tissue engineering lecture 13, 3/26/15 paper review 3d gels for ischemia
TRANSCRIPT
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Tissue Engineering
Lecture 13, 3/26/15Paper Review
3D gels for ischemia
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What is the motivation of this study?
• Much of current cell therapy relies on dosing cells at the site – many of which are lost during delivery.
• One mechanism to improve cell therapy is to encapsulate cells into a biomaterial – keeping the cells alive during the harsh delivery.
• The authors propose to deliver adipose(fat)-derived mesenchymal stem cells in very small injectable gels to protect them during delivery.
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• Show supplementary video 1
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Figure 1a-e: Jemima Lamothe
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Figure 1f-i: Jonathan Hummel
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Figure 2a-c: Michael Mulroy
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Figure 2d: Ezra Aurian-Blajeni
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Figure 3: Sarah Johnson
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Figure 4a-b: Kyle Pariseau
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Figure 4c-d: Ronen Zeidel
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Figure 5: Matt Tiller
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• Show supplementary movies 2-4
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Figure 6: Christine Davis
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Conclusions, Perspectives
• By encapsulating cells in 3D microniches, they could use a dose more than 10 times lower than previous cell based therapies.
• Accumulation of ECM and paracrine signaling in the niches likely provided survival signals to cells.
• Priming was a key step to improving MSC differentiation prior to delivery.