the neurophysiology of...
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F.H. WIllard, Ph.D.Anatomy Section
University of New EnglandCollege of Osteopathic Medicine
Biddeford, Maine, U.S.A.
The Neurophysiology of AcupuncturePossible Mechanisms and Outcomes
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Quiroz-Gonzalez, S., S. Torres-Castillo, R.E. Lopez-Gomez, and I. Jimenez Estrada. 2017. Acupuncture Points and Their Relationship with Multireceptive Fields of Neurons. J Acupunct Meridian Stud. 10:81-89.
Acupuncture Channels
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Primary Afferent Fibers
Prechtl and Powley, Behav. Brain Sci. 13:289-331, 1990
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Sensitized Primary Afferent Fibers
Histamine Bradykinin Prostaglandins
Small Fiber Neurogenic Inflammatory Cycle
Spinal Cord
Neuropeptides+
Tissue Inflammation
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Central Sensitization - Somatic
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Quiroz-Gonzalez, S., S. Torres-Castillo, R.E. Lopez-Gomez, and I. Jimenez Estrada. 2017. Acupuncture Points and Their Relationship with Multireceptive Fields of Neurons. J Acupunct Meridian Stud. 10:81-89.
Central Sensitization - Visceral
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Text
Large Fiber Touch
Small Fiber
Gate-ControlTheory
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Large Fiber Touch
Small Fiber
Loss of Inhibition on the Segment
Neuropathic Pain
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Visceral input
Somatic input
Viscerosomatic Integration - The Viscerotome
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Cross-Sensitizationin the Dorsal Horn
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Quiroz-Gonzalez, S., S. Torres-Castillo, R.E. Lopez-Gomez, and I. Jimenez Estrada. 2017. Acupuncture Points and Their Relationship with Multireceptive Fields of Neurons. J Acupunct Meridian Stud. 10:81-89.
ViscerosomaticIntegration & Acupuncture
Points
ViscerosomaticReceptive Fields
ReciprocalSensitization
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Primary Afferent Fibers Central Processes
Tract of Lissauer
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Quiroz-Gonzalez, S., S. Torres-Castillo, R.E. Lopez-Gomez, and I. Jimenez Estrada. 2017. Acupuncture Points and Their Relationship with Multireceptive Fields of Neurons. J Acupunct Meridian Stud. 10:81-89.
ViscerosomaticIntegration
ofAcupuncture
Points
BidirectionalCommunication
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ReferredPain
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Pancreaticosomatic Reflexes
• Stimulation of the pancreatic duct with trypsin
• Enhance EMG activity in the acromiotrapezius muscle of the back
Hoogerwerf et al,. Trypsin mediates nociception via the proteinase-activated receptor 2: a potentially novel role in pancreatic pain. Gastroenterol. 127 (3):883-891, 2004.
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Referred Gall Bladder Pain
M. A. Giamberardino, G. Affaitati, and R. Costantini. Referred pain from internal organs. Hdbk Clin.Neurol. 81 (3rd Series):343-361, 2006
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Trophic Changes
• Increased thickness of the subcutaneous tissue
• Firmness not related to edema
• Decreased thickness in the associated muscle layers
• Muscle atrophy
• Degree of change related to duration of painful episodes
M. A. Giamberardino, G. Affaitati, and R. Costantini. Referred pain from internal organs. Hdbk Clin.Neurol. 81 (3rd Series):343-361, 2006
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Referred Uterine Pain
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Referred Pain From The Uterus
• Rats pretreated with Evans Blue vital dye
• Subjected to noxious uterine stimulation
• Extravasation of dye over the low abdomen and back, sacral and perineal region
• U. Wesselmann and J. Lai. Mechanisms of referred visceral pain: uterine inflammation in the adult virgin rat results in neurogenic plasma extravasation in the skin. Pain 73 (3):309-317, 1997.
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Uterus
Spinal Cord
Cutaneous Blood Vessel
Extravasation
Autonomic Reflex
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Uterus
Spinal Cord
Extravasation Cutaneous Blood Vessel
Dorsal Root Reflex
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Cross-sensitization of Pelvic Organs
Winnard KP, Dmitrieva N, Berkley KJ. 2006. Cross-organ interactions between reproductive, gastrointestinal, and urinary
tracts: modulation by estrous stage and involvement of the hypogastric nerve. Am.J.Physiol Regul.Integr.Comp Physiol
291: R1592-R601
Spinal cord as anintegrator of afferent
fibers
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Ascending Nociceptive Pathways
Farquhar-Smith WP. 2009. Anatomy, physiology and pharmacology of pain.
Anaesthesia and Intensive Care Medicine 9: 3-7
Brainstem-Subcortical Thalamocortical
Control of Spinal Cord Activity
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Descending Spinal Control SystemsEndogenous Pain Control
Raphe-spinal systemNoradrenergic-spinal system
Diffuse Noxious Inhibitory Control
Spino-Reticulospinal Loop
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Limbic Forebrain
Hypothalamus
PAG
Medullary or SpinalDorsal Horn
Emotions Hormones
Raphe
Somaticactivity
PeripheralNerve
NeuropeptidesGABA
OpioidsGABA
SerotoninNorepinephrine
EAA
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PeriaqueductalGray
PAG
IC
OpioidSystems
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Naloxone Sensitive
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Insular Cortex
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Cingulate Gyrus, Medial Prefrontal Lobe,
& Amygdala
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Dorsolateral PrefrontalCortex
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Pain Neuromatrix
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Pain Neuromatrix
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Kucyi A, Davis KD. 2015. The dynamic pain connectome. Trends Neurosci 38: 86-95
Pain Connectome
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Bai L, Qin W, Tian J, et al. Acupuncture modulatesspontaneous activities in the anticorrelated resting brainnetworks. Brain Res 2009;1279:37–49.
Hui KK, Liu J, Makris N, et al. Acupuncture modulates thelimbic system and subcortical gray structures of the humanbrain: evidence from fMRI studies in normal subjects. HumBrain Mapp 2000;9:13–25.
Wu MT, Sheen JM, Chuang KH, et al. Neuronal specificity ofacupuncture response: a fMRI study with electroacupuncture.NeuroImage 2002;16:1028–37.
Acupuncture Can Influence Cerebral Cortical Activity
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Following acupuncture needle stimulation, activation in the sensorimotor cortical network, including the insula, thalamus, anterior cingulate cortex, and primary and secondary somatosensory cortices, and deactivation in the limbic-paralimbic neocortical network, including the medial prefrontal cortex, caudate, amygdala, posterior cingulate cortex, and parahippocampus, were detected and assessed
Functional MRI Studies
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Lin, Y.J., Y.Y. Kung, W.J. Kuo, D.M. Niddam, C.C. Chou, C.M. Cheng, T.C. Yeh, J.C. Hsieh, and J.H. Chiu. 2016. Effect of acupuncture 'dose' on modulation of the default mode network
of the brain. Acupunct Med. 34:425-432.
TNA and SNA+MS induced DMN-insula activity and extensive DMN activity compared to SNA, despite comparable levels of de qi sensation. The TNA and SNA+MS groups exhibited a delayed and enhanced modulation of the DMN, which was not observed followed SNA and TENS. Furthermore, TNA increased precuneus activity and increased the DMNrelated activity of the cuneus and left insula, while SNA+MS increased activity in the right insula.
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Zou, Y., W. Tang, X. Li, M. Xu, and J. Li. 2019. Acupuncture Reversible Effects on Altered Default Mode Network of Chronic Migraine Accompanied with Clinical Symptom Relief. Neural
Plast. 2019:5047463
HC CM - Pretreatment CM - Post-treatment
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Quiroz-Gonzalez, S., S. Torres-Castillo, R.E. Lopez-Gomez, and I. Jimenez Estrada. 2017. Acupuncture Points and Their Relationship with Multireceptive Fields of Neurons. J Acupunct Meridian Stud. 10:81-89.
Cerebral Cortex
Brainstem
Spinal Cord
Peripheral Nerve
The Neurophysiology of Acupuncture