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Campo Alpha-Ceramidein

Campo CD Version 3.7.6ri updated © US Library of Congress, Washington D.C 1989-2016 © 23rd

Jan 2017, from 1989,

1990, 1991, 1992,1993,1994,1995,1996, 1997, 1998, 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017 © Campo Research All rights reserved. © US Library of Congress, Washington D.C 1989-2017 ©

Campo Research Pte Ltd

ALPHA-CERAMIDEIN

CAMPO RESEARCH PTE LTD

Level 30, 6 Battery Road

Singapore 049909

Tel: (65) 63833203 Fax (65) 63833632

E-mail: [email protected] Subsidiary of Campo Toyo Eisai Research Group, Japan



Jan 2017, from 1989,


INDEX

PRODUCT ANNOUNCEMENT

SPECIFICATION

TECHNICAL SPECIFICATION

MICROBIOLOGICAL DATA SHEET

MATERIAL SAFETY DATA SHEETS

Final Report

SALMONELLA TYPHIMURIUM - REVERSE MUTATION ASSAY

CAMPO SCIENCE BEHIND THE ALPHA-CERAMIDEIN

AHA - Ceramide complex for clear formulations

HOW TO PREPARE LIQUID ALPHA-CERAMIDEIN GEL

Ask about our Herbal Natural Products Chemistry Consultancy Services – Product Registration EEC/UK New

Drug Development (NDA-US); Quasi-Drug Topicals (MOHW_Japan); Development of Standards, Analysis &

Profiles of Phytochemicals; Literature searches, Cultivation of Medicinal Plants, Clinical-Trials, Development of

new uses for Phytochemicals and Extracts; Contract Research and Development Work in Natural Products for

Novel Drugs, New Cosmetic Active Ingredients for Active Topica/OTC Cosmetic with functionality and

Consumer-perceivable immediate-results, New Food Ingredients for Nutraceuticals & Functional Foods.

IMPORTANT NOTICE Specifications may change without prior notice. Information contained in this technical literature is believed to be accurate and is offered in good faith for the benefit of the customer. The company, however, cannot assume any liability or risk involved in the use of its natural products or their derivatives, since the conditions of use are beyond our control. Statements concerning the possible use are not intended as recommendations to use our products in the infringement of any patent. We make no warranty of any kind; expressed or implied, other than that the material conforms to the applicable standard specifications.



Jan 2017, from 1989,


PRODUCT ANNOUNCEMENT

ALPHA CERAMIDEIN

CAMPO RESEARCH PTE. LTD., SINGAPORE

This new development based on cell culture and hydroponics provides a simple, one-step answer to the problem of formulating clear AHA - ceramide systems for advanced skin care. Ceramide RW is a biologically engineered ceramide complex identical to human skin ceramides, and L- (+)-lactic acid is produced from hydroponically grown tomatoes, where total control over nutrients and root temperatures optimizes lactic acid content. The two are brought together to form ALPHA-CERAMIDEIN - your one- step answer to the formulation of advanced skin care systems.

ALPHA CERAMIDEIN

Background information

ALPHA HYDROXY ACIDS……….

Facial cosmetics based on sour milk have been used since ancient Egyptian times, a period of some 5000 years. The main active ingredients are believed to be the alpha-hydroxy acids, predominantly lactic acid and its derivatives. Alpha-hydroxy acids (Ahas) are naturally occurs substances isolated from a variety of sources, such as sour milk, sugar cane, tomatoes and other fruit. They perform a number of functions at the level of the stratum corneum on the skin’s surface. There are many different kinds of alpha-hydroxy acids, and some out- performs others - even low usage levels. Intensive research has identified lactic acids, particularly the L-form as one of the most effective forms of AHA. Perhaps not surprisingly, this occurs naturally in the body. Campo’s L-lactic acid is isolated from tomatoes cultivated by hydroponics using root temperature control to optimize yields of L-lactic acid.

………. And CERAMIDES

Ceramide(s) are found in human skin and comprise of 43-46% of the stratum corneum where they play a major role as a water retention barrier. They include sphingosine and fatty acids, and are generally linked with sugars to form structures called glycosphingolipids. Six kinds of ceramides have been identified in the human skin. Clinical studies of the application of the materials on the forearms of ten healthy male volunteers confirm the augmentation of water-retention, cell-to-cell adhesion, and in the prevention of barrier changes. Further clinical studies confirms that human ceramide levels decrease with increasing age, especially on the face, and in one third of individuals studied, on the hands as well. Campo’s Ceramide RW is a new complex of biologically engineered material, identical to human skin ceramide and is a spin-off from the P34 cdc2 (gene expression) research work on cellular signal transudation, especially in the area of skin cancer proliferation and down-regulation activities of certain natural products; conducted by Kampoyaki Research, Singapore.



Jan 2017, from 1989,


AHA + CERAMIDES = ALPHA CERAMIDEIN

We have considered the skin as a structure akin to bricks and mortar. The bricks are the stratum corneum cells of the surface skin, and the mortar the intercellular cement that holds the cells together. As skin ages, cells lose their shape, inter-cellular material loosens its grip and the cells slide apart. This gives the skin a slack appearance, it loses its tone and fine lines and wrinkles begin to appear. Alpha-hydroxy acids work to restore the youthful appearance of the skin. However, they can only complete part of the job. They need the help of ceramides that act like a molecular mortar to reinforce the newer, smaller cells. Since Elizabeth Arden’s “Alpha-ceramide” 4 steps hit the market in the summer of the 1994, many cosmetic raw material suppliers have been trying to produce a clear, colorless, ceramide liquid based that is soluble in ethanol and water. These efforts have been unsuccessful except for a couple of vegetable ceramide powder types with poor stability. These turn into cloudy opaque liquids from which it is virtually impossible to formulate a clear, colorless, generic to the Arden product.

The answer is Campo Alpha -Ceramidein!!!!!

It has now become possible to super-charge AHA with ceramides, the moisture-enhancing lipids that support and hydrate young skin. Ceramides help to reinforce the skin’s moisture barrier and generally improve the skin’s condition creating a strengthened barrier upon which the AHA complex can work gently and effectively. The L-lactic acid complex works progressively as part of the alpha-ceramides unique step-by-step system and in this way, all skin types slowly adjust and acclimatize themselves to produce optimal results without the possibility of irritation.

Alpha-Ceramidein is a power-packed system to combat fine lines and wrinkles with L-lactic acid isolated from tomatoes and natural alpha-ceramides produced by cell culture.

Proposed CFTA name (USA)

CFTA-Proposed Name

Lactic Acid (and) Ceramide III (Ceramide 3) L-lactic acid (and) ceramide 3 complex

Color /odour: Colorless, clear liquid with faint characteristic odour

Application as an additive for emulsion and alcoholic lotions, Particularly suggested for addition in W/O and Non-inorganic emulsions

Application level 5 - 8%

Active Ingredients L-lactic acid and ceramide.

Storage Dark and cool in closed containers. Crystals which may Form due to long storage or low temperatures have no Effect on the quality of the product and can be dissolved.

By heating and stirring

ALPHA-CERAMIDEIN was developed and is produced by CAMPO RESEARCH PTE. LTD of Singapore.



Jan 2017, from 1989,


CAMPO CERAMIDE RW & L-LACTIC ACID COMPLEX

(ALPHA - CERAMIDEIN)

PRODUCT #94-01-33AC

SPECIFICATION

BIOLOGICAL COMPONENTS, CONCENTRATIONS AND THEIR KNOWN ACTIONS

(In the Bio-technologically produced Campo Ceramide RW Complex)

Dihydrosphingosine (sphinganine) 0.006% Biosynthetic precursor of sphingosine: inhibits PKC, also directly inhibits phospholipase A2 and D (ref.#1)

N-sphingosine, N-acetyl (C2 ceramide)

0.00003% Biologically active, cell permeable, but non-physiological ceramide analogue. Inhibits cell proliferation and induces mono-cystic differentiation of HL-60 cells. Stimulates a cytosolic serine/threonine protein phosphates in T9 cells at concentration as low as 100nM (ref. #2)

Sphingosine , N,N-diethyl 0.0000012% Inhibits PKC and enhances src-kinases.

Inhibits cell surface expression of selections that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. (Ref. #3)

Sphingosine, N-hexanoyl (C6 ceramide)

0.005% Biologically active, cell-permeable, but non-physiological ceramide analogue. Stimulate cytosolic serine/threonine protein phosphates in T9 cells and induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinases (ref #4).

N-sphingosine, N-palmitoyl- Abundantmolecular species of

naturalceramide that stimulates cytosolic serine/threonine protein phosphates in T9 cells and induces phosphorylation on Thr-699 in A-431 cells by stimulation of ceramide-activated protein kinase.(see lit #5)

L-(+)-lactic acid, salt complex 5% Cell rejuvenation, mildly exfoliating.

References:

#1 Zakar, Tetal. 1992 Biochem. Biophys. Acta 1136. 169: Freeman, R.C, et al 1992. Biochem. Biophys. Acta 1136, 169; Merrill, A.H., Jr., Biochemistry 28, 3138 #2 Dobrowsky, R.T., and Hannun, Y.A., 1992 J.Biol. Chem., 267,5048: Ballou, L.R., et al., 1992 J. Biol. Chem. 267. 20044. #3 Kimura, S., et al 1992, Biochem, Pharmacol 44, 1585: Hanada K., ET al 1991 Biochemistry 30, 11682; Igarashi, Y, et al J. Bio Chem. 265, 5385 #4 Dobrowsky, R.T., and Hansin, Y.A., 1992: J. Bio. Chem 267,5048. #5 Matthias, S., et al, 1991 Proc. Natl. Acad. Sci. USA 88. 10009. #6 (AHA L-lactic acid and derivatives) Merck Index 11, 5216..



Jan 2017, from 1989,


CAMPO RESEARCH Pte Ltd

TECHNICAL SPECIFICATION

PRODUCT Name (Campo Research)

Other Trade Names(CampoResearch) CAMPO ALPHA-CERAMIDEIN

ALPHA-CERAMIDE COMPLEX

CTFA TRADE NAME ALPHA-CERAMIDE COMPLEX

Existing CTFA/INCI Name L-Lactic Acid (and) Ceramide 3

Chinese Translation 乳酸 (LACTIC ACID)

神经酰胺 3 (CERAMIDE 3)

CAMPO PRODUCT # 94-01-33AC

HS Code: 1302.19.0000

CTFA Monograph ID: 1399 – Lactic Acid

10447 – Ceramide 3

CAS#

CAS# EU

50-21-5 / 79-33-4 – Lactic Acid

50-21-5 (EU) – Lactic Acid

72068-43-5 / 100403-19-8 – Ceramide 3

100403-19-8 (EU) – Ceramide 3

EINECS Number and Name

EINECS# EU

200-018-0 (1) / 201-196-2 (1) – Lactic Acid


277-140-6 (1) / 309-560-3 (1) – Ceramide 3

309-560-3 (EU) – Ceramide 3

EINECS Number and Name

EINECS# EU

European Commission–Health & Consumer

Cosmetics–Cosing

Lactic Acid

http://ec.europa.eu/consumers/cosmetics/cosing/index.cfm?fuseaction=

search.details_v2&id=34809

Lactic Acid – 200-018-0 (EU)

Ceramide 3

http://ec.europa.eu/consumers/cosmetics/cosing/index.cfm?fuseaction=

search.details_v2&id=32498

Ceramide 3 – 309-560-3 (EU)

BATCH/LOT # See COA Batch Lot

PRODUCT DESCRIPTION STANDARDIZED CELL & FRUIT EXTRACT

PARTS USED TISSUE CULTURED CELL CERAMIDE COMPLEX < 1%

TOMATOES FRUIT ISOLATE - L-LACTIC ACID &

DERIVATIVES 5%

COMMENTS This novel cosmetic ingredient is manufactured from totally organic

cultivated raw materials from the Kampoyaki tissue culture labs and

hydroponic raceways in the Far East.

A Quality Management System, compliant to the International

Standard ISO 9001,was used to manufacture and test this material

*Please take note that all specifications are liable to changes

without prior notice.

Specification Parameter Analysis Specification Range Results Methods

Physical Form Liquid Conforms Visual

Colour Clear Colorless to Yellowish

Tint Conforms Visual

Odour Almost Odourless, with faint

characteristic sweet aroma Conforms Olfactory

http://ec.europa.eu/consumers/cosmetics/cosing/index.cfm?fuseaction=search.details_v2&id=34809






Jan 2017, from 1989,


Specific Gravity(20deg.C) 1.010 - 1.200 See COA USP XX IX/Paar,DMA35

Refractive Index(20deg.C) 1.355 - 1.370 See COA USP XX IX/DGF IV C (52)

pH(20deg.C.) (100% concentrate) 3.50 - 6.50 See COA USP XX IX/DGF H III (92)

Solvent Purified Distilled Water, 94.0% See COA -

Saponification Value - - -

Viscosity - - -

Dry Residue (160deg.C/2hrs) 12.0 - 18.0% See COA 2.5g - 105°CAMPO-15h

Preservation None Conforms -

Pesticide Content None Conforms Pflanzaniaschuttal 1989

Total Germs <100 CFU/ml Conforms USP XX IX/Ph.Eur.2.6.12(97)

Total Yeast/Mold <10 CFU/ml Conforms USP XX IX/Ph.Eur.2.6.12(97)

Heavy Metals(Total)As,Pb,Hg <0.60 ppm Conforms USP XX IX/Ph.Eur.2.6.12(97)

CAMPO RESEARCH Pte. Ltd, SINGAPORE CAMPO RESEARCH USA, INC SAN DEIGO CA 92111, & Manhattan, New York City, USA

CAMPO RESEARCH s.r.o., Brno, Czech Republic

CAMPO RESEARCH Pvt. Ltd, CHENNAI , INDIA CAMPO RESEARCH CANADA LTD, TORONTO, CANADA

MATERIAL SAFETY & CONSUMER SAFETY TESTING LABS.

DIV. OF JTC KAMPOYAKI SINGAPORE

EMERGENCY MATERIAL SAFETY / ACCIDENTAL RELEASE CENTER Contact: Emergency Tel.no: +(65)-63833202/63833631(24hours) /63228551/63228503

Emergency Fax No: +(65)-63833632(24hours),63824680, 63228558

EMAIL: [email protected]

Campo Alpha Ceramidien ©. © US. Library-of Congress 1989-2017 ©



Jan 2017, from 1989,


CAMPO R & D SYSTEMS

MICROBIOLOGICAL DATA SHEET

For products of this series defined as 94.01-33AC Alpha-Ceramidein:

These products meet the requirements for pharmaceutical preparation according to the DAB (German Pharmacopoeia) category 2:

Per 1ml: * Maximum 102 aerobic micro-organisms * Absence of enterobacteria * Absence of Pseudomonas aeruginosa * Absence of Staphylococcus aureus

The testing is carried out according to the DAB (V.2.1.8.1) and (2.1.8.2) Additional requirements for liquid products under DAB, category 3: are also met as follows:

Per 1ml: * Maximum 102 yeasts and molds * Absence of Escherichia Cole * Absence of Salmonella

1 (The testing for Salmonella is carried out with 50ml) CAMPO R&D SYSTEMS SINGAPORE.1ST AUGUST 1994.



Jan 2017, from 1989,


“(SAFETY DATA SHEET – compliant to GHS)”

CONFIRMS TO EC DIRECTIVE 91/155/EEC, EC REGULATION

NO#1272/2008, AMENDED EC REGULATION NO#790/2009 and Complies to

The EU Cosmetic Products Regulation (Regulation (EC) No 1223/2009) effective

on July 2013., and to EU Commission Regulation No.358/2014/9 of 9th

April 2014

amending Annexes II and V, to EU Regulation No No.1223/2009 of The European

Parliament and of The Council on Cosmetic products, (Effective Date 31st October

2014) AND to US DEPT.OF LABOR-Occupational Safety & Health Admin

directives and compliant to Globally Harmonized System of Classification and

Labeling of Chemicals (hereinafter referred to as “the GHS”)., and Complies and

Confirms to the Requirements of State of California Proposition 65. A Quality Management System, compliant to the International Standard ISO 9001, was used to manufacture and test this

material

http://www.osha.gov/dsg/hazcom/ghs.html

http://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html

http://www.hc-sc.gc.ca/ahc-asc/intactiv/ghs-sgh/index-eng.php

DATE OF FIRST ISSUE

DATE OF LATEST REVISION

February 10th 1992-Reviewer -

Dr Balasubramaniam PhD

Dec. 10th 1996- Rev’wer-

Dr Fergus Jes .G.Velasquez Bsc. Med Tech, MD

April 27th

2004 Asogan

February 10th

2012 – Reviewer=Joshua Teo

February 5th

2013 – Reviewer =

Balasubramaniam M PhD

12th

February 2015 - Joshua Teo BSc. Chem,

Balasubramaniam M PhD & Oksana Nemchenko MD

15th

May 2016 - Joshua Teo BSc. Chem,

Balasubramaniam M PhD & Oksana Nemchenko MD

1 PRODUCT AND COMPANY

IDENTIFICATION

COMMERCIAL NAME:

OTHER TRADE NAME:

CTFA ADOPTED NAME / INCI NAME:

Chinese Translation

INTERNATIONAL CHEMICAL

IDENTIFICATION

(EC REGULATION NO#1272/2008

AMENDED NO#790/2009)and Compliant

to the GHS

MANUFACTURER :

(cGMP MFG. FACILITIES) :

EMERGENCY TELEPHONE NUMBERS:

CAMPO ALPHA-CERAMIDEIN CAMPO CERAMIDE RW & L-LACTIC ACID COMPLEX

- Ceramidein (Alpha- ceramidein)

L-lactic acid (and) ceramide complex

乳酸 (LACTIC ACID)

神经酰胺 3 (CERAMIDES 3)

- Ceramidein (Alpha- Ceramidein)

L-Lactic acid

Ceramide Complex

CAMPO RESEARCH Pte Ltd

Level 30, 6 Battery Road

Singapore 049909.

(65)-63833631/(65)-63228503 (Singapore)

2 HAZARDS INDENTIFICATION

NOT CLASSIFIED AS DANGEROUS

ACCORDING TO DIRECTIVE 67/548/EEC OR

ITS AMENDMENTS.

DIVISION 1.6; NON-HAZARDOUS

NO HAZARD STATEMENT



Jan 2017, from 1989,


HAZARD CLASS and CATEGORY CODE(s)

HAZARD STATEMENT CODE(s)


AMENDED NO#790/2009) and compliant to

the GHS

GHS CLASSIFICATION :

This material is Non-hazardous according

To UN-GHS Criteria.

GHS LABEL ELEMENTS:

PICTOGRAM : NONE

No GHS Pictogram (Totally Non-Hazardous)

Division

1.6; NO HAZARD STATEMENT

PICTOGRAM : NONE


Division 1.6: No Hazard Statement.



3 COMPOSITION / INFORMATION ON

INGREDIENTS

TISSUE CULTURED CELL CERAMIDE

COMPLEX <1% & TOMATOES FRUIT

ISOLATE - L-LACTIC ACID &

DERIVATIVES 5% IN WATER

CTFA Monograph ID:

CAS#

CAS# EU

CAS NO# (CAS Name)


AMENDED NO#790/2009)and compliant

to the GHS

EINECS Name and Number

EINECS# EU

EINECS# (EINECS Name)


AMENDED NO#790/2009) and compliant

to the GHS

EINECS Name and Number

EINECS# EU

European Commission–Health & Consumer

Cosmetics–Cosing

RISK PHRASES

SAFETY PHRASES 25-26

GHS CLASSIFICATION :

This material is Non-hazardous according

To UN-GHS Criteria.

GHS LABEL ELEMENTS:

Lactic Acid

Ceramide 3

1399 – Lactic Acid

10447 – Ceramide 3

50-21-5 / 79-33-4 – Lactic Acid


72068-43-5 / 100403-19-8 – Ceramide 3

100403-19-8 (EU) – Ceramide 3

50-21-5 – Lactic Acid

100403-19-8 – Ceramide 3

200-018-0 (1) / 201-196-2 (1) – Lactic Acid


277-140-6 (1) / 309-560-3 (1) – Ceramide 3

309-560-3 (EU) – Ceramide 3

200-018-0 – Lactic Acid

309-560-3 – Ceramide 3

Lactic Acid

http://ec.europa.eu/consumers/cosmetics/cosing/index.cfm?fu

seaction=search.details_v2&id=34809

Lactic Acid – 200-018-0 (EU)

Ceramide 3

http://ec.europa.eu/consumers/cosmetics/cosing/index.cfm?fu

seaction=search.details_v2&id=32498

Ceramide 3 – 309-560-3 (EU)

None

Not mandatory

PICTOGRAM : NONE









Jan 2017, from 1989,


4 FIRST AID MEASURES

EYE CONTACT:

ORAL INGESTATION:

SKIN CONTACT:

Irritation of the eye immediately woth flowing water for 5

minutes is a good safety practice. Seek medical advice, if

irritation occur and persist.

Essentially edible in small quantities

Wash with water or shower.

5 FIRE FIGHTING MEASURERS

COMBUSTIBLE AND PRESENTS NO

SPECIAL FIRE HAZARD.

EXTINGUISHING MEDIA:

PROTECTIVE EQUIPMENTS FOR

FIGHTERS:

Treat as oil fire when store in HDPE drums with CO2, dry

foam or dry chemical.

Standard Equipments.

6 ACCIDENTAL RELEASE MEASURES

ABSORB ONTO AN INERT MATERIAL AND

SCRAPE UP. REMOVE RESIDUE BY

SCRUBBING WITH HOT WATER OR

DETERGENT SOLUTION.

7 HANDLING AND STORAGE

STORE IN SEALED CONTAINERS UNDER

DARK AND NORMAL COOL, DRY

WAREHOUSING CONDITIONS.

CRYSTALS WHICH MAY FORM DUE TO

LONG STORAGE OR LOW

TEMPERATURES HAVE NO EFFECT ON THE

QUALITY OF THE PRODUCT.

8 EXPOSURE AND PERSONAL PROTECTION

IN ACCORDANCE WITH GOOD

INDUSTRIAL PRACTICE AND HANDLING

USING STANDARD EYE PROTECTION.

9 PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL FORM:

COLOUR:

ODOUR:

BOILING POINT:

MELTING POINT:

VISCOSITY:

FLASH POINT:

FLAMMABILITY SOLID/GAS:

AUTO FLAMMABILITY:

SPECIFIC REFRACTIVE:

EXPLOSIVE PROPERTIES:

pH (20deg.C) (100% Concentrate)

OXIDIZING PROPERTIES:

VAPOUR PRESSURE:

DENSITY: (20 deg. Cent.)

WATER SOLUBILITY:

OTHER SOLUBILITY:

BULK DENSITY:

PARTITION COEFFICIENT:

(OCTANOL/WATER)

EXPLOSIVE LIMITS:

Liquid

Clear Colorless to Yellowish Tint

Almost Odourless, with faint characteristic sweet aroma

100 deg. cent.

-

-

Closed cup

N/A

N/A

1.355 - 1.370

N/A

3.50 - 6.50

N/A

N/A

1.010 - 1.200

COMPLETE

In most cosmetic solvents

-

-

10 STABILITY AND REACTIVITY

THERMAL DECOMPOSITION: Stable. Hazardous Polymerization will not occur.

11 TOXICOLOGICAL DATA Animal Tests Last Done 1992, as requirements of the then EC

DIRECTIVE 91/155/EEC

ORAL:

LD50 > 36,000 MG/KG (Body Wt.) Rat

Essentially Non-Toxic and Edible in Small Quantity.



Jan 2017, from 1989,


DERMAL:

INHALATION:

SPECIFIC CONCENTRATION LIMITS

M-FACTORS


AMENDED NO#790/2009) compliant to

the GHS.

TOXIC EFFECTS:

SKIN:

EYE:

Expected To Be Essentially Non Toxic.

Slight Ethanolic Sting – irritation

36,000 MG/KG (Body Wt.); CATEGORY 5

Essentially Non-Toxic and Edible in Small Quantity.

Primarily Irritation Index (PII) = 0.0 ( Non- Irritating -

Skintex ), Not A Primarily Irritant.

Non-irritant / Non-sensitizer as per Repeated Patch Insult

Test on 50 Human volunteers.

Human Repeated Patch Test 48 hours:

50/50 completely non-irritating / non-erythema causing

ingredient at 10% concentrate in water on 50 human

volunteers

Very Mild/Minimal - Not A Transient Conjunctival Irritant at

10% concentrate in water (Eyetex - Eyetex classification).

Summarized toxicological data as shown here are formation

bounded under Non-Disclosure Agreement with various

clients as when these Toxicological Data were established or

their exclusive uses.

12 ECOLOGICAL INFORMATION

BIODEGRATION:

FISH TOXICITY:

BACTERIAL & VIRAL TOXICITY:

WGK CLASS:

Expected to be ultimately biodegradable.

No data

No data

WGK (Self Classification)

13 DISPOSAL CONDITIONS

DISPOSE OFF ACCORDING TO A

RECOGNISED METHOD OF CHEMICAL

WASTE DISPOSAL.

14 TRANSPORT INFORMATION

UN NUMBER# :

UN NAME:

IMDG CODE/CLASS:

IMDG CODE PAGE NO.

ICAO/IATA AIR CLASS:

ICAO/IATA AIR CLASS PACKING GROUP:

RID/ADR CLASS:

ADNR CLASS:

LABELLING:


AMENDED NO#790/2009) and compliant to

the GHS.

PICTOGRAM SIGNAL WORD CODE(s):

HAZARD STATEMENT CODE(s):

SUPPLEMENTARY HAZARD

STATEMENT CODE(s):

N/A

Not Assigned

Not Hazardous

N/A

Non-Hazardous

N/A

Non-Hazardous

Non-Hazardous

No GHS Pictograms (Totally Non-Hazardous)

Division 1.6; No Hazard Statement

Similar Division 1.6; No Hazard Statement

15 REGULATORY INFORMATION

OCCUPATIONAL EXPOSURE LIMITS: N/A

16 OTHER INFORMATION

USES AS A COSMETIC ADDITIVE

5 -8 %

*Please take note that all specifications are liable to

changes without prior notice.

Campo Alpha Ceramidien ©. © US. Library-of Congress 1989-2017 ©



Jan 2017, from 1989,


MATERIAL SAFETY AND CONSUMER PRODUCT

SAFETY TESTING LABS. (DIVISION OF JTC KAMPOYAKI, SINGAPORE)

REPUBLIC OF SINGAPORE

F I N A L R E P O R T

DIVISION / COMPANY/ GROUP: ONES CO. Ltd. Shin-Hwa Bldg., 805-1-34 Mapo-dong, Mapo-ku, Seoul, Korea

ATTENTION: Mr. D.H. Lee - President

TEST: The MATREX In Vitro Toxicity testing system Salmonella Typhimurium Reverse Assay

TEST ARTICLE: ALPHA-CERAMIDEIN EXPERIMENT REFERENCE NO: 1994 - 9 -10

________________________ __________________________

Dr. Fergus Jes Velasquez, M.D*. Dr. Balasubramaniam M, Ph.D.* Director of Microbiology Laboratory Director

Date: Oct. 19th, 1994 This report is submitted for the exclusive use of the person, partnership, or corporation to whom it is addressed and neither the report nor the name of these Laboratories nor of any member of its staff may be used in connection with the advertising or sale of any product or process without written authorization. *Computer generated requires no signature



Jan 2017, from 1989,


OBJECTIVE:

To evaluate the test article for irritancy potential utilizing the MATREX in vitro toxicity testing system.

INTRODUCTION:

TESTSKIN and MATREX are sophisticated in vitro systems. Developed in Organogenesis Inc. of Cambridge, Massachusetts, they closely mimic human skin in structure and function. The Living Dermal Matrex (LDM) consists of a three-dimensional construct comprised of living cells in a collagen matrix. Nutrition is provided through the base via a permeable membrane, leaving the surface open to the atmosphere. This makes an ideal system for applying a variety of materials, including liquids, powders, oils, gels and creams. The Living Skin Equivalent (LSE) has all the features previously described, plus the formation of an actual epidermis complete with stratum corneum.

TESTSKIN and MATREX, when used with the recommended cell metabolism assay can quickly provide toxicological profiles. The procedure involves a solubilized, reactive tetrazolium salt (MTT), which is metabolized by the mitochondria of living cells and converted to a purple formazan dye. The color intensity of the skin replica extract, measured photometrically, correlates directly with its viability. When measured against controls, values ranging from 0% to 100% (plus or minus approximately 20%) can be calculated for each dose of an applied substance.

Test Article: CAMPO CERAMIDE RW& AHA 1 - LACTIC ACID Reference Articles: PROPYLENE GLYCOL & MORPHOLINE



Jan 2017, from 1989,


METHOD:

The appropriate dilutions of test sample and control articles were applied to MATREX. After the appropriate exposure period, the articles were rinsed from the MATREX surfaces. MTT (tetrazolium salt) assay medium was utilized in order to quantify cell metabolism. At the end of the staining period, excised portions of each MATREX were immersed in acidified isopropanol, which extracted the converted MTT from tissue samples. A Dynatech MR 4000 Automatic Microplate Reader was used to determine the absorbance of each extract at 570 nm. With the absorbance of a negative control defined as 100%, the percent absorbencies of the test and control articles were determined. The percentages listed below directly correlate with the cell metabolism in the MATREX samples.

RESULTS:

Test Article Percent Percent (% & Exposure) System Viability Inhibition

Campo Ceramide RW & AHA l-lactic

(100% - 1 hr.) LDM 90% 10% (10% - 1 hr.) LDM 88% 12% (1% - hr.) LDM 91% 9%

Propylene glycol (100% - 1 hr.) LDM 73% 27% (10% - 1hr.) LDM 99% 1% (1% - 1hr.) LDM 96% 4%

Morpholine (100% - 1hr) LDM 6% 94% (10% - hr.) LDM 4% 96% (1% - hr.) LDM 100% 0%

HISTORICAL IN VITRO RESULTS: Propylene glycol has historically been categorized as virtually non-irritating when tested using the Draize irritation methodologies. Morpholine has been categorized as moderately irritating when tested in the same manner. DISCUSSIONS: The sponsor-submitted sample elicited in vitro results comparable to those recorded for propylene glycol.

CONCLUSION: The results indicate that the sponsor-submitted product has virtually no irritation potential, under the conditions of this test.



Jan 2017, from 1989,


CCR-Cytotest Cell Research

CCR PROJECT 95

SALMONELLA TYPHIMURIUM

REVERSE MUTATION ASSAY

REPORT ON

Study Completion Date:

March. 03, 1993



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Test Report CCR Project 32

CONCLUSIONS

The test article Campo Alpha-Ceramidein was assessed for its potential to induce gene mutations according to the plate incorporation test (experiment I) and the pre-incubation test (experiment II) using Salmonella typhimurium strains TA 1553, TA 1537, TA 100 and TA 102. The assay was performed in two independent experiments both with and without liver microsomal activation. Each concentration, including the controls, was tested in triplicate. The test article was tested at the following concentrations: 33.3; 100.0; 333.3; 1000.0; 2500.0; and 5000.0 ug/plate

No toxic effects occurred in the test groups with and without metabolic activation in experiment I and II in all strains used. The plates incubated with the test article showed normal background growth up to 5000.0 ug/plate with and without S9 mix in all strains used. No substantial increases in revertant colony numbers of any of the five tester strains were observed following treatment with Campo Alpha Ceramidein at any dose level, either in the presence or absence of metabolic activation (S9 mix). There was also no tendency of higher mutation rates with increasing concentrations in the range below the generally acknowledged border of significance. A slight decrease (0.001%) in revertant colony numbers was observed in strain TA 102 at 333.3 and 1000.0 ug/plate in experiment I in the presence of metabolic activation. However, this effect is considered not to be relevant since it could not be reproduced in the normally more sensitive pre-incubation assay. Appropriate reference mutagens were used as positive controls and showed a distinct increase in induced revertant colonies. In conclusion, it can be stated that during the described mutagenicity test and under the experimental conditions reported, the test article did not induce point mutations by base pair changes of frameshifts in the genome of the strains used.



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Toxicological Profile

Toxicological: LD50 Dose

Rat oral 24,000 mg / kg body weight Mucous membrane sublingual 18,000 mg / kg body weight Mice oral 32,000 mg / kg body weight Human volunteers 50 7 days repeat -patch insult test - Non-erythema

- Non-irritating Human volunteers 100 oral ingestion of 25 grams @ day - Essentially non-toxic edible For 30 day as grain alcohol USP (5%) Based drink

Tolerance exhibited by Campo Alpha-Ceramidein

So as to ensure a good level of innocuity Campo Alpha-Ceramidein was tested in vitro as follows: Irritation potential of the chorioallantoic membrane of an egg. When tested on the chorioallantoic membrane of a chicken egg, according to The technique developed by LUEPKE in a 30 % active aqueous solution. Campo Alpha-Ceramidein is classified as non-irritant. LUEPKE, N.P., Hen’s egg chorioallantoic membrane test for irritation potential. Fd. Chem.1986, 24, 6-7, 495-496. Cytotoxicity on human fibroblasts When tested on human fibroblasts using a method patented by BIOGIR (which can be applied to hydrosoluble products as well as to liposoluble). Campo Alpha-Ceramidein in a 30 % active Aqueous phase or oily phase does not show any signs of toxicity towards fibroblasts in a culture.

Eyetex According to this technique, in a 10% active solution. Campo Alpha-Ceramidein is classified as Non-irritant. * Skintex According to this technique, in a 10% active solution, Campo Alpha-Ceramidein is not irritant. This tolerance data is confirmed by the tests carried out in vivo on healthy humans.



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Test on healthy humans

When patch test were carried out at increasing concentrations (0.5%, 1.1%, 2.2%, 4.7%,10% and 100%) on 10 subjects, Campo Alpha-Ceramidein did not show any significant irritating Reaction its tolerance is satisfactory.

COMEDOGENSIS

Campo Alpha-Ceramidein tested in a 10% active solution on human volunteers, according to the usual protocols has proved to be free of comedogenic effect. Because of its good level of innocuity, Campo Alpha-Ceramidein has proved to be a first class skin moisturizer for very Many skin-moisturizing formulae where tolerance is imperative (dermatological cream, anti-acne cream, baby cream, face Whitening, moisturizers, moisturizing cream, whitening essence, moisturizing lotion, etc.)

BIODEGRADABILITY

The ultimate aerobic biodegradability of Campo Alpha-Ceramidein is measured according to STURM test

(OCDE 301 B, guideline EEC 84/449, Annex V, Method C5). Under this condition a level of biodegradability of Campo Alpha-Ceramidein is 100% in 28 days, at 500 mg/l. The level of biodegradability of Campo Alpha-Ceramidein is considered to be excellent…



Jan 2017, from 1989,


CAMPO SCIENCE BEHIND THE ALPHA-CERAMIDEINTM

Modern laboratory and analytical facilities BIOTECHNOLOGY CERAMIDE ISOLATION PLANT FACILITIES

CAMPOTM PURE CERAMIDE

IMUNNODOT WITH BCIP/NBT DETECTION ON BA 85.200 UL SAMPLES CONTAINING A DILUTION SERIES OF CERAMIDE ISOLATED FROM OLIVE FRUIT CELLS (21

ST GENERATION) WHICH ARE PREVIOUSLY MOLECULAR

CLONED WITH HUMAN CERIMIDE GENOMIC GENES WERE APPLIED TO BA 85 BY VACUUM-FILTERATION (S & I Minifold I). AFTER BLOCKING WITH A 3% BSA, A 1 ug/ml SOLUTION OF A MONOCLONAL ANTI-CERAMIDE KNIASE ANTIBODY WAS ADDED THE MEMBRANE AND ALLOWED TO BIND. THE MEMBRANE WAS THAN WASHED AND INCUBATED WITH A 1: 10,000 DILUTION OF AN ALKALINE PHOSPHATASE-CONJUGATED 1Gg. AFTER WASHING, THE BLOT WAS DEVELOPED USING THE 5-BROMO-4-CHLORO-3 –INDOYL PHOSPHATE (BCIP) INTRO BLUE TRTRAZOLIUM (NBT) SUBSTRATE SYSTEM.

CAMPO CERAMIDE COMPLEX IS BIOTECHNOLOGICALLY PRODUCED FROM OLIVE CELLS MOLECULAR CLONED WITH DIEASE AND DEFECTIVE FREE HUMAN GENNOMIC DNA TO PRODUCE IDENTICAL HUMAN SKIN CERAMIDE.

CAMPOTM

REINFORCED PURE CERAMIDE

NON-ISOTOPIC DETECTION OF THE xba I SATELLITE REPEAT SEQUENCE IN OLIVE FRUIT MOLECULAR CLONED HUMAN GENOMIC DNA IMMOBILIZED ON BA-S 85. GENOMIC DNA WAS PREPARED FROM A SINGLE INDIVIDUAL BY A MODIFICATION* OF THE GENOMIC DNA ISOLATION PROCEDURES DETAILED IN THE S&S ELU-QUIK KIT INSTRUCTIONS. THE ISOLATED NOVEL DNA (5ug) FROM 3 DIFFERENT PREPARATION WAS DIGESTED WITH xba (10 units/ug) FOR 2 HOURS, ELECTROPHORESED IN A 1 AGAROSE GEL AND TRANSFERRED TO A BA-S 85 MEMBRANE. HYBRIDIZATION WAS PERFORMED WITH 200 Ng/ml DIGOXIGENIN LABELLED Pxe 1 (A PLASMID CONTAINING- THE 682 bp Xba 1 REPEAT SEQUENCE) AND DETECTED WITH AN ALKALINE PHOSPHATASE CONJUGATED ANTI-DIGOXIGENIN ANTI-BODY USING THE BCIP/NBT SUBSTRATE SYSTEMS

* Bush, C & Harvey, M Rapid Isolation of Gnomic DNA forms Olive Cells by binding to borosilicate particles (1991) 43

rd

Nation meeting of the American Asso. For Clinical Chemistry

Ng

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ram

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kin

ase



Jan 2017, from 1989,


GEL ELECTROPHORESIS ANALYSIS OF ISOLATED GENOMIC DNA OF CERAMIDE DNA WAS ISOLATED FROM SKIN (LANE 1TO 4), FROM OLIVE CELLS (LANE 5 TO 8, FROM OLIVE –HUMAN MOLECULAR CLONED CELLS (9 TO 14). THE ISOLATED DNA WAS ELECTRO-PHORESED THROUGH A 0.6% GEL AT 30 V FOR 8 HOUR.


While You Spent Few Hours doing this to the Vegetable Ceramide

PCR* ANALYSIS OF ISOLATED GENOMIC DNA OF CERAMIDE DNA WAS ISOLATED FROM OLIVE-HUMAN MOLECULAR CLONED CELLS (LANE 5 TO 8), FROM OLIVE-HUMAN MOLECULAR CLONED CELLS (9 TO 10) USING THE PURE GENE DNA ISOLATION KIT AND TESTED IN A PCR DNA AMPLIFICATION ASSAY. PRIMERS SPECIFIC FOR CONSERVED C-# LIKE HUMAN CERAMIDE RIBOSOMAL SEQUENCES WERE USED TO AMPLY 100ng ISOLATED DNA OVER CYCLES. * THE PROCESS (PCR) IS COVERED BY US PATENTS OWNED BY HOFFMAN- LAROCHE INC.



Jan 2017, from 1989,


LOOK AT ALL WE’VE BEEN UP TO WITH BIOTECHNOLOGY CERAMIDE




Jan 2017, from 1989,


WHAT OUR BIOTECH CERAMIDE CAN DO???

UNDER THE MICROSCOPE AT THE SKIN CERAMIDE LOSS SKIN CERAMINDE ENHANCEMENT

MOLECULAR LEVEL IN AN AGING SKIN IN AGING SKIN. AFTER 2 X DAILY APPLICATION FOR 48 DAYS.


THE L-LACTIC ACID STORY OF THE MILDEST BUT MOST EFFECTIVE OF THE AHAS’ FOR YOUNG SKIN RE-JUVENATION & RE –VITALIZATION

TISSUE –CULTURED YOUNG TOMATO PLANTS IN LIQUID GROWTH MEDIUM

AN UNIQUE STRAIN OF TOMATO PLANT THAT GROWS WITH A WOODY TRUNK TO A HEIGHT OF 2 METERS THE TOMATO TREES ARE GROWN IN HYDROPHONIC RACEWAYS.



Jan 2017, from 1989,


THE L-LACTIC ACID IS ISOLATED AT 400 TIMES OVER THAN OF A REGULAR TOMATO PLANT’S FRUIT: FROM OUR TREE TOMATO FRUITS.

THIS HIGH YIELD OPTIMIZATION IS CONTROLLED AT THE ROOT LEVEL VIA

PROPRIETARY ROOT TEMPERATURE CONTROL TECHNIQUE.


THE L-LACTIC ACID STORY OF THE MILDEST BUT MOST EFFECTIVE OF THE AHAS’ FOR YOUNG SKIN RE-JUVENATION & RE-VITALIZATION. AN UNIQUE STRAIN OF TOMATO PLANT THAT GROWS WITH A WOODY TRUNK TO A HEIGHT OF 2 METERS – THE BIOTECH TOMATO TREES – ARE GROWN IN HYDROPHONIC RACEWAYS. THE L-LACTIC ACID ARE ISOLATED AT 400 TIMES OVER THAN THAT OF A REGULAR TOMATO PLANT’S FRUIT: FROM OUR TREE TOMATO FRUITS. THIS HIGH YIELD OPTIMIZATION IS CONTROLLED AT THE ROOT LEVEL VIA PROPRIETARY ROOT TEMPERATURE CONTROL TECHNIQUE. FEAST THE EYES ON

CAMPOTM TOMATO TREES!!!!



Jan 2017, from 1989,



ALPHA HYDROXY ACIDS – L-LACTIC ACID AND CERAMIDE = CAMPOTM ALPHACERAMIDEIN

WHAT CAN CAMPOTM ALPHA-CERAMIDEIN DO ????

SCHEMATIC DIAGRAM OF CELL ATTACJMENT (A, B) VS CELLS SPREADING © OF CELL TO CELL ADHESION OF

TYPICAL FIBROBLAST ON A TWO-DIAMENSIONAL SUBSTRATUM. DURING CELL ATTACHMENT, NEWLY FORMED

CELL (A) IS SOMEWHAT SPHERICAL. WITH TIME OF 50 DAYS, FOCAL ADHESIONS DEVELOP (B, PROFIL-VIEW).

FLATTENED LAMELLAE (C) ARE TYPICAL OF A CELL WHICH HAS ATTACHED AND SUBSQUENTLY SPREAD ON THE

SUB-STRATUM, WITH 50 DAY X TWICE DAILY APPLICATION OF 10% ALPHA-CERAMIDEIN IN A INERT

COSMETIC BASE. ON APPLICATION FIRST… THAN.. The active ingredients penetrate Reduction in cellular cohesion: the A message is received by the skin dead cells begin to dissociate. basal Cell layer, new cells

begin to replace the dead cells progressively.



Jan 2017, from 1989,



WHAT OUR CAMPOTMALPHA-CERAMIDEIN CAN DO???

NEW LOOK NEW BEGINNINGS WITH 10% CAMPOTM ALPHA-CERAMIDEIN

AFTER - 10 % CAMPOTM

ALPHA-CERAMIDEIN IN AN INERT COSMETIC BASE. TWICE DAILY FOR 14

DAYS

REDUCTION OF THE APPEARANCE OF FINE LINES, WRINKLES, AGE SPOTS, AND OTHER SIGNS OF AGING.

BEFORE- THE APPLICATION OF 10 % ALPHA CERAMIDEIN CRÈME

30 DAYS APPLICATION WITH 10% ALPHA-CERAMIDEIN

TM



Jan 2017, from 1989,



THIS IS WHAT CAMPOTMALPHA-CERAMIDEIN DID

AT MOLECULAR LEVEL OF THE AGING SKIN!!!!

0.2 um 4000x

0.2 um 4000x

0.1 um 4000x

WEEKS

7-------------------------------------------------------------------------------------

6 5 4---------------------------------------------------------- 3 2------------------------------------ 1

0 10 20 30 40 50 60 70 80 90 100 (%)

DISAPPEARANCE OF SKIN FINE LINES & WRINKLES, AGE SPOTS, AND OTHER SIGNS OF AGING

BEFORE- LOSS OF THE SKIN CERAMIDE, POOR CELL ADHESION AND DISARRAY OF CELL FORMATION WHICH CAUSE LOSS OF WATER RETENTION, FINE LINES, WRINKLES, AGING SPOTS AND OTHER SIGNS OF AGING.

AFTER – 10% CAMPO ALPHA-CERAMIDEIN IN AN INERT COSMETIC BASE FOR 18 DAYS OF TWICE DAILY APPLICATIONS, SIGNS OF PROGRESSIVE IMPROVEMENT.

AFTER – 10% CAMPO ALPHA-CERAMIDEIN IN AN INERT COSMETIC BASE, APPLIED 30-50 DAYS – TWICE DAILY; SIGN OF TOTAL PROGRESS IN CELL CERAMIDE MOISTURIZATION, WATER-RETENTION; COMPLETE CELL-ADHESION, AND FORMATION OF NEW CELLS



Jan 2017, from 1989,



TO BE A SUCESSFUL END-COSMETIC FORMULATION IN THE COSMETIC MARKET

FORMULATION CONCEPTS WITH CAMPOTM ALPHA-CERAMIDEIN

ALPHA-CERAMIDEINTM EYE GEL A CAMPOTM CHINESE NUCHEN 1,3-BG EXTRACT 30.00 CAMPOTM CHINESE I TUNG 1,3-BG EXTRACT 30.00 CAMIGEL 20.00 B CAMPOTM SEAWATER 100.00 CAMPO AQUEOUS I TUNG EXTRACT 50.00 CAMPO AQUEOUS NUCHEN EXTRACT 80.00 C ALPHA-CERAMIDEIN 1.00 2-BROMO-2-NATROPROPANE 1,3 DIO 0.50 CAMPOTM BROAD SPECTRUM PLANTSERVATIVE 1.00 PROCEDURE BLEND A; ADD B AND STIR; ADD C AND STIR.

HOW TO PREPARE LIQUID ALPHA-CERAMIDEIN GEL

+ DISPERSE 10GM OF CAMIGEL POWDER IN 20GM OF CAMPOTM 1,3-BG EXTRACT + ADD 965GM OF CAMPOTM SEAWATER (HEATED TO 40-45 DEGREES CENT.) UNDER STRONG AGITATION; ADD 5-10% CAMPOTM ALPHA-CERAMIDEIN UNDER STRONG AGITATION + LEAVES IT TO COOL UNTIL THE GEL IS OBTAINED THE GEL IS NO MORE OPALESCENT BUT HARDER THAN THAT OBTAINED WITH CARBOPOL 940 AT THE SAME LEVEL OF USE

CAMIGEL WITH 5-10% CAMPOTM ALPHA CERAMIDEIN ABLE TO FORM A GEL WITHOUT BEING NEUTRALIZED



Jan 2017, from 1989,


CAMPO SCIENCE BEHIND THE ALPHA-CERAMIDEINTM WHAT OUR CAMPOTMALPHA-CERAMIDEIN CAN DO???

BEFORE – THE APPLICATION OF 10% ALPHA-CERAMIDEIN CRÈME ON FACIAL SKIN & HANDS



Jan 2017, from 1989,


AHA - Ceramide complex for clear formulations

Alpha-Ceramidein a skin care ingredient has been developed by Campo Research and Development of Singapore. It is said to be an answer to the problem of formulating clear AHA-Ceramide systems for advanced skin care.

Facial cosmetics based on sour milk have been used since ancient Egyptian times. The main active ingredients are believed to be the alpha-hydroxy acid (Ahas) predominantly lactic acid and its derivatives. Ahas are naturally occurs substances isolated from a variety of sources, such as sour milk, sugar cane, tomatoes and other fruits. They perform a number of functions at the level of stratum corneum on the skin’s surface. There are many different kinds of AHA, and Campo says that some out-perform others. Intensive research has identified lactic acid, particularly the L- isomer, as one of the most effective forms. Campo’s L-lactic is isolated from tomatoes cultivated by hydroponics. Ceramides are found in the human skin and comprise 43-46% of the stratum corneum where they play a major role as a water retention barrier.

They include sphingosines and fatty acids, and are generally linked with sugars to form structures called glycosphingolipids. Six kinds of ceramides have now been identified in human skin. Campo’s Ceramide RW is a new complex of biologically engineered material, truly identical to human skin ceramides. It is a spin-off from the p34 cde2 (gene expression) re, especially on skin cancer proliferation and down regulation activities of some natural products, which has been carried out by Kampoyaki Research, Singapore. Since Elizabeth Arden’s Alpha-ceramide 4 steps hit the market in the summer of 1994, many cosmetics raw materials suppliers have been trying to produce a clear, colorless ceramide liquid base that is soluble in ethanol and water. These efforts have been unsuccessful except for a couple of vegetable ceramide powder types with poor stability. These turn into cloudy liquids from which it is virtually impossible to formulate a clear, colorless product.

Alpha-Ceramidein is distributed in Europe and USA Contact Campo Research, Singapore; Tel: (65)-63833631 / Fax: (65)-638338632 For a list of representative(s) in your area Reprinted with permission MANUFACTURING CHEMIST, FEBRUARY 1995. Page 39.

A



Jan 2017, from 1989,


DISCLAIMER: The information contained herein is accurate to the best knowledge and belief of Campo Research Pte Ltd, and specification quoted may change without prior notice. Information contained in this technical literature is believed to be accurate and is offered in good faith for the benefit of the customer. The company, Campo Research Pte Ltd, however, cannot assume any liabilities or risks involved in the use of its natural products or their derivatives or raw materials or ingredients, since the conditions of use are beyond Campo Research Pte Ltd’ s control. Statements concerning the possible use are not intended as recommendations to use our materials in the infringement of any patents or infringements of mandatory regulatory requirements or without any safety evaluations conducted when used in combination with materials of other suppliers. We make no warranty of any kind, expressed or implied, other than that the material conforms to the applicable standard specifications. Campo Research Pte Ltd accepts no liabilities of whatsoever either expressed or as otherwise arising out of the information supplied, the application, adaptation or processing of the products described herein, or the use of other materials in lieu of the Campo materials or the use of Campo raw materials or ingredients in conjunction with any other products and raw materials. The use of Campo Research Pte Ltd's raw materials or ingredients in any formulations are to be compulsory tested and to be assayed for safety and toxicology profiles evaluations and according the mandatory regulations as required by the laws and regulations of the countries where the evaluation and use of Campo Research Pte Ltd's raw materials or ingredients has been formulated as single components in any carrier systems or as in multi-components formularies. The end-users, marketers; manufacturers, formulation laboratories or importers of Campo Research Pte Ltd' raw materials and ingredients which are incorporated into any formularies as formulated or re-sold or re-exported or assayed in accordance with any mandatory regulatory requirements of any country or infringement of any patents assume all liabilities as that may arise out of the use of Campo Research Pte Ltd's raw materials and ingredients in any formularies in combination with raw materials and ingredients of other suppliers or as single components in any carriers. The definition of users as mentioned in these instances are manufacturers, marketers, formulation laboratories, consultants, and importers assumed all liabilities arising as either personal injuries suits, infringements of patents suits, infringements of or failures to meet regulatory requirements suits of a formulary either as single components in any carrier systems or in as multi-components formularies in which are may consist of a Campo Research Pte Ltd's raw material or ingredients.

IMPORTANT NOTICE Specifications may change without prior notice. Information contained in this technical literature is believed to be accurate and is offered in good faith for the benefit of the customer. The company, however, cannot assume any liability or risk involved in the use of its natural products or their derivatives, since the conditions of use are beyond our control. Statements concerning the possible use are not intended as recommendations to use our products in the infringement of any patent. We make no warranty of any kind; expressed or implied, other than that the material conforms to the applicable standard specifications.

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