individual, team,organisational, network) in order to develop programmetheories.

Initial scoping of the literatureIn 2005, a scoping review, Re:Cap – Identifying theEvidence Base for Research Capacity Development inHealth and Social Care [10], was commissioned by theNational Coordinating Centre for Research Capacity De-velopment, in partnership with the National SteeringCommittee of Research and Development Support Units,to “identify, map, and describe the literature available toinform research capacity development (RCD) activities in

health and social care, and to inform the work of RDSUs[Research and Development Support Units]” (the thenUnited Kingdom regional research and development sup-port units) [10]. A scoping review is “a preliminary assess-ment of the potential size and scope of the availableresearch literature” [24] and does not seek to conduct for-mal assessments of evidence quality. One component ofthe scoping review sought to identify existing RCDmodels, frameworks and theories. Four limitations wereidentified for this component of the wider scoping review,namely (1) models, frameworks and theories were derivedfrom a heterogeneous range of sources and disciplinesmaking comparison and specific application to health andsocial care problematic, especially as some models origi-nated from outside the context of research capacity; (2) norecognised procedures existed for identifying models,frameworks and theories in a systematic way; (3) timeconstraints did not permit a formal attempt to examine anempirical base for each identified model, framework ortheory; and (4) related to (3), there was limited opportun-ity to link the theories identified to eight RCD activities(Box 1) prioritised for the scoping review. Several yearslater, two authors of the original scoping review (JC &AB), working with a trained information specialist (PG),therefore sought to return to the topic area to consolidateopportunities identified from the quantity and characteris-tics of the literature in order to extend the conceptualthinking that underpins RCD.A considerable body of literature describes models for

RCD together with evaluations of specific individualRCD activities. However, none of the identified studiessought to explore beneath the level of actual interven-tions to examine the mechanisms by which interventionsmight achieve their intended effects. We hypothesisedthat some of these effects would be specific to the con-text of research capacity.

Search strategyStructured database searches were conducted across sevendatabases (MEDLINE, EMBASE, ASSIA, CINAHL, ERIC,PsycInfo, and Web of Science) to identify papers thatexamined RCD in a health or social care context. Searcheswere conducted across the period 1998–2013. In addition,given the diversity of terminology, 10 key articles wereselected from the original Re:CAP review [10] and desig-nated as ‘citation pearls’. Citation searches were thenconducted across Google Scholar and Web of Science forarticles citing these conceptual works.

Inclusion/exclusion criteriaFor inclusion in the initial review project a paper should:

1. Describe an RCD model/theory/framework OR

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2. Evaluate a model/theory/framework cited fromelsewhere OR

3. Report an evaluation of an intervention that wasbased on or cites model/theory/framework

AND

4. Be specific to a health or social care setting5. Be published in English between 1999 and 2013

Note that subsequent phases of the project requiredvalidation and refreshment of the original dataset to ex-tend coverage between 2014 and 2017. For details seebelow.

KeywordsThe Research question was formulated according to theBeHeMoTH question structure [25]. This formulation isspecifically designed to help to specify theory-related lit-erature searches, as follows:

Be – Behaviour of Interest: RCD (including eightspecific interventions: Prioritisation; Mentoring forresearch; Research leadership; Research facilitation;Research skills training; Funding (including bursariesand fellowships); Networks and collaborations;Infrastructure).H – Health Context: Health and social care.E – Exclusions: Capacity development for other(non-research) purposes; Models of RCD not tried orproposed for a health and social care context.MoTh – Models or Theories: operationalised as ageneric ‘model* or theor* or concept* or framework*’strategy together with named models or theories ifrequired. Illustrative keywords are given in Table 1.

Key citation pearlsA list of 10 previous models identified for the Re:CAPproject [1, 6, 9, 14, 18–21, 26, 27] (designated as ‘citationpearls’) was searched in 2014 using Google Scholar, Webof Science and Scopus. Supplementary search approachesproved of particular importance given the significantvariation in terminology and the update role of the review.In addition, reference lists of included articles were exam-ined for additional references not retrieved by the databasekeywords search. An update procedure was conducted,specifically for systematic reviews, in December 2017 (seethe section Validation and refreshment of programme the-ories below).

Date and language restrictionsPapers were published between 2000 and 2015. OnlyEnglish language papers were considered given theintended target audience for the review findings.

Quality assessmentNo accepted instruments have been developed to assessthe theoretical sufficiency of conceptual papers. Ouroverall goal was interpretative (configurative), not aggre-gative [28], so we did not exclude any studies based onstudy quality alone. However, we did examine includedpapers in relation to their perceived proximity to theUnited Kingdom context for which we were producingthe review [29].

Data extractionData were extracted on author, year, country, contextand, where appropriate, RCD activity and study type. Forthis work package, articles with RCD theories, modelsand frameworks were used to extract causative relationsof components within them in the form of ‘If-Then’statements. The level at which the activity was described

Table 1 Summary of search strategies and search terms

Research Capacity development Health and social care Models, etc.

Research AND ‘capacity development’ OR ‘capacitybuilding’ OR ‘capacity evaluation’ OR‘community development’ OR‘community building’ OR ‘buildingcommunities’

AND Not specified on health/socialcare databases

AND model* OR theor* ORconcept* OR framework*

prioritis* OR prioritiz* OR mentor* ORleader* OR facilitat* OR training OR ORfunding OR bursaries OR fellowship*OR network* OR collaboration* ORinfrastructure*

On non-health/social caredatabases:Health OR Nurs* OR MedicalOR doctor OR paramedic* ORtherapy OR therapist ORPhysiotherap* OR ‘social work*’

NEAR/ SAME/ ADJ/WITHa

‘capability’ OR ‘capacity’ OR ‘productivity’OR ‘output’ OR ‘strategy’.

Research capacity

Researcher development

Researcher career*aAccording to Database functionality

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as taking place was also extracted (individual, team, or-ganisation and network level). These data were extractedinto Excel sheets.

Data synthesisAccessing the programme theoriesCareful reading and re-reading of identified conceptualpapers was undertaken individually by two investigators(AB, JC). Particular attention was focused on identifyingcausal chains by which an RCD programme or specificintervention might achieve either proximal (e.g. know-ledge or skill gains) or long-term gains (i.e. improve-ments in health, increases in wealth or the achievementof an evidence-formed organisation or society). Datawere extracted as If-Then statements into an Excelspreadsheet [30].In cases of uncertainty, the If-Then statements, and

proposed causal links, were discussed within the team.Chains of If-Then statements were constructed to yieldinsights on overall generic RCD approaches. A furthercomplexity related to the level at which particular activ-ities might be targeted, for example, at an individual,team, organisation or network level. If-Then statementswere grouped by level of targeted intervention, withmechanisms that occurred at more than one contextuallevel being identified. In line with realist approaches, theteam reasoned that similarities in mechanism, as op-posed to the actual activities themselves, would extendacross all levels of operations (context), to enableprogramme theory building.

Validation and refreshment of programme theoriesAn essential feature of the realist synthesis method is theprocess of validating the original programme theoriesagainst a further independent dataset. Citation searcheswere repeated for the 10 citation pearls in December 2017and all reviews published between 2014 and 2017 meetingthe original inclusion criteria and exhibiting a recognisabledegree of systematicity were analysed for confirmatoryand original programme theory.

ResultsLiterature baseThe literature search was conducted across nine data-bases. Potentially relevant articles (n = 2763) were identi-fied from searching electronic databases, and 14additional potentially relevant articles were identifiedfrom follow-up of models and framework papers in-cluded in the earlier Re:CAP scoping review (the desig-nated ‘citation pearls’). Of the potentially relevantarticles, 2081 were excluded because their primary focuswas not on RCD, leaving 682 potentially relevant papersfrom electronic databases; 468 articles were subsequentlyexcluded at abstract stage, being either not relevant, only

available in abstract form or written in a language otherthan English and 214 articles from electronic databaseswere retained, 116 of which reported on specific inter-ventions or initiatives or their evaluation. A subset of 98articles were discussion papers or explicitly sought tomake a theoretical contribution. These 98 articles wereread carefully by one of the review team (JC/AB) and,where the study was considered appropriate to the re-view question, selected for data extraction. A final list of36 conceptual papers, reflecting consensus between thereviewers, were ultimately included. Figure 1 outlinesthe PRISMA diagram.The 36 papers (Table 2) reflected international interest

in RCD, with prominent players including the UnitedKingdom (n = 11), Australia (n = 6), the United States ofAmerica (n = 5), Canada [31] and Canada/United Statescombined [27] (North America). Five papers representedinternational perspectives, typically in the form of litera-ture reviews. Low- and middle-income countries wererepresented by five collective papers and individual pa-pers from Bangladesh [5], Liberia [20] and South Africa[21]. Primary care was the most prevalent field of re-search (n = 12), with nursing (n = 10), health and healthservices research (n = 9) also being well represented.Three papers examined allied health (n = 3) and the finalpaper looked at public health [21]. Collectively, the pa-pers represented all the identified activities of RCD, withricher papers yielding programme theory relating tothree or more activities (Table 2).Given that the aim of the project was interpretative

and explanatory it was not considered necessary to com-prehensively sample every possible RCD model, frame-work or theory. Instead, we were looking to constructtheory and therefore employed a purposeful samplingapproach described as ‘intensity sampling’. In the con-text of a research synthesis, intensity sampling involvesselecting papers that are “excellent or rich examples of thephenomenon of interest, but not highly unusual cases…cases that manifest sufficient intensity to illuminate thenature of success or failure, but not at the extreme” [32].This method of sampling appears particularly appro-priate given that the intent of realist synthesis is todelve into inconsistencies of evidence in order tobuild programme theories to offer to policy-makers[29]. Sampling was operationalised through initial se-lection of the 10 citation pearls and, subsequently,through selection of articles that specifically sought totheorise or conceptualise RCD.

Literature classificationThe final list of included studies comprised 36 theor-etical and conceptual papers (Table 2). The includedliterature reflected a wide range of environments and

Cooke et al. Health Research Policy and Systems (2018) 16:93 Page 5 of 22

Page 6: Uncovering the mechanisms of research capacity development

settings within which RCD might take place. The ap-plied context for this synthesis meant we were par-ticularly interested in United Kingdom-based studies,although Australia and the United States were par-ticularly well represented. Primary care as a contextwas particularly prominent. Reasons for this may betemporal, with acute hospital infrastructures being ata later stage of development than primary care coun-terparts, related to saleability, with primary care orga-nisations and networks being more able to facilitateactionable change, or may relate to external develop-ments and priorities. We also identified papers thatdescribed North–South partnerships as exemplars ofcollaborations or networks.

The focus of this paperThis paper focuses on 36 conceptual and theoreticalpapers (Table 2), including papers containing some formof framework or model of RCD. Models and frameworkswere handled in the same way and were deconstructedinto their original elements (in the form of If-Then state-ments). Thus, hypothesised relationships were not privi-leged within the original deconstruction but emergednaturally from the synthesised data.A process of discussion and consensus led to identifica-

tion of eight overarching programme theories, identifyingmechanisms triggered across multiple (i.e. at least morethan one) macro contexts (Table 3). Several programmetheories recognise RCD as a collaborative effort facilitating

Fig. 1 Flowchart for the systematic review following the PRISMA reporting methodology

Cooke et al. Health Research Policy and Systems (2018) 16:93 Page 6 of 22

Page 7: Uncovering the mechanisms of research capacity development

Table

2The36

stud

ieswith

includ

edresearch

activities,aim

ofstud

yandindicativeIf-Then

statem

ents

Autho

r(Year)[Ref]

Con

text

Discipline

Includ

edresearch

activities

Aim

ofstud

yIndicativeIf-Then

s

1.Albert&

Mickan(2003)

[4]

Australia

Prim

aryCare

Training

Toprop

oseaparadigm

shift

inthe

conten

tof

capacity-buildingas

astep

towards

closingthegaps

betw

een

research,p

olicyandpractice

IFresearch

ideasandim

plem

entatio

nstrategies

arediscussedandtranslated

across

severalo

rganisationalcon

texts

andcultu

res,TH

ENresearch

influen

ces

practice

2.Breenet

al.

(2005)

[21]a

SouthAfrica

PublicHealth

Leadership,N

etworks,Resou

rces,

Training

Toseek

improved

unde

rstand

ing

ofho

wRC

Bcanbe

achieved

andto

prop

oseaframew

orkto

improve

unde

rstand

ingandde

liveryandto

achievebe

tter

cong

ruen

cebe

tween

expe

ctations

andou

tcom

esrelatin

gto

RCB

IFinvestmen

tisinadeq

uate

and

incentives

inapprop

riate,THEN

organisatio

nsareun

ableto

sustainRC

Dbe

yond

thelifespanof

aspecificproject

3.Coe

net

al.

(2010)

[31]

Canada

Health

andHealth

Services

Research

Infrastructure,Leadership,

Networks

Toexplorepo

tentialfor

anexpand

edconcep

tualisationof

research

infrastructure,that

specifies

itslargely

assumed

qualities

whilstextend

ingto

articulatetheinteractiverelatio

nships

amon

gtang

ibleandintang

ible

system

sandstructures

unde

rlying

centre

functio

ning

IForganisatio

nalleade

rsde

velopan

approp

riate

organisatio

nalresearch

cultu

re,THEN

mem

berscollabo

rate

onresearch

IFresearchersshareaparticular

research

iden

tity,TH

ENresearchersacqu

ireasense

ofbe

long

ingor

a‘ready-madeaffinity

grou

p’

4.Con

dell&

Begley

(2007)

[8]

International

Nursing

Fund

ing,

Leadership,Training,

Tocond

uctaconcep

tanalysisof

capacity-buildingandits

relatio

nship

toresearch

IForganisatio

nsen

gage

indynamicRC

Dactivities,THEN

organisatio

nscanachieve

sustainabilityandultim

atelyeffect

social

change

5.Con

net

al.

(2005)

[49]

UnitedStates

ofAmerica

Nursing

Fund

ing,

Prioritisation

Tode

scrib

ethesuccessof

one

scho

olof

nursingin

movingfro

mhaving

noNIH

fund

ingto

being

ranked

intop20

scho

olsforNIH

fund

ingforconsecutiveyears

IFstaffin

grantsupp

ortservices

areno

tinvolved

ingraduate

stud

ented

ucation

orresearch

presen

tatio

nmaterials,THEN

thisconveysaclearmessage

abou

tthe

impo

rtance

ofprep

aringcompe

titive

grantapplications

IFan

organisatio

nfre

quen

tlycommun

icates

abou

tgrantactivity,THEN

theorganisatio

ncultivatesan

environm

ent

thatiscond

uciveto

high

research

prod

uctivity

6.Coo

ke&Green

(2000)

[50]

International

Nursing

Research

Prioritisation,

Training

Toiden

tifyfactorsthat

might

affect

theresearch

capacity

ofde

partmen

tsof

nursingin

high

ered

ucation,

and

tomakerecommen

datio

nsto

enablede

partmen

tsto

develop

theircapacity

toun

dertakeresearch

IFnu

rseed

ucatorsareen

couraged

topu

rsue

furthe

rqu

alificatio

ns,p

articularly

high

erde

grees,TH

ENteaching

stafffeel

ableto

engage

inresearch

activity

7.Coo

keet

al.

(2005)

[9]a

UnitedKing

dom

Prim

aryCare

Networks,Training

Tode

velopthede

bate

arou

ndRC

Bby

sugg

estin

gaframew

orkfor

planning

change

andmeasurin

gprog

ress,b

ased

onsixprinciples

ofRC

B

IForganisatio

nssupp

ortresearch

‘close

topractice’,THEN

stakeholdersperceive

that

research

isuseful

IForganisatio

nsde

veloplinkage

s,partne

rships

andcollabo

ratio

ns,THEN

organisatio

nscanbu

ildup

intellectual

capital(know

ledg

e)andsocialcapital

(relatio

nships)

Cooke et al. Health Research Policy and Systems (2018) 16:93 Page 7 of 22

Page 8: Uncovering the mechanisms of research capacity development

Table

2The36

stud

ieswith

includ

edresearch

activities,aim

ofstud

yandindicativeIf-Then

statem

ents(Con

tinued)

Autho

r(Year)[Ref]

Con

text

Discipline

Includ

edresearch

activities

Aim

ofstud

yIndicativeIf-Then

s

IForganisatio

nsbu

ildup

intellectualcapital(know

ledg

e)andsocial

capital(relatio

nships),TH

ENtheirabilityto

doresearch

isenhanced

IFresearch

fund

ersinclud

econtinuity

and

sustainabilityin

fund

ingprovision,TH

ENorganisatio

nscanmaintainandcontinue

newlyacqu

iredskillsandstructures

toun

dertakeresearch

8.Coo

keet

al.

(2015)

[12]

UnitedKing

dom

Health

andHealth

Services

Research

Fund

ing,

Leadership,N

etworks,

Prioritisation,

Training

Toillustratetheuseof

collabo

rative

priority-settingin

aUnitedKing

dom

research

collabo

ratio

n(Collabo

ratio

nandLeadership

inApp

liedHealth

Research

andCare–CLA

HRC

)

IFresearch

netw

orks

iden

tify‘needs-led,

meaning

ful’research

projects,THEN

research

isconsidered

timely

IFresearch

netw

orks

harnessflexible

resources(peo

ple,fund

s,skills),THEN

research

canbe

respon

sive

IFresearch

leadership

isrespon

sive

and

transformative,TH

ENresearch

canbe

co-produ

ced

9.DelMar

&Askew

(2004)

[18]a

Australia

Prim

aryCare

Fund

ing,

Networks,Training

Toprom

oteinterven

tions

forfamily/

gene

ralp

racticeRC

Bby

describ

ing

successful

internationalexamples

(e.g.d

iseasesandillne

ssresearch

aswellasprocessresearch);mon

itor

output

ofresearch;increasenu

mbe

rof

research

journals;encou

rage

and

enableresearch

skillsacqu

isition

(includ

ingas

partof

profession

altraining

);streng

then

academ

icbase;

andprom

oteresearch

netw

orks

and

collabo

ratio

ns)

IFgo

vernmen

tshave

family

med

icine

research

ontheiragen

das(asshow

nby

fund

ingforRC

Bandforresearch

activity

itself),TH

ENgo

vernmen

tssend

aclear

message

toclinicalandacadem

iccommun

ities

that

family

med

icine

research

isim

portantandworthyof

supp

ort

10.Edw

ards

etal.

(2009)

[51]

LMICs

Nursing

Research

Fund

ing,

Men

torin

g,Training

Toiden

tifylong

-stand

ingbarriersto

nurses’eng

agem

entin

research

and

todiscussstrategies

toen

ableLM

ICnu

rses

tolead

research

ofhigh

relevance

tolocaland

internationalp

olicy

decision

saffectingpo

pulatio

nhe

alth

IFresearchersaregivenop

portun

ities

toworkalon

gsidesenior

researchers,bo

thon

-site

andby

distance,THEN

they

can

discusswaysto

balanceresearch

with

teaching

,clinicalandadministrative

demands

11.Farmer

&Weston

(2002)

[19]a

Australia

Prim

aryCare

Fund

ing,

Men

torin

g,Networks

Toprop

oseaconcep

tualmod

elto

assistprim

arycare

RCBinitiatives

IFresearch

fund

ersem

ploy

awho

lesystem

approach

providingfund

ingand

resourcesat

multip

lelevels,THEN

practitione

rscanen

terthesystem

atan

approp

riate

level,andthen

prog

ress

toa

high

erlevelo

fresearch

capacity

IFresearch

fund

ersaccommod

ate

diversity,THEN

practitione

rsde

velop

research

interestsin

topics

ofon

going

person

alinterest

IFresearch

fund

ersprovideprotectedtim

eforresearch,TH

ENindividu

alsparticipatein

research

Cooke et al. Health Research Policy and Systems (2018) 16:93 Page 8 of 22

Page 9: Uncovering the mechanisms of research capacity development

Table

2The36

stud

ieswith

includ

edresearch

activities,aim

ofstud

yandindicativeIf-Then

statem

ents(Con

tinued)

Autho

r(Year)[Ref]

Con

text

Discipline

Includ

edresearch

activities

Aim

ofstud

yIndicativeIf-Then

s

12.Fen

tonet

al.

(2001,2007)[52,53]

UnitedKing

dom

Prim

aryCare

Networks

Toreflect

ontheun

derstand

ingof

netw

orks

from

organisatio

nalscien

ceandho

wthisun

derstand

ingcaninform

thede

velopm

entandevaluatio

nof

prim

arycare

research

netw

orks

IFresearchersde

mon

strate

socialisation,

team

workandop

enne

ss,

THEN

researchersresistthetend

ency

towards

grou

pthink

andop

enup

oppo

rtun

ities

fortheexchange

ofideas

andknow

ledg

e

13.Fitzge

rald

etal.

(2003)

[54]

UnitedStates

ofAmerica

Nursing

Men

torin

g,Networks

Todiscusstw

opaed

iatriccriticalcare

clinicalnu

rsespecialists’p

articipationin

acollabo

rativeresearch

team

ledby

university

faculty

IFhealthcare

professio

nalsareinclud

edas

anintegralpartof

theresearch

team

,TH

ENhealthcare

professio

nalsreceive

mentoringinmanyaspectsof

theresearch

process

IFhealthcare

professio

nalsarepu

lledaw

ayfro

mtheirclinicalun

itto

engage

inresearch

respon

sibilities,TH

ENotherstaff

may

resent

theintrusionor

see

involvem

entintheprojectasfrivolous

whenthey

areleftwith

moreworkor

with

outready

accessto

consultatio

n

14.G

adsby(2011)

[16]

LMICs

Health

andHealth

Services

Research

Fund

ing,

Networks,Training

Toinform

unde

rstand

ingof

RCS,and

how

toconsider

theeffectiven

essof

theseinitiatives

byexam

ining(1)

unde

rstand

ings

ofandapproaches

toRC

S,and(2)different

waysin

which

RCSismon

itoredandevaluated

IFdo

norssupp

ortindividu

alcapacity

developm

entat

theexpe

nseof

system

capacity

developm

ent,TH

ENindividu

als

from

LMICsleaveforb

etterjob

selsewhere

15.G

olen

koet

al.

(2012)

[55]

Australia

Allied

Health

Infrastructure,Leadership

Tode

scrib

eandanalysealliedhe

alth

senior

manager

perspe

ctives

ofho

worganisatio

nalfactorsim

pact

onRC

B

IFstaffaresupp

ortedfro

mastaff-tim

eperspectiveto

doresearch,THEN

staffare

motivated

toparticipateinresearch

IFstaffreceiverecogn

ition

forresearch

participation,

THEN

staffaremotivated

toparticipatein

research

16.G

reen

etal.

(2007)

[56]

UnitedKing

dom

Nursing

Research

Leadership,N

etworks,Training

Toevaluate

different

approaches

toRC

Dandto

answ

er:‘How

doun

iversity

departmen

tsde

veloptheresearch

capacity

oftheirnu

rsing/midwifery

staff,what

approaches

dothey

use,andwhy

are

outcom

esas

they

are?

IFresearchersform

alliances

betw

een

novice

andexperienced

researchers,TH

ENorganisatio

nsachieveabalancebetween

capacitydevelopm

entandleading-edge

developm

ent

17.Jen

erette

etal.

(2008)

[6]a

UnitedStates

ofAmerica

Nursing

Research

Networks

Tode

scrib

ethemod

elsof

research

collabo

ratio

nem

erging

from

theYale-

How

ardPartne

rshipCen

teron

Redu

cing

Health

Disparitiesby

SelfandFamily

Managem

ent

IFpartne

rsde

mon

strate

effective

commun

icationandaresensitive

tothe

historyandun

ique

characteristicsof

the

partne

ringinstitu

tionas

wellasits

popu

latio

n,TH

ENinvestigatorssuccessfully

completeprojectson

timeanddeliver

subsequent

presentatio

nsandpu

blications

18.Joh

nson

etal.

(2005)

[20]a

Libe

riaHealth

andHealth

Services

Research

Infrastructure,Training

Topresen

tan

RCBmod

elto

streng

then

HIV/AIDSservicede

liverysystem

throug

haprop

osed

Libe

ria–U

nitedStates

ofAmericaresearch

partne

rshipthat

focuseson

establishing

andstreng

then

ing

HIV/AIDSservicede

liverysystem

IFparticipantperceivesthesalienceof

the

North–Sou

thpartnership,TH

ENthe

participantisreadyto

participatein

research

IFparticipantsarereadyto

participatein

research,THEN

theirorganisatio

n

Cooke et al. Health Research Policy and Systems (2018) 16:93 Page 9 of 22

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Table

2The36

stud

ieswith

includ

edresearch

activities,aim

ofstud

yandindicativeIf-Then

statem

ents(Con

tinued)

Autho

r(Year)[Ref]

Con

text

Discipline

Includ

edresearch

activities

Aim

ofstud

yIndicativeIf-Then

s

infrastructureanden

hancingresearch

andapplicationskillsof

Libe

rian

scientistsandprofession

als

sustains

itsresearch

activities

19.Jon

eset

al.(2003)

[26]a

Australia

Prim

aryCare

Training

Tode

term

inege

neralp

ractition

ers’

research

training

need

sandthe

barriersto

involvem

entin

research

IFGPs

perceive

that

they

dono

tpo

ssess

thene

cessaryresearch

skills,TH

ENthey

arereluctantto

engage

inresearch

20.Lansang

&Den

nis

(2004)

[1]a

LMICs

Health

andHealth

Services

Research

Fund

ing,

Infrastructure,

Men

torin

g,Networks,Training

Toreview

thebroadapproaches

takento

RCBandthelikelihoo

dthat

theseeffortswillprovesustainable

IFresearch

fund

ersprom

ote‘learning

bydo

ing’approaches,suchas

developm

ental

orseed

grants,hands-ontraining

inon

goingresearch

prog

rammes

ormentorshipprog

rammes,THEN

practitionersareencouraged

toparticipate

inresearch

IFde

veloping

coun

triesde

velop

partnerships

andnetworks

with

developed

coun

triesor

otherd

evelop

ingcoun

tries,

THEN

theircollectiveou

tputsaregreater

than

thesum

oftheirisolatedefforts

21.Levineet

al.

(2013)

[13]

UnitedStates

ofAmerica

Health

andHealth

Services

Research

Fund

ing,

Infrastructure,Men

torin

g,Networks,Training

Tostud

ytw

oRC

Bprog

rammes

with

similargo

alsandto

expand

upon

the

know

ledg

ebase

ofstrategies

and

approaches

toRC

Dandthus

provide

abe

tter

unde

rstand

ingof

contextual

factorsthat

may

influen

cetheefficacy

ofRC

Dstrategies

IForganisatio

nsde

velopgo

odexternal

andinternalhe

alth

services

research

partne

rs,THEN

they

canbu

ildresearch

capacity

IForganisatio

nsareableto

build

onor

leverage

larger

organisatio

nalchang

es,

THEN

they

canachievesuccessful

RCB

22.M

acfarlane

etal.

(2005)

[14]a

UnitedKing

dom

Prim

aryCare

Fund

ing,

Infrastructure,Leadership,

Networks,Training

Toiden

tifykeystructural,d

evelop

men

tal

anden

vironm

entalcharacteristicsassociated

with

successful

andsustaine

dinvolvem

ent

inresearch,and

toinform

natio

nalstrateg

yforRC

Bin

prim

arycare

IForganisatio

nsprod

uceamission

statem

entthat

acknow

ledg

esthevalue

ofresearch,THEN

GPs

developaresearch

practice

23.M

ahmoo

det

al.

(2011)

[5]

Bang

lade

shHealth

andHealth

Services

Research

Fund

ing,

Prioritisation

Toiden

tifyprob

lemsfacedby

ahe

alth

research

institu

tein

Bang

lade

sh,d

escribe

twostrategies

develope

dto

addressthese

prob

lems,andiden

tifytheresults

after

3yearsof

implem

entatio

n

IForganisatio

nsdevelopamon

itoringand

evaluatio

nframew

ork,TH

ENdo

norsdo

notexertan

influence

over

organisatio

nal

research

priorities

24.N

chinda

(2002)

[57]

LMICs

Health

andHealth

Services

Research

Training

Tode

scrib

esomeexpe

riences

inRC

Sover

thelastfew

decade

sandto

prop

ose,

from

these,mechanism

sforsustainableRC

B

IFreturningresearcherslearnne

wskills

andtechniqu

eswhe

ntraining

overseas,

THEN

theseresearchersrequ

ireaccess

toapprop

riate

equipm

entandresources

whe

nreturningto

theirow

ninstitu

tions

25.N

orth

American

Prim

aryCareResearch

Group

(2002)

[27]a

North

America

Prim

aryCare

Infrastructure,Leadership,M

entorin

g,Training

Topresen

tapo

sitio

npape

rto

guide

developm

entof

astrategicplanning

process

IFacadem

icleadersun

derstand

the

research

processandthetype

sof

infrastructureservices

andskillsrequ

ired

tosupp

ortasuccessful

inde

pend

ent

investigator,THEN

organisatio

nscan

iden

tifyexpe

rienced

investigatorswilling

tosupp

orteach

othe

randto

men

tor

othe

rs

Cooke et al. Health Research Policy and Systems (2018) 16:93 Page 10 of 22

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Table

2The36

stud

ieswith

includ

edresearch

activities,aim

ofstud

yandindicativeIf-Then

statem

ents(Con

tinued)

Autho

r(Year)[Ref]

Con

text

Discipline

Includ

edresearch

activities

Aim

ofstud

yIndicativeIf-Then

s

26.N

uyen

s(2007)

[15]

International

Health

andHealth

Services

Research

Prioritisation

Tolook

atmajor

issues

emerging

from

coun

tries’expe

riences

insettingpriorities

durin

gthepast15

yearsandat

the

challeng

esstillto

beaddressed

IFnatio

nalo

rganisations

institu

tea

bottom

-upapproach

tothe

gene

ratio

nof

research

priorities,TH

ENa

context-sensitive

andcultu

rally

sensitive

processof

priority-settingoccurs

27.O

’Byrne

&Sm

ith(2011)

[58]

UnitedKing

dom

Nursing

Facilitation,

Infrastructure,Leadership,

Men

torin

g,Networks,Prio

ritisation

Toiden

tifymod

elsused

toprovidelocal

research

oppo

rtun

ities

andthereb

yde

velopresearch

capacity

and

capabilityin

clinicalnu

rses

intheUnitedKing

dom

Iforganisatio

nsprioritiseexpansionof

research

initiatives

forn

ursesandallocates

resourcesforanaccompanying

infrastructure,TH

ENorganisatio

nsachievesuccessfulRC

B

28.Pickstone

etal.

(2008)

[59]

UnitedKing

dom

Allied

Health

Fund

ing

Tode

scrib

ethenature

ofRC

Bin

allied

health

profession

sandto

explorethe

vision

ofRC

BusingtheUnitedKing

dom

asan

exam

ple

IFprofessio

nalsreceivesustainedtargeted

fund

ingto

releasethem

toun

dertake

research,THEN

professio

nalsareableto

resistworkloadpressures

29.Priestet

al.

(2007)

[60]

UnitedKing

dom

Nursing

Networks

Toexplorenu

rsinglecturers’RC

Dthroug

htheiren

gage

men

tas

co-researche

rsin

alarger

case

stud

yproject

IForganisatio

nsiden

tifyaspecificpe

rson

asaresearch

contact,TH

ENstaffinterested

inresearch

involvem

entfeelableto

approach

thatperson

30.Raghu

nath

etal.

(2004)

[61]

UnitedKing

dom

Prim

arycare

Fund

ing,

Networks,Training

Toexplorethemeaning

,und

erstanding

,usefulne

ssandreality

ofmultid

isciplinary

research

inprim

arycare

andprovide

exam

ples

IFexternalassessmen

tprovides

definable

indicatorsof

success,TH

ENorganisatio

nsareableto

demon

strate

accoun

tabilityand

valueform

oney

31.Riedet

al.

(2005,2006,2007)

[62,63,64]

Australia

Prim

arycare

Networks,Training

Toun

derstand

thebackgrou

ndandskills

ofthemem

bershipandto

tailorSouth

AustralianPrim

aryHealth

CareResearch

Network(SARN

et)services

tomem

bers’

need

s

IForganisatio

nsutilise

awho

lesystem

approach

toRC

B,TH

ENdiverseindividu

als

areencouraged

toparticipateinresearch

activities

32.Sarre

&Coo

ke(2009)

[65]

UnitedKing

dom

Prim

arycare

Infrastructure,Leadership,Training

Toprovidepracticalsupp

ortto

prim

ary

care

organisatio

nsthroug

hthe

developm

entof

indicatorsagainstwhich

toplan

andmeasure

prog

ress

ofRC

Dat

anorganisatio

nallevel

IFRC

Doccursatdifferent

structurallevels,

includ

ingchange

andsustainable

developm

entinindividu

als,team

sand

organisatio

ns,THEN

itcandemon

strate

clearlinks

totheeffectivenessandqu

ality

ofhealthcare

organisatio

nsinimproving

health

andwell-b

eing

33.Seg

rottet

al.

(2006)

[66]

International

Nursing

Facilitation,

Prioritisation,

Training

Torepo

rtacriticalo

verview

ofnu

rsing

RCDin

academ

icde

partmen

ts,m

ajor

barriersto

RCD,and

capacity-building

strategies

from

theliterature,andto

exam

inethewider

contextwith

inwhich

capacity-buildingtakesplace

IFde

partmen

tshave

aflexibleapproach

toresearch

activities,THEN

researchersare

giventhecreativespaceto

pursue

their

ownresearch

interestsalon

gsidecore

research

priorities

34.Steph

enset

al.

(2011)

[67]

UnitedStates

ofAmerica

Health

andHealth

Services

Research

Fund

ing,

Leadership

Tosynthe

sise

andsharewhathasbe

enlearne

dabou

tRC

Bto

help

organisatio

nsandinstitu

tions

developanden

hance

theirability

toplan

andcond

ucthe

alth

services

research

andob

tain

fund

ingfor

theirresearch

IForganisatio

nssecure

departmen

tal

andinstitu

tionalleade

rshipsupp

ortfor

capacity-buildingactivities,THEN

this

facilitates

future

research

activities

IFresearch

leadersde

mon

strate

how

ade

partmen

t/organisatio

n’sexistin

gexpe

riences

canbe

used

toleverage

andbu

ildan

interdisciplinaryteam

in

Cooke et al. Health Research Policy and Systems (2018) 16:93 Page 11 of 22

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Table

2The36

stud

ieswith

includ

edresearch

activities,aim

ofstud

yandindicativeIf-Then

statem

ents(Con

tinued)

Autho

r(Year)[Ref]

Con

text

Discipline

Includ

edresearch

activities

Aim

ofstud

yIndicativeIf-Then

s

health

services

research,THEN

potential

participantsbe

comeless

scep

tical

abou

tthevalueof

health

services

research

35.Van

Weel&

Rosser

(2004)

[68]

International

Prim

aryCare

Networks,Training

TosummariseWorld

Organisationof

Family

Doctors(W

onca)conferen

cediscussion

sandpresen

trecommen

datio

nsprop

osed

byconferen

ceattend

ees

from

34coun

tries

IFresearch

team

sdisplayresearch

achievem

entsto

policy-makers,he

alth

fund

ers,andacadem

icleaders,TH

ENpo

licy-makersandothe

rshave

agreaterpe

rcep

tionof

therelevanceof

that

research

IFatig

htlinkiscreatedbe

tween

clinicalpracticeandaresearch

environm

ent,TH

ENclinicians

and

policy-makerswillpe

rceive

thegreaterrelevanceof

research

toclinicalpractice

36.W

hitw

orth

etal.

(2012)

[3]

UnitedKing

dom

Allied

Health

Facilitation,

Fund

ing,

Leadership,

Men

torin

g,Networks,Training

Toou

tline

acompreh

ensive

mod

elde

velope

dandsuccessfullyim

plem

ented

byspeech

andlang

uage

therapistsin

North

EastEngland

IForganisatio

nsacknow

ledg

ethe

developm

entalstage

atwhich

the

practitione

rispo

sitio

ned,

THEN

organisatio

nscanarrang

esuitable

pathwaysinto

theresearch

pathway

LMICslow-an

dmiddle-incomecoun

tries,NIH

Nationa

lInstitutes

forHealth

,RCB

research

capa

city-building,

RCDresearch

capa

city

developm

ent,RC

Sresearch

capa

city

streng

then

ing

NB.

Foramorecompletelistof

If-Th

ensseeAdd

ition

alfile1

a Cita

tionpe

arls–keyarticles

Cooke et al. Health Research Policy and Systems (2018) 16:93 Page 12 of 22

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Table

3Overarching

prog

rammetheo

riesforRe:CAP(Expande

d)‘Label’

Elem

entsof

prog

rammetheo

ryLine

sforfurthe

rinqu

iryfro

mmid-range

theo

ryExam

pleof

source

data

Research

capacitywillbe

effected

if…“Thiswas

wha

tweachieved…

.”“Thisiswha

tIthink…

.”

ByActivity

PT1.‘Exceeding

thesum

oftheparts’

Individu

als/organisatio

ns/networks

realiseacontrib

ution

that

they

areun

likelyor

less

likelyto

achievein

isolation

SocialNetworkand

OrganisationalThe

ory

Com

mun

ityof

Practice[69]

SocialCapital

“Buildingresearch

capacityisacomplex

challeng

ean

dneedsto

bethough

tof

asaho

listic

process.Each

constituent

partisvitaltothesuccessof

the

who

le,and

isinextricablyinterlinked

with

allthe

others–agestalt-like

phenom

enon

inwhich

thewho

leisgreaterthan

thesum

ofits

parts”[70]

PT2.‘Learningby

doing’

Individu

als/organisatio

nsprototypeor

practiseactivities

requ

iredforsubseq

uent

fullen

gage

men

t,andsequ

entially

learnthroug

hcycles

ofreflection

Expe

rientialLearningMod

el[55,61]

Learning

Organisation

“‘Learningby

doing’approaches,usuallyin

theform

ofdevelopm

entalo

rseed

gran

ts,han

ds-ontraining

inon

goingresearch

programmes

ormentorshipprogrammes,areeffectiveapproaches

that

complem

ent

academ

icdegree

offerings.Theyarealso

mostappropriate

forbuilding

capacityon

the‘dem

and’sid

eso

that

thosewho

useresearch

finding

sun

derstand

andappreciate

theirvaluein

improvinghealth

outcom

es”[1]

SocialCapital

Learning

Organisation

“Trainingshould

bean

dshould

remainon

eof

thecentralfociw

hen

partnerships

areaw

arded.Training

youn

gscientistsin

thecontextof

such

ongoingprojectsisirreplaceable(so-called‘learning

bydoing’)an

dleadsto

arapidacquisitionan

ddevelopm

entof

research

skillsan

dexperience”

[57]

PT3.1‘Liberatingthetalents’

Individu

als/organisatio

nsreleasethedo

rmantpo

tentialo

ftheirskillsandexpe

rience

Bourdieu

’sTheo

ryof

Practice1977

“Amorefocusedapproach

canaccelerate

progressin

buildingcapacityan

dallowsresearchersan

dteachersto

developtheir‘natural

talents’”

[70]

PT4.‘Releasing

resources’

Resourcesprovided

toovercomeindividu

al/organisational

inhibitio

nandactas

afocusforactivity,and

inform

ationis

freelyshared

abou

ttheseop

portun

ities

Lewin

Mod

elof

Chang

e(Unfreeze/Chang

e/Freeze)

SocialCapital

“Evidenceof

resource

investmentfro

mtheorganisationto

supportpump-

primingof

research,e.g.researchsupportsessions,pum

p-primingmon

eyforpre-protocolor

pilotwork”

PT5.‘Cop

rodu

cing

know

ledg

e’Individu

als/organisatio

nsshareideasandknow

ledg

ede

velopm

entthroug

hne

tworks

andpartne

rships

Beresford[71]

Cop

rodu

ction[72,73]

SocialChang

e

“Eng

agingotherstakeholders–such

asserviceusers,commun

itymem

bers,

health

practitionersan

dpolicy-makers–ishelpfulfor

settingrealisticgoals,

meetinglocalp

rioritiesan

daddressin

gresource

issues.Thisrequiresextensive

participationan

dhencemoreresources”[74]

“Anewkind

ofproductionof

know

ledgeisem

erging

.Thisnewmodelof

know

ledgeproductioniscalled‘Mode2’...M

ode2know

ledgeproductionis

characterized

asmulti-professio

nald

riven,allowingideasan

dknow

ledgeto

begeneratedan

dreflected

upon

within

research

groups

which

combine

heterogeneousskillsan

dexperience.Within

Mode2,research

grouping

schan

gefro

mprojectto

projectan

dtend

towards

non-hierarchical,

networking

arrang

ements”[52]

Symbolic

PT6.‘Feelingthat

youaremaking

adifference’

Individu

als/organisatio

nspe

rceive

that

research

hasan

impact

onhe

alth/w

ealth

/kno

wledg

ecreatio

n/tackling

ineq

ualities

SocialChang

e“Bothnu

rses

hadneverbeen

involved

inresearch

before

butwereactively

interested

intaking

partas

they

perceivedthat

theresearch

processwould

directlybenefit

patientsin

theshortan

dlong

term

,aswella

sgiving

them

theopportun

ityto

learnaboutresearch

throughaproblem-based

approach”[61]

PT7.‘Mod

ellingpo

sitivebe

haviou

rs’

Individu

alsob

servethepo

sitiveim

pact

ofinvolvem

entin

research

byothe

rsin

theorganisatio

n“The

bestaspect

oftheworksho

pwas

having

accessto

senior

GPacadem

ics

–as

rolemodels–an

dmeetingearly

career

researchers—

asreassurance”

“Rolemodellingfro

macadem

icsan

dresearch-m

indedregistrarswas

influential.Itwas

good

todiscover

that

academ

icswereno

tscary!”[75]

PT8.‘Signalling

impo

rtance

and

makingresearch

core

busine

ss’

Individu

alspe

rceive

that

involvem

entin

research

isavalid

activity

inrelatio

nto

compe

tingprioritieswith

intheorganisatio

nSocialNorms

“Som

esawnextstages

asaboutconsolidation,

makingsurethat

gainswere

hard-wiredin

andthat

senior

man

agersthem

selves

wereproactive,forexam

ple

inoperationa

lizingresearch

objectives

throughtheappraisalsystem”[76]

“The

Office

ofResearch

staff…

dono

tbecomeinvolved

ingraduate

student

educationor

research

presentationmaterials.

Thesupportservices

provide

instrumentala

ssistan

cean

dconvey

aclearmessage

abouttheimportan

ceof

preparingcompetitivegran

tapplications”[49]

Cooke et al. Health Research Policy and Systems (2018) 16:93 Page 13 of 22

Page 14: Uncovering the mechanisms of research capacity development

Table

4Review

s(2014–2017)used

tovalidateprog

rammetheo

ries

Autho

r(Year)[Ref]

Con

text

Discipline

Aim

ofstud

yIndicativeIf-Then

s

Borkow

skietal.(2016)[33]

System

aticReview

Allied

Health

Toevaluate

theeviden

ceto

increase

unde

rstand

ingof

factorsthat

couldinfluen

ceAHresearch

cultu

re,in

additio

nto

iden

tifying

theen

ablersandbarriersforAH

profession

alsto

cond

uctresearch

IFindividu

alsareableto

iden

tifyinvolvem

entin

multip

leresearch

activities

andiden

tifyresearch

intheirjobde

scrip

tions,THEN

they

willhave

confiden

cein

theirresearch

skillsandabilities

IFindividu

alsiden

tifyaprob

lem

that

need

schanging

,TH

ENthey

getinvolved

inresearch

activities

Deanet

al.(2017)[77]

LMICs

Health

andHealth

Services

Research

Tocritically

analysecollectivehe

alth

RCSeffort

regardingthelevel,type

,coh

esionandconcep

tual

soph

isticationof

thecurren

teviden

cebase

IFLM

ICsareto

ownresearch

cond

uctedin

theirow

ncontext,TH

ENreflexivity

ontheapprop

riatene

ssof

particular

research

fortheircoun

tryshou

ldbe

encouraged

Ekerom

aet

al.(2015)[78]

LMICs

Health

andHealth

Services

Research

Toiden

tifyed

ucationaland

othe

rinterven

tions

that

workedforclinicians,the

ircharacteristicsandho

wthey

may

have

worked

IFno

vice

researchersreceivemen

torin

gfro

mexpe

rienced

researchers,TH

ENno

vice

researchers

succeedin

research

activities

IFindividu

alsworktoge

ther

inde

sign

ated

research

team

s,TH

ENindividu

alsaresuccessful

inresearch

activities

Franzenet

al.(2017)[48]

LMICs

Health

andHealth

Services

Research

Toiden

tifyandcritically

exam

inethemainapproaches,

strategies

andtren

dsin

health

RCDandconsolidate

keythinking

inorde

rto

iden

tifyamorecohe

rent

approach

IForganisatio

nsde

velopandshareadatabase

ofresearchers,TH

ENresearchersareableto

netw

orkwith

each

othe

rIForganisatio

nsde

velopLM

ICun

iversity

research

training

capacity

using‘trainthetraine

r’prog

rammes,

THEN

individu

alsfeelableto

engage

with

health

research

Gagliardietal.(2014)[36]

System

aticReview

Know

ledg

eTranslation

Toreview

literaturein

managem

entandsocialsciences

andiden

tifyessentialcom

pone

ntsof

men

torin

gprog

rammes

that

couldbe

adaptedforknow

ledg

etranslationmen

torship

IFapreliminaryworksho

pisused

toconvey

know

ledg

epriortomentoring,TH

ENmentoringcan

reinforcethatpriorkno

wledg

e

Hub

eret

al.(2015)[79]

System

aticreview

Health

andHealth

Services

Research

Toreview

toolsandinstrumen

tsto

aidhe

alth

RCD

initiatives

inselectingapprop

riate

toolsand

instrumen

tsfordata

collectionwith

intheirrespective

context

IFnatio

nalo

rganisations

payattentionto

the

sustainabilityof

prog

rammes

andim

pact

evaluatio

n(e.g.param

etersof

patient

care

orsocietalaspects),

THEN

research

meetstheneedsof

thelocalpop

ulations

Kahw

aet

al.(2016)[80]

LMICs

Health

andHealth

Services

Research

Toexplorede

finition

s,concep

ts,app

roache

sand

framew

orks

forRC

B,to

iden

tifyframew

orks

for

evaluatin

gRC

Bin

healthcare,and

tode

scrib

ekey

challeng

esrelatedto

RCBin

LMICs

IFleadership

operates

atan

individu

alandateam

level,TH

ENsenior

researcherssupp

ortjunior

researchers

andcham

pion

thedevelopm

entof

institutio

nalsup

ports

forresearch(includ

ingprotectedtim

eforresearch)

IForganisatio

nsofferon

goingtraining

,men

torin

gand

supe

rvision,sharingof

skillsandexpe

rtiseas

wellas

providingop

portun

ities

toapplyacqu

iredskills,TH

ENindividu

alsde

velopresearch

skills,self-assuredn

essand

apo

sitiveattitud

etowards

doingandusingresearch

IFresearch

questio

nsaregeneratedinconsultatio

nwith

users(practition

ersandotherservice

providers,and

policy-makers),THEN

researchersprod

uceresearch

that

isrelevant

toprevailinghealth

issuesandconcerns

IForganisatio

nssupp

ortapprop

riate

dissem

ination,

THEN

thisen

hances

thesocialim

pact

ofresearch

and

ensuresthat

iteffectivelyinfluen

cespractice

Cooke et al. Health Research Policy and Systems (2018) 16:93 Page 14 of 22

Page 15: Uncovering the mechanisms of research capacity development

Table

4Review

s(2014–2017)used

tovalidateprog

rammetheo

ries(Con

tinued)

Autho

r(Year)[Ref]

Con

text

Discipline

Aim

ofstud

yIndicativeIf-Then

s

IForganisatio

nsestablishessentialresearchstructures

andprovideop

portun

ities

toapplyandextend

know

ledg

eandskillsgained

into

practice,TH

ENorganisatio

nscanachievecontinuity

andsustainability

IForganisatio

nsinvolveacadem

icandmanagem

ent

stafftosupervise

andmanageprojects,provide

protected

timeforresearch,createresearch

positions,and

enhance

know

ledg

eabou

tand

accessto

research

fund

ing

oppo

rtunities,TH

ENorganisations

supp

ortp

articipationin

research/related

capacity-buildinginitiatives

IFresearchersde

veloppartne

rships

andlinkage

sand

thus

expand

intellectualand

socialcapital,TH

ENthis

facilitates

theexchange

ofresearch

skills,know

ledg

eandexpe

rtise

Lode

etal.(2015)[34]

System

aticReview

Nursing

Toiden

tifyandevaluate

eviden

ceof

clinicalnu

rses’

RCBin

practice

IForganisatio

nsstreng

then

nurses’beliefinthevalueof

research

andof

research

team

s,TH

ENnu

rses

will

participateinresearch

activities

Mug

aboet

al.(2015)[81]

LMICs(Africa)

Health

andHealth

Services

Research

Tocontrib

uteto

RCDeffortsby

providinginsigh

tsfro

mdifferent

approaches

that

couldbe

appliedto

othe

rlocatio

nsandto

encouragemorecompleterepo

rting

ofsuch

initiatives

IForganisatio

nsde

velopastrong

institu

tional

infrastructure,TH

ENorganisatio

nssucceedin

securin

gresearch

fund

ing

IFexpe

rienced

researchersmen

torno

vice

researchers

onpu

blications,THEN

novice

researchersareableto

publishtheirresearch

inhigh

profile

international

journals

Nortonet

al.(2016)[35]

System

aticReview

PublicHealth

Toiden

tifyevaluatedstrategies

used

byorganisatio

nsandprog

rammede

velope

rsto

build

theprog

ramme

evaluatio

ncapacity

oftheirworkforce,and

tode

scrib

esuccessfactorsandlesson

slearne

d

IForganisatio

nsde

mon

strate

that

evaluatio

nisan

organisatio

nalfocus

orpriority,TH

ENindividu

alswill

consider

involvem

entin

evaluatio

nto

beim

portant

IForganisatio

nsem

bedevaluatio

ninto

workprocesses

throug

hpo

licyandproced

ures

that

upho

ldevaluatio

nexpe

ctations,THEN

organisatio

nsde

mon

strate

strong

evaluatio

nleadership

AHAllied

Health

,LMICslow-an

dmiddle-incomecoun

tries,RC

Bresearch

capa

city

build

ing,

RCDresearch

capa

city

developm

ent,RC

Sresearch

capa

city

streng

then

ing

Cooke et al. Health Research Policy and Systems (2018) 16:93 Page 15 of 22

Page 16: Uncovering the mechanisms of research capacity development

academic engagement in health systems. Therefore, forexample, the ‘more than sum of parts’ includes valuingand recognising as an asset, the contribution that each in-dividual brings to the partnership, enabling discussion andjoint thinking, access to different networks, and dividingworkload across disciplines. This promotes respectful andmeaningful discussion that can lead to trust and on-goingdialogue and can be underlying mechanisms throughoutdiverse interventions, for example, in priority-setting,grant writing groups, communities of practice, knowledgetransfer partnerships and doctoral training networks. Add-itionally, the resulting outcome provides a new contextthat can activate other mechanisms, for example, ‘copro-duction of research’ and ‘learning by doing’. Thus, the out-come of one mechanism can produce the context tostimulate mechanisms in others. Reviewing theprogramme theories in Table 3 reveals that they formchains of ‘context (C) – mechanism (M) – outcome (O)’,where the outcome of one part of the chain shapes a sub-sequent context within which to stimulate the mechanismin others in the RCD programme. Similarly, ‘liberating tal-ents’, ‘learning by doing’ and ‘releasing resources’ formchains, which may be usefully harnessed when developingfellowship and secondment interventions, for example.A major finding from the qualitative synthesis and

analysis was that many activities fulfil an emblematic(symbolic) role in signalling the importance of RCDwithin the organisations, networks or teams. Therefore,for example, the ‘protected time’ or ‘buy out from otherresponsibilities’ interventions initially seem to serve aninstrumental role in freeing staff from their other dutiesin order to participate in research. On closer examin-ation, however, it is clear that such activities are equallyimportant in demonstrating to staff within an organisa-tion that research is important and should be consideredan organisational/system priority. Similarly, the develop-ment of small funding schemes in research networks or

organisations, engagement in writing workshops and thepromulgation of mentorship schemes assume signifi-cance beyond their monetary value in signalling that re-search is valued and hence an activity in which it islegitimate for staff to engage. A common trigger for allmechanisms is ‘making a difference’, which can stimulatemotivation in stakeholders across the RCD programme,and can be seen as a community building exercise.

Validation and refreshment of programme theoriesCitation searches for the 10 citation pearls in December2017 identified a further 10 systematic reviews publishedbetween 2014 and 2017 that met our original inclusioncriteria (Table 4). Collectively, these covered all the RCDactivities (Box 1) and reflected the diversity of contextsidentified in the original dataset (e.g. high- (n = 5) andlow- and middle-income countries (n = 5); allied health[33], nursing [34], public health [35], and health andhealth services research (n = 6), etc.). A new additionwas in the emerging field of knowledge translation [36].Again, the papers represented all the identified activitiesof RCD (Box 1), yet, since they were all reviews, theywere more likely to describe multiple activities than theoriginal dataset (Table 5).

Table 5 Activities identified in reviews (2014–2017)

Author (Year) [Ref] Research capacity development activitiesincluded

Borkowski et al. (2016) [33] Infrastructure, Leadership, Mentorship,Training

Dean et al. (2017) [77] Infrastructure, Networks, Training

Ekeroma et al. (2015) [78] Mentoring, Networks, Training

Franzen et al. (2017) [48] Leadership, Mentoring, Networks, Training

Gagliardi et al. (2014) [36] Mentoring

Huber et al. (2015) [79] Infrastructure

Kahwa et al. (2016) [80] Funding, Infrastructure, Leadership, Mentoring,Networks, Training

Lode et al. (2015) [34] Funding, Leadership, Networks, Training

Mugabo et al. (2015) [81] Infrastructure, Mentoring, Training

Norton et al. (2016) [35] Infrastructure, Leadership, Training

Box 1 Activities undertaken in research capacitydevelopment (RCD) (from Re:CAP [10])

1. Prioritisation: Developing research priorities from consensus

views of informed participants.

2. Mentoring: where an experienced, highly regarded person

(the mentor) guides another individual (the mentee) in the

development and examination of their own ideas, learning,

and personal and professional development.

3. Leadership: the process of influencing group activities

towards the achievement of RCD goals.

4. Research facilitators: individuals whose role is explicitly to

promote and enable the conduct of a research by those with

limited research experience.

5. Training: interventions that aim to increase skills and

knowledge.

6. Funding to develop RCD including bursaries and

fellowships.

7. Networks and collaborations: structures and functions that

support people to work together to improve knowledge

transfer, innovation, a research process or an output.

8. Infrastructure: a range of activities used to enhance support

of RCD.

Cooke et al. Health Research Policy and Systems (2018) 16:93 Page 16 of 22

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The identified reviews confirmed the originalprogramme theory, adding a nuanced understanding ofmany RCD activities. However, the new dataset did notidentify any new strands of programme theory, possiblyindicating that theoretical saturation had been reached.Evaluation, debatably an RCD activity in its own right,emerged as increasingly prominent in the recent litera-ture. However, evaluation was considered to be a subtextto all the other activities and was not included as anadditional activity. Future conceptual models should en-sure that they feature evaluation, albeit to be handleddifferently from other activities.

DiscussionMany governments and global partnerships invest consid-erable funds to support RCD in healthcare, and it is amoral and ethical imperative to develop, shape and evalu-ate such activity [37] in order to plan and attain thedesired effect, and to justify continued funding [16]. Thisunique realist synthesis of the conceptual literature onRCD has uncovered mechanisms that operate beneathsuch activities which, we suggest, can function across andwithin different structural levels with an emphasis ofmeaningful societal impact. We suggest that theprogramme theories developed here might help to planand demonstrate cohesion and alignment across structurallevels. Several authors recognise that RCD activities needto take place concurrently at a number of different levels[1, 8, 13], with many calling for a ‘whole systems’ approachto RCD [3, 19]. We propose that the programme theoriesdeveloped here could act as a guide for application acrossthe diverse individual, organisational and network levels inorder to promote synergy and ensure RCD activities ‘pull’in the same direction.Social change is the ultimate outcome for RCD [8]. The

programme theories presented here, particularly thosedescribed as ‘symbolic’, can provide visible mechanisms ofhow RCD might influence culture, leadership and motiv-ation. Many of these mechanisms have foundations intheories of social change and social capital, and provide anexplanation of how interventions that adopt such anapproach can engender a research culture within organisa-tions and networks, and reciprocity and leadership inindividuals.Our programme theories resonate with others that

explain how research activity can promote impact inhealthcare organisations and communities [38, 39, 40].Whilst training in research traditionally includes researchmethods, data collection and analysis skills, the co-pro-duction programme theory suggests diverse skills of crossboundary working, negotiation and creative practices inknowledge production [39]. Researchers using aco-productive approach are more likely to align research

with stakeholder and organisational objectives [1] andform dynamic partnerships using assets from different or-ganisations and networks [38] to make a difference.Under what circumstances are RCD interventions

most likely to achieve their intended effect? Our analysishas identified several principal components from a the-oretical perspective:

1) RCD interventions may act as a catalyst forreleasing potential research energies from withinindividuals and organisations. This is most clearlyseen in the programme theories that relate to‘Exceeding the sum of the parts (PT1)’, ‘Liberatingthe talents (PT3)’ and ‘Releasing resources (PT4)’.The implication is that, without such triggers, theorganisation and individuals remain essentially inertor slow moving with regard to their engagement inresearch activities.

2) RCDs must meet criteria for observability, meaningthat current and potential participants must be ableto perceive potential and actual benefits from theirinvolvement. This is most clearly seen in thecollective programme theories labelled as symbolic(or emblematic), i.e. ‘Feeling that you are making adifference (PT6)’, ‘Modelling positive behaviours(PT7)’ and ‘Signalling importance (PT8)’. However,it is additionally present within the ‘Learning bydoing (PT2)’ programme theory, where trainers andtrainees receive almost synchronous confirmation ofpersonal growth and skills acquisition.

3) RCDs must secure the engagement andcommitment of their stakeholders and beneficiaries.Such commitment may be overtly signalled throughexplicit strategies or statements on research,through the celebration of achievements andthrough the provision of protected time from thedemands of competing activities (‘Signallingimportance PT8). It can also be secured by co-creation opportunities through ‘Releasing resources(PT4)’ and ‘Coproducing knowledge (PT5)’ withadded opportunities for ‘Feeling that you aremaking a difference (PT5)’.

4) Possible linkages and C-M-O chains are emerging,where the outcome of one mechanism stimulatesanother within the programme architecture, andcan act as leverage within it. For example, themechanisms that are symbolic (PT6–8) maynurture a research culture that acts as a backdropto other activities (P1–7). Variation in this culturalbackdrop can be conceived as the effect of adimmer switch [41] by which the range ofoutcomes of the symbolic mechanisms havecorrespondingly greater or lesser influence onassociated RCD activities. The more evident a

Cooke et al. Health Research Policy and Systems (2018) 16:93 Page 17 of 22

Page 18: Uncovering the mechanisms of research capacity development

research culture, the more assets/resources thatculture is able to bring to the RCD architectureand, correspondingly, the more power releasedwithin the dimmer switch to stimulate a range ofmechanisms across the programme.

Thus, the findings from this realist synthesis of theconceptual RCD literature offer a starting point for con-structing a RCD framework shaped by these programmetheories. Future work should include exploration, elabor-ation and iterative refinement of these programme the-ories through exploration with other theory (somesuggestions are included in Table 3), and testing againstempirical data from intervention studies [42, 43].

StrengthsWe have taken a first step in developing components ofan overarching theory to determine what works forwhom to accomplish ‘more research done well’. Searcheswere conducted across a wide range of databases andwere supplemented by exhaustive reference checkingand citation tracking. The 36 conceptual and theoreticalpapers we identified are derived from diverse settingsand describe RCD activities at multiple levels, strength-ening confidence in the identification of candidatemechanisms. All major RCD activities are identifiable inboth the included set of papers and in the validation setof recent reviews with which we tested our initial find-ings. Our realist-based approach offers an opportunityfor a more nuanced understanding of how interventionsmight work and, indeed, in understanding circumstancesin which they may not, which goes beyond the merepresence or absence of a specific intervention, a seren-dipitous bundle of collective interventions or a tailoredpackage of synergistic initiatives.

LimitationsThe systematic mapping process was subject to time andresource constraints and was primarily conducted byone investigator. Validation of a 20% sample was per-formed by the other two investigators to sensitise teammembers to the characteristics of the evidence base. Theteam reached a consensus on what should be recognisedas constituting a model, theory or framework but didnot distinguish between these three contested terms.The articles studied for the presence of programme the-ory were purposively sampled from a wide range of can-didate studies and were selected to represent diversesettings and contexts and because of the perceived rich-ness of their data.Our preliminary findings have already been shared with a

group of nine National Health Service organisations whomeet to promote organisational development in RCD,called ACORN (Addressing Capacity in Organisations to

do Research Network) [44]. Individuals were able to com-ment on the extent to which these programme theories fitwith their practical experience of RCD.Potential implications, based upon our theoretical

frameworks, for those planning RCD at different con-textual levels are given in Box 2.

ConclusionsRealist evaluation approaches are increasingly commonwhen evaluating specific interventions in RCD [45, 46,47]. Other authors are further using innovative literaturereview methods in order to explore development strat-egies for RCD [48]. We believe that this is the first timethat the innovative approach of realist synthesis has beenapplied to conceptual papers on RCD in order to isolatethe underpinning RCD programme theories. The valueof this approach is in drilling down beneath the activitiesof a programme to identify the mechanisms that are de-ployed therein.This review found that, collectively and individually,

RCDs engage with multiple defined programme theoriesto achieve their potential impact. Such programme theor-ies have a role in developing new RCD interventions, inmodifying existing initiatives, and in creating a compre-hensive evaluation framework against which to measureachievements. We have been able to tentatively explorehow C-M-O might link to develop ‘trigger’ chains andspeculate how symbolic mechanisms may link to interven-tional ones. This needs to be explored further within inter-vention studies. Our initial work requires furtherdevelopment to extend the analysis and thus cover a fullrange of RCD interventions, mapping both activities andevaluation measures by intervention, stage in the develop-ment lifecycle, and by programme theory.Our investigation represents an overt attempt to capital-

ise on the utility of realist synthesis for the specific tasksof theory generation and subsequent exploration of poten-tial mechanisms. Gough et al. [28] characterise the poten-tial contributions of synthesis in general in terms ofgenerating, exploring and testing (G-E-T) of theory. Asubsequent stage of this project is therefore to test theseemergent concepts with reference to empirical studies,either relating to research capacity as a composite activityor to the individual interventions by which we characteriseresearch capacity activities. Planned outcomes from thesubsequent stages of this project include identifying whichmechanisms are associated with specific types of interven-tion and the development of an evaluation frameworkwith which to assess the achievements of general RCDprogrammes and their constituent interventions.Our novel evidence-based model identified 36 concep-

tually rich papers relevant to RCD. Although we acknow-ledge that other papers hold the potential to inform our

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Box 2 Potential implications when planning RCD

Funding bodies

� Develop research priority-setting mechanisms to release resources to fund research that can ‘make a difference’. Priorities should be

agreed between stakeholders to co-produce knowledge that will have an impact on health and wealth.

� Develop funding opportunities to support ‘learning by doing’ opportunities for individuals, to compliment more formal research

training.

� Fund career pathways and liberate talents through actively seeking individuals with potential, and fund coaching and mentorship to

maximise this.

� Fund appointments between healthcare and academic organisations to support partnerships that exceeds sum of parts and co-

production of research, and provide positive role models.

� Develop funding calls to a release resource and signal importance of research activity within healthcare organisations. For example,

through a matched funding model in large research programmes, and protected time agreed with managers in ‘learning by doing’

opportunities.

� Fund novel methods of research dissemination that promote action in clinical and healthcare practice so that the research findings

can make a difference, and signal importance of implementing research knowledge into practice.

Healthcare organisations

� Signal the importance of research activity within the organisation through job descriptions, mission statements, training and R&D

strategies. Support business plans in order to release resources that will include protected research time and ring-fenced research

resources.

� Recognise and celebrate positive research behaviours in clinical academic staff, managers and services through award schemes and

communication channels.

� Enable mentoring and coaching schemes to be undertaken in their organisation in order to release potential talent and support

learning by doing activities.

� Seek and support ‘learning by doing’ programmes as well as more traditional research training opportunities.

� Develop a needs and assets register to recognise and liberate talent.

� Develop a sense of ownership and commitment to research activity, through co-creation of research ideas, observable instances of

quick wins and impact success stories, to demonstrate research that makes a difference.

� Work proactively in partnership with other organisations, networks and academic institutions to maximise synergies, coproduction,

‘learning by doing’ opportunities.

Individuals:

� Recognise the personal, organisational and long-term benefits from their own involvement in research to make a difference and to

demonstrate positive research behaviours.

� Seek and use leaning by doing opportunities.

� Support release of their own talents, and that of others around them. Be both a mentor and a mentee. Use coaching opportunities

to release their own potential.

� Work with managers to negotiate protected time to signal importance of research alongside practice.

� Develop skills to support coproduction of research, and plan research activity that has an impact on practice to make a difference.

� Are able to develop skills and knowledge through practical involvement in research activities, including alignment to organisational

objectives.

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theory development, particularly in relation to the charac-teristics of individual interventions, we believe that wehave identified the more common and significantprogramme theories that relate to RCD. We anticipatethat further exploration will reveal a point of theoreticalsaturation and may help in identifying some of the nu-ances or, indeed, disconfirming cases, associated with spe-cific RCD initiatives. Ultimately, we hope that theconceptual framework presented in this paper will con-tribute to the demonstration of long-term outcomes inhealth, wealth and knowledge as commissioners and ser-vice providers work together to increase RCD.

Additional file

Additional file 1: The 36 studies describing conceptual models,frameworks or theory for research capacity development. (DOCX 35 kb)

AbbreviationsKM: knowledge mobilisation; RCD: research capacity development;Re:CAP: Research Capacity – A scoping review to identify the evidence-basefor Research Capacity development in health and social care

FundingThe authors of this paper were funded and supported by the NationalInstitute for Health Research (NIHR) Collaboration for Leadership in AppliedHealth Research and Care Yorkshire and Humber (NIHR CLAHRC YH)(www.clahrc-yh.nihr.ac.uk). The views and opinions expressed are those ofthe authors, and not necessarily those of the National Health Service, theNIHR or the Department of Health.

Availability of data and materialsThe datasets used and/or analysed during the current study are availablefrom the corresponding author on reasonable request.

Authors’ contributionsJC and AB conceived the study. PG conducted the subject searches andpursued the citation pearls. All three authors undertook study selection. JCand AB extracted data from included studies. All authors participated in theanalysis and the interpretation of review findings. All authors read andapproved the final manuscript.

Ethics approval and consent to participateNot relevant, this is a literature review with no primary research data or datafrom human subjects.

Consent for publicationNo individual person’s data in any form.

Competing interestsThe authors declare that they have no competing interests.

Publisher’s NoteSpringer Nature remains neutral with regard to jurisdictional claims in publishedmaps and institutional affiliations.

Author details1NIHR CLAHRC Yorkshire & Humber, Research Capacity and EngagementProgramme Management, 11 Broomfield Road, Sheffield S10 2SE, UnitedKingdom. 2Department of Public Health and Pediatrics, University of Turin,Turin, Italy. 3School of Health and Related Research, University of Sheffield,Regent Court, 30 Regent Street, Sheffield S1 4DA, United Kingdom.

Received: 7 April 2018 Accepted: 17 August 2018

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