TREA

TMEN

T COMPA

RISON

Trea

tmen

t typ

e -Fo

r mod

erate

to sev

ere ps

oriasis an

d ps

oriatic

ar

thritis

Otezla

Metho

trex

ate

Cyclosp

orine

Soriatan

e

Indica

tion

- W

hich

disea

ses the

drug

trea

tsPso

riatic arthr

itis

Orally

via ta

blet

Pso

rias

isPso

riatic arthr

itis

Pso

rias

isPso

rias

is

Metho

d of deliver

y - How

the dr

ug

is given

or take

nOrally

via liqu

id or pill or by

subc

utan

eous

injection

Orally

via liqu

id or ca

psule

Orally

via cap

sule

Freq

uenc

y - How

often

the dr

ug

mus

t be take

n30

mg tw

ice da

ilyOnc

e pe

r wee

k; dos

es m

ay be

divide

d an

d take

n three tim

es

over 24 ho

urs

Daily

Daily

Dur

ation - How

long

the dr

ug

mus

t be take

nCon

tinuo

usly to

maintain resu

ltsCon

tinuo

usly to

maintain resu

lts

Up to one

yea

r max

imum

Con

tinuo

usly to

maintain resu

lts

Com

mon

side effects - A side

effect is

an un

desirable se

cond

ary

effect of a

med

ication. Side effects

may var

y for ea

ch in

dividu

al

depe

nding on

disea

se state, a

ge,

weigh

t, ge

nder, e

thnicity and

ge

neral h

ealth. All med

ications

ha

ve side effects.

Nau

sea

Diarrhe

a Hea

dach

e

Nau

sea

Tiredn

ess

Diffi

culty slee

ping

Ligh

t hea

dedn

ess

Mou

th ulcers

Vo

miting

Hea

dach

e Ea

sy bru

ising

Fe

ver

Chills

Dec

reas

ed kidne

y func

tion

Hea

dach

e High bloo

d pres

sure

High ch

oles

terol

Sk

in sen

sitiv

ity

Flu-

like sy

mptom

s Ups

et stomac

h Tiredn

ess

Mus

culosk

eletal pain

Hair loss

Cha

pped

lips

Dry skin

Bleed

ing gu

ms

Pee

ling fin

gertips

Cha

nges

in blood

-fat le

vels

Dep

ress

ion

Hea

dach

e Jo

int p

ain

Pos

sible risk

s - T

he pos

sible

risk

s lis

ted includ

e se

riou

s ad

verse ev

ents th

at have be

en

repo

rted

in ass

ociatio

n with

thes

e med

ications

dur

ing an

d after

clinical tr

ials.

Une

xplained

weigh

t loss

Liver da

mag

e Birth defec

ts Red

uced

white blood

cell c

ount

Increa

sed toxicity in

patients

w

ith poo

r kidn

ey fu

nctio

n

Kidne

y da

mag

e Sk

in m

aligna

ncies

Hyp

ertens

ion

Exces

sive hair grow

th Trem

or

Birth defec

ts Elev

ated

cho

lesterol

Liver da

mag

e

Mon

itor

ing -So

me ad

verse

reac

tions

can

be de

tected

by

labo

ratory te

sts su

ch as bloo

d co

unts or liv

er fu

nctio

n tests.

Non

eCom

plete bloo

d co

unt

Che

m scree

n (liver, kidn

ey

func

tion)

Occ

asiona

l liver biops

ies

Blood

press

ure mon

itoring

Kidne

y func

tion mon

itoring

Liver en

zyme testing

Cho

lesterol scree

ning

Triglyce

ride

mon

itoring

Apre

mila

st

Nat

iona

l Pso

rias

is F

ound

atio

n ed

ucat

iona

l mat

eria

ls a

re m

edic

ally

rev

iew

ed a

nd a

re n

ot in

tend

ed to

rep

lace

the

coun

sel o

f a p

hysi

cian

. The

Pso

rias

is F

ound

atio

n do

es n

ot e

ndor

se a

ny

med

icat

ions

, pro

duct

s or

trea

tmen

ts fo

r ps

oria

sis

or p

sori

atic

art

hriti

s an

d ad

vise

s yo

u to

con

sult

a ph

ysic

ian

befo

re in

itiat

ing

any

trea

tmen

t.

TRADITIONAL SY

STEM

IC AND NEW

ORAL TR

EATM

ENTS

(SEE

REV

ERSE

FOR BIOLO

GIC TREA

TMEN

TS)

Trea

tmen

t typ

e - Fo

r mod

erate

to sev

ere ps

oriasis an

d ps

oriatic

ar

thritis

Enbr

el

Etan

erce

ptCimzia

Cert

oliz

umab

peg

olHum

ira

Adal

imum

abRem

icad

eIn

flixi

mab

Simpo

niGo

limum

abStelar

aU

stek

inum

ab

Indica

tion

- W

hich

disea

ses the

drug

trea

tsPso

rias

isPso

riatic arthr

itis

Pso

rias

isPso

riatic arthr

itis

Pso

rias

isPso

riatic arthr

itis

Pso

riatic arthr

itis

Pso

riatic arthr

itis

Metho

d of deliver

y - How

the dr

ug

is given

or take

nSu

bcutan

eous

self-

injection

Subc

utan

eous

self-

injection

Intraven

ous infusion

by

health care profes

sion

alSu

bcutan

eous

self-

injection

Subc

utan

eous

injection by

a he

alth care profes

sion

al

Freq

uenc

y - How

often

the dr

ug

mus

t be take

n1-2 tim

es wee

kly

Ever

y othe

r wee

k3 tim

es in

first 6

wee

ks,

then

every 8 wee

ksMon

thly

Wee

k 0, wee

k 4, th

en

ever

y 3 mon

ths

Dur

ation - How

long

the dr

ug

mus

t be take

nCon

tinuo

usly to

maintain

resu

lts

Con

tinuo

usly to

maintain

resu

lts

Con

tinuo

usly to

maintain

resu

lts

Con

tinuo

usly to

maintain

resu

lts

Con

tinuo

usly to

maintain

resu

lts

Con

tinuo

usly to

maintain

resu

lts

Com

mon

side effects - A side

effect is

an un

desirable se

cond

ary

effect of a

med

ication. Side effects

may var

y for ea

ch in

dividu

al

depe

nding on

disea

se state, a

ge,

weigh

t, ge

nder, e

thnicity and

ge

neral h

ealth. All med

ications

ha

ve side effects.

Injection site rea

ctions

Upp

er res

piratory

in

fections

Hea

dach

es

Injection site rea

ctions

Upp

er res

piratory

in

fections

Hea

dach

es Hea

dach

e Fa

tigue

Nau

sea

Urina

ry tr

act infec

tions

Ras

h Nau

sea

Res

piratory in

fections

Hea

dach

e Ras

h Ras

h Cou

ghing

Stom

ach pa

in

Upp

er res

piratory

in

fection

Upp

er res

piratory

in

fection

Nau

sea

Abn

ormal liver tests

Injection site rea

ctions

High bloo

d pres

sure

Bronc

hitis

Dizzine

ss

Flu

Upp

er res

piratory

in

fections

Hea

dach

e Tiredn

ess

Fa

tigue

Pos

sible risk

s - Th

e po

ssible

risk

s lis

ted includ

e se

riou

s ad

verse ev

ents th

at have be

en

repo

rted

in ass

ociatio

n with

thes

e med

ications

dur

ing an

d after

clinical tr

ials.

Se

riou

s infection

Ner

vous

system

problem

s New

or worse

ning

hea

rt

fa

ilure

Allergic rea

ctions

Lu

pus-lik

e sy

ndrome

Ly

mph

oma

Hep

atitis B rea

ctivation

Se

riou

s infection

Ner

vous

system

problem

s New

or worse

ning

hea

rt

fa

ilure

Allergic rea

ctions

Lu

pus-lik

e sy

ndrome

Maligna

ncies

Hep

atitis B rea

ctivation

Sk

in can

cer

Se

riou

s infection

Ner

vous

system

problem

s New

or worse

ning

hea

rt

fa

ilure

Allergic rea

ctions

Lu

pus-lik

e sy

ndrome

Ly

mph

oma

Hep

atitis B rea

ctivation

Sk

in can

cer

Se

riou

s infection

Ner

vous

system

problem

s New

or worse

ning

hea

rt

fa

ilure

Allergic rea

ctions

Lu

pus-lik

e sy

ndrome

Ly

mph

oma

Hep

atitis B rea

ctivation

Sk

in can

cer

Ana

phylax

is Liver en

zyme

abn

ormalities

Hep

atitis B rea

ctivation

New

or worse

ning

hea

rt

fa

ilure

Ner

vous

system

problem

s Liver failu

re Lo

w blood

cou

nt Lu

pus-lik

e sy

mptom

s Allergic rea

ctions

Ly

mph

oma

Increa

sed risk

of

serious

infections

Rea

ctivation of la

tent

in

fections

, inc

luding

tu

berculos

is Rev

ersible po

sterior

le

ukoe

ncep

halopa

thy

syn

drom

e Hyp

erse

nsitivity

rea

ctions

Mon

itor

ing - So

me ad

verse

reac

tions

can

be de

tected

by

labo

ratory te

sts su

ch as bloo

d co

unts or liv

er fu

nctio

n tests.

Tube

rculos

is scree

ning

Ann

ual b

lood

cou

nt and

liv

er fu

nctio

n tests

Tube

rculos

is scree

ning

Ann

ual b

lood

cou

nt and

liv

er fu

nctio

n tests

Tube

rculos

is scree

ning

Ann

ual b

lood

cou

nt and

liv

er fu

nctio

n tests

Tube

rculos

is scree

ning

Ann

ual b

lood

cou

nt and

liv

er fu

nctio

n tests

Tube

rculos

is scree

ning

Ann

ual b

lood

cou

nt and

liv

er fu

nctio

n tests

Tube

rculos

is scree

ning

Subc

utan

eous

injection by a

health care profes

sion

al, o

rse

lf-injection

Wee

k 0, wee

k 2, and

wee

k 4,

and either every tw

o wee

ks

or every fo

ur wee

ks

therea

fter

BIOLO

GIC TR

EATM

ENTS

(SEE

REV

ERSE

FOR NEW

ORAL

AND TRAD

ITIONAL

SYS

TEMIC TREA

TMEN

TS)

Nat

iona

l Pso

rias

is F

ound

atio

n ed

ucat

iona

l mat

eria

ls a

re m

edic

ally

rev

iew

ed a

nd a

re n

ot in

tend

ed to

rep

lace

the

coun

sel o

f a p

hysi

cian

. The

Pso

rias

is F

ound

atio

n do

es n

ot e

ndor

se a

ny m

edic

atio

ns,

prod

ucts

or

trea

tmen

ts fo

r ps

oria

sis

or p

sori

atic

art

hriti

s an

d ad

vise

s yo

u to

con

sult

a ph

ysic

ian

befo

re in

itiat

ing

any

trea

tmen

t.

Pso

rias

isPso

riatic arthr

itis