the miracle moleclue-l-arginine - amazon s3miracle+moleclue-l-arginine.pdf · the body needs...

T H E M I R A C L E M O L E C U L E : L - A R G I N I N E

Copyright 2015 by PacificCoast NutriLabs All rights reserved. No part of this book may be reproduced by any

means whatsoever without the written permission from PacificCoast NutriLabs, except brief portions quoted for purpose of review.

All information in this book has been carefully researched and checked for factual accuracy. However, PacificCoast NutriLabs makes no warranty, express or implied, that the information contained herein is appropriate for every individual, situation, or purpose, and assumes no responsibility for errors or omissions. The reader assumes the risk and responsibility for all actions, and PacificCoast NutriLabs will not be held responsible for any loss or damage, whether consequential, incidental, special or

otherwise that may result from the information presented in this publication.

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T A B L E O F C O N T E N T S

L-Arginine: The Road To Heart-Healthy Living…………….….. 4 It’s Not You, It’s Your Lifestyle…………………………….. 5 The Miracle Molecule: L-Arginine…………………….….. 9

Risks of Low L-Arginine Levels…………………………………. 11

Health Benefits of L-Arginine…………………………….….…. 12 Supports your Immune System…………………………… 13 Relieves Chest Pain……………………………………….. 15 Puts the Spark Back In Your Sex Life…………………… 16 Improves Kidney Function……………………………….. 18 Enhances Exercise Performance………………………… 20

The Link Between L-Arginine and Weight Loss………………. 22

Recommended Dosage…………………………………………. 24

Interactions and Side Effects………………………………….. 26

5 Tips To Improve Heart Health………………………………. 28

Customer Loyalty Discount…………………………………… 37

Conclusion…………………………………………………..… 38

Sources & References…………………………………………. 39


L - A R G I N I N E t h e r oa d to

h e a lt h y l i v i n g

Did you know that your heart beats 100,000 times a day? With all the hard work it’s doing, you shouldn’t take it for granted. According to the Centers for Disease Control and Prevention (CDC), heart disease is the leading cause of death for both men and women in the U.S., and around 600,000 Americans die from it each year. To reduce your risk, dietary and lifestyle changes are required. Yes, it’s tough to change your eating habits, especially if you have years of unhealthy meals under your belt. There’s a new solution: L-Arginine. What does L-Arginine do for the heart, and what are the potential side-effects? Read on to learn more.


I T ’ S N O T Y O U , I T ’ S Y O U R L I F E S T Y L E

You might think you still have years or decades before you have to worry about heart disease. Here’s the reality – the

heart needs attention no matter what your age. Take a look at your daily habits. They can have a big impact on the

health of your heart. Are you living a toxic lifestyle?

The following signs can tell you.


Y o u r eg u l a r ly e at

fa st fo o d

Fast food is the worst kind of food you can eat when it comes to improving your lifestyle. If you find yourself craving a double cheeseburger more than a healthy green salad most of the time, you’ve already become accustomed to eating starchy, fat-laden fast food, which only leads to weight gain and poor bodily function. Reduce synthetic chemicals from your diet by buying organic options. Avoid refined sugars, processed foods and trans fat. Cook at home more often and bring easily prepared meals instead of eating out at lunch.

Y o u r a r e ly g e t

e x e r ci s e When was the last time you got off the couch and squeezed in some cardio? Even at the office, you hate going for walks at lunchtime, and getting up to talk to colleagues.


The solution to ending a sedentary lifestyle is to get moving. Your heart is a muscle, and it needs exercise to get stronger. Getting your blood pumping can also stimulate your liver, kidneys and lungs. It’s an important way to decrease your risk of heart disease.

Y o u a r e t ec h n o lo g y -

o b s es s e d As technology continues to advance, you’re managing nearly your entire life on-screen from working and shopping, to socializing. You’ve become technology-obsessed, and you enjoy not having to get up from your chair. Why not make technology work for you? Download apps that can help you manage your meals, and connect with others for support. Schedule your exercise dates and set reminders in your smartphone, tablet or computer.

Y o u a r e s l e e p

d e p r i v e d


You consistently sleep less than six hours a day, and you’re so used to being deprived that you remain oblivious to how impaired you are. You can’t make simple decisions, you overeat, and you easily get colds. Sleep deprivation puts you at risk for health conditions such as obesity, cardiovascular disease, and diabetes. Establish a bedtime ritual and remove all distractions from your bedroom. Smoking, lack of exercise, exposure to pollution and choosing processed food over organic options – these are just some of the factors that affect your body’s ability to absorb nutrients and fully use what you eat. That’s why nutritional supplements are needed. With today’s lifestyles, the heart becomes more at risk to various diseases.


T H E M I R A C L E M O L E C U L E : L - A R G I N I N E

Twenty percent of the human body is made up of protein. Building blocks, called amino acids, carry out many important bodily functions and play a key role in the transport and storage of nutrients. However, certain stresses can diminish your body’s supply of amino acids, which can lead to a number of health problems. L-Arginine is one particular amino acid supplement that’s quickly gaining popularity. Once ingested, it is converted to nitric oxide. It then boosts circulation and blood flow by dilating your blood vessels. It also helps eliminate ammonia and stimulate the release of insulin. With improved blood flow, you’ll look and feel healthier.

In 1998, the Nobel Prize for Medicine was awarded to specific research regarding L-Arginine and its conversion to nitric oxide. The American researchers involved revealed how nitric oxide can regulate your entire cardiovascular system. Increased blood circulation to different areas of your body can promote cell growth and organ function. It means that


your vital organs get the oxygen and nutrients they need. What’s more, it keeps your mind sharp and focused. The Journal of Cardiovascular Pharmacology recently looked into the effects of L-Arginine on patients with cardiovascular risk factors. After evaluating their arterial elasticity, it was revealed that the group treated with L-Arginine have significantly lower systemic vascular resistance, and decreased systolic blood pressure.

L-Arginine may be abundant in many different types of foods, but for those who aren’t making smart dietary choices, the body may fail to produce a sufficient amount. Under such circumstances, amino acid supplements can be useful to fulfill the body's need for amino acids.


R I S K S O F L O W L - A R G I N I N E L E V E L S

The body needs L-Arginine not only to make protein, but also to create urea, which is necessary for elimination of the toxic ammonia from the body. If a person has a low level of L-Arginine, it may cause various skin problems such as rash, hair loss, or worse, poor wound healing. There are many reasons for deficiency of L-Arginine. For one, people following a low-protein diet may need supplementation. Not to mention those with excessive ammonia production, urea synthesis disorder, infections and burns. Your liver may also be at risk to different problems, as well as your blood vessels.


H e a lt h B e n e f i ts o f

L - A r gi n i n e Taking L-Arginine on top of a healthy diet lets you reap its maximum benefits. It’s a simple amino acid, but it takes on a big job in keeping your blood flowing freely throughout your body. That’s why it’s important during periods of illnesses such as hypertension, and type 2 diabetes.

Here are other ways it can boost your health.


# 1 S u p p o rts Y o u r

I m m u n e S y st e m The immune system protects the body from foreign invaders in all their forms. With the help of white blood cells, widespread infections are prevented. Sadly, the immune system’s efficiency declines as you age. This puts you at risk to various diseases. In one study done by the American Journal of Critical Care, a strong evidence suggests that nutritional supplementation with L-Arginine can effectively improve your immune function. It was found that the amino acid has a direct effect on T-cell activity, which enhances your body’s disease-fighting capability. The benefits of taking L-Arginine are most significant after surgeries. During this time, the body’s need for L-Arginine increases because the amino acid is required for protein synthesis and white blood cell production. These are the two main factors for wound repair and preventing infection.


Researchers at the University of Amsterdam also documented that taking supplements before surgery can benefit the immune system. The study involved 50 patients at high risk of infection after cardiac surgery. Half of the group was given daily supplementation of L-Arginine 5-10 days before surgery, and the other half received placebo. After looking at their immune response, researchers found that the cells from those who received L-Arginine performed better. The infection rate of the treatment group was only 18% post-surgery, which was dramatically lower compared to the control group which had 55%.


# 2 R e l i e v es C h est P a i n

Chest pain is a common symptom of coronary heart disease. The discomfort can also affect the back, shoulders, arms, neck and jaw. At the same time, it may include other symptoms such as shortness of breath, fatigue, sweating and dizziness. These usually occur when the heart muscle doesn’t get enough blood supply. Several studies have shown that increasing L-Arginine levels in the body can ease the symptoms in people experiencing chest pain. This is because the amino acid improves blood flow in the arteries of the heart.

NYU Langone Medical Center conducted a double-blind study on the effects of L-Arginine on angina pectoris or chest pain, and found that supplementation reduced the symptoms. Treatment also improved exercise tolerance for those suffering from angina.


# 3 P u ts t h e S pa r k B ac k

I n Y o u r S e x L i f e No one really wants to talk about their inability to fully enjoy sexual intercourse. However, like it or not, sexual dysfunction is an existing problem. Women often experience it as a difficulty in maintaining their sex drive. Men, on the other hand, suffer from impotence or erectile dysfunction. L-Arginine is one of the most recognized nutrients that have the ability to bring back the spark in your sex life. The amino acid is a known precursor of nitrous oxide, which helps in restoring normal sexual function in both men and women. It comes down to circulation. Since L-Arginine has been shown to increase blood flow, it can help increase the frequency of erections, and enable the clitoris to be more responsive to sexual stimulation. What’s more, adequate levels of L-Arginine in the body can lead to stronger and more powerful orgasms.

This effect was demonstrated in a double-blind, placebo-controlled study published in the British Journal of Urology


International. Researchers evaluated the nitric oxide levels of 50 men, who were given either L-Arginine or a placebo per day. It was found that 5 grams of L-arginine daily for six weeks can improve erectile dysfunction in men. This is because the amino acid stimulates the release of nitric oxide in the body and increases blood flow to the genital area. In another study, 77 women were given L-Arginine supplements. After four weeks, 73.5% of the test participants reported that they had experienced greater sexual satisfaction. Other than that, less vaginal dryness, frequency of orgasm, heightened desire and clitoral sensation were also observed.


# 4 I m p r o v es K i d n e y

F u n c t io n Healthy kidneys process around one liter of blood every minute. Their main function is to filter and get rid of waste products from your body. They also regulate water and salt balance, as well as produce essential hormones needed for optimum health. A team of researchers at the Teikyo University Ichihara Hospital in Japan studied the effects of L-Arginine on renal blood flow. It is known that nitric oxide helps in regulating kidney function, particularly in patients with high blood pressure and renal disorders. The researchers conducted a double-blind crossover trial. There were 17 CHF (Congestive Heart Failure) patients selected and closely monitored throughout the study. They were given 15 grams of L-Arginine orally per day. Upon analysis, it was concluded that L-Arginine does have beneficial effects on the kidneys. It was reported that the treatment improved the kidneys’ ability to filter wastes, and maintain sodium and water. They


also found a link between the effects of L-Arginine and the production of nitric oxide inside the walls of the blood vessels. As people age, degradation occurs in the membranes of the glomerulus, the key structure actively involved in the filtration of the blood. L-Arginine provides the protection the membranes need to fully function. It inhibits the reaction that can damage the proteins in membranes. Thus, kidney filtration of metabolic wastes is improved.


# 5 E n h a n c es E x e r ci s e

P e r fo r m a n c e L-Arginine is popular among fitness enthusiasts because of its ability to increase exercise capacity and reduce hypoxic stress. Because L-Arginine gives the blood circulation a boost, it also increases oxygen delivery throughout the body. This increases the efficiency of your body to produce energy. When oxygen levels are low, the muscles aren’t able to perform at their full capacity. This can lead to exercise intolerance. Part of optimizing health, and preventing heart disease, is regular physical activity. L-Arginine supplementation is the answer to enhance exercise performance. A recent study was performed to determine the effects of L-Arginine on exercise capacity. It involved 16 participants. Those in the treatment group were supplemented with 0.5g of L-Arginine per 10 kg of body weight three times daily, for one week.


Researchers measured the exercise capacity of all patients by evaluating their performance on a stationary bicycle. Based on their observations, increased exposure to nitric oxide can improve oxygen uptake by the lungs. Results show that one week of supplementation has increased peak oxygen volume by 8% and exercise capacity by 12%.


T H E L I N K B E T W E E N L -A R G I N I N E & W E I G H T L O S S Are you struggling to lose some weight? L-Arginine may just be the solution you’re looking for. Scientific studies have shown that the most relevant effects of L-Arginine for weight loss lie with nitric oxide. The said substance regulates the metabolism of glucose, fatty acids and amino acids.

L - A r gi n i n e L es s e n s

B o d y F at Aside from its muscle-building effects, L-Arginine has been known to fight obesity and reduce body fat. A natural growth hormone booster, L-Arginine has the ability to properly distribute and break down fat. Additionally, achieving a healthier weight can decrease your risk of cardiovascular disease.

L - A r gi n i n e D e v e lo p s

L e a n T i s s u e


The amino acid can also be an excellent supplement for anyone wanting to develop lean tissue. It can help convert more protein into muscle, and lessen fat storage. Incorporating L-Arginine into your diet can result in a noticeable reduction in body fat.

L - A r gi n i n e a n d L i p i d

B r e a k d o w n As mentioned, L-Arginine boosts the levels of nitric oxide. The gas not only improves muscular strength, but also increases fat and glucose metabolism. Don’t wait for fat and sugar to pile up in all the wrong places throughout your body. Trim them down with L-Arginine. Because L-Arginine increases nutrient delivery and energy levels, it enables a person to train longer and harder in the gym. It is with no doubt that supplementing with L-Arginine can help those wanting to build muscle and lose weight.


R E C O M M E N D E D D O S A G E L-Arginine has been studied as a treatment for many conditions. Based on scientific research, there is no standard dose for supplementation. However, dosing varies depending on the person’s health condition and treatment. To realize the therapeutic effect for your heart, you’ll need around 4-6 grams of L-Arginine per day. As the body begins to replenish the amino acid, you should start to experience positive health changes approximately four to eight weeks after supplementation. Continuous treatment can lower blood pressure and prevent atherosclerosis. To get the optimum benefits for weight loss, it is recommended to take 2-3 grams of L-Arginine, three times daily. The doses should be taken upon waking, before a workout and before going to bed. For best results, take it on an empty stomach. When it comes to erectile dysfunction, a dosage of 3-5 grams per day is preferable and may be increased up to 10 grams. The same goes with improving the quality of sperm and treating poor sperm mobility. Results are expected within two to three months.


If you want to take L-Arginine to improve physical performance, the suggested dosage is up to 6 grams. The amino acid can also be used as a treatment for hair loss, taken 500mg per day.

These dosages are consistent with medical studies. If you’re already taking a prescription for any current condition, you should always consult your physician first.


I N T E R A C T I O N S A N D S I D E E F F E C T S

L - A r gi n i n e

I n t e r ac t io n s L-Arginine can interact with other medications. Using the supplement with drugs that decrease blood pressure may cause it to drop to dangerous levels. When the two products are used together, it may lead to serious side effects and uncomfortable complications. Common examples of antihypertensive drugs include captopril (Capoten), losartan (Cozaar), enalapril (Vasotec), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), furosemide (Lasix), hydrochlorothiazide (HydroDiuril) and many others. Taking L-Arginine with nitrate-based drugs, or those that increase blood flow to the heart, can cause dizziness and lightheadedness. These include isosorbide (Imdur, Isordil, Sorbitate) and nitroglycerin (Nitrostat, Nitro-Dur). Sildenafil,


an erectile dysfunction drug, should also not be taken with L-Arginine. Their combination may also lead to a sudden drop in blood pressure. Blood thinners, which is known to interact with many herbs and supplements, should not be taken with L-Arginine. It could increase an individual’s risk for bleeding and excessive bruising. Warfarin is a powerful blood thinner, and ibuprofen and aspirin have similar effects.

L - A r gi n i n e S i d e

E f f ec ts L-Arginine oral supplements are considered safe for most people when taken appropriately. In clinical trials and studies, the amino acid only showed minimal side effects, including abdominal pain, nausea, cramps, allergic reactions and bloating. It was also found that L-Arginine can worsen breathing in people with asthma. Absolute contraindications have not been identified. Several trials have been performed in pregnant women, and no ill effects were found. However, to stay on the safe side, pregnant and nursing women should talk to their doctors first, before taking the supplement. This also applies to children.


5 T I P S T O I M P R O V E H E A R T H E A L T H

It’s time to put your best foot forward and take charge of your heart health. Cardiovascular disease being the leading cause of death in the US is a wake-up call you shouldn’t ignore. Sedentary lifestyles, fast-food-heavy diets, not getting enough sleep – these habits are slowly putting you at risk. Understanding the importance of prevention, making good diet choices and promoting your own physical health are all part of the necessary changes. To boost your odds for a healthier and longer life, take your daily dose of L-Arginine and consider the following tips to improve heart health through a change in lifestyle.


# 1 D e - c lu t t e r yo u r

k i t c h e n Outward clutter is often a sign of inner turmoil, and it includes your diet. Your kitchen may be keeping you from moving forward towards a healthier eating habit. Think about it, there may be tons of leftover take-out and junk foods lurking in your fridge. Transform your kitchen into a healthy place to cook and make room for the good stuff. Raid your fridge, pantry, and cupboards and toss out all the empty-calorie foods and half-eaten containers of take-out meals. It also means your stock of sugary cereals, sodas, and full-fat ice cream must go. Once you have space, it’s time to fill up with fruits, vegetables, whole grains, lean meats and oily fish like salmon and mackerel. Most people think that healthy eating equates to bland, tasteless dishes, but it’s about simply finding the right kinds of food and recipes. Start the day with a breakfast that includes lean protein and fiber. Snack wisely mid-morning and mid-afternoon to


prevent you from overeating at mealtime. It also helps to keep an eye on the beverages you drink. Cut back on sugar, caffeine and alcohol as much as possible, or do it in moderation.


# 2 G e t yo u r b o d y

m o v i n g You can get your heart stronger with regular exercise. You don’t really need to go to the gym or some fancy equipment. Just a simple 30-minute walk or jog five days a week can improve your cardiovascular fitness and reduce your risk of heart disease. Make it a habit to simply move more. Burn calories by taking the stairs instead of the elevator, walk your dog a few blocks, or mow the lawn on weekends. Whether done outdoors or indoors, what’s important is to take small steps that will lead to bigger benefits. Avoid sticking with the same routine. Try different activities or find something you truly enjoy. Unique activities like martial arts and dancing are often enjoyable forms of exercise. Don’t forget to set your fitness goals to track your progress.


# 3 C h a n n e l t h e p o w e r

o f s l e e p Your sleeping habits have a more profound effect on your health than you think. Lack of quality sleep can alter your metabolism, which can make you prone to weight gain. It stimulates your stress hormones, making you depressed, which can lead to more food cravings. Most adults need at least six to eight hours of sleep each night. If you’re always sleep deprived, you increase your risk of high blood pressure, obesity and heart disease. Avoid doing things that can disrupt your normal sleep patterns such as drinking alcohol before going to bed. You’ll know you’re getting enough sleep when you’re able to wake up without your alarm, and you feel refreshed. If you’re struggling to get up, it’s a sign that you need to sleep more. It’s time to make sleep a priority. Set a schedule and stick to it. Keep your bedroom dark and quiet.


# 4 S m o k e - f r e e l i f est y l e

Smoking is considered as the leading preventable cause of premature deaths in the US, which includes heart disease. Studies show that women smokers are two to six times more likely to suffer from heart attack as non-smoking women. This risk increases with the number of cigarettes consumed. According to the American Heart Association (AHA), for a person to be in the ‘ideal’ category for heart health, one must have never smoked, or s/he has quit for more than a year. When you quit smoking, your risk of heart disease actually drops to that of a nonsmoker in about five years. Smokers are at higher risk for developing health problems such as atherosclerosis, which can ultimately lead to a heart attack. This is because the chemicals in cigarettes can damage your blood vessels and promote the buildup of fatty material in the arteries. Smoking also increases your blood pressure and heart rate. It forces your heart to work harder in order to supply sufficient oxygen throughout the body. No amount of smoking is safe.


Exposure to secondhand smoke is also as dangerous. If you quit now, you’ll start reaping the benefits.


# 5 R eg u l a r h e a lt h

s c r e e n i n g s It’s important to know your body’s numbers such as your body weight, blood sugar and blood pressure. Those with high cholesterol and hypertension are at risk of damaging their blood vessels. Without testing, you won’t know whether you have these conditions. Regular health screenings can help you determine your numbers and the actions you should take. For adults, blood pressure must be checked at least every two years. If the numbers aren’t ideal or if you’re already at risk for heart disease, then you’ll need to check it frequently. Cholesterol levels should be measured once every five years starting at the age of 20. This is the case for individuals who are obese, or those with strong family history of heart disease. Depending on your risk factors, the American Diabetes Association also recommends doing a Diabetes screening at age 45.


Combining these tips and applying them to your lifestyle brings you one step closer to optimum health and wellness. However, even a healthy and balanced diet may not be enough. You can still miss essential nutrients. This is the reason why you should consider adding supplements to your daily routine.


C U S T O M E R L O Y A L T Y D I S C O U N T

At PacificCoast NutriLabs, we want to ensure you are getting the best value possible. And, as a loyal customer, we are committed to your satisfaction.

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S O U R C E S A N D R E F E R E N C E S

L-‐Arginine on WebMD: h1p://www.webmd.com/vitamins-‐supplements/ingredientmono-‐875-‐l-‐arginine.aspx?

acDveingredienDd=875&acDveingredientname=l-‐arginine

Bailey, S. J., Winyard, P. G., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., and Jones, A. M. Acute L-‐arginine supplementaDon reduces the O2 cost of moderate-‐intensity exercise and enhances high-‐

intensity exercise tolerance. J Appl.Physiol 2010;109(5):1394-‐1403.

Beale, R. J., Bryg, D. J., and Bihari, D. J. ImmunonutriDon in the criDcally ill: a systemaDc review of clinical outcome. Crit Care Med. 1999;27(12):2799-‐2805. View abstract.

L-‐arginine. Review of Natural Products. Facts & Comparisons [database online]. St. Louis, MO: Wolters

Kluwer Health Inc; October 2010.

L-‐Arginine and Weight Loss. Cardio Health Research. AgriLife Research Centre from the University of Maryland School of Medicine; 2008 h1p://cardiohealthresearch.com/l-‐arginine-‐weight-‐loss/

Melle1 LH, et al. Heart-‐healthy exercise. CirculaDon. 2013;127:e571.

Understand your risk of heart a1ack. American Heart AssociaDon. h1p://www.heart.org/HEARTORG/

CondiDons/HeartA1ack/UnderstandYourRiskofHeartA1ack/Understand-‐Your-‐Risk-‐of-‐Heart-‐A1ack_UCM_002040_ArDcle.jsp. Accessed Sept. 6, 2013.

Erhardt L. Cigare1e smoking: An undertreated risk factor for cardiovascular disease. Atherosclerosis.

2009;205:23.

Stühlinger & Stanger: Asymmetric DimethyL-‐arginine (ADMA): A possible link between homocyst(e)ine and endothelial dysfuncDon. Current Drug Metabolism, 2005, 6, 3-‐14 ”

“Bednarz B et al.: Efficacy and safety of oral Arginine in acute myocardial infarcDon. Results of mulDcenter, randomized, double-‐blind, placebo-‐controlled ARAMI pilot trial. Kardiol. Pol.. 2005, 62, 421-‐26 ” ↩ -‐ See

more at: http://aminoacidstudies.org/l-arginine/#sthash.k45tg9md.dpuf


http://aminoacidstudies.org/l-arginine/#sthash.k45tg9md.dpuf

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