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The Science of Biomechanics and It’s Practical Application Primerus 2016 PPII Winter Conference February 24 - 27, 2016 Delray Beach, FL Mariusz Ziejewski, Ph.D., Inż Professor Director of Impact Biomechanics Laboratory, College of Engineering Director of Automotive Systems Laboratory, College of Engineering Mechanical Engineering Department North Dakota State University and Adjunct Associate Professor Department of Neuroscience, School of Medicine University of North Dakota

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Page 1: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

The Science of Biomechanics and It’s Practical Application

Primerus – 2016 PPII Winter ConferenceFebruary 24-27, 2016

Delray Beach, FL

Mariusz Ziejewski, Ph.D., InżProfessor

Director of Impact Biomechanics Laboratory, College of Engineering

Director of Automotive Systems Laboratory, College of Engineering

Mechanical Engineering Department

North Dakota State University

and

Adjunct Associate Professor

Department of Neuroscience, School of Medicine

University of North Dakota

Page 2: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Who We Are

Founded in 2003

Mission

The mission of the NABISis to move brain injury science into practice.

VisionNABIS is the pre-eminent society for professionals involved in

state-of-the-art brain injury research, education and treatment.

A Society of Multidisciplinary Brain Injury Professionals

Page 3: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

WHO WE ARE

Founded in 2003

MissionThe mission of the NABIS

is to move brain injury science into practice.

VisionNABIS is the pre-eminent society for professionals involved in

state-of-the-art brain injury research, education and treatment.

A Society of Multidisciplinary Brain Injury Professionals

Page 4: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Who We Are

Founded in 2003

MISSION

The mission of the NABISis to move brain injury science into practice.

VisionNABIS is the pre-eminent society for professionals involved in

state-of-the-art brain injury research, education and treatment.

A Society of Multidisciplinary Brain Injury Professionals

Page 5: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Who We Are

Founded in 2003

Mission

The mission of the NABISis to move brain injury science into practice.

VISIONNABIS is the pre-eminent society for

professionals involved in state-of-the-art brain injury research, education and treatment.

A Society of Multidisciplinary Brain Injury Professionals

Page 6: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

A Society of Multidisciplinary Brain Injury Professionals

WHAT WE BRING TO THE TABLE

Continuing EducationThe largest annual conference for multidisciplinary brain injury

professionals in North America (avg. over 400 attendees)

Information ResourcesBrain Injury Professional, the largest circulation of any professional

publication on brain injury (over 6000 copies distributed per issue)

ExpertiseTransdisciplinary expertise across the lifespan to promote life quality through research, treatment, service delivery and advocacy efforts

(over 350 active members)

Page 7: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

A Society of Multidisciplinary Brain Injury Professionals

WHAT WE BRING TO THE TABLE

CONTINUING EDUCATIONThe largest annual conference for

multidisciplinary brain injury professionals in North America

(avg. over 400 attendees)

Information ResourcesBrain Injury Professional, the largest circulation of any professional publication on

brain injury (over 6000 copies distributed per issue)

ExpertiseTransdisciplinary expertise across the lifespan to promote life quality through

research, treatment, service delivery and advocacy efforts(over 350 active members)

Page 8: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

A Society of Multidisciplinary Brain Injury Professionals

WHAT WE BRING TO THE TABLE

Continuing EducationThe largest annual conference for multidisciplinary brain injury professionals in

North America (avg. over 400 attendees)

INFORMATION RESOURCESBrain Injury Professional, the largest circulation of

any professional publication on brain injury (over 6000 copies distributed per issue)

ExpertiseTransdisciplinary expertise across the lifespan to promote life quality through

research, treatment, service delivery and advocacy efforts(over 350 active members)

Page 9: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

A Society of Multidisciplinary Brain Injury Professionals

WHAT WE BRING TO THE TABLE

Continuing EducationThe largest annual conference for multidisciplinary brain injury professionals in North America

(avg. over 400 attendees)

Information ResourcesBrain Injury Professional, the largest circulation of any professional publication on brain injury

(over 6000 copies distributed per issue)

EXPERTISETransdisciplinary expertise across the

lifespan to promote life quality through research, treatment, service delivery and

advocacy efforts(over 350 active members)

Page 10: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Chairman

Mariusz Ziejewski, PhD

Vice Chairman

Debra Braunling-McMorrow, PhD

Secretary

Brian Greenwald, MD

Treasurer

Bruce Stern, Esq.

Family Liason

Skye MacQueen

A Society of Multidisciplinary Brain Injury Professionals

Board of Directors

Michael Davis, CBIST

Sharon Grandinette, M.S., Ed. CBIST

Harvey E. Jacobs, PhD, CLCP

Brent Masel, MD

Jonathan Silver, MD

Louis Siracusano, Esq.

Tina Trudel, PhD

Barry Willer, PhD

Alan Weintraub, MD

THE 2015-2017 NABIS BOARD OF DIRECTORS

To learn more or to join NABIS, visit: www.nabis.org

Page 11: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Involvement with Department of Defense

Researcher:

1. Current, $600,000 grant, “Blast Pressure Gradients and Fragments on Ballistic Helmets and the Head and Brain Injury – Simultaneous MultiscaleModeling with Experimental Validation,” Department of the Army, US Army Research, Development and Engineering Command (2010-2013)

2. Current, $500,000 grant, “Blast and the Consequences on Traumatic Brain Injury – Mulitscale Mechanical Modeling of Brain” Air Force Office of Scientific Research, (2007-2010)

Chair:

1. Chairman, Scientific Peer Review Panel, “Physics of Blast as it relates to Brain Injury”, Intramural proposals, DoD PTSD/TBI Research Program, Congressionally Directed Medical Research Program (CDMRP). (Nov. 2007)

2. Chairman, Scientific Peer Review Panel, “Physics of Blast as it relates to Brain Injury”, Extramural proposals, DoD PTSD/TBI Research Program, CDMRP. (Dec. 2007)

Reviewer:

1. Reviewer, Proposals for the Military Operational Medical Research Program, US Army Materiel Research Command (USAMRMC) (May 2010)

2. Reviewer, Proposals for the Military Operational Medical Research Program, US Army Materiel Research Command (USAMRMC) (April, 2010)

3. Reviewer, Intramural Proposals for the Department of Defense (DoD) Defense Medical Research and Development Program, Intramural Applied Research and Advanced Technology Development Award (Nov. 2009)

4. Reviewer, Proposals for the Military Operational Medical Research Program, US Army Materiel Research Command (USAMRMC).(Oct., 2008)

5. Reviewer, Intramural Proposals for the Department of Defense (DoD) Intramural War Supplement Program.(Nov.,2008)

6. Reviewer, Scientific Peer Review Panels, Concept Proposals related to brain injuries caused by blasts for the DoD (PTSD/TBI) Research Program, CDMRP. (Oct., 2007)

7. Reviewer, Scientific Peer Review Panels, Intramural Proposals on Clinical Diagnosis related to brain injuries caused by blasts for the DoD(PTSD/TBI) Research Program, CDMRP. (Nov., 2007)

Invited Faculty:

1. Invited Faculty, Invited by former US Air Force Surgeon General P.K. Carlton to make a presentation on the Physics of Blast Injury to a specialconference/think tank session on allocation of Department of Defense (DoD) funding for TBI/blast injuries.

2. Invited Faculty, National Veteran’s Health Administration/Department of Defense (VHA/DoD) Conference: “Visual Consequences of Traumatic Brain Injury.”

3. Invited Faculty, National Veteran’s Health Administration/Department of Defense (VHA/DoD) Conference: “Sensory Impairment Issues in Traumatic Brain Injury.”

Page 12: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

~ 7000 Human TestsMaximum Acceleration: 80 G

Maximum Velocity: 17 m/s

Pulse Duration: 40-180 ms

AFRL/HEPA Vertical Deceleration Tower

Page 13: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

~ 900 Tests Analyzed with Humans

Six (6) Research Contracts, 1996-2010

Biofidelity of Hybrid II head/neck research

AFRL/HEPA Vertical Deceleration Tower

Page 14: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Direction of Our Research (Sponsored by DoD)

Multiscale modeling method proposed for brain cell adhesion modeling:

(a) MD (molecular dynamics)Simulation of Cell-ECM (extracellular matrix)interaction

(b) Average traction-separation data from MD simulation

(c) Axon- ECM continuum modeling of the interface

(d) Undulated RUC (repeating cell unit) of brain material and fiber reinforced composite modeling of the tissue

(e) Micromechanics modeling of RUC under different load cases for material characterization

Page 15: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary
Page 16: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

BIOMECHANICS

“… the application of the principles and techniques of mechanics to the structure, functions and capabilities of

living organisms.”

Webster’s New World Dictionary of the American Language Ed. David B. Guralnik. 2nd College Ed. New York: World Pub. Co., 1970

Page 17: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

“…evaluation based on

mechanism (cause) of injury.

Such an approach relies on

knowledge of the typical

physical and psychological

sequelae associated with a

particular mechanism of injury

to guide patient assessment

and treatment.”

Scott S., H. Belanger, R. Vanderploeg, J. Massengale, J. Scholten “Mechanism-of-Injury Approach to Evaluating Patients With Blast-Related Polytrauma”,

Journal of American Osteopathic Association Vol. 106, No.5, May 2006 pp. 265-270

Page 18: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Injury Exceeds Juror Expectations

Page 19: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Some people get hurt in a collision and

others do not get hurt in the same collision.

?

Page 20: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Each collision for each individual has its own

unique set of parameters that

control the outcomeof the impact.

Page 21: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

We must incorporate all the significant

parameters cumulatively in a case

specific analysis.

Page 22: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

PROVING THE CASE THROUGH

SCIENCEThe CSI Effect

Page 23: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Biomechanical Evaluation

ADVANTAGES:• Event specific• Unlimited resolution• Time History

DISADVANTAGES:• Accuracy of information• Accuracy of the software

To compliment the medical diagnosis of TBI

Page 24: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Biomechanical Engineer and

Nuclear Medicine

Page 25: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Top-Horizontal View

Ziejewski, M., G. Karami, W. Orrison, E. Hanson, “Dynamic Response of Head Under Vehicle Crash Loading,” 21st International Technical Conference on Enhanced Safety of Vehicles, Sponsored by Mercedes Benz and the National Highway Traffic Safety Admiistration (NHTSA), Stuttgart, Germany June 15-18th, www.nrd.nhtsa.dot.gov, SAE International, Head Injury Biomechanics, Vol. 1 P 144-187, 2011

Biomechanical MRI

Page 26: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Mid-Sagittal View

Biomechanical MRI

Ziejewski, M., G. Karami, W. Orrison, E. Hanson, “Dynamic Response of Head Under Vehicle Crash Loading,” 21st International Technical Conference on Enhanced Safety of Vehicles, Sponsored by Mercedes Benz and the National Highway Traffic Safety Admiistration (NHTSA), Stuttgart, Germany June 15-18th, www.nrd.nhtsa.dot.gov, SAE International, Head Injury Biomechanics, Vol. 1 P 144-187, 2011

Page 27: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

What Biomechanics Can Do in Your Case

1. Explain what happened in the accident

2. Connect the collision to the injuries

3. Determine whether or not the collision was sufficient to cause traumatic brain injury (probability over 50%)

4. Case specific probability of TBI (95%???)

5. Identify the risk factors

Page 28: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Biomechanical EvaluationIdentify and Quantify Risk Factors

• Impact Force (Magnitude, direction, time duration)

• Gender

• Body Position

• Pre-existing Conditions

• Etc..

28

Page 29: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

• Impact Force (Magnitude, direction, time duration)

• Gender

• Body Position

• Pre-existing Conditions

• Etc..

29

Biomechanical EvaluationIdentify and Quantify Risk Factors

Page 30: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

• Impact Force (Magnitude, direction, time duration)

• Gender

• Body Position

• Pre-existing Conditions

• Etc..

30

Biomechanical EvaluationIdentify and Quantify Risk Factors

Page 31: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

• Impact Force (Magnitude, direction, time duration)

• Gender

• Body Position

• Pre-existing Conditions

• Etc.

31

Biomechanical EvaluationIdentify and Quantify Risk Factors

Page 32: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Demonstrate the vulnerability

of the human brain

Page 33: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Relative Motion of the Brain

Page 34: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Relative Motion of the Brain

Because:

3D Dynamic Response Micro Damage

Page 35: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Relative Motion of the Brain

Because:

3D Dynamic Response Micro Damage

Page 36: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

36

(Panjabi et al., 2001)

Page 37: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Relative Motion of the Brain

Because:

3D Dynamic Response Micro Damage

Page 38: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

(a)(b)

Countercoup

(C, D)

Coup

(A, B)

Extremely Dynamic Oscillation of the Brain Tissue

.0002s

Ziejewski, M. and Karami, G. , “Biomechanical Perspective on Blast Injury,” in Concussive Brain Trauma: Neurobehavioral Impairment and Maladaptation by Dr. Rolland Parker, Taylor & Francis Group, Boca Raton, FL, 2012

Brain Oscillation

Page 39: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Relative Motion of the Brain

Because:

3D Dynamic Response Micro Damage

Page 40: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

VEHICLEDYNAMICS ANALYSIS

HUMAN BODYDYNAMICS ANALYSIS

HUMAN TOLERANCEANALYSIS

Page 41: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

The significant parameters of the collision include, but are not limited to:

A. Severity of Vehicle Dynamics

• Δv (Change in velocity)

• PDOF (Direction of impact)

• Δt (Duration of impact)

B. Severity of Human Body Dynamics

• Gender

• Height

• Weight

• Body position

• Vehicle interior characteristics

• Individual tolerances

Page 42: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

VEHICLEDYNAMICS ANALYSIS

HUMAN BODYDYNAMICS ANALYSIS

INJURY MECHANISMS

Page 43: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Newton’s 2ND Law

(acceleration)

F = m . a(Force) (mass)

Page 44: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

(acceleration)

F = m .(Force) (mass)

V t

What is Delta-V (V)?

Page 45: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

TIME

VEL

OC

ITY

Pre-Impact

Post-Impact

Severity of Collision for Specific Δt

Impact (Delta V, ΔV)

Page 46: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Linder, A., et al. “Change of Velocity and Pulse Characteristics in Rear Impacts: Real World and Vehicle

Tests Data.” 18th ESV Conference, Paper #285, 2003.

100 – 120 ms

Page 47: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Heinrichs, B., J. Lawrence, B. Allin, J. Bowler, C. Wilkinson, K. Ising and D. King. Low-Speed Impact Testing of Pickup Truck

Bumpers Society of Automotive Engineers, Inc. 2001.

7.5 mph

60 ms

100 ms

Page 48: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

A

t = 2.5 ms

Simulation Test

Dynamic Progressive Buckling

•Ziejewski, M., B. Anderson, M. Rao and M. Hussain, “Energy Absorption for Short Duration Impacts,” SAE Paper #961851, Indianapolis, IN, 1996•Ziejewski, M., B. Anderson, “The Effect of Structural Stiffness on Occupant Response For A -Gx Acceleration Impact,” SAE Paper #962374, São Paulo, SP, Brazil, 1996•Ziejewski, M., H. Goettler, “Effect of Structural Stiffness and Kinetic Energy on Impact Force,” SAE Paper #961852, Indianapolis, IN, 1996•Anderson, B., M. Ziejewski, H. Goettler, “Method to Predict the Energy Absorption Rate Characteristics for a Structural Member,” Society of Automotive Engineers (SAE) Paper #982388, Detroit, MI, 1998•Pan, X., M. Ziejewski, H. Goettler, “Force Response Characteristics of Square Columns for Selected Materials at Impact Loading Combinations Based on FEA,” SAE Paper #982418, Detroit, MI., 1998

Page 49: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Uniqueness of the Loading Conditions

μs

(kPa

)

• Supersonic overpressurization shockwave• Timescale in μs (microseconds) • 1atm ≈ 100 kPa

Page 50: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Uniqueness of the Loading Conditions

(kP

a)

μs

(kP

a)

• Supersonic overpressurization shockwave• Timescale in μs (microseconds) • 1atm ≈ 100 kPa

Page 51: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Time Matters

∆V = 7.5 mph

∆t = 120 ms aaverage= 2.8 g apeak= 5.7 g

∆t = 60 ms aaverage= 5.7 g apeak= 11.4 g

∆t = 2.5 ms aaverage= 136.6 g apeak= 273.2 g

Page 52: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

VEHICLEDYNAMICS ANALYSIS

HUMAN BODYDYNAMICS ANALYSIS

INJURY MECHANISMS

Page 53: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary
Page 54: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

RAPID HEAD VELOCITY CHANGE

BRAIN DEFORMATION

BRAIN DAMAGE

→LINEAR→ANGULAR

→LINEAR→ANGULAR

→CHANGE IN SHAPE→CHANGE IN VOLUME

→STRESS→STRAIN→INTERCRANIAL PRESSURE

APPLICATION OF FORCE

54

ENGINEERING PARAMETERS

INJURY QUANTIFICATION

YESYES

YESYES

--

--YES

Page 55: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Mechanical Properties of Brain Tissue

• Incompressible (High resistance to change in size, high bulk modulus)

• Deformable (Low resistance to change in shape, low shear modulus)

• Heterogeneous (Different properties within the brain)

• Anisotropic (Different properties in different directions)

• Viscoelastic (Time dependent properties: magnitude, duration, rate of change)

Page 56: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Mechanical Properties of Brain Tissue

• Incompressible (High resistance to change in size, high bulk modulus)

• Deformable (Low resistance to change in shape, low shear modulus)

• Heterogeneous (Different properties within the brain)

• Anisotropic (Different properties in different directions)

• Viscoelastic (Time dependent properties: magnitude, duration, rate of change)

Page 57: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

B.R. Donnelly and J. Medige, “Shear Properties of Human Brain Tissue,” Journal of Biomechanical Engineering, Nov. 1997, Vol. 119, 423-432. Shames, I.H. and Cozzarelli, F.A., 1992, Elastic and Inelastic Stress Analysis, New Jersey: Prentice Hall, Englewood Cliffs, NJ

Incompressible/Deformable

• Bulk modulus is approximately 105 (100,000) times larger than shear modulus.

• Deformation of brain tissue can be assumed to depend on shear modulus only.

• This behavior is common with viscoelasticmaterials (Shames and Cozzarelli, 1992)

Page 58: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Mechanical Properties of Brain Tissue

• Incompressible (High resistance to change in size, high bulk modulus)

• Deformable (Low resistance to change in shape, low shear modulus)

• Heterogeneous (Different properties within the brain)

• Anisotropic (Different properties in different directions)

• Viscoelastic (Time dependent properties: magnitude, duration, rate of change)

Page 59: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Mechanical Properties of Brain Tissue

• Incompressible (High resistance to change in size, high bulk modulus)

• Deformable (Low resistance to change in shape, low shear modulus)

• Heterogeneous (Different properties within the brain)

• Anisotropic (Different properties in different directions)

• Viscoelastic (Time dependent properties: magnitude, duration, rate of change)

Page 60: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Demonstration

Slow Application of Force

Rapid Application of Force

Page 61: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

• macro scale (mm) (10-3 m) – MRI detection limit – Fig. A, B, C• Diffusion Tensor Imaging (DTI) – 1x1x5 mm3

• Susceptibility Weighted Imaging (SWI) – 0.2x0.2x0.2 mm3

• micro scale (μm) (10-6 m) – the cell – Fig. D• MR Microscopy (MRM) – 100 μm3, 7 – 9.4 Tesla• Performed only on autopsied brain

• nano scale (nm) (10-9 m) – the axon neural filaments – Fig. E• Electron microscope to visualize

Invisible Injury – Why?

•Carpenter, M., Human Neuroanatomy. Baltimore, MD: Williams and Wilkins, 1976•Williams TH, Gluhbegovic N. Jew JY. The human brain: dissections of the real brain. Virtual Hospital, University of Iowa, 1997; www.vh.org/Providers/Textbooks/BrainAnatomy and www.brain-iniversity.com [21/10/22]•Callot, et. al, Short-scan-time multi-slice diffusion MRI of the mouse cervical spinal cord using echo planar imaging, NMR in Biomedicine, 2008

Page 62: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

Accelerometer

Page 63: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

TYPES OF ACCELERATION

Ax = Linear Acceleration, Forward-Backward DirectionAy = Linear Acceleration, Side to Side Direction

Az = Linear Acceleration, Vertical Direction

a x = Rotational Acceleration, About Forward-Backward Axis

a y = Rotational Acceleration, About Side to Side Axis

a z = Rotational Acceleration, About Vertical Axis

Linear Acceleration

Rotational Acceleration

Y

X

Z

Page 64: The Science of Biomechanics and It’s Practical Application · injury research, education and treatment. A Society of Multidisciplinary Brain Injury Professionals. A Society of Multidisciplinary

TYPES OF ACCELERATION

Ax = Linear Acceleration, Forward-Backward DirectionAy = Linear Acceleration, Side to Side Direction

Az = Linear Acceleration, Vertical Direction

a x = Rotational Acceleration, About Forward-Backward Axis

a y = Rotational Acceleration, About Side to Side Axis

a z = Rotational Acceleration, About Vertical Axis

Linear Acceleration

Rotational Acceleration

Z

Y

X

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TYPES OF ACCELERATION

Ax = Linear Acceleration, Forward-Backward DirectionAy = Linear Acceleration, Side to Side Direction

Az = Linear Acceleration, Vertical Direction

a x = Rotational Acceleration, About Forward-Backward Axis

a y = Rotational Acceleration, About Side to Side Axis

a z = Rotational Acceleration, About Vertical Axis

Linear Acceleration

Rotational Acceleration

Y

Z

X

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TYPES OF ACCELERATION

Ax = Linear Acceleration, Forward-Backward DirectionAy = Linear Acceleration, Side to Side Direction

Az = Linear Acceleration, Vertical Direction

a x = Rotational Acceleration, About Forward-Backward Axis

a y = Rotational Acceleration, About Side to Side Axis

a z = Rotational Acceleration, About Vertical Axis

Linear Acceleration

Rotational Acceleration

Y

X

Z

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TYPES OF ACCELERATION

Ax = Linear Acceleration, Forward-Backward DirectionAy = Linear Acceleration, Side to Side Direction

Az = Linear Acceleration, Vertical Direction

a x = Rotational Acceleration, About Forward-Backward Axis

a y = Rotational Acceleration, About Side to Side Axis

a z = Rotational Acceleration, About Vertical Axis

Linear Acceleration

Rotational Acceleration

Y

X

Z

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TYPES OF ACCELERATION

Ax = Linear Acceleration, Forward-Backward DirectionAy = Linear Acceleration, Side to Side Direction

Az = Linear Acceleration, Vertical Direction

a x = Rotational Acceleration, About Forward-Backward Axis

a y = Rotational Acceleration, About Side to Side Axis

a z = Rotational Acceleration, About Vertical Axis

Linear Acceleration

Rotational Acceleration

Y

X

Z

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TYPES OF ACCELERATION

Ax = Linear Acceleration, Forward-Backward DirectionAy = Linear Acceleration, Side to Side Direction

Az = Linear Acceleration, Vertical Direction

a x = Rotational Acceleration, About Forward-Backward Axis

a y = Rotational Acceleration, About Side to Side Axis

a z = Rotational Acceleration, About Vertical Axis

Linear Acceleration

Rotational Acceleration

Y

X

Z

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TYPES OF ACCELERATION

Ax = Linear Acceleration, Forward-Backward DirectionAy = Linear Acceleration, Side to Side Direction

Az = Linear Acceleration, Vertical Direction

a x = Rotational Acceleration, About Forward-Backward Axis

a y = Rotational Acceleration, About Side to Side Axis

a z = Rotational Acceleration, About Vertical Axis

Linear Acceleration

Rotational Acceleration

Y

Z

X

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4. External vs. Internal Injuries

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Comparison of Pressure Contours on Brain and Skull

T=3.2ms

T=4.2ms

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A. Angular Acceleration (1 of 3):

B. Linear Acceleration (1 of 3):

+

-

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74

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Angular Acceleration of the head has an effect on the entire brain

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Equipment

Skull/Gel Model• Skull: A20/1

(Anatomical Chart Company; Hagerstown, MD)

• Gel: Sylgard 527 A&B Silicon Dielectric Gel(Dow Corning Corporation; Midland, MI)

Subject Seat• 1997 Ford F250

(VIN: 1FT HW26F 8 VE A67707)

Accelerometer• Type: ICSensors 3028

• Range: +/- 100g

• Serial Number: 0021-029

High Speed Camera• MotionScope®, Redlake Imaging

• Model: PCI 2000

• Model Number: 1108-0004

• Serial Number: 98P-0095

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Skull: A20/1(Anatomical Chart Company; Hagerstown, MD)

Equipment

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9hr cure 14hr cure

12hr cure

Silicon Gel PropertiesSylgard 5-27 A&B Silicon Dielectric Gel

(Dow Corning Corporation; Midland, MI)

Equipment

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Brands, D., P. Bovendeered, G. Peter, et al. “Comparison of the Dynamic Behaviour of Brain Tissue and Two Model Materials”, SAE

99C21, Society of Automotive Engineers, Inc. 1999.

Properties Comparison Silicon Gel & Brain Tissue

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0

2

4

6

8

10

12

14

0 0.01 0.02 0.03 0.04 0.05

Time(Sec)

Lin

ea

r A

cc

ele

rati

on

(G)

14.09g 10.55g

A. SEVERITY OF IMPACT

B. POSITION OF HEAD

75º

Simulation Experimental

Simulation Experimental 75º75º

Test Conditions (per ATB Simulation)

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Skull/Gel Model Testing

• Severity of Impact (X = 10.10g, Y = 14.09g, Z = 4.02)•Tested at Y = 10.55g •Position of Head (Yaw 75º, Pitch 7º, Roll 6º)

Test Conditions (per ATB Simulation) :

Video Parameters:• Capture rate: 10,000 frames/sec• Slow motion (1/60th of actual velocity)

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Skull/Gel Model Testing

• Severity of Impact (X = 10.10g, Y = 14.09g, Z = 4.02)•Tested at Y = 10.55g• Position of Head (Yaw 75º, Pitch 7º, Roll 6º)

Test Conditions (per ATB Simulation) :

Video Parameters:• Capture rate: 10,000 frames/sec• Slow motion (1/60th of actual velocity)

Transformed MRI Data

Source of Original Data:

• Dr. Orrison, Nevada Imaging Centers

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Skull/Gel Model Testing

• Severity of Impact (X = 10.10g, Y = 14.09g, Z = 4.02)•Tested at Y = 10.55g• Position of Head (Yaw 75º, Pitch 7º, Roll 6º)

Test Conditions (per ATB Simulation) :

Video Parameters:• Capture rate: 10,000 frames/sec• Slow motion (1/60th of actual velocity)

Transformed MRI Data

Source of Original Data:

• Dr. Orrison, Nevada Imaging Centers

Approach

Rebound

Dynamic Pattern at Impact

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The Head Model simulates all essential anatomical features of a male head, including the brain, falx and tentorium, CSF, dura mater, pia mater, skull and scalp.

Finite Element Modeling of the Human Head- Continuum Scale(Model currently used in Military Brain Trauma Analysis)

(US Department of Defense Research)

M Sotudeh Chafi, V Dirisala, G Karami, and M Ziejewski, A finite element method parametric study of the dynamic response of the human brain with different

cerebrospinal fluid constitutive properties, Proc. IMechE Part H: J. Engineering in Medicine, 2009; 223, 1003-101984

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Variation of ICP and Shear Stress on the Brain with time

ICP

Shear

Stress

2.9

ms4.9

ms

4 ms

7 ms4.9

ms

3 ms

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(kPa

)

• Supersonic overpressurization shockwave (>300m/s)

• Pressure increased to 10-100 MPa (1atm ≈ 100 kPa)

• Timescale in μs (microseconds)

Automotive Blast

Cavitation

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Scanning Electron Micrograph

Crater

Brass Plate

Cavitation

Liquid Jet

~ 1 mm

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Scanning Electron Micrograph

Crater

Brass Plate

Cavitation

Liquid Jet

~ 1 mm

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CAVITATION DAMAGE

Macroscale

A. Spherical Bubble Collapse

B. Non-Spherical Bubble Collapse

Bubble Collapse

(Classical Approach)NanoscaleBubble Inception

(New Brain Injury Mechanism)

Liquid Jet

MassSpring

Fracture Point

Recoil pressure waves

MassSpring

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VEHICLEDYNAMICS ANALYSIS

HUMAN BODYDYNAMICS ANALYSIS

INJURY MECHANISMS

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Human Tolerance to Impact Conditions as Related to Motor Vehicle Design, SAE International, Revised Dec. 2003, SAE J885, Temporo-Parietal Bone p13.

Mean: 1910 lb Min: 1050 lb

Skull Fracture Research

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Prasad, P., et al., (1985). The Position of the United States Delegation to the ISO Working Group on the Use of HIC in the

Automotive Environment. Ford Motor and G M Corp. SAE 851246

16%

25%

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Prasad, P., et al., (1985). The Position of the United States Delegation to the ISO Working Group on the Use of HIC in the Automotive Environment. Ford Motor and G M Corp. SAE 851246

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•Depreitere, B., Van Lierde, C., Vander Sloten, J., Van Audekercke, R., Van Der Perre, G., Plets, C., Goffin, J. (2006). Mechanics of acute subdural hematomas resulting from bridging vein rupture, Journal fo Neurosurgery, Vol. 104, J Neurosurg 104.

10,000rad/sec2

Tolerance Level:

Subdural Hematoma

Pulse Duration:

Shorter than: 10 ms

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•Bandak, F., Eppinger, R. (1994). A Three-Dimensional Finite Element Analysis of The Human Brain Under Combined Rotational and Translational Accelerations, National Highway Traffic Safety Administration (NHTSA), SAE 942215.

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Biomechanical Analysis Outcomes

1. Visualization of injury (beyond MRI’s)

• Resolution for MRI 0.25mm macroscale (10-3 m)• Details of biomechanic modeling nanoscale (10-9 m)

2. Mechanism of injury (beyond the current understanding)• Extremely dynamic oscillation of the brain tissue• Nanoscale Cavitation (New Brain Injury Mechanism)

3. Benefits• Current patients (location, extent of injury)• Prevention (protective systems, helmet)

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6. Male vs.

Female

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Quinlan, K., J. Annest, B. Myers, et.al. “Neck strains and sprains among motor vehicle occupants”,

Accident Analysis and Prevention 36, 2004.

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~ 7000 Human TestsMaximum Acceleration: 80 G

Maximum Velocity: 17 m/s

Pulse Duration: 40-180 ms

AFRL/HEPA Vertical Deceleration Tower

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M. Ziejewski and E.M. Yliniemi, “Prediction of Head Acceleration and Neck Loading in Vertical Impact”, The Impact of Technology on Sport III, 2009.

1.4 x

138 Tests

Female

Male

6.8 g

5.0 g

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1.8 X

6mph

Female

Male

12g

6.5g

Hell W., S. Schick, and K. Langwieder “Biomechanics of Cervical Spine Injuries in Rear End Car Impacts: Influence of Car Seats and Possible Evaluation Criteria”, Traffic Injury Prevention, 2002.

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2.5 XVan den Kroomerberg, M. Philippens, H. Cappon, J. Wismans, “Human Head-Neck Response During Low-Speed Rear Impacts”

SAE 983158.

6 mph

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7. Humanvs.

Hybrid III

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Kleinberger, M., R. Eppinger, M. Haffner, and M. Beebe, “Enhancing Safety with an Improved Cervical Test Device” Safety in Football, ASTM 1997.

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3.5X5X

3X

2X

Stiffness in Neck

Stiffness in Neck

Human - Max

Human - Min

Hybrid III

Hybrid III

Human - Max

Human - Min

100°

80°

75°

55°

25°

20°

Kleinberger, M., R. Eppinger, M. Haffner, and M. Beebe, “Enhancing Safety with an Improved Cervical Test Device” Safety in Football, ASTM 1997.

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2X3X

2X1.5X

Human - Max

Human - Min

Hybrid III

Human - Max

Human - Min

Hybrid III

Stiffness in Neck

Stiffness in Neck

105°

85°

35°

90°

70°

45°

Kleinberger, M., R. Eppinger, M. Haffner, and M. Beebe, “Enhancing Safety with an Improved Cervical Test Device” Safety in Football, ASTM 1997.

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Gender: M Initial Head Angle: -9.0°

Weight: 175 Human Head Rotation: Forward

Human/Manikin Curve Matching

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Gender: F Initial Head Angle: -28.9°

Weight: 136 Human Head Rotation: Forward

Human/Manikin Curve Matching

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Headgear

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Underwash: Fluid Flow Dynamics

Streamlines around unprotected and helmeted heads

0

100

200

300

400

500

600

700

800

-0.002 1E-17 0.002 0.004 0.006 0.008

Pre

ssu

re (

kP

a)

Time (s)

Helmeted

Velocity vectors- Top view

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1) CPSC Headform 3) Human Head 4) Hybrid III2) Test Area

5) Human Head 6) Injury Diagram

7) Hybrid III with Exemplar Helmet

Impact Site Location

Temporal Bone Fracture

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1) CPSC Headform 3) Human Head 4) Hybrid III2) Test Area

5) Human Head 6) Injury Diagram

7) Hybrid III with Exemplar Helmet

Impact Site Location

Temporal Bone Fracture

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5) Human Head 6) Injury Diagram

7) Surrogate with Exemplar Helmet

Approximate impact site elevation for test to back of the helmet (1 in above the test line for the back impact)

1) DOT Headform 3) Human Head 4) Hybrid III2) Test Area

Impact Site Location

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SNELL M2005 ECE 22.05

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•Scheer, D., Karami, G., Ziejewski, M. (2015). An Evaluation of the Riddell IQ HITS System in Prediction of an Athlete’s Head Acceleration, 7th Asia-Pacific Congress on Sports Technology, SAE 942215.

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Lateral Plane

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•Scheer, D., Karami, G., Ziejewski, M. (2015). Effects of Helmet Surface Geometry on Head Acceleration in High Velocity Water Sports, 7th Asia-Pacific Congress on Sports Technology, SAE 942215.

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•Scheer, D., Karami, G., Ziejewski, M. (2015). Effects of Helmet Surface Geometry on Head Acceleration in High Velocity Water Sports, 7th Asia-Pacific Congress on Sports Technology, SAE 942215.

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•Scheer, D., Karami, G., Ziejewski, M. (2015). Effects of Helmet Surface Geometry on Head Acceleration in High Velocity Water Sports, 7th Asia-Pacific Congress on Sports Technology, SAE 942215.

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•Scheer, D., Karami, G., Ziejewski, M. (2015). Effects of Helmet Surface Geometry on Head Acceleration in High Velocity Water Sports, 7th Asia-Pacific Congress on Sports Technology, SAE 942215.