This Month in JnmDEPART-MENTS

18F-FDOPA and neuroendocrine tumors:Minn and colleagues provide an overview ofthe use of this tracer in PET and PET/CTimaging of neuroendocrine tumors, pancre-atic b-cell hyperplasia, and other disordersand discuss future applications in diagnosisand therapy. . . . . . . . . . . . . . . . Page 1915

Improving lung scintigraphy: Parker pre-views 2 articles on lung scintigraphy in thisissue of JNM and reviews the current statusof the procedure in the diagnosis of acutepulmonary embolism. . . . . . . Page 1919

Nonrigid registration of chest PET/CT:Grgic and colleagues apply intraindividualanalysis to determine whether a nonrigidregistration algorithm can improve fusionquality of 18F-FDG PET and CT thoracicimages and describe optimal breathingprotocols. . . . . . . . . . . . . . . . . . Page 1921

Tracers in pulmonary NET tumors: Kayaniand colleagues compare the performanceof 68Ga-DOTATATE, a novel selective so-matostatin receptor 2 ligand, and 18F-FDGin detection of pulmonary neuroendocrinetumors. . . . . . . . . . . . . . . . . . . . . .Page 1927

Fitted input function to estimate MRglc:Vriens and colleagues report on and validatea mathematic function to describe the arterialplasma time–activity concentration curve forquantification of glucose metabolic rate andtherapy response monitoring with dynamic18F-FDG PET. . . . . . . . . . . . . . . Page 1933

18F-FDG PET in HNSCC follow-up:Krabbe and colleagues assess the role and

timing of serial 18F-FDG PET scans assurveillance for early locoregional recurrence,distant metastases, and second primary tumorsafter treatment for advanced head and necksquamous cell carcinoma. . . . . . .Page 1940

18F-FDG and 62Cu-ATSM in lung cancer:Lohith and colleagues delineate intratumoraluptake and tracer distribution of 62Cu-ATSM,a hypoxic imaging tracer, and 18F-FDG inpatients with lung cancer of pathohistologi-cally different types. . . . . . . . . . . .Page 1948

Cerebral P-gp inhibition by tariquidar:Wagner and colleagues use PET with(R)-11C-verapamil, a permeability gluco-protein (P-gp) substrate, to measure P-gpfunction at the human blood–brain barrierafter administration of tariquidar, a potentP-gp inhibitor. . . . . . . . . . . . Page 1954

11C-MET PET and glioma progression:Ullrich and colleagues investigate thepotential of 11C-MET PET to detect tumor

progression in patients with gliomas andassess changes in tracer uptake andmolecular immunohistochemical markersduring progression. . . . . . . . Page 1962

Ischemia in cerebral amyloid angiopathy:Chung and colleagues use 99mTc-ECD brainperfusion SPECT to characterize cerebralhypoperfusion in patients with cerebralamyloid angiopathy. . . . . . . . . . . Page 1969

Reference tissue models in BBB disruption:Folkersma and colleagues assess and validatea simplified reference tissue model for ana-lyzing dynamic (R)-11C-PK11195 scans intraumatic brain injury, where blood–brainbarrier disruptions are likely. . . . .Page 1975

Endothelial dysfunction in diabetes:Djaberi and colleague explore the diag-nostic challenge presented by diabeticpatients with myocardial perfusion defectsbut no evidence of obstructive epicardialcoronary disease. . . . . . . . . . Page 1980

V/Q SPECT and low-dose CT vs. MDCTin PE: Gutte and colleagues compare thediagnostic abilities of ventilation–perfusion(V/Q) SPECT, V/Q SPECTwith low-dose CT,and pulmonary multidetector CTangiographywith a combined SPECT/MDCT scanner inpulmonary embolism. . . . . . . . . .Page 1987

Cerebral blood flow in diabetes: Kaplarand colleagues look for differences in globalor regional cerebral blood flow resulting

THIS MONTH IN JNM 11A

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from microvascular damage in types 1 and 2diabetes mellitus. . . . . . . . . . . Page 1993

SPECT for pulmonary embolism: Steinand colleagues provide an educational over-view on the current status and accuracy ofSPECT in acute pulmonary embolism anddiscuss its role in the context of increased useof CT angiography. . . . . . . . . . . . Page 1999

Pretargeted RIT of pancreatic cancer:Karacay and colleagues report on a novelpretargeting procedure for therapeutic de-livery of 90Y-labeled PAM4 IgG, a mono-clonal antibody that recognizes a uniqueepitope associated with a mucin in pan-creatic cancer. . . . . . . . . . . . Page 2008

177Lu-AMBA in GRP-R prostate cancer:Maddalena and colleagues evaluate thetumor binding and imaging potential ofthis radiolabeled bombesin derivative inlow gastrin-releasing peptide receptormodels of prostate cancer and determinehow reduced expression affects radiother-apeutic efficacy. . . . . . . . . . . Page 2017

Systemic radionuclide therapy and glio-mas: Samnick and colleagues test thetherapeutic potential of 131I-IPA, a tumor-specific amino acid derivative, combinedwith external-beam photon radiotherapy inglioma-bearing rats. . . . . . . . Page 2025

RIT with 125I-mAbs: Santoro and col-leagues assess the in vivo biologic efficiency

of internalizing and noninternalizing 125I-labeled monoclonal antibodies for the treat-ment of small solid tumors. . . . . Page 2033

18F-labeled phosphoramidate: Lapi andcolleagues report on studies exploring phos-phoramidates as novel small-molecule pros-tate-specific membrane antigen inhibitorsto develop more effective prostate cancerimaging agents with improved specificityand clearance properties. . . . . . . Page 2042

Mutant TK/GFP fusion reporter: Hsiehand colleagues construct a mutant thymidinekinase/green fluorescent protein reportergene with low cytotoxicity and high temporalresolution for real-time optical and PETmonitoring of transcription induction andother biochemical changes. . . . . Page 2049

Imaging VEGF receptors in abscesses:Levashova and colleagues determinewhether labeled forms of single-chainvascular endothelial growth factor (VEGF)can be used to image VEGF receptors in ananimal model of sterile soft-tissue inflam-mation. . . . . . . . . . . . . . . . . Page 2058

PET radioligand for H3 receptors: Plissonand colleagues synthesize and evaluate thepotential utility of 11C-GSK189254, a hista-mine H3 receptor antagonist, for PETimaging of these receptors. . . . . Page 2064

Therapy and 111In-vinorelbine liposomes:Chow and colleagues investigate the thera-peutic effectiveness of specific amounts ofthese PEGylated liposomes by varyingradiation dosage and concentrations ofchemotherapeutic agents in animal tumorgrowth suppression studies. . . . . Page 2073

Radiolabeled divalent gastrin peptide:Sosabowski and colleagues expand onprevious studies of 111In-labeled divalentgastric peptides with potential for radio-nuclide therapy in tumors overexpressinggastrin/cholecystokinin subtype 2 recep-tors. . . . . . . . . . . . . . . . . . . Page 2082

O N T H E C O V E R

Both ventilation–perfusion SPECT and multidetector CT angiographyhave high accuracy in the diagnosis of pulmonary embolism, butonly limited data comparing the two are available. A prospectivestudy using a hybrid scanner has concluded that ventilation–perfusionSPECT in combination with unenhanced low-dose CT has excellentdiagnostic performance and should probably be considered first-lineimaging in the work-up of most cases of pulmonary embolism.

See page 1990.

12A THE JOURNAL OF NUCLEAR MEDICINE • Vol. 50 • No. 12 • December 2009

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2009;50:11A-12A.J Nucl Med.     This Month in JNM

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