translating complex genetic information into better patient ......translating complex genetic...
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Translating Complex Genetic
Information into Better
Patient Outcomes
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Type 2 diabetes – type 3, 4 & 5
• Joel Dudley Mount Sinai Hospital
• obesity, high blood sugar, kidney disease, and eye disease, were limited to subtype 1, whereas other comorbidities such as cancer and neurological diseases were specific to subtypes 2 and 3
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Figure 2
Trends in Pharmacological Sciences 2011 32, 72-81DOI: (10.1016/j.tips.2010.11.008)
Copyright © 2010 Elsevier Ltd Terms and Conditions
Genes Determine Drug Effects
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Issues
Adverse
Drug Events
4th leading
cause of death
Ineffective
Drugs
60% of
prescribed
drugs do NOT
benefit the
individual
Genetic
Variations
97% of the
population has
at least 1
actionable
genotype
Medication
Selection
Genetics is only
1 element of the
complex drug
selection
process
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Medication Selection Processes
Patients wishes
Current medications
Patients sex
Patients age
Harm of interventions
Effect of interventions
Potential harms
I only have one minute
Potential Medications
Biophysical results
Laboratory results
The less time in the consultation the more inappropriate the prescription
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Current Support System for Prescribing
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BC choice in genomics
1. Is BC going to profit from this revolution by
investing in biotech?
2. Or are we going to pay other provinces for it?