umor segmentation and dense deformable registration of ...umor segmentation and dense deformable...
TRANSCRIPT
![Page 1: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/1.jpg)
Joint Tumor Segmentation and Dense Deformable Registration of Brain MR Images
Sarah Parisot1,2,3, Hugues Duffau4, Stéphane Chemouny3, Nikos Paragios1,2
1. Center for Visual Computing, Ecole Centrale Paris
2. Equipe GALEN, INRIA Saclay-Ile de France
3. Intrasense SAS, Montpellier
4. Département de Neurochirurgie, Hôpital Gui de Chauliac, Montpellier
![Page 2: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/2.jpg)
Introduction
Brain Tumor Segmentation and Registration from healthy to pathological subject treated separately
• Fuzzy boundaries
• inhomogeneous appearances
• Various shapes
• intensity overlap with healthy tissue
Methods
• Classification techniques + pairwise smoothingLee et al. MICCAI 2008
• Atlas based segmentation: dependent on registration qualityPrastawa et al. Academic Radiology 2003
Methods
• Growth models: computationally expensive/user interactionCuadra et al. Comput. meth. prog. bio. 2006 Zacharaki et al. Neuroimage 2009
• Masking the pathology: dependent on segmentation qualityStefanescu et al. MICCAI 2004
• No correspondences in the tumor area: use of common methods impossible
![Page 3: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/3.jpg)
Introduction
Brain Tumor Segmentation and Registration from healthy to pathological subject treated separately
• Fuzzy boundaries
• inhomogeneous appearances
• Various shapes
• intensity overlap with healthy tissue
Methods
• Classification techniques + pairwise smoothingLee et al. MICCAI 2008
• Atlas based segmentation: dependent on registration qualityPrastawa et al. Academic Radiology 2003
Methods
• Growth models: computationally expensive/user interactionCuadra et al. Comput. meth. prog. bio. 2006 Zacharaki et al. Neuroimage 2009
• Masking the pathology: dependent on segmentation qualityStefanescu et al. MICCAI 2004
• No correspondences in the tumor area: use of common methods impossible
![Page 4: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/4.jpg)
Method OverviewSimultaneously register a healthy subject to a diseased subject and find the tumor’s segmentation map
Tumor segmentation
Healthy to diseased registration
3
![Page 5: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/5.jpg)
Method OverviewSimultaneously register a healthy subject to a diseased subject and find the tumor’s segmentation map
Similarity criterion between the images
glocker et al. Medical Image Analysis, 2008
Find correspondences
Tumor segmentation
Healthy to diseased registration
3
![Page 6: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/6.jpg)
Method OverviewSimultaneously register a healthy subject to a diseased subject and find the tumor’s segmentation map
Similarity criterion between the images
glocker et al. Medical Image Analysis, 2008
Find correspondences
Tumor segmentation
High score
Learned classifier
Friedman et al.The Annals of Statistics 2000
Healthy to diseased registration
3
![Page 7: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/7.jpg)
Method OverviewSimultaneously register a healthy subject to a diseased subject and find the tumor’s segmentation map
Similarity criterion between the images
glocker et al. Medical Image Analysis, 2008
Find correspondences
Detect tumor:Areas without
correspondences(low similarity)
Tumor segmentation
High score
Learned classifier
Friedman et al.The Annals of Statistics 2000
Healthy to diseased registration
3
![Page 8: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/8.jpg)
Method OverviewSimultaneously register a healthy subject to a diseased subject and find the tumor’s segmentation map
Similarity criterion between the images
glocker et al. Medical Image Analysis, 2008
Find correspondences
Detect tumor:Areas without
correspondences(low similarity)
Deformation in the tumor:
interpolationTumor
segmentation
High score
Learned classifier
Friedman et al.The Annals of Statistics 2000
Healthy to diseased registration
3
![Page 9: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/9.jpg)
Method OverviewSimultaneously register a healthy subject to a diseased subject and find the tumor’s segmentation map
Similarity criterion between the images
glocker et al. Medical Image Analysis, 2008
Find correspondences
Detect tumor:Areas without
correspondences(low similarity)
Deformation in the tumor:
interpolationTumor
segmentation
High score
Learned classifier
Friedman et al.The Annals of Statistics 2000
Healthy to diseased registration
Discrete Markov Random Field Formulation 3
![Page 10: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/10.jpg)
ParametrizationA I
4
![Page 11: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/11.jpg)
ParametrizationA I
4
T (x)A �T (x) = I(x)
Deformation field
![Page 12: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/12.jpg)
ParametrizationA I
4
T (x)A �T (x) = I(x)
Deformation field
S(x)Segmentation map
![Page 13: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/13.jpg)
ParametrizationA I
4
• Free form deformation approach:
• Deformation and Segmentation estimated on a grid G superimposed to the images
• Evaluation on the whole image by interpolation
T (x)A �T (x) = I(x)
Deformation field
S(x)Segmentation map
![Page 14: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/14.jpg)
ParametrizationA I
4
• Free form deformation approach:
• Deformation and Segmentation estimated on a grid G superimposed to the images
• Evaluation on the whole image by interpolation
T (x)A �T (x) = I(x)
Deformation field
S(x)Segmentation map
![Page 15: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/15.jpg)
Markov Random Field Model
• Assign to each grid node p a label lp corresponding to a pair segmentation (sl) /displacement (dl)
5
lp = {slp ,dlp}�{0,1}× {d1,...,dk}
![Page 16: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/16.jpg)
Markov Random Field Model
• Assign to each grid node p a label lp corresponding to a pair segmentation (sl) /displacement (dl)
5
lp = {slp ,dlp}�{0,1}× {d1,...,dk} Discrete displacement set
![Page 17: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/17.jpg)
Markov Random Field Model
• Assign to each grid node p a label lp corresponding to a pair segmentation (sl) /displacement (dl)
• Find the optimal labeling:
Evaluate the optimal segmentation and displacement in a one shot optimization
lopt = argminlEdef ,seg (l)
5
lp = {slp ,dlp}�{0,1}× {d1,...,dk} Discrete displacement set
![Page 18: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/18.jpg)
Markov Random Field Model
• Assign to each grid node p a label lp corresponding to a pair segmentation (sl) /displacement (dl)
• Find the optimal labeling:
Evaluate the optimal segmentation and displacement in a one shot optimization
• Markov Random Field Energy
Edef ,seg (l) =
1|G |
Vpp�G� (lp )+ Vpq
q�N ( p)�
p�G� (lp ,lq )
lopt = argminlEdef ,seg (l)
5
lp = {slp ,dlp}�{0,1}× {d1,...,dk} Discrete displacement set
![Page 19: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/19.jpg)
Markov Random Field Model
• Assign to each grid node p a label lp corresponding to a pair segmentation (sl) /displacement (dl)
• Find the optimal labeling:
Evaluate the optimal segmentation and displacement in a one shot optimization
• Markov Random Field Energy
Edef ,seg (l) =
1|G |
Vpp�G� (lp )+ Vpq
q�N ( p)�
p�G� (lp ,lq )
• Pairwise term with neighbor nodesLocal consistency of the segmentation
Registration regularization
lopt = argminlEdef ,seg (l)
5
lp = {slp ,dlp}�{0,1}× {d1,...,dk} Discrete displacement set
![Page 20: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/20.jpg)
Markov Random Field Model
• Assign to each grid node p a label lp corresponding to a pair segmentation (sl) /displacement (dl)
• Find the optimal labeling:
Evaluate the optimal segmentation and displacement in a one shot optimization
• Markov Random Field Energy
Edef ,seg (l) =
1|G |
Vpp�G� (lp )+ Vpq
q�N ( p)�
p�G� (lp ,lq )
Vp (lp ) =�Vdef (lp )+ (1�� )Vseg (lp )• Pairwise term with neighbor nodes
Local consistency of the segmentation
Registration regularization
lopt = argminlEdef ,seg (l)
5
lp = {slp ,dlp}�{0,1}× {d1,...,dk} Discrete displacement set
• Unary term
![Page 21: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/21.jpg)
Unary Term: Segmentation
• Learning of a tumor vs background classifier
• Features extracted from images
• Gentle Adaboost algorithm
Construction of a strong classifier as a combination of weak classifiers (decision stumps)
• Any classification technique can be used
• Nodes with high classification probability of being tumor should be labeled accordingly
Vp (lp ) =�Vdef (lp )+ (1�� )Vseg (lp )
Boosting probability map6
![Page 22: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/22.jpg)
Unary Term: Registration
Vp (lp ) =�Vdef (lp )+ (1�� )Vseg (lp )
Sim I (x),A(x + dlp )( ) if slp = 0, Background
Ctm if slp = 1,Tumor
���
��
7
![Page 23: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/23.jpg)
• Outside the tumor area: Find correspondences
Compute the similarity measure for all possible displacements
Unary Term: Registration
Vp (lp ) =�Vdef (lp )+ (1�� )Vseg (lp )
Sim I (x),A(x + dlp )( ) if slp = 0, Background
Ctm if slp = 1,Tumor
���
��
A I 7
![Page 24: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/24.jpg)
• Outside the tumor area: Find correspondences
Compute the similarity measure for all possible displacements
Unary Term: Registration
Vp (lp ) =�Vdef (lp )+ (1�� )Vseg (lp )
Sim I (x),A(x + dlp )( ) if slp = 0, Background
Ctm if slp = 1,Tumor
���
��
A I 7
![Page 25: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/25.jpg)
• Outside the tumor area: Find correspondences
Compute the similarity measure for all possible displacements
Unary Term: Registration
Vp (lp ) =�Vdef (lp )+ (1�� )Vseg (lp )
Sim I (x),A(x + dlp )( ) if slp = 0, Background
Ctm if slp = 1,Tumor
���
��
A I 7
![Page 26: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/26.jpg)
• Outside the tumor area: Find correspondences
Compute the similarity measure for all possible displacements
Unary Term: Registration
Vp (lp ) =�Vdef (lp )+ (1�� )Vseg (lp )
Sim I (x),A(x + dlp )( ) if slp = 0, Background
Ctm if slp = 1,Tumor
���
��
A I 7
![Page 27: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/27.jpg)
• Outside the tumor area: Find correspondences
Compute the similarity measure for all possible displacements
Unary Term: Registration
Vp (lp ) =�Vdef (lp )+ (1�� )Vseg (lp )
Sim I (x),A(x + dlp )( ) if slp = 0, Background
Ctm if slp = 1,Tumor
���
��
A I 7
![Page 28: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/28.jpg)
• Outside the tumor area: Find correspondences
Compute the similarity measure for all possible displacements
Unary Term: Registration
Similarity measure Sim(I(x),A(T (x))
Vp (lp ) =�Vdef (lp )+ (1�� )Vseg (lp )
Sim I (x),A(x + dlp )( ) if slp = 0, Background
Ctm if slp = 1,Tumor
���
��
A I 7
![Page 29: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/29.jpg)
• Outside the tumor area: Find correspondences
Compute the similarity measure for all possible displacements
Unary Term: Registration
Similarity measure Sim(I(x),A(T (x))
Vp (lp ) =�Vdef (lp )+ (1�� )Vseg (lp )
Sim I (x),A(x + dlp )( ) if slp = 0, Background
Ctm if slp = 1,Tumor
���
��
A I 7
Any kind of similarity criterion
![Page 30: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/30.jpg)
Unary Term: Registration
• In the tumor area: No correspondences
Constant cost independent of the displacement
Constant Cost
Vp (lp ) =�Vdef (lp )+ (1�� )Vseg (lp )
Sim I (x),A(x + dlp )( ) if slp = 0, Background
Ctm if slp = 1,Tumor
���
��
A I 8
![Page 31: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/31.jpg)
Implementation• Incremental Approach
• 3 image levels, 4 grid resolutions
• Increasing influence of the segmentation (progressive diminution of � value)
• Optimization
• Linear programming (Komodakis et al. CVIU, 2008)
• Overall run time: 6 min (matlab implementation) 9
![Page 32: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/32.jpg)
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• Database: 97 T2 FLAIR volumes
• Data likelihood learned on 40 volumes
• Evaluation on 57 volumes
• Segmentation
• Evaluated w.r.t manual segmentations
• Compared with boosting classification with added pairwise smoothing (right on boxplots)
• Median Dice: 77 to 80%, False positives: 30 to 20%, Mean Absolute Distance (MAD): 4.8 to 4.2mm
• Registration
• Qualitative evaluation
• Compared with Glocker et al. 2008, with masked pathology
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Experimental Validation
10
Dice Score
False positive rate
MAD
Our method Boosting
![Page 33: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/33.jpg)
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• Database: 97 T2 FLAIR volumes
• Data likelihood learned on 40 volumes
• Evaluation on 57 volumes
• Segmentation
• Evaluated w.r.t manual segmentations
• Compared with boosting classification with added pairwise smoothing (right on boxplots)
• Median Dice: 77 to 80%, False positives: 30 to 20%, Mean Absolute Distance (MAD): 4.8 to 4.2mm
• Registration
• Qualitative evaluation
• Compared with Glocker et al. 2008, with masked pathology
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Experimental Validation
10
Dice Score
False positive rate
MAD
Our method Boosting
![Page 34: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/34.jpg)
Red: Ground truth Blue: Automatic segmentation 11
![Page 35: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/35.jpg)
Original image Glocker et al. 2008Deformed image
Left:Glocker 08
Deformation field
Our methodDeformed image
RightOur method
Deformation field
12
![Page 36: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/36.jpg)
Conclusion• Simultaneous registration and segmentation method
• Modular w.r.t image modality, similarity criterion and classification technique
• Can be adapted to any clinical context
• Fast and efficient optimization (ongoing work to reduce the run time to a few seconds)
• State of the art results
• Future work
• Local spatial position prior information
• Registration uncertainties
• Adaptation to registration/segmentation before and during surgery with tumor resection13
![Page 37: umor Segmentation and Dense Deformable Registration of ...umor Segmentation and Dense Deformable Registration of Brain MR Images Sarah Parisot1,2,3fau4, Stéphane Chemouny3, Nikos](https://reader033.vdocuments.site/reader033/viewer/2022053123/60ad6b14374f9e2eb829c57d/html5/thumbnails/37.jpg)
Thank you for your attention
Questions?
14
Poster Th-1-AG-14 Thursday 13:30-15:00