U05-23088

19 yo African female student (here since 2001) Medical exam for Immigrationnotable for protein-uria and Hematuria. Serum Creatinine 81umol/L (88 Aug 5)No h/o UTI's or Pyelo.Headaches....Advil over 5 monthsIntermittent swellings lower ExtremityNonsmoker social EtohInduced Aborton. Single partner (Sero -ve)24 hour urine 5.6gmsNegative Sero( ANA,C3,C,Hepatitis).Normal U/sLeft lower pole Bx

IF

• IgG- Negative• IgA- Moderate to strong mesangial staining• IgM- Mild mesangial staining • C3- Mild to moderate mesangial staining• C1q- Negative • Kappa- Mild mesangial staining• Lambda- Mild to moderate mesangial staining• Fibrin- Mild mesangial staining • Albumin- Negative

IgA

IgM

C3

Kappa

Lambda

Fibrin

Diagnosis:Renal Biopsy:IgA Nephropathy with proliferative and necrotizing lesions including crescent formation