Tissue EngineeringInitiative

Drexel University &

MCP Hahnemann University

Philadelphia, PA

www.biomed.drexel.edu

Tissue Engineering at Drexel/MCPHUCollege of College of EngineeringEngineering

College of College of MedicineMedicine

BiomedicalBiomedicalEngineeringEngineering

Center for Advanced Bio-Materials & Tissue Engineering

Center for Fibrous Materials Research

Implant Research Center

Nanotechnology Center

Tissue Engineering at Drexel/MCPHU

MatrixMatrixDevelopment Development

PolymericPolymericScaffoldsScaffolds

Cellular & Cellular & Molecular BiologyMolecular Biology

ImplantImplantResearchResearchg Bioreactorsg Bioreactors NanofiberNanofiber

CompositesComposites

Replacement Replacement OrgansOrgans

Comp. TissueComp. TissueEngineeringEngineering

Stem CellStem CellResearchResearch

Cardiac & NeuroCardiac & NeuroTissue Engineering Tissue Engineering

Bone and LigamentBone and LigamentResearchResearch

Nanotechnology Center

100 nm

Nanotube

$10.5M Nanotechnology Center will: Nucleate sustained regional growth in

nano-biotechnology Achieve national recognition in bio-

nanoechnology

Research Enterprise Building & Graduate Facilities

150,000 ft2 of Modern facilities ($30M) theme-based laboratories includingNano & Micro TechnologyBiosensorsTissue and Organ EngineeringNeuro Engineering

Research Enterprise Building

TissueA group of similar cells united to

perform a specific function

Engineering The design and

manufacture of complex products

through the application of science and mathematics

Tissue EngineeringScientific American 280(4); April 1999

Tissue EngineeringMatrix Development

Trabecular Bone Replacement

Ligament Replacement

Nanotechnology

Cato Laurencin, PhD , M.D.Moorehead Chair ProfessorOf Chemical Engineering and Biomedical Engineering

Tissue Engineering of BoneCellular and Animal Studies

Cellular Tissue Engineering

Stem Cells Scaffolds / Nanotechnology+

Functional Replacement Tissues

Bioreactor Biotechnology (NASA)

Cellular / Molecular Biology:Development and Differentiation

Computer-Based Modeling

Peter I. Lelkes, PhD, Calhoun Chair Professor of Cellular Tissue Engineering

Cellular Tissue Engineering:Primary Target Tissues/Organs

Cardiovascular Tissues:

•Blood Vessels •Heart

Neural Tissues:

• Brain• Peripheral Nerves

Endocrine Tissues:

• Pancreas• Adrenal

3-D Nanofiber Scaffold forTissue Engineered Cartilage

Frank Ko, Ph.D Professor of Materials

Engineering and Biomedical Engineering

Cell Mechanics & Tissue Engineering

Micrometer

Cone Assembly

z

o

r

Stepper Motor

Heating Element

Circulation Ports

WellBase Unit

Vascular Tissue Engineering

Cell-Seeded Construct

Silicone SleeveGlass Mandrel

Simulating the in vivo Mechanical Environment …

to Promote the Development of Tissue Structure

Kenneth A. Barbee, Ph.D Associate Professor of

Biomedical Engineering

Atomic Force Microscopy for Measuring Mechanical Properties of Cells in Engineered Constructs

Control of Smooth Muscle Injury During Angioplasty to Prevent Restenosis

Mechanics of Neural Cell Injury and Acute Therapy for Preservation of Neural Function

Michele MarcolongoAssociate Professor of Materials Engineering• Orthopedic biomaterials and tissue engineering (Partners: Rocky Tuan and Noreen Hickock, Orthopedic Surgery, Thomas Jefferson University)

Wei SunAssistant Professor of Mechanical Engineering• Computational tissue engineering and modelling

Fred AllenAssistant Professor of Biomedical Engineering• Cell matrix interactions for orthopedic applications• Cell motility and adhesion in tissue engineering

Day 3 Day 7 Day 12Immediately after

encapsulation

In vitro growth of encapsulated cells(genetically modified fibroblasts producing BDNF)

Margaret WheatleyProfessor of Biomedical Engineering• Responsive drug delivery for diabetes management• Nanofiber mat (Partner: Frank Ko)• Spinal cord repair (Partners: Itzhak Fisher and Marion Murray, Neurobiology, MCP Hahnemann University)

Other Members of the Cellular Tissue Engineering Team

                   

January 15, 2001

Yasha J. KreshProfessor and Research Director, Cardiothoracic Surgery and Cardiovascular Biophysics & Computing, MCP Hahnemann & Drexel University• Complex cellular network dynamics (Partner: Banu Onaral)• Cardiac regenerative medicine

IMPLANT RESEARCH INITIATIVE

The implant research effort is the result of  a strategic research alliance of Drexel University with two medical partners, MCP Hahnemann and Thomas Jefferson Universities and two corporate partners, Exponent, Inc., and Stryker Howmedica Osteonics Corporation.

Director: Steven Kurtz, Drexel University & Exponent IncAssociate Directors: Michele Marcolongo, Drexel University & Av Edidin, Howmedica Corp

The goal of this initiative is to conduct research on implantable medical devices and to provide insight back to the surgical and engineering communities for improving the longevity of implants. The initial focus of is on orthopaedic total joint replacement and spinal implants. Future directions will include ophthalmic, dental, cardiovascular, and urologic implant research.

Other Members of the Cellular Tissue Engineering Team (Cont.)

Visit us on the web

WWW.BIOMED.DREXEL.EDU

School of Biomedical Engineering,Science & Health Systems