the national association for pancreatic cancer prese nts
TRANSCRIPT
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The National Association for Pancreatic Cancer Pres
ents
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This Year…
• 3% of the population, over 43,000 people, will be diagnosed with pancreatic cancer.
• Over 37,000 people will die from the disease.
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What is Cancer?
Alison and Sarraf, Understanding Cancer, Cambridge University Press, 1997
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Cancer Trends
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Cancer Survival
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P53 is a Regulator of ApoptosisExternal pathway – induced by exposure to chemical signals released by other cells – are “death signals”
From L. J. Kleinsmith, Principles of Cancer Biology. Copyright (c) 2006 Pearson Benjamin Cummings.
Death signals activate
death receptors
Internal pathway – induced by excessive DNA damage
Leaches frommitochondria &
activates caspase cascade
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Prevalence of p53 Mutations
From L. J. Kleinsmith, Principles of Cancer Biology. Copyright (c) 2006 Pearson Benjamin Cummings.
p53 is the most commonly mutated gene in human cancers
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The Chemotherapy Industry
• In 2003, worldwide market for products was ~$36.8 billion US
• Currently, oncology-related products represent ~10% of total $430 billion worldwide market for pharmaceuticals (Pharmaceutical Therapeutic Categories Outlook: Comprehensive Study 375, S.G. Cowan & Co., NY, 2004)
• Market expansion driven by:Increased therapeutic optionsWillingness to treat older patientsHigh price of newer drugs
• At present, more than 1,300 small U.S. biotech companies focused on molecular target drug development, >50% cancer focused
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Is Timing Everything?
Figure 16.9 The Biology of Cancer (© Garland Science 2007)
PanINs = pancreatic intraepithelial neoplasias arediscrete stages in tumor progression
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What Can You Do?
Be part of
Fundraise · Volunteer · Participate
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What is Carnival for a Cure?
• A day of fun for college students, their families and people in the community• Fundraising event for pancreatic cancer treatments and research
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Games
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Activities
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Entertainment
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Why Host Carnival for a Cure?
• Participating towards a great cause• Great public relations event• Gives students something to participate in• Gets people on campus