ths edu acsspring2013
TRANSCRIPT
An Introduction to Flow Chemistry and its Benefits:“The Future Of Chemical Synthesis”
Who are we?
• ThalesNano is a technology company that gives chemists tools to perform novel, previously inaccessible chemistry safer, faster, and simpler.
• Market leader: Over 700 customer install base on 6 continents.
• Own chemistry team.• 11 years old-most established flow reactor company.• R&D Top 100 Award Winner.
Catalysis reactor: Modular: H-Cube Pro
H-Cube ProH2 Generation150°C, 100 barHydrogenationSelective C-C coupling
Gas Module12 Extra gases100 bar
Phoenix Module450°CNovel heterocycles
Automated injection & collection.Optimization
Mettler Toledo’s FlowIR™ Instant results
ThalesNano Markets
Agrochemical Food, Cosmetics
PetrochemicalPharmaceuticalBiotech
Catalysis
Discovery Development Production
Why do we need new synthetic techniques?
Any change?
Conventional laboratory, 1900
IT effectivity ca.10,000,000 xInstrumental ca. 100,000 x
Conventional lab,2005:effectivity changed cca. 100 x
Organic Synthesis – Growing Complexity
• 1980’s – 2-3 Steps• 1990’s – 3-4 Steps• Today – 4-8 Steps• Future – 8-50 Steps
Industry Trends NCE
What is the issue with chemical space?
Region covered in a conventional laboratory
At ThalesNano
pressure / bar
Temp
erature / °C
100 200 300
Unexploited chemistry space
-100
0
100
200
300
400
500
Expanding the Range of Reaction Conditions
“prepare what you designed and really want rather than what you can readily synthesize”
To achieve the above goal we need a chemical technology toolbox aiming at acceleration of synthetic problem solving!
Nature Reviews Drug Discovery 11, 355-365 (May 2012)
Safety Issues
Chemical Production and E-Factors in Industry
The push for flow
• This has led companies to look at new techniques to: Cut down on number steps→Lower cost Increase yields→less purification downstream Reduce catalyst screening time Re-examine untouchable chemistries→
novel molecules→competitive edge Automate→more efficient
• Flow is one of these techniques being investigated.
What is flow chemistry and how does it differ to batch?
What is flow chemistry?
Performing a reaction continuously, typically on small scale,
through either a coil or fixed bed reactor.
OR
PumpReactor Collection
Kinetics In Flow Reactors
• In a microfluidic device with a constant flow rate, the concentration of the reactant decays exponentially with distance along the reactor.
• Time in a flask reactor equates with distance in a flow reactor
X
A
dX/dt > 0
dA/dt < 0
Improving Mixing:Speeding UpProcesses
Mixing (batch vs. flow)
Flow reactors can achieve homogeneous mixing and uniform heating in microseconds (suitable for fast reactions)
•Benefits• Safety• No filtration necessary • Enhanced phase mixing
Fixed Bed Mixing: Catalyst System-CatCart®
•Over 100 heterogeneous andImmobilized homogeneous catalysts
10% Pd/C, PtO2, Rh, Ru on C, Al2O3
Raney Ni, Raney CoPearlmans, Lindlars CatalystWilkinson's RhCl(TPP)3
Tetrakis(TPP)palladiumPd(II)EnCat BINAP 30
H-Cube Pro Overview
• HPLC pumps continuous stream of solvent • Hydrogen generated from water electrolysis• Sample heated and passed through catalyst• Up to 150°C and 100 bar. (1 bar=14.5 psi)
NH
O2N
NH
NH2
Hydrogenation reactions: Nitro Reduction Nitrile reduction Heterocycle Saturation Double bond saturation Protecting Group hydrogenolysis Reductive Alkylation Hydrogenolysis of dehydropyrimidones Imine Reduction Desulfurization
Reaction times comparison batch vs. flow
Aldoxim reductionAldehyde reduction
0
5
10
15
20
25
30
t /m
in
Flow
Batch
Hydrogenation in batch vs. flow systems
0
200
400
600
800
1000
1200
t /
min
Alkylation Suzuki-Miyaura Azide synthesis Sonogashirareaction
Flow
Batch
Reactions performed in X-Cube™ vs. batch mode
Cover a much bigger parameter space within a very short period of time
H-Cube® Reaction Examples
N
O
OEt
Ar
NH
O
OEt
Ar
Acetic Acid
20% Pd(OH)2/C, 70 bar, 70oC
70% Yield, 5g
RuO2, 100 C
100 bar, 1 mL/min
99% Conversion
Batch: 200°C, 200 bar, 48 hours
Batch: 150°C, 80 bar, 3 days
Gas Module
• Versatile: Compressed Air, O2, CO, C2H4, SynGas, CH4, C2H6, He, N2, N2O, NO, Ar.
• Fast: Reactions with other gases complete in less than 10 minutes
• Powerful: Up to 100 bar capability.
• Robust: All high quality stainless steel parts.
• Simple: 3 button stand-alone control or via simple touch screen control on H-Cube Pro™.
Problems with Oxidation
Alcohol oxidation: Optimization
100 • Area% of desired product in GC-MS / (100 – Area% of reactant in GC-MS)
General conditions: H-Cube Pro with Gas Module, 50 mL/min oxygen gas, 1 mL/min liquid flow rate (0.05M in acetone, 20 mL sample volume), CatCart: 70mm., 1 % Au/TiO2 (cartridge: 70mm, THS 01639),
Batch ref.: Oxygen; perruthenate modified mesoporous silicate MCM-41 in tolueneT=80°C; 24 h; Bleloch, Andrew; et al. Chemical Communications, 1999 , 8,1907 - 1908
Very fast addition of alcohol to gold surface.Alkoxide formation.
ImprovedTemperatureControl
Miniaturization: Enhanced temperature control Large surface/volume rate
• Volume is equal to the length cubed, while surface area is equal to length squared.
• When the length is shortened, surface-to-volume ratio increases. • Microreactors have surface-to-volume ratio than macroreactors, heat
transfer occurs rapidly in a flow microreactor, enabling precise temperature control.
Yoshida, Green and Sustainable Chemical Synthesis Using FlowMicroreactors, ChemSusChem, 2010
Heating Control
Batch Flow
- Lower reaction volume. - Closer and uniform temperature control
Outcome:
- Safer chemistry.- Lower possibility of exotherm.
- Larger solvent volume. - Lower temperature control.
Outcome:
-More difficult reaction control. - Possibility of exotherm.
Heat In:Enabling New Chemistries
Heat in
Q amount of heat transferredt time takenk conductivity of the materialS surface aread distance between the two endsT1 higher temperature endT2 lower temperature end
Flow reactor
Microwave
Oil Bath
Heat transfer of Microwave, Flow reactor, Oil Bath (Flask)
0 100 200 300 400 500 600 700
0
50
100
150
200
250
300
350
400
T /
°C
t / sec
Heat transfer works two ways allowing rapid and safe control of reactions
Phoenix Flow Reactor: High Temperature
Stainless steel coil(1000 mm i.d.)
Razzaq, T.; Glasnov, T. N.; Kappe, C. O. Eur. J. Org. Chem. 2009, doi:10.1002/ejoc.200900077
Temperature: RT- 450°C
H-Cube Pro
Phoenix
Phoenix reactor possibilities
Loop Materials - sizes Stainless steel (1 – 32 ml) – up to
450oC and 100bar PTFE coil (4 – 16 ml) – up to
150oC and 20bar Hastelloy (4 – 16 ml) – up to 450oC
and 100bar
Cartridge Reactor types• CatCart (30, 70 mm) – up to
300°C and 100bar• MidiCart – up to 150°C and
100bar• Special high temperature
cartridge – up to 450°C and 100bar
Heterocyclic rings of the future, J. Med. Chem., 2009, 52 (9), pp 2952–2963.
• 3000 potential bicyclic systems unmade• Many potential drug like scaffolds
Why?• Chemists lack the tools to expand into new chemistry space
to access these new compounds.• Time• Knowledge
The quest for novel heterocycles
Gould-Jacobs Cyclization
• Standard benzannulation reaction• Good source of:
• Quinolines• Pyridopyrimidones• Naphthyridines
• Important structural drug motifs
Disadvantages:• Harsh conditions• High b.p. solvents• Selectivity• Solubility
Condensation
Cyclization
Saponification Decarboxylation
methylenemalonic ester
W. A. Jacobs, J. Am. Chem. Soc.; 1939; 61(10); 2890-2895
The nature of the substituents is critical because they increase or decrease the nucleophilicity of the ring:
Electron donating groups increase yields, Electron withdrawing groups decrease yields.
35
Process exploration
Meldrum’s acidic route to pyridopyrimidones and to hydroxyquinolines
Meldrum-savCH(OEt)3
3a-eBatch Flow
1a-e 2a-e
a: R=H, R'=H, X=Nb: R=H, R'=H, X=N,c: R=F, R'=H, X=C(CH3)d: R=H, R'=CN, X=CHe: R=H, R'=OCH3, X=CH
in THF
R
N H 2X
RO
OO
O
NH
X
R' R'
3d (43%) 3e (60%)3a (89%) 3b (60%) 3c (62%)
O
NN
F
N
O
N
N
N
OHOH
NC
OHOH
Cyclization conditions:
a: 300 °C, 160 bar, 0.6 min
b: 300 °C, 100 bar, 0.6 min
c: 360 °C, 100 bar, 1 min
d: 350 °C, 130 bar, 4 min
e: 300 °C, 100 bar, 1.5 min
Lengyel L., Nagy T. Zs., Sipos G., Jones R., Dormán Gy., Ürge L., Darvas F., Tetrahedron Lett., 2012; 53; 738-743
No THF polymerization !
AA
NH2
A
AN
O
O
O
A
A
A
A
F V PD ie thyl k e to m a lo na te N
O
O
O
O
A
AA
NHNH2
AA
A
A
F V PD ie thyl k e to m a lo na teNH
NO
OO
O
AA
A
A NH
N
OO
OA
AA
A
NH2
AA
A
A
F V PD ie thyl k e to m a lo na te
NO
OO
O
AA
A
A
OO
O
NA
A
A
A
New Scaffold Generation
PhoenixNH
O
O
O
O
A
A
A
A
M e ld ru m a c id F V PA
A
A
A NH2A
A
A
ANH
O
O
OO
O
AA
A
A
NH2
M e ld ru m a c id F V P
A
A
A
A
NH2
O
OA
A
NH
A
A
O
AA
A
A
F V PM e ld ru m A c id
OO
O
O
AA
A
A
A
A
A
A
O
5 novel bicyclic scaffolds generated-fully characterized.Many more to follow
HN
N
R
O
R
HO
HN
OR
HN R
Phoenix
T3P, 300C80 bar, THF
Ring closure on aryl NH : key step• Mitsunobu reaction or traditional heating with T3P did not
furnish the bicyclic heterocycle.• Reaction proceeded smoothly in Phoenix reactor at 300oC with
65% yield despite requirement for the cis amide conformer in transition state.
Flow offers options to dead ends.
Heat Out:Improving SafetyOf High EnergyProcesses
Heat Out=Exothermic Chem: in situ generation of reactive intermediates
• In batch the reaction can be controlled by low temperature (it slows down the reaction)• In flow it can be at room temperature applying short residence time
Heat Out
Lithium Bromide Exchange
Batch
Flow
• Batch experiment shows temperature increase of 40°C.• Flow shows little increase in temperature.
Ref: Thomas Schwalbe and Gregor Wille, CPC Systems
Setup of the Ice Cube
Ozone Module generate O3 from O2 100 mL/min, 15 % O3
Cooled Reactor Module – teflon tube or glass chip; -50°C.
Pump Module – Peristaltic or Gear PumpOptional: 1 or 2
Selective Ozonolysis Of Eugenol
Reaction parameters:Reagent flow rate 0.7 mL/minQuench flow rate 1.4 mL/minO3 flow rate 17.5 mL/min (~2 eq.)T -5 °CcEugenol 0.05 McNaBH4
0.05 M
Solvent EtOHResults:Conversion 100 %misolated 326.2 mgmmax. yield 504 mgIsolated yield 65 %Purity of isolated product 98 %
ThalesNano lab based chemistry-unpublished
Nitration in flow
OH
HO OH
OH
NO2
NO2
OHOH
O2N
Molecular Weight: 261,10
Molecular Weight: 126,11
Phloroglucinol
Pump A Pump B Temperature (oC)
Loop size (ml)
Conversion (%) Selectivity (%)
SolutionFlow rate (ml/min) Solution
Flow rate (ml/min)
ccHNO3 0.41g PG/15ml
ccH2SO4 0.4 5 - 10 7 1000 (different products)
1.48g NH4NO3/15ml ccH2SO4 0.7
1g PG/15ml ccH2SO4 0.5 5 - 10 13 100 100
1.48g NH4NO3/15ml ccH2SO4 0.5
1g PG/15ml ccH2SO4 0.5 5 - 10 13 50 80 (20% dinitro)
70% ccH2SO4 30% ccHNO3 0.6
1g PG/15ml ccH2SO4 0.5 5 - 10 13 (3 bar) 100 100
70% ccH2SO4 30% ccHNO3 0.6
1g PG/15ml ccH2SO4 0.5 5 - 10 13 (1 bar) 80
70 (30% dinitro and nitro)
Batch reference: 30ml ccH2SO4, 1g PG, 1.48g NH4NO3, 5-10oC 10 min, Conversion: 91%
ImprovingSelectivity
Flow rate vs. residence time
• Increasing the flow rate decreases the residence time - a tool for selectivity
Reactants
Products
By-products
Traditional Batch Method
Gas inlet
Reactants
Products
By-products
Batch vs. Flow
Better surface interactionControlled residence timeElimination of the products
Flow Method
H-Cube Pro™
0,4 0,6 0,8 1,0 1,2 1,4 1,6 1,8 2,0 2,2
85
90
95
100
105
110
Conversion Selectivity
%
Flow rate / mLmin-1
1% Pt/C (V) catalyst at 0,02 concentration of 4-bromo-nitrobenzene
Conditions: 70 bar, EtOH, 25°C
Selectivity through residence time control
Increase and decrease of residence time on the catalyst cannot be performed in batch.
Catalyst Flow rate mL/min
Residence time / sec
Conc. mol/dm3
Conv. %
Sel. %
IrO2 2 9 0,2 52 69
Re2O7 2 9 0,2 53 73
(10%Rh 1% Pd)/C 2 9 0,2 79 60
RuO2 (activated)2 9 0,2 100 100
1 18 0,2 100 99
0,5 36 0,2 100 98
Ru black 2 9 0,2 100 83
1% Pt/C doped with Vanadium
2 9 0,2 100 96
1 18 0,2 100 93
0,5 36 0,2 100 84
Selective dehydrochlorination
Ar
F
F
Cl Ar
F
F
H Ar
F
H
H Ar
H
H
H
A B C D
Flow rate
(mL/min)
Pressure (bar)
Temperature (oC)
Bubdet Catalyst Amount A (%)
Amount B (%)
Amount C (%)
Amount D (%)
1 20 (∆p:5 bar) 110 50 10% Pd/C 26.7% 61.5% - 7%1 20 (∆p:3 bar) 110 50 1% Pd/C 61,90% 29,40% - 2,50%1 20 (∆p:13
bar)110 50 5% Rh/C 78.9% 5.1% - 9.2%
1 20 (∆p:10 bar)
110 50 5% Pd/C 26.7% 60.9% - 6.7%
1 20 (∆p:5 bar) 110 50 5% Pd/C(S) 25% 63.4% - 6.6%
Objective: Match similar selectivity of 60% but without additives of CsF, S, K2CO3 and PPh3
Selective Suzuki coupling (Cl, Cl)
The conditions were:
1 equivalent of 2,6-dichloroquinoxaline with 1.2 equivalent of o-Tolylboronic acid
Concentration set to 0.02MSolvent: MethanolBase: NaOHAnalytics: GC-MS
N
N Cl
Cl
B
HO OH
N
N ClFlow rate (ml/min)
Pressure TemperatureCatalyst Base
Result
(bar) (oC) LC-MS, 220nm
0.8 20 100 Fibrecat 1007 (70mm) 3 ekv
Conversion: 82%Selectivity: 48%
0.3 20 100 Fibrecat 1007 (70mm) 3 ekv
Conversion: 99%Selectivity: 48%
0.8 20 100Fibrecat 1035
2.5 ekvConversion: 16%
(30mm) Selectivity: 100%
0.8 20 100 Fibrecat 1029 (30mm) 2.5 ekv
Conversion: 18%Selectivity: 100%
0.8 20 100 Fibrecat 1048 (30mm) 2.5 ekv
Conversion: 40%Selectivity: 100%
0.8 20 10010% Pd/C
2.5 ekvConversion: 89%
(30mm) Selectivity: 14%
0.5 20 50Fibrecat 1048
2.5 ekvConversion:17%
(30mm) Selectivity: ~100%
0.5 20 100Fibrecat 1048
2.5 ekvConversion: 35%
(30mm) Selectivity: ~100%
0.2 20 100Fibrecat 1007
2.5 ekvConversion: 93%
(70mm) Selectivity: 73%
0.2 20 100Fibrecat 1007
2.5 ekvConversion: 93%
(70mm) Selectivity: 80%
0.2 20 100Fibrecat 1029
2.5 ekvConversion: 12%
(30mm) Selectivity: 100%
Faster OptimizationAnd Analysis
Enabling faster optimization
• Batch reactions gave 1 results after 4 hours!
H2 / cat.+
diphenyl-acetylene
cis-stilbene
trans-stilbene
1,2-diphenylethane
H2 / cat.
H. H., Horváth; G, Papp; Cs., Csajági; F., Joó; Catalysis Communications; 8; 3; 2007; 442-446
30 40 50 60 70 800
20
40
60
80
diphenylethane cis-stilbene trans-stilbene conversion%
T (0C)
Hydrogenation of diphenylacetylene, one day optimization, %f(T)
• [RuCl2(mTPPMS)2]/Molselect DEAE
• p(H2) = 30 bar, [S] = 0.1 M• Solvent: toluene/ethanol 1/1• 24 experiments in 2 hours.
H. H., Horváth; G, Papp; Cs., Csajági; F., Joó; Catalysis Communications; 8; 3; 2007; 442-446
O-Cube™ – H-Cube® - ReactIR™ ozonolysis of decene
Ozonolysis Quenching withH-Cube®
T = -30 ºC
CSM = 0.02 M (in EtOAc)
O3 excess = 30 %
T = -30 ºC to r.t.
p = 1 bar
Cat: 10 % Pd/C
MettlerFlow IR™
O-Cube and ReactIR are trademarks of ThalesNano Inc. and Mettler Toledo International Inc., respectively, H-Cube is registered trademark of ThalesNano Inc.
H2 10%Pd/C
ThalesNano lab based chemistry-unpublished
Ozonide eluted into cool vial under N2
O-Cube ™ -H-Cube ™ -ReactIR ™ reference IR spectra
Specific absorption:Decene: monosubstituted alkene: 917 cm-1, 999 cm-1 (917 cm-1 selected)Nonanal: carbonyl: 1711 cm-1
decene
nonanal
O-Cube™ -H-Cube® -ReactIR™ monitoring
Results: Full Conversion(GCMS)Purity 97% (NMR), no work up neededYield: 85%
Reaction of SM
Increase in Product
FR reduction
Increase in Product
FR increase
Oxidation followed by inline FlowIR
SM
T= 50°C
T= 65°C
T= 80°C
T= 95°C T= 110°C T= 125°C
vflow= 0.5
vflow= 0.75
vflow= 1vflow= 1.5
vflow= 2
p (bar) T (°C) Vflow (ml/min)
33 50 0.533 65 0.533 80 0.533 95 0.533 110 0.533 125 0.533 125 0.7533 125 133 125 1.533 125 2
OCH3
OH Au-TiO2
acetone / O2OCH3
H
O
OH
OF
FCl
OH
OF
FH
First results: reaction was carried out in batch reaction was followed by Picospin 1H NMR product was identified in the crude reaction mixture purified product was also identified Picospin was tuned to 19F
COOH F2HC-
Hydrodehalogenation followed by Picospin
Solvent H2-source T (°C) t (h) Product
water Zn/HCl 100 5 100%
Automating More Processes
H-Cube Autosampler™
Gilson 271 Liquid Handler 402 single Syringe pump (10 mL) Direct GX injector (Valco) Low-mount fraction collection (Bio-Chem) Septum-piercing needle Static drain wash station Tubes, connectors, fittings
Open vial collectionCollection through probe (into closed vial)
Step 1: Optimization
Step 2: Library Production
Library Deprotection
NH2
NH
53
71
80
60
69
63
81
Yield (%) Iodobenzoicacid
Amine
30
55
88
89
25
80
Yield (%)AmineIodobenzoicacid
53
71
80
60
69
63
81
Yield (%) Iodobenzoicacid
Amine
30
55
88
89
25
80
Yield (%)AmineIodobenzoicacid
NH2
Automated test library synthesis Carbonylation
I
OH
O
NH
NH2
NH2
IOH
ONH
NH2
I
OHO NH
NH
NH2
NH2
NH2
I
OH
OCO
NH
OH
O
N
O++X-CUBE
MultistepSynthesis
Reaction at 0 °C instead of -70 °CMultistep syntheses
X = O, S
Yoshida, ChemSusChem 2012, 5, 339 – 350
Residence time = 3.4 s
MeO
MeO
(±)-oxomaritidine
NH
O
Br
HONMe3N3
N3
HO
MeCN:THF (1:1), 70 oC
O
MeO
OMe
(1)
(2)
catch, react, release
MeO
OMe
N
HO
rt to 55 oC
Ph(nBu)2P
H2OH2 (g)electrolysis
Flow hydrogenation
10% Pd/C, THF
MeO
OMe
NH
HO
O
F3C O
O
CF3
MeO
OMe
N
HO
CF3O
80 oC
NMe3RuO4OH
MeO
OMe
PhI(O2CX3)2rt
NMeO
MeO
CF3
O
OMeOH / H2O (4:1)
NMe3OH
35 oC
I.R. Baxendale, J. Deeley, C.M. Griffith-Jones, S.V. Ley, S. Saaby, G. Tranmer, J. Chem. Soc., Chem. Commun., 2006, 2566.
Flow Synthesis of Oxomaritidine
Faster and Safer Scale up
Continuous Process Advantages
Speed• 50 + times faster reactions
Better Process Yields • The continuous process ensures
greater reproducibility • less out of spec and by-products.
Safety• Dangerous reactions, toxic
intermediates• High pressure • High temperature • Supercritical reactions
Environmental impact, green chemistry
• Greener solvents (SCCO2)• Less hazardous waste:• Lower energy consumption
Cost Benefits• Lower Cost Production • Lower Material costs • Greater material yields are
achieved• Considerable savings in
utility costs. • Space requirements are
significantly lower • Less waste management
and disposal costs • Shorter Development &
Scale-up Time
Regulatory aspects• Fits into the FDA PAT
initiatives
H-Cube Midi™ reactor for scale-up
Kilo Scale
N
OH
OHHO
OH
● Genzyme needed 1.2 kg of Zavesca for an internal study, which was priced at 47K USD per 100 g.
N
OH
OHHO
OH
HN
OH
OHHO
OH
H2 / Pd(OH)2 on C
O
H
Saved~ 500K as opposed to purchasing it. It assayed with higher purity than previous commercial lots. Kilo scale.
Genzyme Chemistry
Number up or Scale Out?
Advantages for both, but scale out too much and lose flow advantages!
Survey Conducted
Small scale: Making processes safer Accessing new chemistry Speed in synthesis and
analysis Automation
Large scale: Making processes safer Reproducibility-less batch
to batch variation Selectivity
Why move to flow?
Survey Conducted
What chemistries?
Difficult to perform chemistries
• Low temperature exothermic reactions• Reactions with gases• Very slow reactions or unaccessible chemistry• Reactions with selectivity issues
Approx. 30% of reactions!
Survey Conducted
What are the major blockers?
• Where do I start?• Literature: Flow chemistry Society• Quick Start Guides
• Solubility issues• Test solvents.
What sets us apart?
ThalesNano focuses on designing reactors around specific chemistrysolutions and where flow can be applied best. We don’t try to applyflow chemistry to everything like our competitors!
Exothermic Reactions
• Safety• New chemistry• Speed
Exothermic Reactions
• Safety• New chemistry• Speed
Endothermic Reactions
• Speed• Green
Endothermic Reactions
• Speed• Green
Reactions with gases
• Safety• Simplicity• Speed• Green
Reactions with gases
• Safety• Simplicity• Speed• Green
Scale up
• Safety• Selectivity• Reproducibility• Speed
Scale up
• Safety• Selectivity• Reproducibility• Speed
Flow University
• Practical Lab Manual• Presentation tutorial• Background notes• Educational Videos
In English In Mandarin Chinese Subtitled
Chemistry Services Clients
"ThalesNano delivered to Koste Biochemicals catalyst screening and reaction optimization services of an uncompromising quality with full analytics performed in record-breaking time. A great team to work with !“-Charles Carey, Co-founder Koste Biochemicals
ComInnex Chemistry Services – Our Sister Company
• Our sister drug discovery service provider.• A leader in chemistry, library and medicinal chemistry services• Track record collaborations with >250 customers in US, EU, and Asia.• >800 focused libraries in past 12 years.• European IP standards• Excellent reputation for customer service.• Advantages:
• Located in heart of Europe, Budapest. • European standards and expertise at competitive prices on your doorstep.• CADD, Biology, and ADMET support possible.• Access to ThalesNano’s full equipment inventory.• Novel heterocycles platform based on innovative proprietary technologies.
Acknowledgements
Thank you for your attention!Any questions?
Booth 821
Some slides reproduced with the permission of the Flow Chemistry Society.