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The New England Journal of Medicine Downloaded from nejm.org at UNIVERSITY OF WINDSOR on July 12, 2014. For personal use only. No other uses without permission. Copyright © 1993 Massachusetts Medical Society. All rights reserved.

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The New England Journal of Medicine Downloaded from nejm.org at UNIVERSITY OF WINDSOR on July 12, 2014. For personal use only. No other uses without permission.

Copyright © 1993 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UNIVERSITY OF WINDSOR on July 12, 2014. For personal use only. No other uses without permission.

Copyright © 1993 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UNIVERSITY OF WINDSOR on July 12, 2014. For personal use only. No other uses without permission.

Copyright © 1993 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UNIVERSITY OF WINDSOR on July 12, 2014. For personal use only. No other uses without permission.

Copyright © 1993 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UNIVERSITY OF WINDSOR on July 12, 2014. For personal use only. No other uses without permission.

Copyright © 1993 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UNIVERSITY OF WINDSOR on July 12, 2014. For personal use only. No other uses without permission.

Copyright © 1993 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UNIVERSITY OF WINDSOR on July 12, 2014. For personal use only. No other uses without permission.

Copyright © 1993 Massachusetts Medical Society. All rights reserved.