thermo scientific hyperforma ds 300 single-use mixer (s.u

Thermo Scientific HyPerforma DS 300 Single-Use Mixer (S.U.M.) User’s GuideDOC0011 • Revision BFebruary 2018

ContentsWarnings, safety, and warranty information 1

How to use this guide 5

Chapter 1 DS 300 Single‑Use Mixer (S.U.M.) overview 71.1 Introduction to the DS 300 S.U.M. 8

1.2 Hardware characteristics 9

1.3 BPC characteristics 13

1.3.1 S.U.M. BPC features 13

1.3.2 Open-top mixing configurations 13

1.3.3 Closed-top mixing configurations 14

1.4 Operating characteristics 14

1.4.1 Operating pressure 14

1.4.2 Working volume 14

1.4.3 Dispensing 14

Chapter 2 Setup and operating information 152.1 Site preparation 16

2.1.1 Electrical connections 16

2.1.2 Protective earth grounding 16

2.2 Initial setup 16

2.3 Docking station preparation 21

2.4 BPC preparation and setup 23

2.4.1 BPC handling instructions 23

2.4.2 Working volume 24

2.4.3 Liquid transfer 24

2.4.4 Dispensing 24

2.5 BPC loading 24

2.5.1 Open-top liner loading 24

2.5.2 Closed-top BPC loading 27

2.6 Operating information 30

2.6.1 Powering on 30

2.6.2 Height adjustment 30

2.6.3 Motor angle adjustment 31

2.6.4 Reusable bearing hub insertion for open-top liners 31

2.6.5 Drive shaft insertion 32

2.6.6 Drive shaft rotation 35

2.6.7 Controlling agitation 35

Chapter 3 Maintenance and troubleshooting 363.1 Routine maintenance 37

3.2 Preventive maintenance 37

3.3 Troubleshooting 38

Chapter 4 Specifications and part numbers 404.1 Hardware features and specifications 41

4.1.1 Hardware features 41

4.1.2 Hardware specifications 42

4.2 BPC specifications 42

4.2.1 Closed-top BPC for 50 L, 100 L, and 200 L drums 43

4.2.2 Open-top liners for 50 L, 100 L, 200 L, and 300 L

drums 44

4.3 General mixing specifications 44

4.4 Part numbers for components, parts, and accessories 45

4.5 Part numbers for replacement and spare parts 48

Chapter 5 General ordering information 495.1 Ordering instructions 50

5.2 Ordering/support contact information 50

5.3 Technical support 51

Contents

Warnings, safety, and warranty information

Congratulations! You have purchased high-quality Thermo Scientific equipment. We have included safety information in this guide, based on our knowledge and experience. It is important, however, for you to work with your Safety Management personnel to ensure that this equipment is integrated into your safety practices. Please take some time to perform your own job safety analysis in order to identify and control each potential hazard.

WARNING: Read and understand this user's guide before operating the equipment.The Thermo Scientific™ HyPerforma™ DS 300 Single-Use Mixer (S.U.M.) is designed to be operated under traditional eukaryotic cell culture conditions. A general understanding of bioreactor systems and their operation is important prior to using the system for the first time. Read and understand this user’s guide before operating; failure to do so could result in injury.

WARNING: Hazardous voltage inside.Disconnect power before opening. Service should be performed by trained personnel only. Electrical components are designed into the DS 300 S.U.M., and required for the unit to function properly. The mixing motor, motor controller, electronic lift mechanism, and hand-held control device all have electrical components. Modification, replacement, by-passing, and/or adding any electrical component without the written consent of Thermo Scientific voids any/all warranties, ETL/CE certification(s) and liabilities.

WARNING: Static electricity may build up in BPCs.• BioProcess Containers (BPCs) may act as insulators for

electrostatic charge. If electrostatic charge is transferred to a BPC, the charge may be stored in the BPC and/or the product inside. This phenomena varies by product and use; therefore, it is the sole responsibility of the end user to ensure a hazard assessment is conducted and the risk of electrostatic shock is eliminated.

• Where applicable, a product contact stainless steel coupler may be grounded to the frame to dissipate electrostatic build up from the material within a BPC. It is good practice to dissipate electrostatic buildup by grounding all BPCs prior to coming in contact with them. When working with BPCs, the use of nonconductive materials, such as nonconductive gloves, is recommended.

HyPerforma DS 300 Single‑Use Mixer User's Guide | 1Thermo Scientific

WARNING: Rotating parts—entanglement hazard.Rotating parts can cause severe injury. Keep hands away from moving parts. The safety cap on drive shaft motor must never be removed and must always be locked in place during use. If the safety cap is broken, call Thermo Scientific service personnel to replace it prior to use.

WARNING: Follow lockout/tagout procedures.To prevent injury, when servicing equipment, use your company's lockout/tagout procedures to isolate electrical, mechanical, pneumatic, hydraulic, chemical, thermal, gravitational, or any other potential energy and protect workers from the release of hazardous energy.

WARNING: Use caution with hazardous chemicals or materials.Personnel servicing equipment need to know the hazards of any chemicals or materials that may be present on or in the equipment. Use general hazard communication techniques such as Safety Data Sheets, labels, and pictograms to communicate any hazards.

WARNING: Burst hazard—air under pressure.Under normal operating conditions, the closed-top mixing BPC chamber is under slight pressure. Normal passive venting prevents any excess of pressure building up within the chamber. Chamber pressure and inlet line pressure should be monitored for proper settings. • Contents are under pressure• Do not exceed 0.03 bar (0.5 psi) BPC pressure• Do not exceed 0.34 bar (5 psi) inlet pressure• Assure vent filter is properly positioned and working properly

WARNING: Pinch hazard.Under normal operating conditions, the mixing head can be manually raised and lowered. Caution should be used to avoid pinching or crushing an operator or causing damage to equipment and/or the BPC.

WARNING: The Thermo Scientific HyPerforma DS 300 Single-Use Mixer may not be installed in a potentially explosive atmosphere as set forth in the applicable EU ATEX Directive.

Thermo Scientific


HyPerforma DS 300 Single‑Use Mixer User's Guide | 2

Protective earth grounding

Protective earth grounding for the DS 300 S.U.M. system and controller is provided through the ground terminal of the plug providing power. Source power to the controller must provide grounding to this terminal in order to minimize the hazard of a possible shock in the occurrence of a fault condition. The equipment should NOT be operated without a proper protective earth ground.

Environmental conditions

• Operating: 17 to 27°C; 20 to 80% relative humidity, non-condensing

• Storage: -25 to 65°C• Installation category II (over voltage) in accordance with IEC 664• Altitude Limit: 2,000 meters

Electrical connections

Power should be supplied by a non-GFCI 15 amp circuit. Ground faults occur when current is leaking somewhere, in effect, electricity is escaping to the ground. Electrocution can occur when the human body serves as the path for the leakage to the ground. A ground fault circuit interrupter (GFCI) senses the current flowing to the ground and switches off the power (trips the GFCI) in a fraction of a second at currents well below those that are considered dangerous. Due to the sensitivity of GFCIs to electrical leakage (a few mA), it is recommended that the S.U.B. NOT be plugged into a GFCI outlet. Main power: 20 A 108–240 VAC or 208–250 VAC, 1 Phase, 50/60 Hz circuit.

Warranty information

Any warranties, if applicable, covering this equipment exclude: (a) normal wear and tear; (b) accident, disaster or event of force majeure; (c) your misuse, fault or negligence; (d) use of the equipment in a manner for which it was not designed; (e) causes external to the equipment such as, but not limited to, external puncturing, power failure or electrical power surges; (f) improper storage and handling of the equipment; (g) use of the equipment in combination with equipment or software that we did not supply; (h) equipment sold to you as ‘used’ products; (i) contact with improperly used or unapproved chemicals or samples; (j) installation, removal, use, maintenance, storage, or handling in an improper, inadequate, or unapproved manner, such as, but not limited to, failure to follow the documentation or instructions in the deliverables or related to


Thermo Scientific HyPerforma DS 300 Single‑Use Mixer User's Guide | 3

the equipment, operation outside of stated environmental or other operational specifications, or operation with unapproved software, materials or other products; (k) manufacture in accordance with requirements you gave us; (l) installation of software or interfacing or use of the equipment in combination with software or products we have not approved; (m) use of the deliverables or any documentation to support regulatory approvals; (n) the performance, efficacy or compatibility of specified components; and (o) the performance of custom equipment or products or specified components or achievement of any results from the equipment, specified components or services within ranges desired by you even if those ranges are communicated to us and are described in specifications, a quote, or a statement of work. ADDITIONALLY, ANY INSTALLATION, MAINTENANCE, REPAIR, SERVICE, RELOCATION OR ALTERATION TO OR OF, OR OTHER TAMPERING WITH, THE EQUIPMENT PERFORMED BY ANY PERSON OR ENTITY OTHER THAN US WITHOUT OUR PRIOR WRITTEN APPROVAL, OR ANY USE OF REPLACEMENT PARTS WE HAVE NOT SUPPLIED, WILL IMMEDIATELY VOID AND CANCEL ALL WARRANTIES WITH RESPECT TO THE AFFECTED EQUIPMENT. IF THE EQUIPMENT IS TO BE USED IN THE UNITED STATES, WE MAY VOID YOUR WARRANTY IF YOU SHIP THE EQUIPMENT OUTSIDE OF THE UNITED STATES.

Use restrictions

You must use this equipment in accordance with our documentation and if applicable, with our other associated instructions, including without limitation, a “research use only” product label or “limited use” label license. This equipment is intended for research use or further manufacturing in bioprocessing applications and not for diagnostic use or direct administration into humans or animals, we do not submit the equipment for regulatory review by any governmental body or other organization, and we do not validate the equipment for clinical or diagnostic use, for safety and effectiveness, or for any other specific use or application.



How to use this guideScope of this publication

This user's guide contains information about the standard Thermo Scientific™ HyPerforma™ DS 300 S.U.M. systems, including hardware, components, product design verification methods, installation, operation and specifications. It is intended for use by people who may or may not have experience with Thermo Scientific systems, but who have some knowledge of bioproduction processes and large-scale mixing systems.

Document change information

Rev. Date Section Change made Author

A 03/2013 -- Initial release G. Brau

B 02/2018 --Updated formatting to current brand standards

E. Hale

B 02/2018 Ch. 4Removed hardware and BPC part numbers

E. Hale

Input into Thermo Scientific publications

The accuracy of the information in this publication and your satisfaction with the scope and content of this publication are important to us. Please send any corrections or suggestions you have for this user's guide (or for any other Thermo Scientific technical publication) to [email protected].

Related publications

Please contact your local sales representative for information about the related publications listed below.

Publication Description

Thermo Scientific HyPerforma DS 300 S.U.M. Unpacking Guide (DOC0010)

Information about validation procedures

Thermo Scientific HyPerforma DS 300 S.U.M. Data Sheets

Product descriptions and ordering information

Thermo Scientific

How to use this guide


Abbreviations/acronyms

Refer to the list below for definitions of the abbrieviations and acronyms used in this publication.

BPC BioProcess ContainerE-Box Electrical control panelE-Stop Emergency stopETP Equipment Turnover PackageGFCI Ground fault circuit interrupterID Inner diameterIEC International Electrical CodeOD Outer diameterS.U.M. Single-Use Mixer

Thermo Scientific

How to use this guide


DS 300 Single-Use Mixer (S.U.M.) overview

Chapter contents1.1 Introduction to the DS 300 S.U.M.1.2 Hardware characteristics1.3 BPC characteristics1.4 Operating characteristics

1


Figure 1.1. HyPerforma DS 300 S.U.M. docking station and drum (front view)

1.1 Introduction to the DS 300 S.U.M.

The Thermo Scientific™ HyPerforma™ DS 300 Single-Use Mixer (S.U.M.) offers a single-use alternative for traditional stirred tank mixing. It is designed using the same mixing principles as the stainless steel Thermo Scientific S.U.M. Both systems use an impeller linked to an overhead mixing motor, and a sealed bearing assembly which allows the impeller to turn while maintaining the integrity of the system. The HyPerforma DS 300 S.U.M. is intended for powder-to-liquid and liquid-to-liquid mixing in either open-top or closed-top bags with single-use contact surfaces.

The major components of the DS 300 S.U.M. system are shown in Figures 1.1 and 1.2, and described in more detail in the sections that follow.

1

23

4

5

6

7

8

9

1011

12

14

13

1. Motor assembly2. Vertical lift3. Horizontal support arm4. Drive shaft (stored)5. Handheld control device6. E-Stop reset button7. Main disconnect switch8. E-Box

9. Height indicator and cable management housing

10. Dolly11. Plastic drum12. Liquid drain port13. Mounted drive shaft, sleeve,

and impeller14. Conical insert

Chapter 1 | DS 300 S.U.M. overview


15. Adjustable handle (in stored position)16. Reusable bearing hub (open top applications only)17. Square torque wrench18. Spanner wrench19. Drum positioner (optional)20. Locking rear casters

1.2 Hardware characteristics

Hardware docking stationThe stainless steel DS 300 S.U.M. is designed for mobility and easy integration with single-use containers, and utilizes a simple operator interface for mixing. It is designed for easy maneuverability, is lightweight, and has a small footprint. Control of the system is managed through a tethered handheld device that manages the agitation speed and manual height adjustment. The mast assembly and E-Box house the electrical components and the main power switch. The mixer is pre-assembled, and is comprised of the following sub-assemblies and parts:

• Docking station base with locking casters in the rear• Adjustable handle that can be locked in position or stored away• Mast support structure that houses the main control unit

1817

16

19

20

15

Figure 1.2. HyPerforma DS 300 S.U.M. docking station and drum (back view)

Thermo Scientific



• Handheld control device• Vertical lift mechanism• Height indicator and cable management housing• Motor mount and motor• Drive shafts (customer-specified)• Tools (spanner wrench and torque wrench)

Available options include an adjustable motor mount mixing head capable of angular adjustments from 0–30°, drum positioner, and reusable bearing hub for use in open-top mixing.

Mixing drums and dolliesLightweight, reusable plastic mixing drums (Figure 1.3) are available in four sizes: 50 L, 100 L, 200 L, and 300 L. Plastic dollies for the drums are available in two sizes, one for 50–200 L drums, and another for 300 L drums.

Figure 1.3. Reusable plastic mixing drum

Single-use BioProcess ContainerThe single-use BioProcess Container (BPC) provides gamma irradiated, ready-to-use single-use contact surfaces, including:

• Drive shaft sleeve • Sealed bearing assembly (closed-top option only) • Tubing for liquid transfer

Available options include:• Open-top liner for media or buffer preparation• Impeller sleeve with quick connect fitting (used with the reusable

bearing hub in open-top mixing applications)

Thermo Scientific



• Closed-top BPCs designed for liquid-to-liquid applications and critical sterile solutions

• Containers are available in 50 L, 100 L, 200 L, and 300 L sizes

Handheld agitation and height control deviceThe operation of the DS 300 is simple and user-friendly. The handheld control device (Figure 1.4) gives the user freedom to move around the mixer with all controls available. The handheld device includes a digital rpm display, motor control knob, on/off power to the motor, vertical lift up and down buttons, and emergency stop (E-Stop) button. The height is visually indicated in inches on the height indicator bar and labeled for each standard drum size.

Figure 1.4. Handheld control device

Fixed motor head or optional adjustable motor headOn the standard model, the mixing motor head (Figure 1.5) is fixed at a 10° angle. On adjustable motor head models, the angle of the adjustable motor head may be changed. The adjustable motor head option enables fixing the motor head at an angle in 5° increments from 0–30°.

Figure 1.5. Motor head

Thermo Scientific



Mixer control systemElectronic components inside the unit control motor power, motor fan, vertical lift, main incoming power, Ethernet (in a future enhancement), handheld device power, motor hall-effect sensors, and the main disconnect switch. The control system (Figure 1.6) is located in the mast support structure of the DS 300 S.U.M. mixer unit. Component cables run from the mixer control system to the tethered handheld control device.

Figure 1.6. Mixer control system

Optional drum positionerAn optional drum positioner (Figure 1.7) is designed to be used with the dolly that is supplied with the DS 300 S.U.M. The drum postitioner may be utilized when the location of the drum, relative to the impeller location in the drum, is critical.

Figure 1.7. Optional drum positioner

Mixing motor assemblyThe mixing motor assembly is a directly coupled drive assembly that supplies power to the drive shaft and impeller to initiate the mixing process. The mixing motor assembly is made up of the parts shown in Figure 1.8.

Drum positioner

Thermo Scientific



1.3 BPC characteristics

1.3.1 S.U.M. BPC features

Two standard BPC configurations are available for the S.U.M.: a closed-top configuration, and a linear with a separate impeller sleeve for open-top mixing. The BPC (or open-top liner) contains the mixing process. The BPC chamber is manufactured from CX 5-14 film and the open-top liner from CX 3-9 film. Both are co-extruded film structures specifically designed for biopharmaceutical process usage. All materials are qualified for a range of physical, mechanical, biological, and chemical compatibility requirements. The BPC is validated using gamma irradiated processes.

1.3.2 Open-top mixing configurations

The open-top mixing configuration (Figure 1.9) includes an open-top liner that also utilizes a separate, single-use sleeve that covers the drive shaft once it is inserted into the mixing assembly. A reusable bearing hub is used for all open-top mixing applications. A quick connect fitting is used to connect the drive shaft sleeve to the bearing hub.

Figure 1.8. Mixing motor assembly

Motor

Latch pin for safety cover

Cap

Safety cover

Drive shaft head

Drive shaft

Figure 1.9. Open‑top liner

Thermo Scientific



1.3.3 Closed-top mixing configurations

The closed-top mixing configuration (Figure 1.10) is a fully integrated BPC with a bearing hub, drive shaft sleeve, bottom drain with sample port, inoculation line, and vent filter.

Figure 1.10. Closed‑top BPC

1.4 Operating characteristics

1.4.1 Operating pressure

The DS 300 closed-top BPC is not rated as a pressure vessel. Gas pressure should not exceed 0.03 bar (0.5 psi) within the BPC. The BPC should not be allowed to become tight during inflation. Excessive pressure may result in BPC damage or personal injury.

1.4.2 Working volume

Each DS 300 drum is designed for a working volume range. The minimum working volume and the rated working volume are listed in the general mixing specifications provided in Chapter 4: Specifications and part numbers. Actual working volumes should not exceed the indicated rated working volumes. Working volumes less than the stated minimums can result in damage to the BPC and hardware malfunction.

1.4.3 Dispensing

The DS 300 drums in the 50, 100, and 200 L sizes are equipped with a bottom drain line that allows for liquid harvest by means of peristaltic pump. Connection of the bottom drain line can be accomplished by use of the provided 1.27 cm (0.5 in.) quick connect fitting. Manipulation of the BPC as the last few liters of liquid are removed can minimize liquid hold-up. Liquid hold-up is 100 ml for 50, 100, and 200 L containers, and 500 ml for 300 L containers.

Thermo Scientific



Setup and operating information

Chapter contents2.1 Site preparation2.2 Initial setup2.3 Docking station preparation2.4 BPC preparation and setup2.5 BPC loading2.6 Operating information


2

Thermo Scientific

2.1 Site preparation

2.1.1 Electrical connections

The DS 300 S.U.M. unit can be used on circuits equipped with GFCI circuit protection. The unit is equipped with a plug connection appropriate to specific countries.

2.1.2 Protective earth grounding

Protective earth grounding for the S.U.M. system and controller is provided through the ground terminal of the plug providing the power. Source power to the controller must provide protective earth grounding to this terminal in order to minimize the hazard of a possible shock in case of a fault condition.

2.2 Initial setup

The DS 300 S.U.M. will arrive with the following items:

• Docking station mixer unit• Handheld control device• Motor and mount• Optional drum positioner• Drive shafts (customer specified)• Torque and spanner wrenches• Equipment Turnover Package (ETP), the standard or detailed

documentation package (if ordered), located on the USB drive provided with the equipment

DS 300 drums will arrive with the following items:

• Outer support container or drum• Drum dolly

Hardware uncratingThe DS 300 S.U.M. will arrive crated. Follow the provided unpacking instructions (DOC0010) in addition to the following instructions.

Note: When uncrating hardware, retain all packing materials for possible future use.

Chapter 2 | Setup and operating information


1. Remove the security screws from each of the four latches on either side of the front of the crate (Figure 2.1).

Figure 2.1. Removing security screws from crate latches

2. Swing the crate door down. The door will create a ramp for moving items in and out (Figure 2.2).

Support brace

Crate door and rampTools

Drive shafts

Figure 2.2. Open DS 300 S.U.M. crate

Thermo Scientific



3. Remove the drive shafts from the crate and set them aside. Depending on the size and number of drive shafts ordered, they may be secured to the bottom of the crate. Longer drive shafts will be secured upright in a front corner of the crate.

4. Remove the uncrating instructions from the plastic sleeve affixed to the inside wall of the crate.

5. Remove the small cardboard box containing the tools. Unwrap the tools and set them aside.

6. Remove the strap that secures the mixer to the top of the crate (Figure 2.3).

Figure 2.3. Removing the strap securing the mixer to the top of the crate

7. Remove the strap that secures the mixer to the eyes screwed into the bottom of the crate (Figure 2.4).

Figure 2.4. Removing the bottom strap

Thermo Scientific



8. Remove the large wing nuts from the front support brace (Figure 2.5). Then pull the front support brace from the crate (Figure 2.6), pulling both sides straight out at the same time to keep the bolts from binding inside the brace.

9. Carefully remove the DS 300 S.U.M. by rolling it forward out of the crate (Figure 2.7).

CAUTION: Do not lift the unit by its casters. If the unit must be lifted, lift by the bottom of the cart frame.

Figure 2.5. (Left) Removing the wing nuts from the front support brace

Figure 2.6. (Right) Removing the front support brace

Figure 2.7. Rolling the DS 300 out of the crate

10. Remove all foam and plastic wrap packaging materials from the unit. The handheld control unit is wrapped separately and attached to the side of the handle. Use caution when cutting the packaging material from the device. Then hang the handheld device on the hook (Figure 2.8).

Thermo Scientific



11. If your unit is equipped with the optional rotating motor head, rotate the motor into working position (Figure 2.9). See section 2.6.3 of this guide for more information about adjusting the rotating motor head.

Figure 2.8. Hanging the handheld control device on the hook

Figure 2.9. Motor head rotation (optional)

12. Inspect the unit to ensure that no damage occurred during shipping. Contact your sales representative immediately if damage has occurred.

13. Place all packaging and shipping materials back into the crate for possible future use.

14. Place the bearing hub, torque wrench, and spanner wrench into the appropriate storage holes on the docking station unit. Place the drive shaft(s) in the appropriate storage holder(s) on the docking station.

Thermo Scientific



2.3 Docking station preparation

To prepare the DS 300 S.U.M. for use, follow the steps below.

1. Use the steering handle to roll the docking station into the desired location for mixing. When the unit is in position and the handle is not in use, lower the steering handle by pulling on the locking pin on the side and pushing the handle down, as shown in Figure 2.10.

Note: All movement of the DS 300 S.U.M. hardware unit should be over smooth surfaces with the unit detached from the drum and dolly and disconnected from all power and feed sources.

Figure 2.10. Lowering the steering handle

2. Verify that the facility's electrical supplies are sufficient to support the power requirements of the DS 300. The unit should be plugged into a minimum 8 amp outlet.

3. Engage the caster brakes on the rear wheels of the docking station (Figure 2.11).

Figure 2.11. Locking the rear wheels

Thermo Scientific



4. Verify that the main power is off and the E-Stop button on the handheld control device is pushed in (Figure 2.12).

WARNING: Electrical shock possible.Use the E-Stop button to disconnect all power to the system.

5. Verify that the main motor power switch is in the "Off" position.

6. Connect the electrical plug to the power in the facility.

7. Refer to hardware/electrical label to ensure that proper electrical voltage is connected to the DS 300. Then turn on the main power switch.

8. Engage the E-Stop button on the top of the handheld control device by turning the red button in the direction of the arrows (Figure 2.13). When engaged, the button will be slightly elevated.

Figure 2.13. Engaging the E‑Stop button

Figure 2.12. Pushing in the E‑Stop button

Thermo Scientific



9. Press the green E-Stop reset button on the side panel of the E-Box (Figure 2.14). The button will light. The unit is now ready for operation.

Figure 2.14. E‑Stop reset button location

E-Stop reset button

Note: The plastic drum and dolly have been wiped clean of debris. After the dolly and drum are unpacked, use your company's approved cleaning solution to clean these items to your clean room specifications.

2.4 BPC preparation and setup

This section outlines the installation and setup of the DS 300 BPC. Please become familiar with the orientation of the BPC and the drum before beginning to install it. For reference, on closed-top BPCs, the front of the bag is designated as the panel containing the bearing port. This should face the bearing port receiver and motor as the bag is loaded. In addition, confirm that the correct volume BPC is being used in a drum with a corresponding volume.

2.4.1 BPC handling instructions

Do not use scissors or any sharp objects when opening outer polybags. When placing the BPC in containers, do not drag it over corners or sharp objects. Do not lift the BPC by the corners or top seams. Allow the BPC to fill to capacity. After filling, disconnect the bag from the fill line. Carefully coil tubing on top of the BPC to prevent puncturing the BPC with cable ties or clamps. Use cushioning between tubing and BPC in storage and transport.

Thermo Scientific



2.4.2 Working volume

Each drum is designed for a specific working volume range. The minimum working volume and the rated working volume are listed in the general mixing specifications in Chapter 4. In normal operation, the actual working volumes should not exceed the indicated rated working volumes.

2.4.3 Liquid transfer

The BPC is designed with thermoplastic tubing, quick connects and tri-clamps for the purposes of adding to and dispensing from the BPC. For closed-top mixing applications, a sterile environment can be maintained as long as all connections are made in an aseptic manner. To maintain the sterility of the mixing system, connect additional lines (quick connects and tri-clamp) under a laminar flow hood or with a sterile tubing welder.

2.4.4 Dispensing

CAUTION: The agitator should not be operated at volumes less than the stated minimum volume or when the level of the liquid falls below the top level of the impeller; doing so will cause splashing and foaming of the remaining product.

With the exception of the 300 L BPC, all BPCs are equipped with a drain line that allows for liquid removal by means of a peristaltic pump. The drain is located at the bottom of the BPC, allowing for minimal hold up volumes. Connect the bottom drain line using the provided 1.27 cm (1/2 in.) quick connect fitting. Be sure to turn off agitation during draining when approaching the minimum working volume.

2.5 BPC loading

2.5.1 Open-top liner loading

Use the following steps to install an open-top BPC liner.

1. If it is not already there, place the drum on the dolly.

2. For ease of installation, move the drum two or three feet away from the docking station.

3. A 50 L BPC may be used in a 100 L drum, if desired. To use this configuration, ensure that the white plastic spacer is placed in the bottom of the 100 L drum, under the conical insert (Figure 2.15).

Thermo Scientific



Figure 2.15. 50 L spacer being placed in the bottom of the drum

4. Carefully unpack the BPC from its two protective polybags. The easy-to-use safety blade polybag opener (available from Thermo Fisher Scientific) is one option. Do not use scissors or a knife to remove the polybag, as this may damage the BPC.

5. For 50, 100, and 200 L BPCs, uncoil and remove protective packaging from the drain line on the bottom of the BPC. Note: 300 L BPCs do not have bottom drain lines.

6. For 50, 100, and 200 L BPCs, ensure that the circular plastic support collar on the drain line is positioned close to the bottom of the bag. This stop will support the BPC over the drain hole. Note: 300 L BPCs do not use support collars.

7. If it is not already open, remove the outside drain line cap and washer from the bottom of 100 and 200 L drums.

8. Insert the drain line through the hole in the bottom of the conical drum insert (Figure 2.16).

Figure 2.16. Inserting the drain line through the hole in the bottom of the drum

Thermo Scientific



9. Carefully lower the bottom of the BPC into the drum with the elbow in the drain line facing the drain port (if present) in the bottom of the drum. Then pull the drain line through the bottom front face of the drum.

10. Check to make sure the drain line and the support collar are positioned correctly (if applicable).

11. Place the liner inside of the drum and fold the edge of the liner over the top lip of the drum (Figure 2.17).

Figure 2.17. Folding the liner over the lip of the drum

12. Roll the drum and dolly under the motor head of the docking station (Figure 2.18).

Figure 2.18. Rolling the drum and dolly under the motor head

Note: To properly place the drum under the docking station, the motor head may need to be lifted. To operate the lift mechanism, see section 2.6.2.

Thermo Scientific



13. If your unit is equipped with the optional drum positioner, secure the drum and dolly to the positioned with the supplied strap (Figure 2.19).

Figure 2.19. Securing the drum and dolly to the positioner with the strap

2.5.2 Closed-top BPC loading

Use the following steps to load a closed-top BPC.

1. If it is not already there, place the drum on the dolly.

2. For ease of installation, ensure that the drum is moved two to three feet away from the docking station.

3. For 50 L BPCs, be sure the plastic spacer is in the bottom of the 100 L drum, under the conical insert (Figure 2.20). The spacer allows a 100 L drum to be used with 50 L BPCs.

Figure 2.20. 50 L spacer being placed in the bottom of the drum

4. Carefully unpack the BPC from its two protective polybags. The easy-to-use safety blade polybag opener (available from Thermo Fisher Scientific) is one option. Do not use scissors or a knife to remove the polybag as this may damage the BPC.

Thermo Scientific



5. Uncoil and remove protective packaging from the drain line on the bottom of the BPC. Do not remove the protective packaging from the top of the BPC as this time.

6. For 50, 100, and 200 L BPCs, ensure that the circular plastic support collar on the drain line is positioned close to the bottom of the bag. This collar will support the BPC over the drain hole.

7. If it is not already open, remove the outside drain line cap and washer from the bottom of 100 and 200 L drums.

8. Insert the drain line through the hole in the bottom of the conical drum insert. Note: 300 L drums do not use drain lines.

9. Thread the drain line through the bottom front face of the drum, if applicable.

10. Carefully lower the bottom of the BPC into the drum with any tubing sets on the top of the BPC draped over the side until the bearing assembly at the top of the BPC is about level with the drive shaft motor (Figure 2.21).

Figure 2.21. Inserting the BPC into the drum

11. Roll the drum directly under the motor assembly of the docking station. Note: To properly place the drum under the docking station, the motor head may need to be lifted. To operate the lift mechanism, see section 2.6.2.

12. Remove the protective black cap from the bearing port and slide the port into the receiver of the motor mount block and lock into place with the retention clamp (Figure 2.22).

Thermo Scientific



Figure 2.22. Inserting the bearing port into the motor mount

Note: When lining up the bearing port with the receiver of the motor mount block, do not twist the BPC in the drum. Rotate the drum and dolly, instead.

13. Ensure that the drain line and support collar are positioned correctly in the drum, if applicable.

14. Remove the protective packaging from the lines at the top of the BPC.

15. If your unit is equipped with the optional drum positioner, use it to secure the drum and dolly in place with the supplied strap (Figure 2.23).

Figure 2.23. Securing the drum and dolly to the positioner with the strap

Thermo Scientific



2.6 Operating information

2.6.1 Powering on

If the power is not already on, use the following steps to turn on the power. These steps are described in greater detail in section 2.3.

1. Toggle the main disconnect switch on the E-Box to the "On" position. This will supply power to the unit without turning on and operating the motor.

2. Ensure that the E-Stop button is engaged by turning and lifting up on the red button on the top of the handheld control device.

3. If it is not already lit, press the green E-Stop button on the E-Box. When the E-Stop button on the E-Box is lit, the system is ready for use.

2.6.2 Height adjustment

Use the following steps to adjust the height of the mixer.

1. Operate the lift assembly by pressing the up or down button located on the handheld control device (Figure 2.24). CAUTION: When raising and lowering the mixing head, caution should be used to avoid pinching or crushing an operator or damaging the equipment or the single-use liner.

Figure 2.24. Adjusting the height using the handheld control device

Thermo Scientific



2. The correct height can be determined using the height indicator labels on the vertical cable management housing. The height should fall within the white area for the size of the drum in use. Note that the labels assume the drum is on a dolly, and are not accurate if the drum is not on a standard dolly.

2.6.3 Motor angle adjustment

Certain models are equipped with motors that can be adjusted to different angles. To adjust the angle of these motors, follow the steps below.

1. Hold the handle on the motor, and pull the knob on the side of the motor block until the motor is free to rotate relative to the horizontal plane.

2. There are pin holes every 5°, from 0–30°. Rotate the motor head, and release the knob when the motor angle is correct. Ensure that it locks into the desired position (Figure 2.25). CAUTION: Never adjust the motor angle while the motor is running.

Release knob for adjustable motor head

Figure 2.25. Motor angle adjustment

2.6.4 Reusable bearing hub insertion for open-top liners

A reusable bearing hub is needed when using open-top containers. Use the following steps to insert the reusable hub.

1. Open the latching mechanism under the motor head and slide the hub into the holder (Figure 2.26).

Thermo Scientific



Figure 2.26. Inserting the reusable bearing hub

Figure 2.27. Closing the bearing hub mounting latch

2. Close and engage the latch (Figure 2.27).

2.6.5 Drive shaft insertion

Use the following steps to insert the drive shaft through the motor head.

1. Remove the latch pin from the safety cover on the motor and lift the clear plastic safety cover (Figure 2.28).

Figure 2.28. Removing the motor head latch pin and safety cover

Thermo Scientific



2. Unscrew the threaded cap covering the hollow pass-through of the motor (Figure 2.29).

Figure 2.29. Removing the cap

3. Use the following steps to insert the drive shaft through the hollow pass-through of the mixing assembly:• Attach the drive shaft and impeller sleeve to the bottom of the

bearing hub, using the quick connect fitting (Figure 2.30).• Use two hands to load the drive shaft through the top of the

motor assembly. A slight back-and-forth twisting motion will aid in insertion.

• When approximately 5.1 cm (2 in.) of shaft remains, twist slightly to engage the impeller (Figure 2.31).

Figure 2.30. Drive shaft sleeve installation

Figure 2.31. Inserting the drive shaft

Thermo Scientific



• When approximately 2.54 cm (1 in.) of shaft remains, twist slightly to engage the bearing assembly.

• When approximately 0.64 cm (0.25 in.) of the shaft remains, twist to align the motor drive keyway with one of the four outer slots on the drive shaft head (Figure 2.32).

CAUTION: In facilities with low ceiling heights, use caution to avoid impacting the ceiling or ceiling fixtures when removing and inserting the drive shaft.

Figure 2.32. Aligning the motor drive (pin is coupled with the notch in the drive shaft)

4. Use the following steps to directly couple the drive shaft to the motor drive:• Place the threaded cap on the hollow pass-through and hand-

tighten clockwise.• Tighten the cap by placing the spanner wrench on the hollow

pass-through and tighten the cap using the supplied torque wrench (Figure 2.33). The torque wrench is a standard 3/8 in. square drive, and it is calibrated at the factory at 150 in-lb.

• Remove the wrenches and place them in storage holders.• Close the safety cover and insert the latch pin.

Figure 2.33. Coupling the drive shaft to the motor drive

Thermo Scientific



2.6.6 Drive shaft rotation

The drive shaft rotates counterclockwise when viewed from the top looking down. The DS 300 is designed to mix in this direction only.

2.6.7 Controlling agitation

Agitation is controlled with the handheld control device as described in the following steps.

1. To supply power to the handheld control device, turn the On/Off knob to the "On" position. The motor speed will be displayed in rpm. CAUTION: Carefully turn the knob on the handheld control device to the "On" position. Before turning the motor on, turn the motor rpm knob all the way to the left to start the motor at the lowest speed.

2. Turn the motor rpm knob to increase or decrease the rate the impeller is spinning (mixing speed). The total mixing speed range is 30–355 rpm and is displayed on the screen of the handheld control device (Figure 2.34). Note: In the event of an emergency, use the red E-Stop button on the top of the handheld control device to shut off power to the motor and handheld control device.

Figure 2.34. Controlling the speed

Thermo Scientific



Maintenance and troubleshooting

Chapter contents3.1 Routine maintenance 3.2 Preventive maintenance3.3 Troubleshooting

3


3.1 Routine maintenance

Environmental conditions, operating parameters, and the ability of the user to adhere to standard operating procedures as outlined in this user's guide can have significant impact upon the useful life of the DS 300 S.U.M. The following maintenance guidelines are based on standard operating conditions.

The mixing system is inherently robust, and requires low levels of routine maintenance. Taking time between mixing batches to clean the exterior of the DS 300 S.U.M. will improve the appearance and overall longevity of the system. The drive motor is an industrial grade induction motor with a permanently sealed and lubricated gear box. The drive shaft is constructed to wear slightly with use and should be visually inspected after each run. Visual inspection of wear and components, and following maintenance guidelines will ensure years of dependable service.

3.2 Preventive maintenance

Replace the worn drive shaft assembly when the drive hex diameter at its widest location measures equal to or less than 1.44 cm (0.56 in.). Measure the diameter at the widest location across the points, as shown in Figure 3.1.

Figure 3.1. Drive shaft hex diameter measurement location

Hex diameter measurement location

If the drive shaft becomes difficult to turn, lightly coat the drive cap threads with food-grade anti-seize.

It is a good idea to have spare parts on hand. See section 4.5 for more information.

Chapter 3 | Maintenance and troubleshooting


3.3 Troubleshooting

The mixer will not operate (height adjustment does not operate or the speed control is unresponsive).

There is an issue with power being supplied to the system.• Ensure that the system is plugged into a correctly-rated wall

outlet, and that the main power switch on the E-Box is in the "On" position.

• Ensure that the facility breaker for the outlet being used by the reactor has not been tripped. If tripped, verify the total current load on the breaker circuit and make modifications, if necessary. Note: The S.U.M. should be on its own dedicated electrical outlet. Only certified electricians are authorized to open the E-Box.

The E‑Stop has disabled the power to the unit.Ensure that the green E-Stop switch on the E-Box is illuminated. If it is not illuminated, twist the red E-Stop button on the top of the handheld control device to return it to the operating position, then press the E-Stop reset button on the E-Box. The green E-Stop button on the E-Box should be illuminated.

There are loose cord connections, or a fuse is tripped or blown inside the unit.• Verify that all cords are plugged in tightly to the connections on

the outside of the E-Box.• Disconnect the main power cord and inspect the electrical

fuses inside the E-Box. Determine the fault condition by visual inspection. If the fault condition cannot be determined by visual inspection, contact Thermo Scientific technical support. Only certified electricians are authorized to open the E-Box.

The rpm display on the handheld control device is inaccurate.

The motor needs to be calibrated. Contact Thermo Scientific support personnel.

Issue:

Cause/solution:

Cause/solution:

Issue:

Cause/solution:

Cause/solution:

Thermo Scientific



There are mixer/agitation problems. The handheld control device enables, but the motor does not respond.

Verify that the motor cables are fully connected to the E‑Box. Ensure that the system has power.

The mixing performance is poor.

Ensure that the drive shaft is correctly loaded.

The barrel is positioned incorrectly.

Reposition the barrel directly under the motor head.

The height needs to be adjusted.

Lower the motor to the height recommended by the markers on the vertical mast for the size of the barrel you are using.Note that these markers assume that the drum is on the standard dolly.

The BPC has been loaded improperly.

Reload the BPC using the instructions provided in Chapter 2.

The motor has been calibrated improperly.

Contact Thermo Scientific support personnel.

There is excess tension in the film near the bearing port of the loaded BPC.

If possible, reload the BPC by carefully following the instructions provided in Chapter 2.Provide excess film to the region of the BPC nearest the bearing port when aligning the BPC in the tank. Do not begin liquid fill until the BPC is properly seated in the tank. Verify that the black bumper located in the motor mount block is present.

Issue:

Cause/solution:

Issue:

Issue:

Cause/solution:

Cause/solution:

Issue:

Issue:

Cause/solution:

Cause/solution:

Issue:

Cause/solution:

Issue:

Cause/solution:

Thermo Scientific



Specifications and part numbers

Chapter contents4.1 Hardware features and specifications4.2 BPC specifications4.3 General mixing specifications4.4 Part numbers for components, parts, and accessories4.5 Part numbers for replacement and spare parts

4


4.1 Hardware features and specifications

4.1.1 Hardware features

See Figure 4.1 below for design features of the DS 300 hardware.

Figure 4.1. HyPerforma S.U.M. model DS 300 docking station and drum (front view) 1

23 4

5

67

8

9

1011

12

14

13

1. Motor assembly2. Vertical lift3. Horizontal support arm4. Drive shaft (stored)5. Handheld control device6. E-Stop reset button7. Main disconnect switch8. E-Box

9. Height indicator and cable management housing

10. Dolly11. Plastic drum12. Liquid drain port13. Mounted drive shaft, sleeve,

and impeller14. Conical insert


Chapter 4 | Specifications and part numbers


Table 4.1. DS 300 S.U.M. specifications.

Power 108–240 VAC, 50–60 Hz

Input amperage 15 A

Footprint 76.2 cm (30 in.) W x 86.4 cm (34 in.) D

HeightLow: 122.4 cm (48.2 in.)High: 162.3 cm (63.9 in.)

Weight 180 kg (398 lb.)

Material 304 Stainless steel

Control panel Built to IP65 standards

Flow type Radial/axial

Maximum speed 350 rpm

Impeller-to-bag location 5:1 off-center

Table 4.2. DS 300 BPC specifications.

Impeller Single impeller with 3 blades

Impeller material USP Class VI, HDPE

Impeller sleeve with quick connect C-Flex™

Open-top mixing liner Chamber made of CX 3-9 film

Closed-top mixing BPC Chamber made of CX 5-14 film

4.2 BPC specifications

See Table 4.2 below for general DS 300 BPC specifications.

4.1.2 Hardware specifications

See Table 4.1 for DS 300 S.U.M. hardware specifications.

Thermo Scientific



4.2.1 Closed-top BPC for 50 L, 100 L, and 200 L drums

Drain line

Addition line 1Addition line 2

Sleeve and impellerRecirculating/sample

line

Vent filter

Description Tubing set (ID x OD x L) End treatment

Bottom drain line 12.7 mm (1/2 in.) x 19.1 mm (3/4 in.) x 3.41 m (11.17 ft.)Polycarbonate quick connect 12.7 mm

(1/2 in.) insert (MPX) and cap

Addition line 1 9.5 mm (3/8 in.) x 15.9 mm (5/8 in.) x 0.61 m (2 ft.)Polycarbonate quick connect 9.5 mm

(3/8 in.) body (MPC) and plug

Addition line 2 19.1 mm (3/4 in.) x 25.4 mm (1 in.) x 1.22 m (4 ft.)38.1 mm (1.5 in.) Tri-clamp with 19.1 mm (3/4 in.) hose barb, with gasket

Steril-Enz™ IIH

Vent filter 6.4 mm (1/4 in.) x 12.7 mm (1/2 in.) x 10.1 cm (3.98 in.) Hydrophobic vent with Emflon™ II, HB

Recirculation/sample line

12.7 mm (1/2 in.) x 19.1 mm (3/4 in.) x 0.91 m (2.99 ft.) splits to 12.7 mm (1/2 in.) x 19.1 mm (3/4 in.) x 30.5 cm (12.01 in.) and 12.7 mm (1/2 in.) x 19.1 mm (3/4 in.) x 0.61 m (2 ft.)

Polycarbonate quick connect 12.7 mm (1/2 in.) body (MPX) and plug

polycarbonate quick connect 12.7 mm (1/2 in.) insert (MPX) and cap

Figure 4.2. Closed‑top BPC

Thermo Scientific



4.2.2 Open-top liners for 50 L, 100 L, 200 L, and 300 L drums

Tank liner without a drain line

Tank liner

Drain line

Description Tubing set (ID x OD x L) End treatment

Drain line 12.7 mm (1/2 in.) x 19.1 mm (3/4 in.) x 1.83 m (6 ft.)Polycarbonate quick connect 12.7 mm

(1/2 in.) insert and cap

4.3 General mixing specifications

Table 4.3. Typical open‑top mixing with standard impeller sizes.

Left-to-right offset

Front-to-back position

Lift height

Motor angle (fixed or

adjustable motor head

models)

Motor rpm

Minimum working

liquid volume

Turn-down ratio

Minimum hold-up

Maximum liquid fill

50 L drum

0 ≈ 1 in. ≈ 3/16 in. 10° 350 10 L 5:1 100 mL 50 L

100 L drum

0 ≈ 2 in. ≈ 7/8 in. 10° 350 20 L 5:1 100 mL 100 L

200 L drum

0 ≈ 2 1/8 in. ≈ 12 1/16 in. 10° 350 40 L 5:1 100 mL 200 L

300 L drum

1/2 in. left ≈ 2 1/2 in. ≈ 15.74 in. 10° 350 79 L 4:1* 500 mL 300 L

* 5:1 turndown ratio can be achieved using the adjustable angle motor head

Figure 4.3. Open‑top liner

Thermo Scientific



Table 4.4. Minimum open‑top mixing for adjustable motor head S.U.M.s with standard impeller sizes.

Left-to-right offset

Front-to-back position

Lift height

Motor angle (fixed or

adjustable motor head

models)

Motor rpm

Minimum working

liquid volume

Turn-down ratio

Minimum hold-up

Maximum liquid fill

50 L drum

≈ 1 in. left ≈ 1/2 in. 0 5° ≈ 180 9.2 L 5.4:1 100 mL 50 L

100 L drum

≈ 1 in. left ≈ 1/2 in. 0 5° ≈ 205 9.8 L 10:1 100 mL 100 L

100 L drum

≈ 1 in. left ≈ 1/2 in. ≈ 7/8 in. 5° ≈ 140 16.7 L 6:1 100 mL 100 L

200 L drum

≈ 3/4 in. left

≈ 1 1/4 in. ≈ 11 1/16 in. 5° ≈ 150 20 L 10:1 100 mL 200 L

200 L drum

≈ 3/4 in. left

≈ 1 1/4 in. ≈ 11 1/8 in. 5° ≈ 140 22.5 L 8.8:1 100 mL 200 L

300 L drum

NA due to flat bottom

NA ≈ 15.24 in. 5° ≈ 164 61 L 5:1 500 mL 300 L

300 L drum

NA due to flat bottom

NA ≈ 15.24 in. 5° ≈ 124 65 L 5:1 500 mL 300 L

Table 4.5. Country‑specific electrical plug part numbers.

Country Cat. no.

Europe SV50177.345

UK SV50177.346

China SV50177.347

US (110 VAC) SV50177.348

US (208 VAC) SV50177.349

India SV50177.350

Italy, Chile SV50177.351

Brazil, Switzerland SV50177.352

4.4. Part numbers for components, parts, and accessories

Thermo Scientific



Table 4.6. Conical drum part numbers.

Size Dimensions (diameter x height) Cat. no.

50 L 60 x 58 cm (23.5 x 23 in.) with insert SH30959.01

100 L 60 x 76 cm (23.5 x 29.75 in.) SH30959.02

200 L 60 x 114 cm (23.5 x 44.75 in.) SH30959.03

300 L 61 x 122 cm (24 x 48 in.) SH30959.04

Table 4.7. Dollies for drums part numbers.

Size Description Cat. no.

50–200 L Plastic dolly SH30958.01

300 L Stainless steel dolly SH30958.02

Figure 4.4. (Left) Plastic dolly

Figure 4.5. (Right) Stainless steel dolly

Table 4.8. Drive shaft part numbers.

Drum size Drive shaft length Cat. no.

50 L 66.3 cm (26.1 in.) SV50959.03

100 L 84.1 cm (33.1 in.) SV50959.01

200 L 108 cm (42.5 in.) SV50959.02

300 L 129.5 cm (51 in.) SV50177.49

Figure 4.6. Drive shaft

Thermo Scientific



Table 4.9. Reusable bearing hub (for open‑top liners) part number.

Size Description Cat. no.

50–300 L Reusable bearing hub SV50177.77

Figure 4.7. Reusable bearing hub for open‑top liners

Table 4.10. Impeller, sleeve, and connector (for open‑top liners) part numbers.

Drum size Description Sleeve length Cat. no.

50 L Impeller, sleeve, and connector for 66 cm (26 in.) drive shaft 35.3 cm (13.9 in.) SH30749.11

100 L Impeller, sleeve, and connector for 83.8 cm (33 in.) 53.1 cm (20.9 in.) SH30749.12

200 L Impeller, sleeve, and connector for 108 cm (42.5 in.) 77 cm (30.3 in.) SH30749.13

300 L Impeller, sleeve, and connector for 129.5 cm (51 in.) 96 cm (37.8 in.) SH30749.08

Figure 4.8. Impeller, sleeve, and connector for open‑top liners

Thermo Scientific



Table 4.11. Optional heavy‑duty tubing clamp part numbers.

Description Cat. no.

Heavy-duty tubing clamp SV20664.01

Heavy-duty tubing clamp (4 pack) SV20664.02

Heavy-duty tubing clamp (10 pack) SV20664.03

4.5. Part numbers for replacement and spare parts

Table 4.12. Part numbers for replacement and spare parts.

Description Cat. no.

BLI lifting column with hall effects SV50961.01

Hub clamp door SV50177C.02

1/4 in. Rubber cord SV50177.124

Surface mount latch SV50177.121

3/8 in. x 150 in-lb. Square torque wrench SV50177.11

Wrench SV50177.10

Motor safety cap SV50177.06

50 L drive shaft safety cap SV50177.90

Common motor sleeve SV50177A.03

Thermo Scientific


General ordering information

Chapter contents5.1 Ordering instructions5.2 Ordering/support contact information5.3 Technical support information

5


5.1 Ordering instructions

BPCs and hardware components for the DS 300 S.U.M. can be ordered directly from Thermo Fisher Scientific. These items include all components that have part numbers beginning with the following digits:• SH• SV• SUM

5.2 Ordering/support contact information

In the Americas and Asia1726 Hyclone DriveLogan, Utah 84321United StatesTel: +1 435 792 8500Email: [email protected]

In EuropeUnit 9 Atley WayCramlington, NE 23 1WAGreat BritainTel: +44 (1) 670 734 093Fax: +44 (1) 670 732 537Email: [email protected]

Chapter 5 | General ordering information


5.3 Technical support

Technical support for the DS 300 S.U.M. is available in a variety of formats. Some or all of the following may be appropriate, depending on individual experience and circumstances.

Technical service hotline and emailContact your Thermo Scientific sales representative for general product pricing, availability, delivery, order information, and product complaints.

Call +1 435 792 8500 (United States) or +44 (1) 670 734 093 (Europe, U.K.) for direct and immediate response to overall product questions, and product technical information (Technical Support). You can also contact Tech Support by emailing: [email protected]

Initial setup and operationAppropriate technical support is available to assist in the initial setup and operation of each DS 300 S.U.M. system. If you require assistance in setting up and operating your DS 300 S.U.M. system, please inquire at the time of purchase.

TrainingTraining can be provided for startup and operation of the DS 300 S.U.M. Contact your Thermo Scientific sales representative.

Chapter 5 | General ordering information


Find out more at thermofisher.com/sumFor Research or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.© 2018 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries

unless otherwise specified. C-Flex is a trademark of Saint-Gobain Performance Plastics. Emflon is a trademark of Pall Corporation.

SterilEnz is a trademark of PAW BioScience. DOC 0011 Version B

Logan, Utah 84321United States of America+(1) 435-792-8500

Cramlington NE23 1WAUnited Kingdom+ 44 (0) 1670-734093

Millersburg, Pennsylvania 17061United States of America+(1) 717-692-2104

Matamoros, TamaulipasMexico+011 (52) 565-8109700

thermo scientific hyperforma ds 300 single-use mixer (s.u

Documents