turning grams into tons
TRANSCRIPT
Bio Base Europe Pilot PlantTurning Grams into Tons
Muriel DewildeBusiness Development Manager
BIO World Congress on Industrial Biotechnology
Philadelphia, July 17, 2018
Bio Base Europe Pilot Plant
• Founded in 2008, not-for-profit SME
• Investments funded by EU, Flanders, Netherlands : 30 M€
• Fully independent, no industrial shareholders
• Operational since 2010
• 70 employees
• ISO 9001, FSSC 22000
The Company
Located in Ghent,
North Sea Port, Belgium
Bio Base Europe Pilot Plant
1. Process Development
2. Scale-Up
3. Toll Manufacturing
For companies (~200) around the world
and within EU consortia (20)
-> From benchtop to 10 t scale
-> Experienced personnel
-> Wide range of equipment
Our Services
Bringing Bio-Based Innovations from Lab to Market
One Stop Shop:From Biomass to Refined Product
Under One Roof
Pretreatment
Biocatalysis FermentationGreen
Chemistry
Downstream Purification
Examples
Glucose, sucrose, lactose
Vegetable oils
Corn stover, wheat straw
Paper pulp
Syngas
Agro Industrial by-products
Bagasse, beet pulp, seed press cakes
Algae
Non-food crops
...
...
Specialty carbohydrates
Industrial Enzymes
Surfactants
Organic acids
Flavors and fragrances
Polymers
Protein concentrates
Nutraceuticals
Fuels
Process Hall 1
Biomass pretreatment, bio-catalysis and Downstream Processing
Process Hall 2
Fermentations and DSP
Process Hall 3
Green chemistry and Solvent Based Processes (ATEX)
Process Hall 4
Q4 2018: More Food Grade Purification at 10 t scale
Laboratory
Tech transfer, Analysis and Liter Scale Process Development
Biomass Pretreatment
• Steam Injection
• Organosolv
• Acid/Alkaline pre-treatments
• Pressure reactions
• Enzymatic hydrolysis
• Solid/Liquid separation
• Multi ton scale
Biocatalysis
• Aqueous, Two-phase and Three-phase Systems
• Batch, Fed-batch, Continuous
• High solids contents
• Reactors up to 50 m³
• Immobilization
• Whole cell biocatalysts
• Enzyme production
Fermentation
• Batch, Fed-batch, Chemostat
• Bacteria, Yeast, Fungi
• Aerobic, Anaerobic
• 10 L Ex proof Gas Fermenter
• Bench top: SF, 4x 1 L (Ex), 4x 7 L, 2x 10 L
• Scale-up: 50 L, 10x 150 L
• Ton scale:2 x 1.5 m³, 4.5 m³, 2 x 15 m³
Green Chemistry
• Glass lined Reactors up to 5 m³
• Filter Dryer, Centrifuge
• Liq-Liq and Sol-Liq extraction
• Crystallisation, filtration
For
Chemical reactions
Solvent based DSP
Corrosive conditions
Downstream Purification• High speed separators
• Dead-end and Membrane filtration: MF, UF, NF
• Ion exchange, activated carbon treatment
• Solvent extraction
• Evaporation
• Crystallization
• Drying
EU Projects
Glycolipid Biosurfactants (sophorolipids, rhamnolipids) and specialty carbohydrates via fermentation. Market sample production
Valorization of sugar beet pulp. Adressing technological hurdles and production of several metric tons of arabinose for application testing and market sampling
Lignocellulosic feedstocks (bark, straw, miscanthus) via various pretreatment technologies to lignin, aromatics, fermentable sugars to chemical building blocks, materials, low sulphur heavy fuel, tannins
Bio-waste to dicarboxylic acids and diamines by fermentationFor biobased polyesters and polyamides in automotive industryProcess development and production at 1 m³ bioreactor scale
Innnovation support for entrepreneurs in North West Europe.Training and Vouchers for piloting, LCA, TEA, ...
More EU projects: www.bbeu.org
Projects
Evonik about Bio Base Europe Pilot Plant:“Excellent personnel trained in industrial processes.Fast response time and excellent organization.”
(former Dyadic) C1 fungal strain: enzyme production at 15 m³ scale
Human milk oligosaccharides (2 fucosyllactose) for infant nutrition: Scale-up, demonstration, regulatory and market introduction samples
Specialty fatty ester as aroma chemical for musk applicationFirst commercial production >1 metric ton
Gas fermentation of steel mill blast furnace gas:Testing of different strains and chemicals since 2012AM will commission 47 ktpa ethanol from syngas plant in 2020
Butanol from whiskey side-products: scale-up of ABE fermentation
