ucsc convegno_milano_oct_2013.pdf

7/27/2019 UCSC Convegno_Milano_Oct_2013.pdf

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Overviewdieffe*dellallenamento

eccentricovs.concentrico

Mar%noFranchi

MRC-ARUKCentreofExcellenceforMusculoskeletalAgeingResearch

DivisionofClinicalandMetabolicPhysiology

SchoolofGraduateEntryMedicine

UniversityofNongham


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Strengthtraining

FromNarici&Franchi,Scienza&Sport2012


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MuscleCrossSec%onalArea(CSA)(Hypertrophy) Musclearchitecture Neuralcontrol MusclelengthandjointangleVelocity

Factorsinfluencingmusclestrength


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Mechanismsofhypertrophy:satellitecells

FromBruusgaardetal.2009


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anterior

lateral medial

Musclemorphologyandarchitecture


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MaincomponentsofRET Completelydifferenttypesofcontrac%on Differentproduc%onofmuscleforce Differen%almuscleadapta%onsinresponsetotraining

EccentricandConcentriccontrac?ons


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Concentricvs.Eccentric

z

x Thin filament

Thick filament

Copyright Elsevier 2004

S2

A

S1

Actin

S1

B C


Sarcomere

TitinActinMyosinZ line Z line


Jonesetal.SkeletalMusclefrommoleculestomovement,2004


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MVC,MRI&

Ultrasound

UnilateralECC

orCON

STUDYDESIGN

12healthyyoungmales(253y.o.)

2traininggroups:CONvs.ECC

Training:4seriesof8-10repsat80ofeitherCONorECC1RM,3%mesper

weekfor10weeks

Musclebiopsiescollectedat30mins

a_erasingleECCorCONtraining

session


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CON ECC

Reeves,Maganaris,Longo&Narici.

2009,ExpPhysiol


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VLfasciclebehaviourduringCONandECC

exercise

CONCENTRIC MOVEMENT ECCENTRIC MOVEMENT

Muscle Architecture during leg-press exercise

Lf (cm) PA (deg)

0.8

1.0

1.2

1.4

End/Starto

fcontraction(Normalised)

CONCENTRIC

ECCENTRIC

^^^ ^^^

***

***

*** *** P < 0.0001^^^ = significantlydifferent betweengroups P < 0.0001

Franchietal.2013,inrevision


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RESULTSMorphological,funcKonalandarchitecturaladaptaKons



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Hypertrophyofpennatemuscle

Addition ofsarcomeresin-parallelECC+, CON+++

Addition ofsarcomeresin-seriesECC+++, CON+

RusselBetal.J.Appl.Physiol.(2000)88:11271132

ECCENTRIC

CONCENTRIC

Distal Proximal


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Kehat et al. Circ Res. 2011: 108: 176-183


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p-p38 MAPKinase

Baseline 30 min0

2

4

615

20

25

30

Norm

alisedValues(AU) CONCENTRIC

ECCENTRIC

*** = P < 0.0001

***

p-ERK 1/2

Baseline 30 min0

2

4

6

NormalisedValues(AU) CONCENTRIC

ECCENTRIC

* = P < 0.05

*

p-p90RSK

Baseline 30 min

0

2

4

6

NormalisedValues(AU) CONCENTRIC

ECCENTRIC

** = P < 0.01

**


RESULTSMolecularresponsestoasingleCONvs.ECCtrainingsession


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ECC CON

VLVOLUME ++ ++

MVC ++ ++

Lf +++ +

PA + +++

p-p38 +++ x

p-ERK1/2 + x

p-p90RSK ++ x

SUMMARY



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CONCLUSIONS

Dis%nctfasciclebehaviourduringECCandCONcontrac%on PureECCandCONtrainingproducedsimilargainsinmuscle

massandstrength

butthroughdis?nctlydifferentarchitecturaladapta?ons Differen%al acute molecular responses to ECC vs. CON

exercise(MAPKac%va%on)

Dis?nctarchitecturalandmolecularadapta?onsmaybelinked

asaresultofcontrac?on-specificresponsestoECCvs.CONRET


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Eccentric/ConcentricandSarcopenia Stretch-shorteningcycle(SCC,Plyometrics) Proteinturnoverinresponse(anabolicresponse)tospecifictraining

protocols(measuredbystableisotopetracingtechniques)

Whatsnext


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ProfMarcoNarici,UoN

ProfMFlck,UniversityofZurich

DrWKMitchell,UoN

DrMRBeltran-Valls,UniversityofRome,ForoItalico

DrASelby,UoN

Acknowledgements

DrPhilipAtherton,UoNProfNeilReeves,MMU


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Neuralcontrol

Fromomietal.2000

FromAagaardetal.2000

ucsc convegno_milano_oct_2013.pdf

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