tomris cesuroglu, md institute for public health genomics
DESCRIPTION
PAOG nascholing Jeugdgezondheidszorg Maastricht, 25 January 2011. Tomris Cesuroglu, MD Institute for Public Health Genomics. Research into Child Health in Europe RICHE. http://childhealthresearch.eu. RICHE. An EU funded project (FP7, Mar 2010 to Feb 2013) - PowerPoint PPT PresentationTRANSCRIPT
Tomris Cesuroglu, MDInstitute for Public Health Genomics
PAOG nascholing JeugdgezondheidszorgMaastricht, 25 January 2011
http://childhealthresearch.eu
Research into Child Health
in EuropeRICHE
http://childhealthresearch.eu
http://childhealthresearch.eu
RICHE
An EU funded project (FP7, Mar 2010 to Feb 2013)A project for child health researchers, practitioners,
policy makers, and those who make decisions affecting children
Defining the current pattern of child health research in Europe, seeing what's not being done, and identifying paths to the future of the research
Future proofing child health research policy in EuropeMeeting the future needs of European policy makers,
funders, and children.
http://childhealthresearch.eu
Home Page
http://childhealthresearch.eu
An example
http://childhealthresearch.eu
What's to be done?
Join us!Put up your own workPut up your colleaguesPut up your projectsPut up your reportPut up your funders
Perspectives in Personalized Health Care
Tomris Cesuroglu, MDInstitute for Public Health Genomics
PAOG nascholing JeugdgezondheidszorgMaastricht, 25 January 2011
Life style
External factors
Genetic structure
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
Genetic diseases External factors Complex diseases
1% of burden of disease
22% of burden of disease
77% of burden of disease
Disease threshold
*Slide used with the courtesy of GENAR Institute for Public Health and Genomics Research
An Example to a Single Nucleotide Polymorphism
(SNP)
TAT TCG TAC GGC TAC ATA CGT ACC GTA AAT TCG ATT CGA TGAATA AGC ATG CCG ATG TAT GCA TGG CAT TTA AGC TAA GCT ACT
Stop Codon
Start Codon
┐└
┐└
An Example to a Single Nucleotide Polymorphism
(SNP)
TAT TCG TAC GGC TAC ATA CGT GCC GTA AAT TCG ATT CGA TGAATA AGC ATG CCG ATG TAT GCA CGG CAT TTA AGC TAA GCT ACT
Stop Codon
Start Codon
┐└
┐└
Genetic Polymorphism
Dark skin Fair skin
Which one is better?
Gene and Environment/Life Style Interaction
*Slide series used with the courtesy of GENAR Institute for Public Health and Genomics Research
Fair skin Dark skin
Norway
Happily living in Fjords
NigeriaHappily living under African sun
Genetic variation: Is it good or bad?
Fair skin Dark skin
Norway
Nigeria
Genetic variation: Is it good or bad?
Fair skin Dark skin
Norway
Nigeria
•Gets red•Burns•Melanoma
develops
Genetic variation: Is it good or bad?
Fair skin Dark skin
Norway
•Not enough sunshine•Vitamin D
deficiency•Develops
osteoporosis
Nigeria
•Gets red•Burns•Melanoma
develops
Genetic variation: Is it good or bad?
Fair skin Dark skin
Norway
•Not enough sunshine•Vitamin D
deficiency•Develops
osteoporosis
NigeriaPositive intervention:Protecion from the sun
Genetic variation: Is it good or bad?
Fair skin Dark skin
Norway
Positive intervention:Vitamin D supplements
NigeriaPositive intervention:Protecion from the sun
Genetic variation: Is it good or bad?
GSTP 1
Effective detoxification
GSTP 1 (A313G Homozygous)
Ineffective detoxification
Transcription (mRNA production)
Translation in ribosom (synthesis of amino acid chain)
Protein
Transcription (mRNA production)
Translation in ribosom (synthesis of amino acid chain)
Protein
Eric Assamoa
Pathology DevelopmentPhase I
DiseasePhase III
Check-Up Early
Diagnosis
Disease Threshold
Early Symptoms Threshold
Diagnosis and
Treatment
Genetic Predisposition
Life Style and Environmental Conditions
Co
nc
ep
tio
n
De
ath
Early Symp.
Phase II
*Slide used with the courtesy of GENAR Institute for Public Health and Genomics Research
Thank you for your attention!
Tomris Cesuroglu, MD [email protected]