truscreen
TRANSCRIPT
TRUSCREEN
TRUSCREEN
Light at specific frequencies is
transmitted through cervical
tissue for identifying changes
in the basal and stromal layers.
This includes increases in
blood circulation and variations
in blood vessels that occur with
pre-cancerous change.
PRINCIPLE
The system also assesses the electrical properties and response of the tissue.
The electrical measurements are stimulated by the delivery of a very small impulse (about one volt) in millisecond pulse sequences that repeat 14 times per second.
The decay response curve will vary according to the capacitance of the tissue - a measurement of the ability of the tissue to either hold or dissipate a charge
ANALYSIS
The console has a microcomputer to calculate these tissue differences, and the results are compared with an integrated database of 2,000 patients from wide geographic and ethnic backgrounds with differing histological diagnoses.
A sophisticated algorithm framework has been developed to distinguish between normal and abnormal (cancerous and precancerous) tissue.
In a multi centre study, TruScreen was shown to detect precursors of cervical cancer (CIN 1-3) at an equivalent sensitivity to a standard Pap smear.
CLINICAL PERFORMANCE
Objective
Devoid of human error in interpretation
Comparable sensitivity and specificity
Immediate report
Uniformity
ADVANTAGES
It uses a handpiece with optical sensors that emit a number of discrete wavelengths in the visible infrared regions of the spectrum as well as an electrical biosensor to stimulate cervical tissue
Up to 24 sites are sampled during the examination
TECHNIQUE
Optical test plug Optical handpiece loaded with SUS(Single Use Sensor )
READY FOR THE TEST
The device then analyses back scattered light, direct reflectance and electrical response curves of the tissue and these are compared with existing database of demographically matched tissue signatures
Results are available instantly
RESULTS
Truscreen is used in conjunction with Pap test to improve accuracy
More trials required