the science behind the solutions...• to build next generation chemical and biological defense...

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Dr. Eric Moore Division ChiefAdvanced and Emerging ThreatsChemical and Biological Technologies Department (J9CB)

Defense Threat Reduction Agency & USSTRATCOMCenter for Combating WMD & Standing Joint Force Headquarters-Elimination(Distribution Statement A: Approved for public release: distribution unlimited)

The Science Behind the Solutions Research and Grant Opportunities April 27, 2015

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THE DTRA/SCC MISSION

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To safeguard the US and its Allies from Weapons of Mass Destruction▪ Chemical▪ Biological▪ Radiological▪ Nuclear▪ High-Yield Explosivesby providing capabilities to reduce, eliminate and counter the threat, and mitigate its consequences.

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RESEARCH AND DEVELOPMENT OVERVIEW

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Information Sciences and Applications• 24/7 Technical Reachback• Hazard and Effects Modeling• Advanced Analytics and Situational Awareness

Nuclear Technologies• Nuclear threat detection• Nuclear forensics• System survivability

(Rad Hard, EMP)• Nuclear weapons effects• Monitoring and verification

technologies

Basic and Fundamental Research• STEM workforce development• 6.1 grants to Universities

Chemical and Biological Technologies• Medical countermeasures• Disease surveillance, threat detection,

and point of need diagnostics• Threat activity sensing and reporting• Rapid Response and Restoration S&T

Counter WMD Technologies• CWMD terrorism

technologies• Persistent ISR for WMD• Defeat concepts• Test facilities and

technology• Deployable sensors

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Diagnostics, Detection, Disease Surveillance Information and Analysis

Translational Medicine

Advanced and Emerging Threats

Physical Science and Technology

ADDRESSING KEY MISSION AREAS

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Diagnostics, Detection & Disease Surveillance

PROJECT AREASBiosurveillance Ecosystem (BSVE)

Data sources & analytic toolsChem-Bio Detection

Wearable TechnologiesHost-Based Biomarker Identification/Verification/Validation

Field Forward DiagnosticsGenetic Sequencing for Clinical Microbial/Viral Diagnostics


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VACCINES & THERAPEUTICS FOCUS AREASViral: Ebola & Marburg; EEEV, VEEV, WEEV

Bacterial: Bacillus anthracis, Francisella tularensis, Burkholderia mallei & pseudomallei, C. Burnetii, Yersina pestis

Toxins: Ricin, Botulinum Neurotoxin

Platform Technologies: Animal Model Development, Ex vivo mimetics, Flexible Manufacturing, Adjuvants and Stabilization


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EXAMPLE PROJECT AREASCatalytic bioscavengers of nerve agents

Centrally-acting reactivators of acetylcholinesterase, neuroprotectantsADMET Center to enhance drug discovery/development efforts

Host response to chemical toxicants, human toxicity estimates and predictive toxicologyCharacterization and predictive environmental fate of chemical and biological agents, especially particulates

Relevant understanding of routes of exposure and the blood-brain barrierAutomatic threat response, including nano- and micromotors

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THE SCIENCE BEHIND THE SOLUTIONS

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Some of our government partners include:▪ Department of Health and Human Services (HHS)▪ Food and Drug Administration (FDA) ▪ Biomedical Advanced Research and

Development Authority (BARDA)▪ U.S. Army Medical Research and

Materiel Command (USMRMC)

Our partners also include non-government entities and universities such as:▪ GlaxoSmithKline▪ George Mason University▪ Duke University

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WHERE TO FIND BUSINESS OPPORTUNITIES

https://www.fbo.gov/

http://www.grants.gov

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Carefully review BAA and Amendment

Plan ahead and allow time for peer reviews and corrections

Revolutionary advancements over existing state of technology required

Ability to achieve program milestones is critical

Partnering is encouraged

TIPS FOR STRONG PROPOSALS

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BUILDING A COMPETITIVE PROPOSAL

Concept Definition ✓ Why is the approach revolutionary? ✓ Challenges ✓ Potential solutions ✓ Risk mitigation

Supporting Technical Analysis ✓ Previous experimental evidence ✓ Technical and quantitative rationale

for ability to meet metrics

Research Plan ✓ Specific, quantitative, intermediate

milestones ✓ How will progress be assessed?

Management Plan ✓ Plan for coordination and roles of

all members ✓ Risk management approaches

Clarity is Key

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Questions

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?For more information visit:http://www.dtra.mil/Home.aspxhttp://www.acq.osd.mil/cp/http://www.dtra.mil/Missions/ChemicalBiologicalDefense/ChemicalBiologicalDefenseHome.aspx

To read more about some of our current scientific progress:http://www.dvidshub.net/publication/538/jsto-in-the-news

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BACKUPS

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J9 CB BASIC RESEARCH FOCUS AREAS

Approaches to predict or trigger technological surprise

BUILDING THE FOUNDATION FOR TOMORROW’S CBDP

Novel countermeasures

Understanding and characterizing threat agents

Novel approaches to sensing

Innovative materials

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Diagnostics, Detection & Disease Surveillance

MISSION Deliver cutting edge Integrated Early Warning, Information Management and Applied Analytic capabilities to the warfighter; virtually connect them to these capabilities and other system users for rapid situational awareness, course of action (CoA) analysis and decision support.


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MISSION Develop vaccines and therapeutics to mitigate

the threat of biological warfare agents


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• MISSION • Deliver novel concepts and • technologies to address current and

emerging chemical and biological threats to protect the lives of our warfighters



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• MISSION • Provide and use Chemical Biological • Radiological Nuclear information

and analysis capabilities to enable and support operational & programmatic decision-making.

Information & Analysis


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Information & Analysis

PROJECT AREASCollective Protection System Performance Model

Individual Protection System Performance ModelDecontamination System Performance Model


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• MISSION • Providing tomorrow’s solutions today • to build next generation chemical and

biological defense capabilities for decontamination and protective materials, and ensuring transition of prototypes to advanced developers serving warfighter needs through advanced demonstrations and exercises.

Physical Science & Technology


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Physical Science & Technology

FOCUS AREASProtective Materials – e.g. Second Skin and Ammonia Breakthrough Filters

Hazard Mitigation – e.g. Material and Equipment Restoration (HaMMER) decontamination system (DFoS)Demonstrations – e.g. Consequence Management Bioresiliency (TaCBRD)

Materials and Imaging Sciences – e.g. Better Biosensors, Nanomaterials for drug delivery, Robust Biomimetic Materials & Devices


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DTRA RDT&E Summary

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• Responds to top national and DOD priorities in CWMD• Supports the strategic deterrent by enhancing system

survivability, nuclear forensics, and targeting effectiveness• Provides DoD’s primary support to USSOCOM for WMD-T

Future Capabilities• Leverages DTRA’s combat support role to provide unique WMD

expertise directly to our warfighters• Infuses WMD-related research into over 100 of our top

universities• Well connected to DoD, Interagency and international partners

DTRA’s steady-state S&T efforts create the expertise and capabilities required for agile responses to urgent operational needs

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THE THREATS ARE REAL

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Chemical ▪ Traditional Chemical Warfare Agents ▪ Toxic Industrial Materials and Toxic

Industrial Chemicals ▪ Emerging and Non-traditional Agents Biological

▪ Traditional Biological Threat Agents ▪ Emerging Diseases ▪ Enhanced Threats

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J9CB APPROACH

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Science & TechnologyInvestment Strategies SENSE

SHAPE

SHIELD

SUSTAIN

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DRIVERS OF SUCCESS

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Collaboration We work with other agencies, academia

and the science community.

Innovation

Performance

Product

Strategy

Warfighter

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Lead DoD science and technology to anticipate, defend, and safeguard against chemical and

biological threats for the warfighter and the nation

DTRA J9CB Mission

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Warfighter Driven Innovation Driven Strategy Driven Product Driven Performance Driven

Collaboration Driven

Warfighter Delivered

MISSION

the science behind the solutions...• to build next generation chemical and biological defense...

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