THE INTERNATIONAL FEDERATION OF SOCIETIES FOR HISTOCHEMISTRY AND CYTOCHEMISTRYANNOUNCES THE

9th International Congressof Histochemistry and Cytochemistry

MAASTRICHT, THE NETHERLANDS

August 30-September 5, 1992

Plenary Lecture topics:In situ hybridization; Intravital microscopy; Cytochemistry at the EM level; Enzyme histochemistry;

Immunocytochemistry; Intracellular transport; Nerve-immune system interactions; Peroxisomes.

Symposia will highlight the impact of histo- and cytochemistry in the areas of:Developmental biology and ageing; Cell growth and differentiation; Neurosciences; Plant Cell Biology;

Diagnostic Pathology; Toxicology; Receptors and Ligands; Intracellular calcium.

Workshops will focus on new trends in:Tissue processing techniques; Flow and image cytometry; Morphometry; Autoradiography;

Confocal microscopy.

Organizing Secretariat:Prof. Dr. F. C. S. Ramaekers, Department of Molecular Cell Biology; University of Limburg; P.O. Box 616;

6200 MD MAASTRICHT, The Netherlands; Tel. 31-43-888642; Fax. 31-43-437640.

21ST ANNUAL MEETING OF THE INTERNATIONAL SOCIETY FOR EXPERIMENTALHEMATOLOGY

PROVIDENCE, RHODE ISLANDJULY 26-30, 1992

An international conference with Plenary, Poster and Simultaneous sessionsexclusively devoted to hematopoietic stem cells, growth factors and experimentalbone marrow transplantation. CME Credits will be available. A commercialexhibition related to hematology and cancer research will be included.

CHAIRPERSONS:A. Anagnostou and M. Miller

ORGANIZING COMMITTEE:A. Anagnostou, M. Miller, E. Cronkite, E. Mazur, N. Dainiak, H. Khan

SCIENTIFIC COMMITTEE:A. Nicnhuis, C. Eaves, H. Broxmeyer, K. Dicke, R. McCaffrey,P. Quesenberry, D. Zipori, T.M. Dexter, J. Adamson, R. Storb

LOCAL SPONSORING INSTITUTIONS:Memorial Hospital of Rhode Island and Brown University

Deadline for submission of abstracts is February 20. 1991. Abstract forms will bemailed to the Society members in December and be available to others through theorganizing Secretariat.

All inquiries should be made to the Organizing Secretariat. ISEH-92. PO Box 6887.Providence. Rhode Island. Q2940. Attn: Janet Balletto. Meeting Coordinator. Fax No.f40n455-4004. Telephone No. (401)455-4139.

MOLECULAR GENETICS OF DEVELOPMENT

Sponsored by the National Institute for Child Health and Human Development

Organized by Igor Dawid, Arthur Levine and Heiner Westphal

Airlie Conference Center, Airlie, Virginia

May 13 to 16, 1992

Speakers:

David Anderson Milan Jamrich Ariel Ruiz i AltabaMartin Chalfie Jim Kennison Gary RuvkunNam Chua Andrew Lumsden Tom SargentIgor Dawid Kathleen Mahon Jim SmithEddy De Robertis Elliot Meyerowitz Monte WesterfieldGregg Dressier Juan Modolell Heiner WestphalDenis Duboule Keiko Ozato Robert WhitePeter Gruss Luis Parada Alan WolffeRudolf Jaenisch Paul Patterson Carl Wu

A POSTER SESSION will be held. If you wish to participate, please contact Igor B.Dawid, NIH, NICHD, LMG, Bldg. 6, Room 408,9000 Rockville Pike, Bethesda, MD 20892,Phone (301) 496-4448; FAX (301) 496-0243.

There is no registration fee, but participants must make their own confirmed roomreservations with the Airlie Conference Center before February 13,1992. For details onrooms reservation and other administrative matters contact Kathy Shoobridge at the NIHaddress.

SEVENTH CONGRESS OF THE INTERNATIONAL SOCIETY FOR DIFFERENTIATION

"CELLULAR PROGRAMMES FOR GROWTH,DIFFERENTIATION AND NEOPLASIA"

Helsinki, Finland 19-23 July 1992

SCIENTIFIC PROGRAMME

LECTURES

T.M. Dexter, Manchester, UKIsaiah J. Fidler. Houston, USAPeter Gruss, Goettlngen, GermanyAndrew Lumsden, London Bridge, UK

Lauri Saxen, Helsinki, FinlandKai Simons, Heidelberg, GermanyMasatoshi Takeichi, Kyoto, Japan

SYMPOSIA consist of main lectures, as listed below, and communications selected from the posters.

Growth Factors and MorphogensBrigid L.M. Hogan, Nashville, USAAndrew P. McMahon, Nutley, USAGregor Eichele, Houston, USA

Cell AdhesionErkkl Ruoslahti, La Jolla, USAMarkku Jalkanen, Turku, FinlandRoger Keynes, Cambridge, England

Cellular Programming of ApoptosisJ. John Cohen, Denver, USAIan CM. MacLennan, Birmingham, UKDavid J. McConkey, Stockholm, Sweden

Embryonic InductionJohn B. Gurdon, Cambridge, EnglandDouglas A. Melton, Cambridge. USAJames C. Smith, London, England

Tumour Cell Heterogeneity and DifferentiationWerner W. Franke, Heidelberg, GermanyGeorge Poste, King of Prussia, USAIsmo Virtanen, Helsinki, Finland

Growth Factors and Cancer GenesRobert N. Eisenman, Seattle. USAJoan Massague New York, USAKari Alltalo, Helsinki, Finland

Cell Lineages in Early Vertebrate EmbryosCharles Kimmel, Eugene, USAClaudio D. Stem, Oxford, EnglandRosa Beddington, Edinburgh, Scotland

POSTER SESSIONS

The call for abstracts will appear in theSecond Circular, due in December 1991.

Pericellular ProteolysisJean-Dominique Vassalli, Geneva, SwitzerlandDenis Monard, Basle, SwitzerlandTor Ny, Umea, Sweden

Signal TransductionAmnon Altaian, La Jolla, USAFrank McCormick, Emeryville, USASara A. Courtneidge, Heidelberg. Germany

Differentiation and Pattern Formation in Higher PlantsEnrico Coen, Norwich, UKElliot Meyerowitz, Pasadena, CA, USAZsuzsanna Schwartz-Sommer, Cologne, Germany

Transcription Factors and Gene ExpressionPeter Herrlich, Karlsruhe, GermanyDavid J. Mangelsdorf, San Diego, USAEdward B. Ziff, New York, USA

Neuronal Growth and DifferentiationHans Thoenen, Martinsried, GermanyNicole Le Douarin, Nogent-sur-Mame, FranceH. Robert Horvitz. Cambridge. USA

Tumour Suppressor GenesEric J. Stanbridge, Irvine, USANicholas Hastle, Edinburgh, ScotlandEdward Harlow, Charlestown, USA

Application of Differentiation as a Cancer TreatmentSamuel Waxman, New York, USALaurent Degos, Paris. FranceReuben Lotan, Houston, USA

For information, please contact:

ISD-92/Ms. Terttu SeppanenAREA Travel Agency LtdP O Box 227SF-00131 HELSINKI. FinlandTel: Int + 358 0 185 5382Fax: Int + 358 0 654 987

t \Peter Hausen

Metta Riebeselly

Development ofXenopus LaevisAn Atlas of the Histology,

Verlag der Zeitschriftfur Naturforschung N ^r

1991. Approx. 160 pp. 42 figs. Hardcover DM 198,- ISBN 3-540-53740-6

Xenopus laevis is the key model for developmental, differential and embryological studies in vertebrates.Using molecular biological techniques it has become possible within the last few years to analyze developmentalprocesses up to the level of genes. On obtaining results it is necessary to correlate them with morphological andhistological stages. This excellent work documents and describes such developmental stages in finite detail.

After an informative introduction to The Early Development of Xenopuslaevis follows the highlight of the book, namely the 42 plates, each consistingof at least four high resolution micrographs. The reader is thus provided witha histological presentation of immaculate quality. Each plate is comple-mented by a schematic diagram describing the details shown on the plate, anadditional scheme indicating the section and an explanatory short text,making this a potentially highly sought after work.

Jointly published by Springer-Verlag Berlin Heidelberg New York London Paris TokyoHong Kong Barcelona and Verlag Zeitschrift fur Naturforschung, Tubingen

D Heidclberger PUu 3. W-KWO Btriln 33, F R Gemuny D 175 Fifth Avt, New Vort, NY 10010, USA D 8 AJtundri Rd, London SW19 7JZ, England• 26, rue des Cirmcs, F-75005 Paris, France D 37-3, Hongo 3-chomc. Bnnkyo-fcu. Tokyo 113, Japan• Room 701. Mirror Tower, 61 Mody Road, TjimshatiuL Kowkxm. Hong Konj D Avinguda Diagonal, 468-4°C, E-08006 Barcelona, Spain

er-Verlag

lm.30.166/V71

BRITISH SOCIETY FOR DEVELOPMENTAL BIOLOGY& BRITISH SOCIETY FOR CELL BIOLOGY

SPRING MEETINGUNIVERSITY OF SUSSEX 7TH-10TH APRIL 1992

GAST-RLLATION SYMPOSIUM ^Wotpert (London). Ettensotm ^Pittsburgh), Jeffrev (Bodega Ba\ >,

Trinkhaus <Yale>, Keller (Berkeley), Bortier (Ghent). Vakaet (Ghent),Beddington (Edinburgh), Lawson (Utrecht), Rutishauser (Case

/Western), McClay {North Carolina), Wylie (Cambridge), Waelsch (New, York), Leptin (Tubingen), Fleming (Southampton), Brown (London),

. ' Warner (Londonj, Slack (Oxford), Smith (London), Stern (Oxford),Gurdon (Cambridge), Bate (Cambridge), Raff (BIoomington>. Ho

(Oregon), Thisse (Strasbourg), Doniach (Berkeley), Durston (Utrecht),Dodd (New York) " .

TRANSCRIPITON FACTORS SYMPOSIUMBaltimore (New York), Roeder, (New York), Bird (Edinburgh),

Busseiinger (Vienna). Engel (Evanston), Fel5enfeld (Bethesda), Graf(Heidelberg), Gruss (Gottingen), Jackie (Gottingen), Krause (Seattle),Levine (San Diego), Lohnes (StrasbourgU Mohun (London), IVasmyth(Vienna)^ Scftaffner (Zurich). Schibler (Geneva), Sthutz (Heidelberg),

R.White (Cambridge)

NEMATODE DEVELOPMENT: Sulston (Cambridge), .1. Thierry-Mieg(Montpelier). La Volpt; (Naples), PJasterk (Amsterdam), Schierenberg

/(Cologne), Hope (Leeds), J.White (Cambridge), Schnabel (Tubingen),% Hodgkin (Cambridge), D. Thierry-Mieg (Montpelier)

A C T I N BINDING P R O T E I N S : Condeelis (New York), Matsudaira^- '(Boston),\\eeds (Cambridge), Pollard (Baltimore). Hall (London^

— „__ Schi.feicher (Martinsreid)

DEVELOPXENr: Schartl (Freibourg), Vielkind (Vancouver),Timmermans (Wageningen), Kimmei (Oregon), Schulte (Tubingen),

Fjose (Bergen), Jowett (Newcastle). Wilson (London), Macleanf/- (Southampwn,) \

KIN VSES A fD PHO^PHORYLASES: Waterfield (London), Courtneidge(Heidelberg^ Parker (London), Cobb (Dallas), Woodgett (London),

Tonks <New York), Henimings (Basel), Cohen (Dundee)

SIGNAL TRANSDLCnoN: Gallione (Oxford), Otte (Utrecht). Green(London), Runyan (Iowa). Muller (Heidelberg), Livingstone (Berkeley)

'VTUMOUR PROMOTERS: Hastie (Edinburgh), Wyllie (Edinburgh), Barrett(Bethesda), Dutritiaux (Paris)

FOR FLRTHER INFOKMA TION CONTACT:Dr. Robert WWttle or Dr. Sandy MacGillhray,

School of Biological Sciences,'" Biology Building, University of Sussex.Falnwr,Brighton BN1 9Q

l% 0Z73 678433

•••••<:•

1992 Keystone Symposia on Molecular & Cellular Biology

Intermediate Biomarkers of Precancw and their

Application In Chemoprevention

Organizers: Martin Lpkh Bernard Lem Ycwg S. Kim and

GaryJKeSoff

October 3-7 .1991, Keystone, Colorado

biftammation, Growth Regulatory Molecules and

Atherosclerosis

Organizers: RusseS Ross and Michael A GimbroneJanuary 13-19,1992, Keystone, ColoradoSponsored by Du Pont Merck Pharmaceutical Co.

and The Upjohn Co.

The Molecular Biology of the Endothelial Cell

Organizers- Laurence A Lasky and Thomas MadagJanuary 13-19,1992, Keystone, ColoradoSponsored by Genentech and Hoffmann- La Roche

* Transcription Regulation In Development,

Differentiation and Disease

Organizers: GeraidR. Crabiree and Matthew P. ScottJanuary 13-20,1992; Tamarron, Colorado

Molecular and Cellular Biology of Host-Parasite

Interactions

Organizers- Nina M. Agaban and Harvey BsenJanuary 15-20,1992, Park City, UtahSponsored by The MacArthw Foundation

Bone Marrow Transplantation

Organizers: Robert Peter Gale and Richard E ChampUnJanuary 19-26,1992; Keystone. ColoradoExclusively Sponsored by Sandoz Pharmaceuticals

Molecular Mechanisms bi DNA Replication &

Recombination

Organizers: Hamscn Echois and Anna Maria SkalkaJanuary 25 - February 1,1992; Taos, New MexicoExclusively Sponsored by U.S. Biochemical Corp.

Negative Growth Control

Organizers: Harold L Moses and Man BalmainJanuary 26 - February 2,1992; Keystone, ColoradoSponsored by Specialty Laboratories, tnc.

* Positive Growth Control

Organizers: Charles J. Sherr, Tony Hunter and Thomas CunanJanuary 26 - February 2,1992; Keystone, Colorado

Nutrition & Central Nervous System Function

Organizers: G. Harvey Anderson John D. Femstrom,Maureen Mackey, GregoryD MM, Barbara J. RolsandThomas A VoSmuthFebruary 2-6,1992; Lake Tahoe, CaliforniaExclusively Sponsored by International Ufe Sciences

Institute-Nutrition foundation

Cytokmes In Growth, Development and Pamogenesb

Organizers: Charles H Evans and Stanley CohenFebruary 1 -8.1992; Taos, New MexicoSponsored by bnmunax and SmithKJIne Beecham

Pharmaceuticals

* Melanoma and Biology of the Neural CrestOrganizers: Michael T Lotze, Margaret A Tucker andMark A IsraelFebruary 1-8,1992; Taos, New Mexico

* Steroid/Thyroid Receptor Gene Super FamOy

Organizers: John A Cidowsk Bed W O'MaleyandHerbert H SamuelsFebruary 21 -27,1992; Tamarron, Colorado

Hematopoiesis

Organizers: David W. GcJde and Charles J. SherrFebruary 27 • March 5,1992; Tamarron, ColoradoSponsored byAmgen, bnmunex and

R. W. Johnson Research Institute

Cell Biology of Virus Entry, Replication and

Pathogenesls

Organizers' Michael BA Oidstone, AnHeterwsandRichard W. CompareFebruary 28 • March 5,1992; Taos, New MexicoSponsored by SmithKBne Beecham Pharmaceuticals

* Recognition of Endotoxin in Biologic Systems

Organizers. Richard J. Uevttch and Peter S TobiasMarch 1 -7,1992; Lake Tahoe, California

Antigen Presentation Functions of the MHC

Organizers Michael J Sevan and Pad M. AlenMarch 5-11,1992; Taos, New MexicoSponsored by Hoffmann-La Roche and

Kt Pharmaceuticals Group

Breast and Prostate Cancer

Organizers. MarcE Lippman and Robert B DicksonMarch 7-13,1992; Lake Tahoe, CaliforniaSponsored by Du Pont Merck Pharmaceutical Co.,

Genentech and Specialty Laboratories, Inc.

* Metal Ion/Molecular Biology Interface

Organizers. Vincent L Pecoraro, Stephen J LippardandMichaelKamMarch 13-19,1992; Lake Tahoe. California

* GfycotalologyOrganizers: JosephK Welply and Gerald W. HartMarch 21 -27,1992; Park City, Utah

Prevention and Treatment of AIDS

Organizer DaniP BobgnesiMarch 27 - April 3,1992, Keystone. ColoradoSponsored by SmittiKllne Beecham Pharmaceuticals

and The Upjohn Co.

Critical Research Directions in Pediatric HIV Infection

Organzers: E Rxhard SSehrn Arthur Ammam and PhMp PizzoMarch 27-31.1992; Fnsco, ColoradoExclusively Sponsored by The Pediatrics AIDS

Foundation

* Fundamental Mechanisms of Transcription

Organzers: Joan and Ron Coreway, Michael Dahmus andRobertScrMMarch 28 - Apri 3,1992, Copper Mountain, Colorado

Advances in Understanding Neurodegenerattve

Disorders

Organzers Denis 0 Cunnngham and Donald L PriceMarch 28 - Apri 4.1992; Btg Sky. MontanaSponsored byAmgen, tnc and Du Pont Merck

Pharmaceutical Co.

Synapse Formation and Function: The Nauromus-

cular Junction and the Central Nervous System

Organizers: Stanley C Froehner and Jm PatrickMarch 28 - Apri 4,1992, Btg Sky, MontanaSponsored by Lilly Research Laboratories

Molecular Biology of Human Genetic Disease

Organizers: Maimon M Cohen, Beverly S. EmanueiDavid H. Ledbetter and Arthur L BeaudetApri 3-10,1992, Copper Mountan, CotoradoSponsored by Du Pont Merck Pharmaceutical Co.

* Gene Transfer, Replacement and Augmentation

Organizers. hderM Verma, FredH GageandRichard C. MulliganApril 3-9,1992, Copper Mountain, Colorado

* Growth and Differentiation Factors bi Vertebrate

Development

Organizers: Ftik Derynck and Zena WerbApril 3-10,1992, Keystone, Colorado

Tissue Engineering

Organizer: Eugene BelApril 3-10,1992, Keystone, ColoradoSponsored by Genentech and Director's Sponsor's

brtegrins: Cell Adhesion and Transmenibrane

Communication In Development and Disease

Organzers: Robert Pytete and Wo QuarantaApri 3-10,1992, Keystone, ColoradoSponsored by Genentech, Kl Pharmaceuticals Group,

R.W.Johnson Pharmaceutical Research Institute and

SmlthKllne Beecham Pharmaceuticals

* Crop Improvement via Biotechnology:

An International Perspective

Organzers: Robert Fraley, Marc Van Montagu,James Peacock and Charles AmtzenApri 10-16,1992; Keystone, Colorado

I I Registration in any meeting in an outlined groupqualifies for attendance in any meeting inthat group

* Keystone Symposia 1992 Director's Sponsor'sMonsanto Co.

Schering Corp.Warner-Lambert Co.

FOR COMPLETE PROGRAMS AND APPLICATIONINFORMATION, PLEASE CONTACT:

Keystone SymposiaDrawer 1630

Silverthorne, CO 80498 USA

Phone: (303)262-1230Fax: (303)262-1525

Journals in the Biomedical Sciences 1992

Welopmp n f DevelopmentISSN: 0950-1991Editors: Chris Wylie (Editor in Chief), Richard Gardner, Walter Gehring, Tom Jessell, PeterLawrence, Doug Melton, Keidi Roberts and Gerry Rubin

Development is now the world's leading developmental journal, offering a speed and quality ofproduction second to none, free use of colour, 200 free reprints of every article published, and nopage charges. It is now an essential reference source for scientists, students, and teachers ofdevelopment courses. The aim of Development is to act as a forum for all research that offers agenuine insight into mechanisms of plant and animal development.

Institutional price: $1005 £585

Journal ofCell Science

Journal of Cell ScienceISSN: 0021-9533Editors: Fiona Watt, A. V. Grimstone, Henry Harris, Robert Johnson, Daniel Louvard,Gary Borisy (USA)

The journal of CeU Science has a wide international readership amongst researchers in Cell Biologyand related fields. Papers published in the journal cover die full range of topics in contemporarycell biology. Each issue has a popular commentary section containing short reviews.

journal of CeU Science offers rapid publication - eight to thirteen weeks from acceptance topublication - and uses die highest quality reproduction for figures and half-tones. There are nopage charges and colour plates can be published free of charge. These advantages ensure diat top-quality articles in cell biology, medicine and molecular biology are published in die journal.

Institutional price: $915 £525

The Journal of Experimental BiologyISSN: 0022-0949Editors: C. P. Ellington, with R. G. Boutilier, W. A. Foster and E. A. Howes

The journal ofExperimental Biology is die leading journal in comparative animal physiology. Publicationin this high quality, prestigious journal gives papers a wide circulation amongst active scientists in allbiological sciences. The journal plays a major role in increasing the cross-fertilisation of techniques andknowledge across specialisation boundaries.

The journal's popularity has resulted in a vast increase in die number of papers being submitted forpublication. In order to increase die opportunities for rapid publication, The journal of ExperimentalBiology will be published monthly in 1992. This will increase the speed of publication, ensuring thatdie journal keeps its readers up-to-date not only widi traditional areas of experimental biology, but alsowith the rapidly developing areas of comparative cell and molecular physiology.Institutional price: $850 £490

Order the above from:Portland Press Ltd (publishers for The Biochemical Society), PO Box 32, Commerce Way, Colchester CO2 8HP, Essex, UK24-hour ordering by FAX: Colchester (0206) 54933 l/International +44 206 549331

BioEssaysISSN: 0265-924-Edited by Adam S. Wilkins. Advisory Editors: B. M. Alberts and D. Bootsma

This journal is owned by ICSU press and published monthly by The Company of Biologists Ltd.BioEssays covers advances in the fields of molecular, cellular and developmental biology. Thejournal is lively, attractive and full of incisive reviews and discussions of new ideas and discoveries.

". . .there is no doubt that BioEssays meets agenume need and meets it welL The reviews are authoritativeand dear, the occasional other articles are lively and the journal is generally weR-written. " NATURE

"The style is lively, the articles informative and not too long, and the whole is eminently readable. It shouldbecome very useful in the teaching of many aspects of biology, especially m making recent advances easilyaccessible to students." TIMES HIGHER EDUCATIONAL SUPPLEMENT

Individual price: $75 £47Library price: $215 £120

Order from: The Company of Biologists Limited, Bidder Building, 140 Cowley Road, Cambridge CB4 4DL, UK24-hour ordenng by FAX: Cambridge (0223) 423353/International +44 223 423353

Information for contributorsManuscriptsSend to: Development Editorial Office, Austin Building, Room S-14,University of Cambridge, Pembroke Street, Cambridge CB2 3ED,UK. Tel: (0223) 311789 or direct to one of the editors (see addresslist on Title page).

Layout and styleManuscripts should be in English, typewritten, double spaced, onone side of the paper, and the pages numbered. Papers should befully ready for press, since revision in proof will not be possible. Theauthor is requested to provide three copies of the typescript andfigures, and should keep a copy. A short title of not more than 40characters, for use as page headings, should be supplied and at least3 key words for indexing papers. A summary must be provided atthe beginning of the text. It should not exceed 500 words.Acknowledgements should be placed before the list of references.

TextUnits(1) Use SI units only, units for time should be written out in full -days, hours, minutes, seconds.(2) Type a space after a digit, e.g. 1 mM (except 1%, 1°C).(3) Use relative molecular mass (MT) and not MW. MT is dimension-less and should be expressed as xlO3. Where kD has been used forthe name of a protein, it should be replaced with the nomenclaturep53, meaning a protein of 53X103 MT.Figure citations - use the abbreviations Fig. or Figs with the figurepart in caps, i.e. Fig. 1A,B or Figs 1A, 2B,C.Foreign words - keep in normal type e.g. in vivo, in vitro, per se, denovo.Genes and gene products - check that genes and restrictionendonucleases are in italic (or underlined) but that the proteinproduct of a gene is in roman.Ampersands (&) should be replaced by 'and'.Statistics - use s.e.m. and s.d. for standard errors etc.Abbreviations - uppercase should be typed without full stops (USA,UK); lowercase with full stops (u.v.)Isotopkally labelled compounds(1) If isotope is of an element in the compound then place symbolfor the isotope in square brackets, as in [ H]thymidine.(2) If compound does not normally contain the isotopically labelledelement then use either r31I-labelled albumin or 13lI-albumin.Ions - use the form, e.g. Ca2+.

References(1) The list of references must be given in alphabetical order ofauthor's names.(2) The titles of journals should be abbreviated in accordance withthe American National Standard.(3) Please put brackets around the date followed by a full stop and astop and space after each initial.(4) The following style is used in the reference list:Jones, P., Beck, C. B. and Sid, J. (1991). Cell division in the sea

urchin. Cell 99, 197-223.Rossant, J. (1977). Cell commitment in early rodent development.

In Development in Mammals, vol. 2 (ed. M. H. Johnson), pp.119-150. Amsterdam: North Holland.

(5) Citations in the text should be given as (Jones and Smith, 1960;Brown, 1991) or Jones and Smith (1960). Where there are morethan 2 authors please use the form (Jones et al., 1960) or Jones etal.(1960).

(6) Citation of unpublished work.(a) Unpublished observations, including results submitted forpublication, should be cited as such in the text only, and not inthe reference list.(b) Personal communications, i.e. the unpublished observationsof other scientists, will only be published when substantiated bywritten permission.

Text figures/photographsThese should be numbered in a single series (Fig. 1, Figs 2, 3 etc), inthe order in which they are referred to in the text. Legends for allillustrations should be typed together, separately from the maintext. Authors should submit three copies for reviewers. Copies ofthe photographic plates must be of suitable standard for reviewersto judge the quality of the work; photocopies are not acceptable.Original figures should be kept by the author until the manuscripthas been accepted for publication.Test figures and photographs ideally should be at final size andoccupy either 1 or 2 columns. The maximum printed size forillustrations is 210 mm x 168 mm for a whole page or 210 mm x 81 mmfor a single column. Labelling should be inserted by the author andshould conform to journal style and size. Figure parts should belabelled in upper case and lettering on the plates should be in lowercase. Magnification should be indicated, where relevant, by a scaleline on the illustration. Each illustration should have the name ofthe author and the figure number written on the back, together withindication of orientation and any proposed reduction in size. If linedrawings are produced by computer, please supply a file of these ondisk together with your text.

TablesPlease submit on separate sheets together with their titles andlegends.

Colour platesThese can be reproduced free of charge at the discretion of theeditor. Any charge for excessive use of colour will also be at theeditor's discretion.

Author's disksDevelopment can use author's word-processor disks for both textand graphics instead of rekeying accepted articles. This increasesboth the speed and accuracy of proof production. With your letterof provisional acceptance, you will be sent full instructions onformatting and saving your manuscript on disk. Please send a copyof your disk with 2 printed copies of your final revised manuscript.Disks will be returned.

ProofsAuthors will receive one set of proofs, which should be correctedand returned to the Editorial Office (a photocopy should be madeand retained by the author). Authors may be required to pay foralterations in proof other than those needed to correct printer'serrors.

ReprintsAuthors will receive 200 reprints free of charge and may orderadditional copies when proofs are returned.

CopyrightIn order to give The Company of Biologists Limited authority todeal with matters of copyright, authors will be required to assign tothem the copyright of any article published in the journal.

ContentsVolume 114 (2) 1992

ESSAY IN DEVELOPMENTSlack, J. M. W. and Tannahill, D.Mechanism of anteroposterior axisspecification in vertebrates: lessons from theamphibians 285-302

CONTRIBUTED PAPERSWang, R., Clark, R. and Bautch, V. L.Embryonic stem cell-derived cystic embryoidbodies form vascular channels: an in vitromodel of blood vessel development 303-316

Bossinger, O. and Schierenberg, E.Transfer and tissue-specific accumulation ofcytoplasmic components in embryos ofCaenorhabditis elegans and Rhabditisdolichura: in vivo analysis with a low-costsignal enhancement device 317-330

Watanabe, M., Kinutani, M., Naito, M.,Ochi, O. and Takashima, Y.Distribution analysis of transferred donor cellsin avian blastodermal chimeras 331-338

Ordahl, C. P. and Le Douarin, N. M.Two myogenic lineages in the developingsomite 339-353

Campos, A. R., Fischbach, K.-F. andSteller, H.Survival of photoreceptor neurons in thecompound eye of Drosophila depends onconnections with the optic ganglia 355-366

Kitamura, K., Takiguchi-Hayashi, K.,Sezaki, M., Yamamoto, H. and Takeuchi, T.Avian neural crest cells express a melanogenictrait during early migration from the neuraltube: observations with the new monoclonalantibody, "MEBL-1" 367-378

Carette, M. J. M. and Ferguson, M. W. J.The fate of medial edge epithelial cells duringpalatal fusion in vitro: an analysis by Dillabelling and confocal microscopy 379-388

Kam, E. and Hodgins, M. B.Communication compartments in hair folliclesand their implication in differentiative control 389-393

Clerk, A., Strong, P. N. and Sewry, C. A.Characterisation of dystrophin duringdevelopment of human skeletal muscle 395-402

Selleck, M. A. J. and Stern, C. D.Commitment of mesoderm cells in Hensen'snode of the chick embryo to notochord andsomite 403-415

Powell, B., Crocker, L. and Rogers, G.Hair follicle differentiation: expression, structureand evolutionary conservation of the hair typeII keratin intermediate filament gene family 417-433

Hirobe, T.Basic fibroblast growth factor stimulates thesustained proliferation of mouse epidermalmelanoblasts in a serum-free medium in thepresence of dibutyryl cyclic AMP andkeratinocytes 435-445

Behrendtsen, O., Alexander, C. M.and Werb, Z.Metalloproteinases mediate extracellular matrixdegradation by cells from mouse blastocystoutgrowths 447-456

Gagnon, M. L, Angerer, L. M.and Angerer, R. C.Posttranscriptional regulation of ectoderm-specific gene expression in early sea urchinembryos 457-467

Lazzaro, D., De Simone, V., De Magistris, L,Lehtonen, E. and Cortese, R.LFB1 and LFB3 homeoproteins aresequentially expressed during kidneydevelopment

Frank, L. H., Cheung, H.-K. and Cohen, R. S.Identification and characterization ofDrosophila female germ line transcriptionalcontrol elements

Simon, J., Chiang, A. and Bender, W.Ten different Polycomb group genes arerequired for spatial control of the abdA andAbdB homeotic products

469-479

481-491

493-505

Chang, W. S., Serikawa, K., Allen, K.and Bentley, D.Disruption of pioneer growth cone guidance invivo by removal of glycosyl-phosphatidylinositol-anchored cell surfaceproteins 507-519

Breier, G., Albrecht, U., Sterrer, S.and Risau, W.Expression of vascular endothelial growthfactor during embryonic angiogenesis andendothelial cell differentiation

Miiller, A. H. J., Angres, B. and Hausen, P.U-cadherin in Xenopus oogenesis and oocytematuration

521-532

533-543

The Company of Biologists Limited, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJISSN: 0950-1991 © The Company of Biologists Limited 1992