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Traumatic Spinal Cord Injury
39th CANP Annual Educational ConferenceMarch 18th, 2016 5:00pm-6:15pm
Carl Wherry, ACNP-bcAmanda Severson, ACNP-bc
Disclosures
• No conflicts of interest to disclose.
Introduction
• Incidence
– 40 cases per million population in the U.S.
– 12,500 new cases each year
– in 2014 estimated 276,000 people in U.S. living with spinal cord injury.
• Males account for 80% of SCI population
• Etiology: Vehicle crash > falls > acts of violence > sports.
Impact
• Hospitalization days average 11 days with 36 days average rehabilitation.
• Impact to health care of spinal cord injury (SCI)
Impact to life expectancy
Basic Anatomy
Tracts
Motor and Sensory
• Motor
• Sensory
Evaluation of Patient
Checklist for the first hour:
• Spine immobilization
• SBP >90
• Supplemental O2
• Early intubation for failure of ventilation
• Rule out other causes of hypotension
Mechanisms of Injury
Immobilization of suspected injuries
• Cervical spine immobilization until reliable
examination is possible (NEXUS or Canadian
C-Spine Rules)
Imaging
• Who to image:NEXUSCanadian C-spine rules (CCR)
Canadian C-Spine Rules
NEXUS Rules
The NEXUS rules are:
● No posterior midline cervical-spine
tenderness
● No evidence of intoxication
● A normal level of alertness
● No focal neurological deficit
● No painful distracting injuries.
Confirmed Injury
• Initial Management
• Airway
• Breathing
• Circulation
Airway
Intubation: Who?
•Complete injury @ C1-C4: early, elective intubation and mechanical ventilation.
•Parameters for urgent intubation – Complaint of "shortness of breath"– Vital Capacity < 10 mL/kg or less– "Belly breathing" or "quad breathing"
(abdomen goes out sharply with inspiration)
Airway
Intubation: How?•Awake, fiberoptic approach by experienced
provider •Urgent or emergent ->rapid sequence
intubation•Cervical in-line stabilization •TSI patients will already have loss of
vasomotor tone; medications that diminish the catecholamine surge may result in hypotension and bradycardia.
Breathing
• Indications for the intubation of the patient with traumatic cervical spine injury:– Complete SCI above C5 level– Respiratory distress– Hypoxemia despite attempts at oxygenation– Severe respiratory acidosis– Relative indications– Complaint of shortness of breath– Development of ‘‘quad breathing’’– Vital capacity (VC) of <10 ml/kg or decreasing VC– Consideration should be given– Need to ‘‘travel’’ remote from ED (MRI, transfer to another
facility)
Circulation
• Blood pressure support:
– Norepinephrine
– Phenylephrine
– Dopamine
– Epinephrine
– Dobutamine
Disability-Neurological Examination
• Motor and Sensory Exams
• ASIA scale
• Syndromes
– Anterior Cord Syndrome
– Central cord syndrome
– Brown-Sequard Syndrome
A mixed picture
Anterior Cord Syndrome
• Loss of pain/temperature and motor but NOT light touch; due to contusion of anterior cord or occlusion of anterior spinal artery.
• Associated with burst fractures of spinal column with fragment retropulsion by the axial compression.
Central Cord Syndrome
● Loss of cervical motor function with relative
sparing of lower extremity strength.
● Typically due to hyperextension injury in
elderly patients with cervical stenosis.
● Often no fracture; rather, buckling of
ligamentum flavum contuses cord, causing
bleeding with the center of cord.
Brown-Sequard Syndrome
● Hemiplegia, loss of ipsilateral light touch,
AND loss of contralateral pain/temperature
sensation due to hemisection of the cord.
● Indicates a penetrating cord injury often from
missile or knife, or a lateral mass fracture of
the spine.
Autonomic Dysreflexia
Treatment
• Steroids?• Temperature
management• Stem cells• Venous thrombus
prevention
• Pediatric Consideration
NASCIS 2:
•Bracken MB, Shepard MJ, Hellenbrand KG, et al. Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury Study. J Neurosurg. 1985 Nov. 63(5):704-13.
NASCIS 3:
•Bracken MB, Shepard MJ, Holford TR, et al. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylatefor 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA. 1997 May 28. 277(20):1597-604.
NASCIS trials reviewed
NASCIS graphs
NASCIS
CONCLUSION: A critical reevaluation of the clinical efficacy of steroid administration in acute SCI demonstrates that, despite a Class I trial and general widespread use, the evidence for 24-hour MP therapy in humans is negligible or weak at best . . . MP therapy should be regarded as potentially harmful and possibly lethal.
Hypothermia
•There are no randomized controlled trials
Stem Cells
Venous thrombus prevention
•Recommendations:
–Level II, Early administration of VTE prophylaxis (within 72 hours) is recommended.
–Level III, Vena cava filters are not recommended as a routine prophylactic measure, but are recommended for select patients who fail anticoagulation or who are not candidates for anticoagulation and/or mechanical devices.
Venous thrombus prevention
•Pharmacologic agents (Chest guidelines)
Case study #1
• 41 y.o. male. no significant PMHx, regular Marijuana user, who was brought in as critical code trauma after being pulled out of shallow water with bilateral arm and leg weakness.
• Patient dove into shallow water and was witnessed to be struggling per family who pulled him out. He was weak in arms and legs.
Case #1 physical assessment
Case #1 admit CT
Case #1 initial management
• CT Cervical Spine show unilateral locked left facet at C3-C4. Patient was placed in halo and 80lb traction for decompression.
• MRI obtained:
Case #1 MRI
Case #1 formal managment
• Admit: spinal cord injury, did external reduction with tongs, followed by halo. MRI and CT shows spinal injury. Ortho surgery handling spine.
• Day #1: appears depressed.• Day #2: Underwent C3- 4 decompression and fusion• Day #3: Hypotension in AM• Day #4: Robaxin for back pain, pan cultured, ongoing cooling• Day #5: emesis overnight, Dopamine weaned. Breathing well.• Day #6: pulmonary edema and infiltrates continue to be an issue. • Day #7: MAP therapy ends, and no significant change in the motor
exam. • Day #8: Transferred to 6N from ICU• Day #9: GI consulted: Methylnaltrexone 8mg SQ given
Case #1 post op imaging
Case #1 ICU transfer to floor:
• C3/4 ASIA B spinal cord injury, s/p C3/4 reduction of unilateral facet dislocation and posterior spinal fusion with instrumentation on by orthopedics. He has shown no signs of neurological recovery since his injury and remains quadriplegic with 0/5 in the UEs, 1/5 proximal LEs, 0/5 distal LEs.
• Sodium goal: 135 - 145
• prosthetics/ orthotics: Wear Aspen cervical collar at all times.Duration: at least 6 weeks and until instructed at follow-up appointment.
• Activity: as tolerated
Case #1 hospital discharge exam:
• Motor scores were: 0/5 strength in all extremities at this time. No change since admission. Internal rotation of hip 1/5 only.
• Motor Exam: Outward movement with pain and withdrawal bilateral lower extremity with painful stimuli. Right leg intermittent spasm.
• Sensory Exam:Light Touch and pinprick: No sensation below C6.
Case Study #2
Case #2 imaging:
References:
• ENLS reference
• NASCIS
• https://www.nscisc.uab.edu/reports.aspx