time activity curve(tac) グラフ area under curve(auc) · 2013-12-27 · 3．4d画像解析 tac...

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３．4D 画像解析 TAC AUC MTT Kinetic Model 解析生体内における血流や薬剤の動態モデルを作成し、 kinetic 画像のトレーサーの動きからモデルパラメーターを解析 Area Under Curve 薬剤通過量 Mean Transit Time 平均通過時間４．生体内における血流や薬剤の動態を画像計測血流 tracer の動き５．Compartment Model 血流 CP Cp C1 C2 ６．Brain １ Compartment Model 解析結果 3-BV131105sec 0.00E+00 5.00E+08 1.00E+09 1.50E+09 2.00E+09 2.50E+09 3.00E+09 3.50E+09 4.00E+09 4.50E+09 5.00E+09 0 100 200 300 400 500 600 700 sec a.u. Brain Heart BV Cp 1　compartment model 2　compartment model C1 tissue Cp : 血中 Tracer 濃度 C1,C2 : Compartment Cp　血中マーカー濃度シミュレーションによるフィッティング Brain 計測部位 PET 画像積分値 K1 k2 フィッティング CT 部位定義部位定義 PET グラフ Time Activity Curve(TAC) Area Under Curve(AUC) Mean Transit Time (MTT)

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Page 1: Time Activity Curve(TAC) グラフ Area Under Curve(AUC) · 2013-12-27 · 3．4D画像解析 TAC AUC MTT Kinetic Model解析生体内における血流や薬剤の動態モデルを作成し、

３．4D画像解析

TAC AUC

MTT

Kinetic Model 解析生体内における血流や薬剤の動態モデルを作成し、kinetic 画像のトレーサーの動きからモデルパラメーターを解析

Area Under Curve 薬剤通過量

Mean Transit Time 平均通過時間

４．生体内における血流や薬剤の動態を画像計測血流 tracer の動き

５．Compartment Model

血流 CP

CpC1

C2

６．Brain １ Compartment Model 解析結果

3-BV131105sec

0.00E+00

5.00E+08

1.00E+09

1.50E+09

2.00E+09

2.50E+09

3.00E+09

3.50E+09

4.00E+09

4.50E+09

5.00E+09

0 100 200 300 400 500 600 700

sec

a.u

.

Brain

Heart

BV

Cp

1　compartment model

2　compartment model

C1 tissue

Cp : 血中 Tracer 濃度C1,C2 : Compartment

Cp　血中マーカー濃度

シミュレーションによるフィッティング

Brain 計測部位 PET 画像積分値K1 k2 フィッティング

CT

部位定義部位定義

PETグラフTime Activity Curve(TAC)

Area Under Curve(AUC)

Mean Transit Time (MTT)

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