There are three scholarships for pre-medical students that are available for the 2010-2011 academic year.  These are:

Whatcom County Medical Society Scholarship:  one $500 award Dr. Ralph & Mrs. Eleanor Rinne Pre-Medical Scholarship:  two $1500 awards

If you would like to apply, please visit 

    http://www.careers.wwu.edu/prehealth_financialaid.shtml 

for a statement of eligibility and for application details. 

Or, you may stop by Old Main 380 or Old Main 280 to pick up an application.  Completed applications are due in Old Main 380 (Academic Advising Center) by Monday, May 3,

2010. 

Figure 6-1 part 4

Protein Data Bank Workshop

pdb Rasmol

Do the protein explorer tour!!!!!

http://www.umass.edu/microbio/chime/pe_beta/pe/protexpl/qtour.htm

Chapter 6 Opener

Figure 6-4

Figure 6-5

Figure 6-6

Figure 6-7

Figure 6-8

Figure 6-9

Figure 6-9a

Figure 6-9b

Figure 6-10

VVP Fig 6-16

pdb

Other Properties of Amino Acids

• Stereochemistry (all biosynthetic proteins made up of L-isomer)

• Hydropathy (partitioning between polar and nonpolar solvents as indicator of polarity) (see Table 6-2 in VVP p 150)

these two properties are major determinants of peptide conformation

Table 6-1

Figure 6-12

Figure 6-15 Keratin: a coiled coil

Figure 6-16 Higher order keratin structure

Globular Protein 3o Structure

2o structural elements (helices, sheets, turns…) pack together to give a folded protein or subunit. This so-called “tertiary” structure is stabilized by non-covalent interactions, the hydrophobic effect and disulfides. Within the 3o structure are “motifs” and “domains”.

The 3o structure can be derived from one or more domains.

Figure 6-20b Protein crystals: flavodoxin

Figure 6-20e Protein crystals: lamprey hemoglobin

Figure 6-21

Figure 6-27 cytochrome c: hydrophillic residues and hydrophobic residues

Figure 6-33 Hemoglobin

Table 6-3

Figure 6-35 Bovine chymotrypsin

Figure 6-38 Molecular dynamics of Mb

Page 159

Figure 6-39

Figure 6-40

Figure 6-41

Many conformational states

Fewerconformational states

A “single”conformational state Low energy

High energy

(Fig 6-38)

Many conformational states

Fewerconformational states

A “single”conformational state

See VVPFig 6-37 p153

“Ideal”“Real” ?See VVP

Fig 6-38 p154

H-bond Fun Fact

• 1984 survey of protein crystal data shows that “almost all groups capable of forming H-bonds do so.” (mainchain amides, polar sidechains)

Table 6-4

Figure 5-3

Fundamentals of Biochemistry

Third Edition

Fundamentals of Biochemistry

Third Edition

Chapter 7Protein Function: Myoglobin and Hemoglobin,

Muscle Contraction, and Antibodies

Chapter 7Protein Function: Myoglobin and Hemoglobin,

Muscle Contraction, and Antibodies

Copyright © 2008 by John Wiley & Sons, Inc.Copyright © 2008 by John Wiley & Sons, Inc.

Donald Voet • Judith G. Voet • Charlotte W. Pratt

Donald Voet • Judith G. Voet • Charlotte W. Pratt

Oxygen is transported to cellswhich are remote from air

•O2 is required in cells, in themitochondria for ATP production

aerobic metabolism

Glucose + O2 ----------------------------> ATP + CO2

oxidative phosphorylation

Normal Red Blood Cells have a flattened discoid shape rather than a spherical shape

vs.O2 O2O2

O2

O2 O2

O2O2O2O2

O2 O2 O2

O2

O2

O2O2 O2

O2

O2O2

O2O2

O2

O2

O2

Table 6-4

Chapter 7 Opener

Figure 7-1

Figure 7-2

Figure 7-3

Figure 7-4

Box 7-1

Figure 7-5