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The Heart of Africa Clinical Profile of an Evolving Burden of Heart Disease in Africa

History & Purpose A decade in the making….

Initial collaborations & discussions via he Heart of Soweto Study Initially proposed as an African textbook Lack of commercial interest Funding for publication (Wiley) provided via Baker IDI/Stewart Revised plan (research-based) & funding via the MacKillop Institute

Purpose….. Designed to provide anyone with an interest in heart disease in Africa with an immediate sense of how the area is progressing from a clinical to research perspective in responding to this evolving epidemic Presents salient research uncovering the evolving burden of communicable and non-communicable forms of heart disease Subsidised (500 copies) distribution of the book to as many African-based researchers and clinicians as possible.

Contributors & Structure Senior Editors

Prof Simon Stewart Prof Karen Sliwa Prof Ana OH Mocumbi Prof Albertino Damasceno Prof Mpiko Ntsekhe

Assoc. Editors Ashley K Keates Cressida J McDermott

Foreword Prof Bongani Mayosi

Authors Clinicians & Researchers from throughout Africa

Section 1: Maternal Heart Health Karen Sliwa MD│ PhD │FESC │FACC Hatter Institute, Faculty of Health Sciences, University of Cape Town, South Africa

Spectrum of maternal cardiac disease in South Africa Karen Sliwa, John Anthony & Denise Hilfiker-Kleiner

Trial of Bromocriptine Treatment for Post-Partum Cardiomyopathy

Karen Sliwa, John Anthony & Denise Hilfiker-Kleiner

Section 2: Infant & Childhood heart disease Ana OH Mocumbi MD│PhD│FESC Instituto Nacional de Saude Ministerio da Saude Doencas Cronicas, Nao Transmissiveis Instituto, Maputo, Mocambique Congenital Heart Disease Ana Mocumbi, Tantchou Tchoumi, Jacques Cabral, John Musuku &

Serigne A Ba

Acquired Heart Disease Ana Mocumbi, Liesel Zuhlke & Peter Zilla

Section 3: Spectrum of risk & CVD in sub-Saharan Africa Simon Stewart PhD │FESC │FAHA Mary MacKillop Institute for Health Research, ACU, Melbourne, Victoria, Australia

Cardiovascular risk in urban and rural African settings Kemi Tibazarwa, Karen Sliwa, Melinda Carrington, Okechukwu

Ogah & Simon Stewart The African INTERHEART Study

Krisela Steyn & Karen Sliwa The spectrum of heart disease in urban Africans: The Heart of Soweto Study

Melinda Carrington, Karen Sliwa & Simon Stewart

Section 4: Infectious heart disease Mpiko Ntsekhe MD │PhD Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

Rheumatic heart disease Simon Stewart, Melinda Carrington, Karen Sliwa

Pericardial disease Mpiko Ntsekhe

HIV-related heart disease Friedrich Thienemann, Melinda Carrington, Karen Sliwa, Mpiko

Ntsekhe & Simon Stewart

Section 5: Noncommunicable heart disease Albertino Damasceno MD │PhD Departamento de Medicina/Faculdade de Medicina Universidade Eduardo Mondlane, Maputo, Moçambique

Acute coronary syndrome in the African context Anthony Becker

Stroke in the African context Albertino Damasceno

Section 6: Heart failure Simon Stewart PhD │FESC │FAHA Mary MacKillop Institute for Health Research, ACU, Melbourne, Victoria, Australia

Acute heart failure Mahmoud Sani, Dike Ojji, Anastase Dzudie & Okechukwu Ogah

Hypertensive heart failure Dike Ojji, Mahmoud Sani, Anastase Dzudie & Okechukwu Ogah

Chronic heart failure Okechukwu Ogah, Anastase Dzudie, Dike Ojji & Mahmoud Sani

Pulmonary hypertension & right heart failure Anastase Dzudie, Friedrich Thienemann, Okechukwu Ogah, Dike

Ojji & Mahmoud Sani

Book Distribution Ensure the book is freely available via the PASCAR website & is

widely distributed 2nd Edition

Identify areas of strength & weakness in the book New research reports Wider distribution of African authors and report

Heart of Africa Textbook Current engagement with future publishers Open access & on-line format African-specific clinical content Wide distribution of African authors/contributions

Future Plans..