the t-cell receptor
DESCRIPTION
The T-Cell Receptor. MHC Restriction TCR Structure & Function Genetic Generation of TCR Diversity Thymus T-cell "Education" and Immunological Tolerance. Folder title: Receptor. November 15, 2006. TCRTitle. Comparison of T-Cell Receptors (TCR) and Antibodies: Differences. - PowerPoint PPT PresentationTRANSCRIPT
The T-Cell ReceptorMHC Restriction
TCR Structure & Function
Genetic Generation of TCR Diversity
Thymus T-cell "Education" and Immunological Tolerance
Folder title: Receptor
November 15, 2006 TCRTitle
Comparison of T-Cell Receptors (TCR)and Antibodies: Differences
TCR
Remains Membrane-bound.
Present in small amounts.
Recognizes binary complex:
Antigen and MHC Protein
Associated with CD3, CD4, & CD8 AccessoryMolecules
Is MHC Restricted
Antibody
Can be membrane bound;
Secreted in large amounts.
Recognizes Antigen alone:
Soluble or particulate
No accessory molecules
involved
Not MHC Restricted
TCRvsAb1
Comparison of T-Cell Receptors (TCR)and Antibodies: Similarities
TCR and Ab
Rearrange V, J, and (Sometimes) D Germ-line Genes, link these, and join them to C-region Gen
es, during somatic cell differentiation.
(V, J, D and C region germ-line genes are different for TCR vs Ab)
Have Complementarity Determining Regions (CDR's) that are hypervariable
Recognize an enormous variety of antigenic determinants
TCRvsAb2
See Figure 8-15,
Kuby, 6th Edition
p. 207
Self-MHC Restriction of TCRKuby, 6th Edition, Fig 9-1, p. 224
MHCRestr
Figure 10-5. Top. Kuby, 6th Edition, p. 249
Figure 10-5. Bottom. Kuby, 6th Edition, p. 249
See Figure 9-3, Right Side, Kuby, 6th Edition, p. 226
costimu
(costimulates)
(inhibits)
Generation of Alpha and Beta Subunits of TCR from Germ-line DNAFigure 11-6, Kuby 3rd Edition
See Table 9-3, Kuby, 6th Edition, p. 229
Allo-Reactivity of T-Cells: orWhy Do T-cells Frustrate Transplant Surgeons?
AlloKill
Figure 11-1
Kuby, 3rd Edition