the immune system the invadersthe defender. antibodiescytokinescomplementinflammatory mediators...
Post on 19-Dec-2015
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THE IMMUNE SYSTEMThe Invaders The Defender
Antibodies Cytokines Complement Inflammatory mediators
COMPONENTS OF THE IMMUNE SYSTEM
Cellular components of the immune system
Soluble mediators of the immune system
Lymphocytes Phagocytes Granulocytes
Large granular lymphocyte
T-cell
B-cell Mononuclear phagocyte
Neurtrophil
Eosinophil
Basophil
Mast cell
Platelets
Others
ORIGINATION OF CELLULAR COMPONENTS
Pluripotent Stem cell
Myeloid Stem cell
Lymphoid stem cell
MonocyteNeutrophil
Macrophage
PlateletsEosinophil Basophil Mast cell
B-cellT-cell Plasma cell
Natural killer cell
THE EVOLUTION OF IMMUNITY
Immunity
Innate immunity Acquired immunity
Non-specific SpecificImmediate onset Delay onset
Humoral Immune Response
Cellular Immune Response
Antibodies production T-cell activation
INNATE IMMUNITY
1st Line Defense
2nd Line Defense
Pathogenic invasion Bacteria Viruses
Skin Ciliated cells Lysozyme Coughing
Blood clot Mast cell Cytokines
Vomitting
Leukocytes
THE INFLAMMATORY RESPONSE
Capillary widening
Increased blood flow
Increasedcapillary
permeability
Release of fluid
Leukocyteattraction
Leukocyticmigration
Systemicresponse
Leukocyticproliferation
Heat, Redness, Tenderness, Swelling, Pain
Tissue injury caused by pathogenic invasion
THE COMPLEMENT CASCADE
The Complement System
Mannose bindingAntibody binding
Opsonization Inflammation Cytolysis
Classical Alternative
ACQUIRED IMMUNITY
B-Cell Activation
Cytotoxic T-Cell Activation
Humoral Immunity
Cell-mediated Immunity
Antibodies Production
Cell lysis
Cytokines
Cytokines
ActivatedTH cell
ATTRIBUTES OF ACQUIRED IMMUNITY
Immunological SpecificityImmunological Tolerance
APC
Receptor
B-cell
Plasma cell
MemoryB-cell
MatureT-cell
MemoryT-cell
Activated T-cell
Immunological memory
THE MHC PROTEINS: CLASS I
THE MHC PROTEIN: CLASS II
RECOGNITION OF CLASS I MHC PROTEIN
RECOGNITION OF CLASS II MHC PROTEIN