The

Laboratory Report Summer 2011

A Publication of the Department of Pathology and Laboratory Medicine

Wayne Chandler, M.D.

Table of Contents

Dr. Leveque Receives Prestigious Overstreet Award

Dr. Awalt to Lead Medical Staff at Willowbrook

Foster Donation Expands Blood Center Services

Methodist Pathologists Chair HSCP Spring Symposium

Hospital Auxiliary Donates New Blood Drive Van

New Diagnostic Test Offerings

Methodist Laboratory Science Students Win TACLS Bowl Com-petition

Trainee Spotlight

New Trainees Start on July 1st

Dr. Zu Leads Hematopathology Research Effort for Department

Dr. Wayne Chandler Joins Department as Vice-Chair of Clinical Innovation

D r. Wayne Chandler joined the

Department in April as the Vice

-Chair of Clinical Innovation

and the medical director of the Coagula-

tion Laboratory. He comes to

Methodist from the University of Wash-

ington in Seattle, where he was chief of

service for Laboratory Medicine at Har-

borview Medical Center.

“The discipline of Pathology is at an

important crossroad, with the new health

care laws and the advent of molecular

medicine,” said Dr. Chandler. “This is an

opportune time to expand laboratory

automation and leverage our tremendous

assets to further develop our molecular

diagnostics and outreach programs.”

While at the University of Washington,

Dr. Chandler was responsible for auto-

mating several clinical service laborato-

ries and developing new hemostasis and

thrombosis assays. He was also co-

director of their reference laboratory

business.

“Wayne has remarkable knowledge and

experience. He is an incredible addition

to our Department and the hospital sys-

tem,” said Dr. James Musser, chair of the

Department of Pathology and Laboratory

Medicine. “His leadership in laboratory

automation will greatly assist us in our

ongoing efforts to bring enhanced diag-

nostic innovation to the Department and

our Methodist patients.”

Dr. Chandler has also made further

development of the Department’s re-

search outreach a priority. “We do a

substantial amount of research here, which

provides us with another opportunity for

considerable growth,” said Dr. Chandler.

“We are well-positioned to provide our

expertise to investigators in the Texas

Medical Center and beyond, whether as a

full collaborator or a provider of novel or

customized research assays.”

Dr. Chandler is board-certified in clinical

pathology, a member of the Academy of

Clinical Laboratory Physicians and Scien-

tists, and a fellow of the College of Ameri-

can Pathologists.

For more information on Dr. Chandler,

please visit methodisthealth.com/Chandler.

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Archives of Pathology and Laboratory Medicine is the

most highly read journal/periodical title among U.S.

practicing pathologists. The June 2011 issue featured several

contributions from our esteemed department faculty! If you

haven't already, please see the important editorial on

third-track pathology by our department chair, Dr. James

Musser, as well as a special section organized by Dr. Jae

Ro, and an original research article by Dr. Gustavo de la

Roza. Congratulations to our department faculty mem-

bers who joined the editorial board in June: Drs. Donna

Coffey, Yimin Ge, Ping Wang, Aleksandar Babic, and

Andreana Rivera. The June issue can be found at

archivesofpathology.org.

Of Note…

The

LABORATORY REPORT

2

Dr. Leveque Receives Prestigious Overstreet Award

thereby reducing the demand for blood

products. To this end, he is currently in-

vestigating the use of various drugs and

growth factors, including basic pancreatic

trypsin inhibitors (BPTIs) and platelet-

rich plasma (PRP), in surgery.

For more information on Dr. Leveque,

please visit methodisthealth.com/Leveque.

Dr. Awalt to Lead Medical Staff at Willowbrook

D r. Hazel Awalt recently became

the president-elect of the medi-

cal staff at Methodist Willow-

brook Hospital and will become presi-

dent in 2013. She is currently medical

“Dr. Leveque is an out-

standing physician. The care

he provides to our patients in

the Blood Donor Center and

Apheresis Clinic is second to

none,” said Dr. James Musser,

chair of the Department of

Pathology and Laboratory

Medicine. “We also appreciate

his contributions to the hospi-

tal’s teaching mission as a

very capable and enthusiastic

mentor to our residents and

fellows.”

Dr. Leveque has subspecialty

certification in transfusion medicine. He

received his medical degree from the

Louisiana State University School of

Medicine in New Orleans in 1981, and

completed a residency in pathology and a

fellowship in transfusion medicine at The

University of Texas Medical Branch in

Galveston, Texas. Dr. Leveque’s research

is focused on outcomes studies that as-

sess strategies to reduce bleeding and

initiate healing after injury or surgery,

D r. Christopher Leveque, medical

director of the Blood Bank and

Transfusion Medicine, received

the John W. Overstreet, M.D. Award on

Wednesday, March 30th during the Doc-

tors’ Day 2011 celebrations in Crain Gar-

den. The Overstreet Award was estab-

lished in 1997 by The Methodist Hospital

to honor and acknowledge a physician on

its medical staff who exemplifies the best

of the medical profession, demonstrates

respect, empathy, and caring in their in-

teractions with patients, family, and staff,

and supports the mission of the hospital.

“I am honored and humbled to receive

this prestigious award named for such an

esteemed doctor,” said Dr. Leveque.

“Methodist is a great place to practice

medicine. I am truly proud to be of ser-

vice to my patients and their families in

such a remarkable environment.”

Dr. Leveque joined The Methodist Hos-

pital in 1990 and became medical director

of the Blood Bank in 2004. He is also the

director of the Blood Banking and Trans-

fusion Medicine Fellowship Program.

director of laboratory services and over-

sees all laboratory operations and pathol-

ogy services at Methodist Willowbrook.

“I look forward to working closely with

the medical staff, administration, and the

board during my term as president-elect

and subsequent term as president of the

medical staff,” said Dr. Awalt. “It is a

very exciting time to be participating in

the growth of our hospital and the ser-

vices we offer the community in North

Houston.”

Elected by the active medical staff of the

hospital, the president has many leader-

ship responsibilities in the areas of medi-

cal staff governance and education, qual-

ity assurance activities, safety initiatives,

and maintaining accreditation standards

such as those from The Joint Commission

or Det Norske Veritas. The president also

serves as a liaison between the medical

staff, the hospital administration, and

Board of Trustees. As president, Dr.

Awalt will chair the Medical Executive

Committee and serve as a member of the

Board of Trustees.

Dr. Awalt received her MD degree from

Baylor College of Medicine in Houston,

Texas and completed a pathology resi-

dency at St. Luke's Episcopal Hospital,

where she served as chief resident in her

final year. She then completed her surgi-

cal pathology fellowship at The Univer-

sity of Texas M.D. Anderson Cancer Cen-

ter. She joined The Methodist Hospital

Physician Organization in 2005, and re-

ceived her faculty appointment at the

Weill Cornell Medical College in 2007.

Dr. Awalt is board certified in anatomic

and clinical pathology by the American

Board of Pathology.

For more information on Dr. Awalt,

please visit methodisthealth.com/Awalt. Hazel Awalt, M.D.

Dr. Leveque in the Apheresis Unit with a grateful patient.

The

LABORATORY REPORT

services in our Donor Center,”

said Dr. James Musser, chair of the

Department of Pathology and

Laboratory Medicine.

Apheresis donation is an auto-

mated process in which a donor’s

blood is drawn and centrifuged to

remove a specific component(s),

then the remaining blood is re-

turned to the donor. This allows

for the donation of blood compo-

nents that are needed most, such

as double red cells, platelets, or

plasma. Collection of stem cells

from the peripheral blood can also

be performed using these ma-

chines. For more information on the Blood

Donor Center at The Methodist Hospital,

please visit methodistbloodcenter.com.

3

Donation from Mr. & Mrs. Joseph Foster Expands Blood Center Services

Methodist Pathologists Chair HSCP Spring Symposiums

T he 51st Annual Spring Symposium

of the Houston Society of Clinical

Pathologists (HSCP) was held on

April 16, 2011 at the Omni Houston Ho-

tel. For the past three years, faculty mem-

bers from the Methodist Department of

Pathology and Laboratory Medicine have

contributed to the academic organization

of this important annual event. This

year’s symposium was co-chaired by Dr.

Mary Schwartz, the medical director of

Anatomic Pathology at The Methodist

Hospital, and Dr. Adel El-Naggar, Profes-

sor of Pathology and Head and Neck

Surgery at The University of Texas M.D.

Anderson Cancer Center.

The theme of this year’s lectures and

exhibits was current advances in the pa-

thology and management of head and

neck neoplasia. Renowned thyroid pa-

thologist from the University of Pennsyl-

vania, Dr. Virginia LiVolsi, presented

findings from her time served on the pa-

thology panel of the Chernobyl Tumor

Bank. Her research revealed a correlation

between molecular changes in thyroid

Dr. Mary Schwartz convenes the 51st Annual Spring Symposium for the Houston Society

of Clinical Pathologists.

T hree new apheresis

instruments became

operational in the

Methodist Blood Donor Center

in May as the result of a gener-

ous donation from Mr. and

Mrs. Joseph Foster. One Trima

Accel Automated Blood Col-

lection System and two Fenwal

Autopheresis-C Systems were

added to the donor apheresis

area of the Blood Donor Center

and will allow the Center to

keep up with the ever-growing

demand for blood products at

the hospital.

“Mr. and Mrs. Foster have

been extremely kind. Their generous gift

has allowed us to significantly increase

the number of patients that can be served

by the Methodist Blood Donor Center,”

said Dr. Christopher Leveque, medical

director of the Blood Bank and

tumors and exposure to radioactive io-

dide in young individuals subjected to

the fallout from the Chernobyl disaster. Another well-received lecture, given by

Dr. William Westra of Johns Hopkins

University, presented data on the chang-

ing epidemiology of oral cancer. A dis-

ease that was once mostly caused by

drinking and smoking in older men from

lower socio-economic backgrounds is

now largely caused by the presence of

human papillomavirus in younger men

from a higher socio-economic level.

Knowledge of this subject is rapidly

emerging and new guidelines for testing,

treatment, and vaccination will likely

follow.

Dr. Philip Cagle, the medical director

of Pulmonary Pathology at Methodist,

will chair the 52nd Annual Spring Sympo-

sium in 2012. It will be held on April 28th

and 29th in the main auditorium of The

Methodist Hospital Research Institute,

and will combine the HSCP Spring Sym-

posium (April 28th) with the Methodist

Department of Pathology and Laboratory

Transfusion Medicine Service. “These ma-

chines have had a tremendous impact on

patient care at Methodist.”

“I thank Mr. and Mrs. Foster for their

extraordinarily kind gift and their leader-

ship in helping us to expand patient

Medicine seminar on advances in lung

cancer (April 29th).

For more information on the HSCP,

please visit houstonpathologists.org.

From left, Dr. James Musser, Mr. John Hagale, Mrs. Harriet Foster, Mr. Joe Foster, and Dr. Christopher Leveque.

The

LABORATORY REPORT

T he Methodist Hospital Auxiliary

and Gift Shop has purchased a

new van for the Blood Donor

Center to be used for mobile blood

drives. The very generous gift will allow

the Center to perform larger blood drives

in the community and, therefore, provide

more blood and blood components for

patient care at the hospital.

“The van will allow us to transport

more staff and equipment to and from

the blood drives in community locations

all over Houston,” said Dr. Christopher

Leveque, medical director of the Blood

Bank and Transfusion Medicine at Meth-

odist. “We are so grateful to Ms. Sophie

Mize and the auxiliary staff at the Gift

Shop for their generosity.”

The Supreme StarTrans Senator Series II

van was purchased in May and is cur-

rently being retrofitted with an electric

4

Hospital Auxiliary Donates New Blood Drive Van lift and special railing system to secure

equipment. The van is expected to be in

operation for the Center by the end of

August.

Steeped in a long history of service

excellence, The Methodist Hospital

Auxiliary and the Methodist Hospital

Service Corps provide many unique

volunteer opportunities. The Auxiliary

assists the hospital in raising funds to

purchase new medical equipment

through the Gift Shop, Thrift Shop,

and vendor sales. Members of the

Service Corps support patients, fami-

lies, and visitors in a variety of important

service areas including the information

desks, surgical waiting rooms, doctors’

coffee bar, and book cart.

For more information on the Methodist

Blood Donor Center, please visit method-

istbloodcenter.com.

The Supreme StarTrans Senator Series II van was pur-chased in May and is currently being retrofitted with an

electric lift and special railing system to secure equip-

ment.

New Diagnostic Test Offerings:

Freelite™ Serum Free Light Chain Assay

The FreeLite assay from The Binding

Site, Ltd. is used for the screening and

monitoring of multiple myeloma and

other B-cell proliferative disorders. It is a

light-based assay that quantifies free

kappa and lambda immunoglobulin light

chains in serum.

The measurement of light chain concen-

tration in serum has recently been recom-

mended by the International Multiple

Myeloma Working Group for the diagno-

sis, prognosis, and monitoring of patients

with multiple myeloma and certain other

B-cell proliferative disorders, and by the

National Comprehensive Cancer Net-

work Clinical Practice Guidelines for the

initial diagnosis of multiple myeloma.

This test, which was previously per-

formed at our reference lab, was brought

in-house in May. It will provide Method-

ist physicians faster access to laboratory

results and allow more timely decisions

to be made regarding patient treatment.

For more information on the assay at

TMHS, please contact Dr. Ping Wang at

713-441-3294 or pwang@tmhs.org. For

more information on serum free light

chain assays developed by The Binding

Site, please visit bindingsite.co.uk/.

H&E section of lymphoma.

InVivoScribe Gene Clonality Assay

In April, The Methodist Hospital Sys-

tem implemented a new immunoglobulin

gene rearrangement assay from InVivo-

Scribe Technologies, Inc. called the Gene

Clonality Assay. The assay uses a PCR-

based amplification strategy to detect

gene rearrangements in both IgH and IgK

that account for 99% of all B-cell malig-

nancies. Because of the improved sensi-

tivity and specificity of the BIOMED-2

primers, this test has a much lower false-

negative rate compared to previous mo-

lecular tests. Validation of a similar up-

grade to the T-cell clonality assay is cur-

rently underway.

For more information on the assay at

TMHS, please contact Dr. Randall Olsen

at 713-441-6802 or rjolsen@tmhs.org. For

more information on molecular diagnos-

tics assays developed by InVivoScribe

Technologies, please visit invivo-

scribe.com .

For more information on The Method-

ist Hospital Auxiliary, please visit meth-

odisthealth.com/auxiliary.

The

LABORATORY REPORT

5

representing our program on a state-

wide level with such acclaim.” The Meth-

odist MLS Program is a twelve-month

Methodist Laboratory Science Students Win TACLS Bowl Competition

T he team of four students cur-

rently enrolled in The Meth-

odist Hospital Medical Labo-

ratory Science (MLS) Program won

first place at the Texas Association

for Clinical Laboratory Science

(TACLS) Student Bowl competition

on April 7th as part of the Sounds of

Science TACLS Annual Meeting in

Austin, Texas. A Methodist team has

won the competition 11 times in the

past 23 years.

“It’s a fun competition and a great

way to prepare for the certification

exam,” said Tatia Feltman, program di-

rector for the Methodist MLS Program.

“We are so proud of our students for

their accomplishment and for

professional course of study that is

fully accredited by the National Ac-

crediting Agency for Clinical Labo-

ratory Sciences (NAACLS). Upon

successful completion of the pro-

gram, students will qualify for the

examination and certification by the

Board of Certification of the Ameri-

can Society of Clinical Pathology

(ASCP). Many of the graduates of

the program go on to work at Meth-

odist in one of our many

pathology laboratories. The Method-

ist MLS Program has been in exis-

tence since 1947.

For more information on the Methodist

MLS Program, please visit method-

isthealth.com/mlsprogram.

Methodist MLS students from left, Cindy Ly, Kendra Orth,

Andre’lyn Williams, and Zoya Khan.

Trainee Spotlight: Kyle Eskue, M.D.

Surgical Pathology Fellow

D r. Kyle Eskue was the recipient of the fourth Department of Pa-

thology and Laboratory Medicine Trainee Leadership and Inno-

vation Award. He received this award for his overall initiative,

leadership, and commitment to excellence in patient care.

Dr. Eskue was recently invited to chair the College of American Patholo-

gists (CAP) NewsPath Editorial Board. NewsPath is an educational re-

source for pathologists in training and practice. Dr. Eskue has been very

active with CAP for many years. He is currently a junior member of the

CAP Member and Public Communications Committee, the CAP Spokes-

persons Network, and the CAP Advocacy Network. He has previously

held several leadership positions in the CAP Residents Forum.

Dr. Eskue received his M.D. degree from The University of Texas Medical

Branch (UTMB) in Galveston, Texas in 2006. He completed his AP/CP resi-

dency at UTMB in 2010, and then completed a fellowship in surgical pa-

thology at Methodist in June of this year.

Dr. Eskue in the histology laboratory.

The

LABORATORY REPORT

Department Acquires Transmission

Electron Microscope

Digital Pathology at Methodist

Laboratory Outreach Program Expands

6

T he Department welcomed 6 new

residents and 8 new fellows on

July 1st during a half-day trainee

orientation session led by Dr. Suzanne

Powell, vice-chair of education for the

Department. The session followed a four-

day orientation provided by the hospi-

tal’s GME office. Dr. Powell and the edu-

cation manager and coordinators greeted

the incoming trainees and apprised them

of the various support services in the

Department, including Graphics Services

and the Office of Academic Development.

The Department will also welcome its

first Clinical Chemistry Fellow on August

1st.

“We have a large department that ser-

vices a multi-site hospital system, and we

want to make sure our new residents and

fellows transition into their new roles

quickly and relatively seamlessly,” said

Dr. Powell. “We are preparing the next

generation of practicing pathologists and

want to ensure they have an outstanding

training experience.”

The Department currently has 37 exist-

ing trainees, with 19 of them completing

their residency or fellowship program

and graduated as of June 30th. With the

addition of the 22 new trainees, the De-

partment will have a total of 41 residents

and fellows for the academic year 2011-

12. The Department of Pathology and

Laboratory Medicine has a residency

program, a resident research program,

and 11 fellowship programs – the most

training programs of any department at

Methodist.

Yu Helen Zhang, M.D.

AP/CP Residency – Temple University

Hospital

Jose Gonzalez-Berjon, M.D.

AP/CP Residency – The Methodist Hospital

Molecular Genetic Pathology

Amanda Peterson, M.D.

Surgical Pathology Fellowship

– The Methodist Hospital

Neuropathology

Adriana Olar, M.D.

AP Residency – Baylor College of Medicine

Jennifer Ross, M.D.

Forensic Pathology Fellowship

– Harris County Institute of Forensic Sciences

Surgical Pathology

Natalia Golardi, M.D.

AP/CP Residency – The University of Texas

Medical Branch

Susan Haley, M.D.

AP/CP Residency – The University of Texas

Medical Branch

Ekene Uzoigwe Okoye, M.D.

AP/CP Residency – The University of Texas

Medical School, Houston

Annisa Lewis, M.D.

AP/CP Residency – The Methodist Hospital

Byron Moore, M.D.

Blood Bank/Transfusion Medicine Fellowship

– The Methodist Hospital

For more information on training

programs in the Department, please visit

methodisthealth.com/pathologytraining.

Incoming Trainees

PGY1 Residents

Eunice Choi, M.D.

Indiana University School of Medicine

Suzanne M. Crumley, M.D.

The University of Iowa Carver College of

Medicine

Rachel Donohue, M.D.

University of New Mexico School of Medicine

Jaclyn L. Jerz, M.D.

The University of Texas Southwestern Medical

School

Nathan E. Lee, M.D.

The University of Texas Medical Branch

Haijun (Steve) Zhou, M.D., Ph.D.

Tongji Medical University/Peking Union

Medical University

Fellows

Blood Bank/Transfusion Medicine

Jian Chen, M.D., Ph.D.

CP Residency – The Methodist Hospital

Clinical Chemistry

Irene Shu, Ph.D.

University of Washington

Cytopathology

Kelly Khan, M.D.

Surgical Pathology Fellowship

– The Methodist Hospital

Aaron Harvey, M.D.

AP/CP Residency – The Methodist Hospital

Adria Hartman, M.D.

AP/CP Residency – University of Kentucky

Hematopathology

Mark Podberezin, M.D.

AP/CP Residency – University of Illinois at

Chicago

New Trainees Start on July 1st

In Our Next Issue…

First Trainee in Resident Research

Program

New Clinical Chemistry Fellowship

… and more!

The

LABORATORY REPORT

7

W ith funding from the

National Institutes of

Health and other

sources, Dr. Youli Zu is develop-

ing novel diagnostic and thera-

peutic methods specific for lym-

phomas. His research laboratory

was the first to demonstrate the

use of oligonucleotide aptamer

probes for both in vitro diagnosis

and in vivo imaging of lymphoma

tumors.

Dr. Zu is the principal investi-

gator on a five-year grant from

the National Cancer Institute

(NCI) that is validating a new

bifunctional nanomedicine to selectively

target anaplastic large cell lymphoma

(ALCL) tumors for in vivo imaging and

specifically silence the lymphoma onco-

gene to induce tumor cell death. In addi-

tion, Dr. Zu is co-principal investigator

(with Dr. Xiaobo Zhou, also at Methodist)

tissue core of an NCI-funded

lymphoma SPORE program.

Dr. Jianguo Wen, an instructor

in Dr. Zu’s TMHRI laboratory,

also has funding from NCI. His

2-year grant aims to use cyto-

toxic T-cells to develop an effec-

tive immunotherapy that targets

myeloma stem cells. Dr. Wen

joined the laboratory in 2005 as a

postdoctoral fellow under the

mentorship of then laboratory

director, Dr. Chung-Che “Jeff”

Chang.

Dr. Zu serves as the co-director

of hematopathology for The

Methodist Hospital.

For more information about Dr. Zu,

please visit methodisthealth.com/Zu.

on a grant from the National Library of

Medicine that aims to develop a systems

biology software package capable of

identifying signal pathways and pathway

signatures in myelodysplastic syndromes

and other diseases with complex pheno-

types. Dr. Zu also leads the pathology

Dr. Zu at TMHRI.

Dr. Zu Leads Hematopathology Research Effort for Department

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RECENT PUBLICATIONS continued

Lassman AB, Iwamoto FM, Cloughesy TF, Aldape KD, Rivera AL, Eichler AF, Louis DN, Paleologos NA, Fisher BJ, Ashby LS, Ciarn-

cross JG, Roldan GB, Wen PY, Ligon KL, Schiff D, Robins HI, Rocque BG, Chamberlain MC, Mason WP, Weaver SA, Green RM,

Kamar FG, Abrey LE, Deangelis LM, Jhanwar SC, Rosenblum MK, Panageas KS. International retrospective study of over 1000 adults

with anaplastic oligodendroglial tumors. Neuro Oncol. 2011 Jun;13(6):649-59.

Lee EY, Ro JY. The 9th Spring Seminar of the Korean Pathologists Association of North America. Arch Pathol Lab Med. 2011 Jun;135

(6):696-7.

Lewis AL, Truong LD, Zhai QJ. Benign Salivary Gland Tissue Inclusion in a Pulmonary Hilar Lymph Node in a Patient with Invasive

Well-Differentiated Adenocarcinoma of the Lung. International Journal of Surgical Pathology. 2011 Jun;19(3):382-5.

Massilamany C, Gangaplara A, Gardner DJ, Musser JM, Steffen D, Somerville GA, Reddy J. TCA cycle inactivation in Staphylococcus

aureus alters nitric oxide production in RAW 264.7 cells. Mol Cell Biochem. 2011 Apr 26. [Epub ahead of print]

Continued page 9

The

LABORATORY REPORT

Ping Wang, Ph.D. Claudia P. Molina, M.D.

Seema Mullick, M.D.

Thu Ngo, M.D.

Steven Shen, M.D., Ph.D.

Paul Sumby, Ph.D.

The Laboratory Report is a publication

of The Methodist Hospital System

Department of Pathology and Labo-

ratory Medicine.

Musser JM.Third-track pathology: in unambiguous support of the Banbury conference report. Arch Pathol Lab Med. 2011 Jun;135

(6):687-8.

Nese N, Martignoni G, Fletcher CD, Gupta R, Pan CC, Kim H, Ro JY, Hwang IS, Sato K, Bonetti F, Pea M, Amin MB, Hes O, Svec A,

Kida M, Vankalakunti M, Berel D, Rogatko A, Gown AM, Amin MB. Pure epithelioid PEComas (so-called epithelioid angiomyoli-

poma) of the kidney: A clinicopathologic study of 41 cases: detailed assessment of morphology and risk stratification. Am J Surg

Pathol. 2011;35:161-76.

Olsen RJ, Watkins ME, Cantu CC, Beres SB, Musser JM. Virulence of serotype M3 Group A Streptococcus strains in wax worms

(Galleria mellonella larvae). Virulence. 2011 Mar-Apr;2(2):111-9.

Paner GP, McKenney JK, Barkan GA, Yao JL, Frankel WL, Sebo TJ, Shen SS, Jimenez RE. Immunohistochemical Analysis in a Mor-

phologic Spectrum of Urachal Epithelial Neoplasms: Diagnostic Implications and Pitfalls. Am J Surg Pathol. 2011 Jun;35(6):787-798.

Plata KB, Rosato RR, Rosato AE. Fate of Mutation Rate Depends on agr Locus Expression during Oxacillin-Mediated Heterogeneous-

Homogeneous Selection in Methicillin-Resistant Staphylococcus aureus Clinical Strains. Antimicrob Agents Chemother. 2011 Jul;55

(7):3176-86.

Powers MP, Alvarez K, Kim HJ, Monzon FA. Molecular Classification of Adult Renal Epithelial Neoplasms Using MicroRNA Expres-

sion and Virtual Karyotyping. Diagn Mol Pathol. 2011 Jun;20(2):63-70.

Ren X, Zhou X, Chang CC.The network properties of myelodysplastic syndromes pathogenesis revealed by an integrative systems

biological method. Mol Biosyst. 2011 Jun;7(6):2048-54.

Saloman JL, Niu KY, Ro JY. Activation of peripheral delta-opioid receptors leads to anti-hyperalgesic responses in the masseter mus-

cle of male and female rats. Neuroscience. 2011 Jun 6. [Epub ahead of print]

Schaaf CP, Blazo M, Lewis RA, Tonini RE, Takei H, Wang J, Wong LJ, Scaglia F. Early-onset severe neuromuscular phenotype associ-

ated with compound heterozygosity for OPA1 mutations. Mol Genet Metab. 2011 May 7. [Epub ahead of print]

Shelburne III SA, Sahasrobhajane P, Suber B, Keith DB, Davenport MT, Horstmann N, Kumaraswami M, Olsen RJ, Brennan RG,

Musser JM. Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein. Mol Microbiol.

2011 Jun 5. [Epub ahead of print]

Sitkiewicz I, Green NM, Guo N, Mereghetti L, Musser JM. Lateral gene transfer of streptococcal ICE element RD2 (region of differ-

ence 2) encoding secreted proteins. BMC Microbiol. 2011 Apr 1;11:65.

Song C, Kang T, Yoo S, Jeong IG, Ro JY, Hong JH, Kim CS, Ahn H. Tumor volume, surgical margin, and the risk of biochemical recur-

rence in men with organ-confined prostate cancer. Urol Oncol. 2011 Jun 28. [Epub ahead of print]

Wang EH, Truong LD, Mendoza L, Jung ES, Choi YJ. 28S-ribosomal RNA is superior to glyceraldehyde-3-phosphate dehydrogenase

as a RNA reference gene in p53-deficient mice with unilateral ureteral obstruction. Exp Mol Pathol. 2011 May 2;91(1):368-372.

Wang P, Hudspeth E. Increased body mass index but not common vitamin D receptor, PPARg and cytokine polymorphisms confer

predisposition to post-transplant diabetes. Arch Pathol Lab Med. In Press.

You D, Shim M, Jeong IG, Song C, Kim JK, Ro JY, Hong JH, Ahn H, Kim CS. Multilocular cystic renal cell carcinoma: clinicopathologi-

cal features and preoperative prediction using multiphase computed tomography. BJU Int. 2011 Jul 1. [Epub ahead of print]

Xia Z, Wen J, Chang CC, Zhou X. NSMAP: A method for spliced isoforms identification and quantification from RNA-Seq. BMC Bio-

informatics. 2011 May 16;12:162.

RECENT PUBLICATIONS continued

9

Editor-in-Chief

April A. Ewton, M.D.

The Laboratory Report

Editorial Committee

Hazel L. Awalt, M.D.

Christopher Leveque, M.D.

The Methodist Hospital

Clare Rose, M.B.A.

Manuel Hinojosa, M.H.A.

Editorial Coordinator

Philip Randall