TheEuropeanSocietyforVascularSurgery 4thSpringMeeting

UCLInstituteofChildHealth,London,UK13th–14thMay2016

PROGRAMMEandABSTRACTS2016

www.esvs.org

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Welcometothe4thESVSSpringMeetinginLondonin2016!Thankyouforjoiningusforthe4thESVSSpringmeeting.

Last Spring, we came together in Frankfurt for 2 days of lively discussions on leading

researchinvascularbiology,novelmaterialsandinnovativedevicescoveringallaspectsof

vasculardisease.

This year, we continue our focus on translational vascular research with 5 scientific

sessions coveringmolecular and cellular biology of vascular diseases, vascular imaging,

vascular modelling, biomaterials and cardiovascular device. There is also a dedicated

poster session and authors of the 5 best posters will be invited to give short oral

presentationsoftheirworkonSaturdayincompetitionfortheposterprize.Thankyouto

everyonewhohassubmittedtheirworktothemeeting.

Wearealsoexcitedtowelcomeourkeynotespeakerswhowillupdateusontheir latest

work,andgiventheincreasingimportancecross-disciplinaryprojects,wehavealsoasked

Tom Schmitz-Rixen to give us his views on the challenges of cross-disciplinary

collaborations.

The networking dinner has always been a fun opportunity to learn more about each

other’sworkanddevelopandconsolidatecollaborations:pleasejoinusforthis.

Thankyouforyoursupportandinput.Wehopeyouwillenjoythemeeting.

JaniceTsui,GeorgeHamilton,ThomasSchmitz-Rixen,JaapHamming,SebastianDebus

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ProgrammeOverview

Friday,13thMay2016

10:45 OpeningCommentsMissJaniceTsui,LocalOrganisingCommittee

ProfMarkEmberton,Dean,FacultyofMedicalSciences,UCL

11:00 Keynotelecture:

VascularAging:Theroleofnon-codingRNA

DrReinerBoon,InstituteofCardiovascularRegeneration,GoetheUniversityFrankfurt/M,Germany

11:25-12:55 OralSession1:MolecularandCellularBiologyofVascular

Diseases

12:55–13:45 Lunch

13:45 Keynotelecture:

Multi-scalemodellingtounderstandatherosclerosisandcalcificationlocations:

comparisonwithin-vivodata

DrVanessaDiaz,DepartmentofMechanicalEngineering,UniversityCollegeLondon,UK

14:10–15:10 OralSession2:VascularImaging

15:10–15:40 Coffeebreak

15:40-15:55 Invitedtalk:

Challengesofcross-disciplinaryresearch

ProfThomasSchmitz-Rixen,DepartmentofVascular&EndovascularSurgery,Goethe-University

Hospital,Frankfurt,Germany

15:55–17:15 OralSession3:VascularModelling

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17:15–19:00 PosterSession

20:00 NetworkingDinner

Saturday,14thMay201608:30 Keynotelecture:

VenousStents–DesignOptimizationfortheClinicalChallengeDrStephenKao,VicePresidentofR&D,Veniti,Inc.

08:55–10:05 Oralsession4:Biomaterials

10:05-10:20 Coffeebreak

10:20 Keynotelecture:

MolecularAspectsofVascularRemodelling

ProfPaulQuax,EinthovenLaboratoryforExperimentalVascularMedicine,LUMC,theNetherlands

10:45-11:25 Posterprizesession

11:25-11:35 Coffeebreak

11:40 KeynotelectureandIntroductiontoISACB

HumanMesenchymalStemCell-BasedTissueEngineeredVascularGraftsProfDavidA.Vorp,UniversityofPittsburgh,USA

12:00-13:20: OralSession5:CardiovascularDevices

13:20 ClosingRemarks

Prof.TSchmitz-Rixen

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FullProgramme

Friday,13thMay2016

10:45 OpeningCommentsMissJaniceTsui,LocalOrganisingCommittee

ProfMarkEmberton,Dean,FacultyofMedicalSciences,UCL

11:00 Keynotelecture:

VascularAging:Theroleofnon-codingRNA

DrReinerBoon,InstituteofCardiovascularRegeneration,GoetheUniversityFrankfurt/M,Germany

11:25-12:55 OralSession1:MolecularandCellularBiologyofVascular

Diseases

Chairs:DrReinerBoon,Frankfurt,Germany&DrMarkellaPonticos,London,UK

11:25 TaisiyaBezhaeva,TheNetherlands

OpposingeffectsofTLR4homologueRP105onVSMCproliferationandmacrophage

polarizationinamurinemodelofarteriovenousfistulafailure

11:35 LukeBrewster,USA

ImpactofAgingonMurineElasticandMuscularArteries

11:45 CharlotteLawson,UK

Effectofdiabetesonwoundhealingandcirculatingmicrovesiclesinaninvivoischaemic

woundmodel

11:55 AlexanderGötze,Germany

HigherconcentrationsofIL10improvehindlimbreperfusionrecoveryinmiceafter

femoralarteryligation

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12:05 RobdeJong,TheNetherlands

Inhibitionofthe14q32microRNA-495reduceslesionformation,intimalhyperplasiaand

plasmacholesterollevelsinmousemodelsforpost-interventionalrestenosisand

atherosclerosis

12:15 KerstinTroidl,Germany

Contributionofsmoothmusclecell-derivedandendothelialcell-derivedmiRNAsduring

vascularremodeling

12:25 MuholanKanapathy,UK

Connexinasabiomarkerforvenousulceration

12:35 NinaMzhavanadze,Russia

Long-termeffectsandpharmacokineticstudiesofnakedplasmidDNAencodingvascular

endothelialgrowthfactorisoformVEGF165transferinpatientswithatherosclerotic

peripheralarterialdisease

12:55–13:45 Lunch

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13:45 Keynotelecture:

Multi-scalemodellingtounderstandatherosclerosisandcalcificationlocations:

comparisonwithin-vivodata

DrVanessaDiaz,DepartmentofMechanicalEngineering,UniversityCollegeLondon,UK

14:10–15:10 OralSession2:VascularImaging

Chairs:Prof.SebastianDebus,Hamburg,Germany&Prof.SebastienOurselin,London,UK

14:10 UlrichRother,Germany

Immediatechangesoftissueperfusionduringtibialangioplasty–measurementswith

respecttoangiosomes

14:20 CraigGoergen,USA

UltrasoundandMagneticResonanceImagingofMurineAbdominalAorticAneurysms

14:30 AlexanderRolls,UK

AComparisonofImage-versusHardware-basedTrackingTechnologiesin2D-3DFusion

inAorticEndografting

14:40 WojciechDerwich,Germany

Kinematicevaluationofinfrarenalaorticaneurysminstabilityusing4Dultrasound

14:50 InezTorres,Brazil

Simulatorfortraininginendovascularinfra-renalaneurysmrepair:theuseof3Dprinters

15:00 SteveGreenwald,UK

Non-contactmeasurementofcarotidarterywallmovementfordiagnosisofvascular

disease

15:10–15:40 Coffeebreak

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15:40-15:55 Invitedtalk:

Challengesofcross-disciplinaryresearch

ProfThomasSchmitz-Rixen,DepartmentofVascular&EndovascularSurgery,Goethe-University

Hospital,Frankfurt,Germany

15:55–17:15 OralSession3:VascularModelling

Chairs:DrVanessaDiaz,London,UK&MrDaryllBaker,London,UK

15:55 JacobSalmon,UK

PhysiologicalvorticesinthesinusesofValsalva:aninvitroapproachforbio-prosthetic

valves

16:05 BahaaNasr,France

Characterizationofthephysiologicalmotionoftheaorticarchandthesupra-aortic

vessels.

16:15 ObiekezieAgu,UK

Patient-specificComputationalmodellingofWallMotioninAorticDissectionusingFluid-

StructuralInteraction

16:25 BenjaminObukofe,UK

PrognosticRiskFactorsUnderlyingAbdominalAorticAneurysm(AAA)Growth

16:35 AndreasWittek,Germany

AMethodforVirtualHypertonicStressTestsofAAAUsingPatient-IndividualFinite

Element-Analyses

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16:45 BenjaminObukofe,UK

AGeneticRiskScore-BasedNomogramtoPredictAbdominalAorticAneurysm(AAA)in

theCaucasianEuropeanPopulation

16:55 SmiljanaDjorovic,Serbia

Athree-dimensionalcomputationalanalysisofbloodflowinpatient-specificaorticstent

graft

17:05 CunnaneConnor,Ireland

APreliminaryStudytoDetermineIfArteriovenousFistulaConfigurationGeneratesHelical

Flow

17:15–19:00 PosterSession

1. GaryBowlin,USA

ANewPerspectiveontheNeutrophilandItsExpandingRoleintheInnateImmune

ResponsetoBioresorbableVascularGraft

2. DebraChong,UK

EngineeringVascularGraftNanopitSurfaceTopography:EffectsonEndothelialCell

Adherence

3. HendrikVanDamme,Belgium

LateFateofcryopreservedarterialAllografts

4. TimothyPennel,SouthAfrica

Transmuralcapillaryingrowthisessentialformid-grafthealing

5. FelixRuben,Argentina

AutologusDermoepidermaldevice(ADED)producedbytissueengineering

6. FlorianStefanov,Ireland

PrimaryversussecondaryinterventionevaluationfortwelveaortictypeBdissections

managedwiththestreamlinermultilayerflowmodulator

7. IharaTsutomu,Japan

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PostoperativechangesinthediameterofthedistallandingzoneafterEVARintroduction

andobjectives

8. GagandeepGrover,UK

CerebralEmbolicProtectiontoinThoracicEndovascularAorticRepair(TEVAR)–APilot

Study

9. HarriHakovirta,Finland

CardiovascularRiskFactorsDifferinInflammationPathologyinPatientswithClinically

SymptomaticLowerLimbAtherosclerosis

10. EoghanCunnane,Ireland

TheMechanical,CompositionalandMorphologicalCharacterisationofFemoral

AtheroscleroticPlaquefortheContinuedImprovementofEndovascularTreatment

11. FlorianSimon,Germany

TimedependencyofH2S-inducedorganprotectionduringlong-termresuscitatedporcine

haemorrhage

12. KonstantinosPapoutsis,Greece

Theroleofrelaxininvasculardiseases:earlyresults

13. BodnarPetro,Ukraine

Assessmentofindicatorsendothelialdysfunctioninpathogenesispost-thrombotic

syndrome

14. ZuzannaRowinska,Germany

TheroleofMMP2indevelopmentofaneurysmincombinationwiththetransplantation

model

15. DanilaKozhevnikov,Russia

Comparativeimageofpigaortaandhumanrupturedabodminalaortabynewhigh

resolutionx-raymicrotomography

16. BenjaminObukofe,UK

MethyleneTetrahydrofolateReductaseC677T(MTHFRC667T)GeneticPolymorphismisa

PrognosticRiskFactorforAbdominalAorticAneurysm(AAA)

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17. BenjaminObukofe,UK

Mechanismofinteractionofangiotensinconvertingenzymeinsertion-deletion

polymorphismwithmethylenetetrahydrofolatereductaseC677Tgeneticpolymorphisms

inthepathogenesisofabdominalaorticaneurysms

18. ChristianGasser,Sweden

Localparametersthatinfluencethelocalgrowthofabdominalaorticaneurysms

19. StephanieTomee,TheNetherlands

Howdoesitfeeltohaveanabdominalaorticaneurysm–apatient-centeredview

20. MeritxellDavins,Spain

Useoftelemedicinetohelpcontrolofperipheralarterialdisease

21. IkeOkonji,UK

TheuseofCTimagingtoidentifythehighriskcarotidplaque

22. PragashKamalathevan,UK

Plaqueulcerationisassociatedwithsymptomaticcarotidarterydisease

23. SusanneRegus,Germany

TimingoffirstAVFscannulationinchildrenonhemodialysis

24. SusanneRegus,Germany

MRItoinvestigateiliacarterywallthicknessintriathletes

20:00 NetworkingDinner

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Saturday,14thMay201608:30 Keynotelecture:

VenousStents–DesignOptimizationfortheClinicalChallenge

DrStephenKao,VicePresidentofR&D,Veniti,Inc.

08:55–10:05 Oralsession4:Biomaterials

Chairs:DrStephenKao,Veniti&DrWenhuiSong,London,UK

08:55 JunHongPang,UK

DevelopmentofPre-polymerCoatingswithPro-endothelialisationPotentialfor

CardiovascularDevices

09:05 LazarenkoGleb,Ukraine

Modifikationofthestentssurfacebytreatmentwithautoalbuminforpreventionofthe

bodyreaction

09:15 JunjieZhao,UK

Nano-surfacePatternedCoatingPromotesin-situEndothelizationforStents

09:25 DebraChong,UK

Nanotopographicalgraftsurfacemodulationtopromoteendothelialisationmaypromote

calcificationbydirectingmesenchymalstemcellstoanosteogeniclineage

09:35 YasminFarhatnia,UK

DevelopmentofPediatriccoveredstentusingnanocompositematerial

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09:45 AllisonFetz,USA

ElectrospunVascularGraftArchitectureandCompositionRegulatesNeutrophilNETosisIn

Vitro:APotentialPredictorofSuccessorFailure

09:55 PopovGury,Russia

Isitpossibletocreatereadilyavailabletissue-engineeredvasculargraftswithoutusing

cells?

10:05-10:20 Coffeebreak

10:20 Keynotelecture:

MolecularAspectsofVascularRemodelling

ProfPaulQuax,EinthovenLaboratoryforExperimentalVascularMedicine,LUMC,TheNetherlands

10:45-11:25 Posterprizesession

Chairs:ProfPaulQuax,TheNetherlands&DrBrianCousins,UK

11:25-11:35 Coffeebreak

11:40 KeynotelectureandIntroductiontoISACB

HumanMesenchymalStemCell-BasedTissueEngineeredVascularGrafts

ProfDavidA.Vorp,UniversityofPittsburgh,USA

12:00-13:20: OralSession5:CardiovascularDevices

Chairs:Prof.DavidVorp,PresidentofISACB,USA&Prof.LukeBrewster,USA

12:00 MichaelGawenda,Germany

Fromtheworkbenchtothehumanbody-Influenceof3-DimensionalAorticmodelon

CasePlanningforFEVAR

12:10 MarcoHorn,Germany

3-DModelingoftheAbdominalAortaforExperimentalEndovascularNavigation

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12:20 Pierre-JeanCottinet,France

Inkjetprintingbasedelectroactivepolymerforsteerableandhapticfeedbackofguidewire

12:30 SelimBozkurt,UK

DevelopmentandHydrodynamicAssessmentofaNovelTranscatheterMitralValve

12:40 MitalDesai,UK

MechanicalprofileofathoracicendograftdevelopedusingPOSS-PCUandshapememory

alloy

12:50 SebastianDebus,Hamburg,Germany

TheHamburgHybridGraft–atechnicalfeasibilitystudyforthoracoabdominalrepairin

pigs

13:00 SabineWipper,Germany

Completepercutaneoustransapicalinstrumentationforsingle-sidebrancharchendograft

usingapercutaneousclosuredeviceinpigs

13:10 RobKrams,UK

MechanosensitivesignallingpathwaysadaptduringTCFAformation

13:20 ClosingRemarks

Prof.TSchmitz-Rixen