to fight cancer new living drug f.d.a. panel urges · ácio lula da silva, was found guilty of...
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A Food and Drug Administra-tion panel opened a new era inmedicine on Wednesday, unani-mously recommending that theagency approve the first-evertreatment that genetically alters apatient’s own cells to fight cancer,transforming them into what sci-entists call “a living drug” thatpowerfully bolsters the immunesystem to shut down the disease.
If the F.D.A. accepts the recom-mendation, which is likely, thetreatment will be the first genetherapy ever to reach the market.Others are expected: Re-searchers and drug companieshave been engaged in intensecompetition for decades to reachthis milestone. Novartis is nowpoised to be the first. Its treatmentis for a type of leukemia, and it isworking on similar types of treat-ments in hundreds of patients foranother form of the disease, aswell as multiple myeloma and anaggressive brain tumor.
To use the technique, a separatetreatment must be created foreach patient — their cells re-moved at an approved medicalcenter, frozen, shipped to a Novar-tis plant for thawing and process-ing, frozen again and shippedback to the treatment center.
A single dose of the resultingproduct has brought long remis-sions, and possibly cures, toscores of patients in studies whowere facing death because everyother treatment had failed. Thepanel recommended approvingthe treatment for B-cell acute lym-phoblastic leukemia that has re-sisted treatment, or relapsed, inchildren and young adults aged 3to 25.
One of those patients, EmilyWhitehead, now 12 and the firstchild ever given the altered cells,was at the meeting of the panelwith her parents to advocate forapproval of the drug that savedher life. In 2012, as a 6-year-old,she was treated in a study at the
F.D.A. PANEL URGESNEW ‘LIVING DRUG’TO FIGHT CANCER
MILESTONE IN MEDICINE
Treatment That Alters aPatient’s Own Cells
to Fight Back
By DENISE GRADY
Continued on Page A13
RIO DE JANEIRO — The for-mer president of Brazil, Luiz In-ácio Lula da Silva, was foundguilty of corruption and moneylaundering on Wednesday andsentenced to nearly 10 years inprison, a stunning setback for apolitician who has wielded enor-mous influence across LatinAmerica for decades.
The case against Mr. da Silva,who raised Brazil’s profile on theworld stage as president from2003 to 2010, stemmed fromcharges that he and his wife ille-gally received about $1.1 million inimprovements and expenses froma construction company for abeachfront apartment.
In exchange, prosecutors said,the company was able to obtain lu-crative contracts from Petrobras,the state-controlled oil giant.
His conviction tarnishes thelegacy of one of Brazil’s most com-manding political figures, a char-ismatic leader who grew up poor,challenged the military dictator-ship and nurtured global ambi-tions for his nation, helping to land
Ex-President Of Brazil GetsYears in PrisonBy ERNESTO LONDOÑO
Continued on Page A8
LUCKNOW, India — A Hinduwarrior-priest has been chosen torule India’s most populous state,and the cable news channels can-not get enough of him. Yogi, as ev-eryone calls him, is so ascetic andincorruptible that he doesn’t useair-conditioners, they say. Yogisleeps on a hard mattress on thefloor. Yogi sometimes eats only anapple for dinner.
But the taproot of YogiAdityanath’s popularity is in amore ominous place. As leader ofa temple known for its militantHindu supremacist tradition, hebuilt an army of youths intent onavenging historic wrongs by Mus-lims, whom he has called “a cropof two-legged animals that has tobe stopped.” At one rally he criedout, “We are all preparing for reli-gious war!”
Adityanath (pronounced Ah-DIT-ya-nath) was an astonishingchoice by Narendra Modi, India’sprime minister, who came into of-fice three years ago promising tousher India into a new age of de-velopment and economic growth,and playing down any far-rightHindu agenda. But a populistdrive to transform India into a“Hindu nation” has drowned outMr. Modi’s development agenda,
shrinking the economic and socialspace for the country’s 170 millionMuslims.
Few decisions in Indian politicsmatter more than the selection ofthe chief minister of UttarPradesh, because the post is seenas a springboard for future primeministers. At the age of 45, the di-minutive, baby-faced Adityanathis receiving the kind of career-making attention that projects anIndian politician toward higher of-fice.
“He is automatically on any-body’s list as a potential contend-er to succeed Modi,” saidSadanand Dhume, an India spe-cialist at the American EnterpriseInstitute. “They have normalizedsomeone who, three years ago,was considered too extreme to beminister of state for textiles. Ev-erything has been normalized soquickly.”
Adityanath did not respond torepeated requests for comment
Anti-Muslim Venom Fuels Rise to Power in India By ELLEN BARRY
and SUHASINI RAJ
Yogi Adityanath is chief minister of India’s most-populous state.JITENDRA PRAKASH/REUTERS
Continued on Page A10
WASHINGTON — The lettershave come in to her office by thehundreds, heartfelt missives fromcollege students, mostly men, whohad been accused of rape or sexu-al assault. Some had lost schol-arships. Some had been expelled.A mother stumbled upon her sontrying to take his own life, recalledCandice E. Jackson, the top civilrights official at the Departmentof Education.
“Listening to her talk aboutwalking in and finding him in themiddle of trying to kill himself be-cause his life and his future weregone, and he was forever brandeda rapist — that’s haunting,” saidMs. Jackson, describing a meetingwith the mother of a young manwho had been accused of sexualassault three months after his firstsexual encounter.
The young man, who main-tained he was innocent, had hopedto become a doctor.
In recent years, on campus af-ter campus, from the University ofVirginia to Columbia University,from Duke to Stanford, higher ed-ucation has been roiled by high-profile cases of sexual assault ac-cusations. Now Education Secre-
tary Betsy DeVos is stepping intothat maelstrom. On Thursday, shewill meet in private with womenwho say they were assaulted, ac-cused students and their families,advocates for both sides andhigher education officials, the firststep in a contentious effort to re-examine policies of PresidentBarack Obama, who made expan-sive use of his powers to investi-gate the way universities and col-leges handle sexual violence.
How university and college ad-ministrations have dealt withcampus sexual misconductcharges has become one of themost volatile issues in higher edu-cation, with many women sayinghigher education leaders have nottaken their trauma seriously. Butthe Obama administration’s re-sponse sparked a backlash, notjust from the accused and theirfamilies but from well-regardedlaw school professors who saynew rules went too far.
In an interview previewing herplans, Ms. Jackson, who heads theEducation Department’s Officefor Civil Rights and organizedThursday’s sessions, made clear
A Review of Campus Rape PolicyAfter Complaints by the Accused
By ERICA L. GREEN and SHERYL GAY STOLBERG
Continued on Page A18
A chunk of floating ice roughlythe size of Delaware broke awayfrom the Antarctic Peninsula thisweek, NASA confirmed onWednesday, producing one of thelargest icebergs ever recordedand providing a glimpse of howthe Antarctic ice sheet might ulti-mately start to fall apart.
A crack more than 120 mileslong had developed over severalyears in a floating ice shelf calledLarsen C. Scientists carefullytracked it in recent months, andimages shot by a NASA satelliteon Wednesday morning showedthat a 2,200-square-mile chunkhad finally broken loose.
There is no scientific consensusover whether global warming is toblame. But the event fundamen-tally changes the landscape of theAntarctic Peninsula, according toProject Midas, a research teamfrom Swansea University and Ab-erystwyth University in Walesthat had been monitoring the riftsince 2014.
“The remaining shelf will be atits smallest ever known size,” saidAdrian Luckman, a lead re-searcher for Project Midas. “This
is a big change. Maps will need tobe redrawn.”
Larsen C, like two smaller iceshelves that collapsed before it,was holding back relatively littleland ice, and it is not expected tocontribute much to the rise of thesea. But in other parts ofAntarctica, similar shelves areholding back enormous amountsof ice, and scientists fear that theirfuture collapse could dumpenough ice into the ocean to raisethe sea level by many feet. Howfast this could happen is unclear.
In the late 20th century, the Ant-arctic Peninsula, which juts outfrom the main body of Antarcticaand points toward South America,was one of the fastest-warmingplaces in the world. That warminghad slowed or perhaps reversedslightly in the 21st century, but sci-entists believe the ice is still catch-ing up to the higher temperatures.
Some climate scientists believethe warming in the region was atleast in part a consequence of hu-man-caused climate change,while others have disputed that,seeing a large role for natural vari-
Antarctica Sheds Huge IcebergThat Hints at Future Calamity
By JUSTIN GILLIS and JUGAL K. PATEL
The Larsen C ice shelf on the Antarctic Peninsula in February. NASA says a chunk of ice broke away this week, producing one of the largest icebergs ever recorded.BRITISH ANTARCTIC SURVEY, VIA ASSOCIATED PRESS
Continued on Page A6
DEFLATED A shorter recess is anadmission of failure by the Sen-ate, Carl Hulse writes. PAGE A17
DELUDED Using email is foolish,but it leaves a marvelous record,Farhad Manjoo writes. PAGE B1
DEFIANT The nominee to lead theF.B.I. said he would stand up tothe president. PAGE A16
Some parents believe the departure ofthe principal at Fieldston Lower wasnot completely voluntary. PAGE A21
Anger Over a Swift Retirement
David Wildstein, who schemed to blocktraffic lanes near the George Washing-ton Bridge, will not go to jail. PAGE A19
NEW YORK A19-21
Probation in Bridge Scandal
Scientists can store video on DNA,retrieving it after generations of growth,and hope someday to use the process torecord cell behavior. PAGE A11
NATIONAL A11-18
Living Cell Used as Hard Drive
The military plane that crashed Mon-day, killing 16 people, spread debrisacross a mile of farmland. PAGE A13
Emergency at High Altitude
France’s leader, Emmanuel Macron, haspositioned himself as President Trump’sfirst point of contact in Europe. PAGE A8
INTERNATIONAL A4-10
France Softens Toward TrumpWarren LeGarie and Albert Hall haveturned the Las Vegas summer leagueinto a booming business. PAGE B11
An N.B.A. Summer Franchise
Andy Murray, above, lost in five sets toSam Querrey, while Novak Djokovic lefthis match with an elbow injury. PAGE B11
SPORTSTHURSDAY B11-14
Big Names Exit Wimbledon
“Flash organizations,” modeled onfilmmaking, are finding their way intomore industries, assembling freelancersand then disbanding. PAGE B1
BUSINESS DAY B1-10
Gone in a Flash
Monica Hesse’s “American Fire” is atwisting story with all the elements of alively crime procedural. PAGE C1
ARTS C1-8
Baffling Tale of an ArsonistAt New York Fashion Week: Men’s, theBelgian designer Raf Simons put on asteamy nighttime show at a marketunder the Manhattan Bridge. PAGE D1
THURSDAY STYLES D1-8
Hometown Edge to Fashion
Gary Cohn and H.R. McMaster PAGE A23
EDITORIAL, OP-ED A22-23
THE FAMILY The Trump siblings Ivanka, Eric and Donald Jr. are caughtin a storm-tossed presidency, and it’s personal for their father. PAGE A14
TASOS KATOPODIS/AGENCE FRANCE-PRESSE — GETTY IMAGES
WASHINGTON — At 6:14 p.m.on June 7, 2016, Donald Trump Jr.clicked the send button on anemail to confirm a meeting with awoman described as a “Russiangovernment attorney” who wouldgive him “information that wouldincriminate Hillary and her deal-
ings with Russia.”Three hours later, his father,
Donald J. Trump, claimed victoryin the final primary races propel-ling him to the Republican presi-dential nomination and a generalelection contest against formerSecretary of State Hillary Clinton.In his victory speech, Mr. Trumppromised to deliver a major ad-dress detailing Mrs. Clinton’s
“corrupt dealings” to give “favor-able treatment” to foreign govern-ments, including “the Russians.”
The White House said the tim-ing was a coincidence. The young-er Mr. Trump said this week thathe never told his father about themeeting with the Russian lawyer,and the president said on Wednes-day that he did not know about ituntil a few days ago. But the timeframe raised questions that inves-tigators will presumably examineas they try to piece together whoknew what, and when, last yearduring what American intelli-gence agencies have called a Rus-sian effort to influence the presi-dential election.
The meeting with the Russianlawyer came at a crucial stage inthe elder Mr. Trump’s against-the-odds campaign as he pivoted to-
Meeting Renews Scrutiny on Trump’s ’16 Actions
By PETER BAKER
Continued on Page A14
Late Edition
VOL. CLXVI . . . No. 57,657 © 2017 The New York Times Company NEW YORK, THURSDAY, JULY 13, 2017
Today, sunshine, afternoon showers,hot, humid, high 93. Tonight, humid,showers, thunderstorms, low 72. To-morrow, cooler, showers, high 76.Weather map appears on Page B9.
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