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5/9/16 1 The Immune System Fourth Edition Chapter 2 Innate Immunity: The Immediate Response to Infection Copyright © Garland Science 2015 Peter Parham Different type of immune responses for extra and intracellular pathogens The complement system marks pathogens for destruction • Plasma proteins : mostly proteolic enzymes of proteases • Complement proteins • Complement fixation

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Page 1: The Immune System - Universiteit Utrechttheory.bio.uu.nl/immbio/sheets/Milene_chp2.pdfPeter Parham Different(type(of(immune(responses(for(extra1and(intracellular(pathogens ... Figure

5/9/16

1

The Immune SystemFourth Edition

Chapter 2Innate Immunity: The Immediate

Response to Infection

Copyright © Garland Science 2015

Peter Parham

Different type of immune responses for extra-‐and intracellular pathogens

The complement system marks pathogens for destruction

• Plasma proteins : mostly proteolic enzymes of proteases

• Complement proteins

• Complement fixation

Page 2: The Immune System - Universiteit Utrechttheory.bio.uu.nl/immbio/sheets/Milene_chp2.pdfPeter Parham Different(type(of(immune(responses(for(extra1and(intracellular(pathogens ... Figure

5/9/16

2

Activation of omplement component 3 (C3)

The alternative pathway

Page 3: The Immune System - Universiteit Utrechttheory.bio.uu.nl/immbio/sheets/Milene_chp2.pdfPeter Parham Different(type(of(immune(responses(for(extra1and(intracellular(pathogens ... Figure

5/9/16

3

iC3Bb complex

Complement receptor 1 recognizes C3b

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