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The European Commission’s science and knowledge service Joint Research Centre

INDOOR AIR TOXICOLOGY Conference 16-18 September 2018, Berlin, Germany

The European Commission’s Information Platform for Chemical Monitoring data (IPCHEM): a reference gateway for searching, accessing, retrieving, assessing and sharing indoor air monitoring data in EU

Stylianos Kephalopoulos (European Commission, DG JRC)

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IPCHEM - policy background

ASSESSING EU REGULATIONS Effectiveness/efficiency of the EU regulatory

framework implementation

Revision/integration of the current EU Regulatory framework

SOLVING DATA AND INFORMATION NEEDS Solving the problem of data and information scattered across a multitude of disconnected systems, repositories and databases

RESPONDING TO POLICY NEEDS EC Communication “The combination effects of chemicals

Chemical mixtures”

7th EU Environment Action Programme (2014-2020)

SOLVE

ASSESS

RESPOND

IPCHEM – Policy Background

European Commission Communication on “The combination effects of chemicals – Chemical mixtures” (COM/2012/0252 final) recognises the need of: “Promoting a more coherent approach to the generation,

collection, storage and use of chemical monitoring data in relation to humans and the environment, through the creation of a platform for chemical monitoring data”.

7th Environment Action Programme (2014-2020) priority objective 5: “To improve the knowledge and evidence base for Union Environmental Policy”

European Commission’s requirement to: Assess the effectiveness and efficiency of the EU regulatory framework implementation; including EU Environmental Monitoring and Reporting

IPCHEM – Policy Background

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IPCHEM – salient elements

One access point, all the information

A strong strategic partnership

A wealth of chemical monitoring data

Expanding recognition and impact

https://ipchem.jrc.ec.europa.eu

IPCHEM – Salient elements

A fast track system to make chemical monitoring data readily accessible and comparable across various media (e.g. environment, humans, food/feed, indoor air and consumer products) and policy domains

Enables an informed policy-making process on the basis of timely delivered and quality data





146.829.052 CONCENTRATION MEASUREMENTS

2040 SUBSTANCES AND COMPOUNDS

34 DATA COLLECTIONS

14 HBM4EU METADATA

+ AROUND 60 NEW HBM4EU METADATA AND DATA IN AUTUMN/WINTER 2018





EC REPORT ON THE SUSTAINABLE USE OF BIOCIDES

March 2016

EC STAFF WORKING DOCUMENT IMPACT ASSESSMENT DEFINING CRITERIA FOR IDENTIFYING ENDOCRINE

DISRUPTORS June 2016

SUBMISSION BY THE EU AND ITS MEMBER STATES IN RESPONSE TO THE REQUESTS TO PREPARE A GLOBAL LEGALLY BINDING INSTRUMENT ON

MERCURY October 2016

EUROPEAN COMMISSION AMR ACTION PLAN A EUROPEAN ONE HEALTH ACTION PLAN AGAINST ANTIMICROBIAL RESISTANCE

(AMR) June 2017

CONCLUSIONS OF THE COUNCIL OF THE EUROPEAN UNION ON THE PROTECTION OF HUMAN HEALTH AND THE ENVIRONMENT THROUGH THE SOUND

MANAGEMENT OF CHEMICALS December 2016

EC STAFF WORKING DOCUMENT TOWARDS A FITNESS CHECK OF EU ENVIRONMENTAL MONITORING AND REPORTING

May 2016

IPCHEM ONE OF THE CASE STUDIES Identified as best fitting into the EC-JRC DATA4POLICY INITIATIVE

May 2017





IPCHEM – Level of data granularity and access groups

Based on: the IPCHEM Data Policy, the Reg. 45/2001 and GDPR

Data retrievable through IPCHEM: shall be made available to all users at highest possible level of data granularity and under the conditions of free, full, open and timely access

Metadata: mandatory by default

Aggregated data: mandatory for European Commission and EU Agencies

Dedicated regimes and rules for Research Projects: for the project duration

Occurrence data (not exposure), i.e. chemical concentrations values measured in various media across Europe and beyond by EC services, EU Agencies, National Bodies, Research centres and consortia, e.g.:

• data collected for legal obligations on ad-hoc or regular basis for reporting monitoring data at European or national levels

• data generated as result of targeted research on the presence of known or unknown chemical substances in specific media

Type of data currently accessible through IPCHEM

Data collections in IPCHEM are grouped under four thematic modules:

Human Biomonitoring data

Environmental monitoring data

Food and Feed monitoring data

Product and indoor air monitoring data

146.829.052 (24.000.000)2017

MEASUREMENT RECORDS (excluding data under integration)

2.040 (1600)2017

NUMBER OF CONTROLLED SUBSTANCES (i.e. quality controlled and not duplicated)

Type of chemical data in IPCHEM module and media Human Biomonitoring data* (20)

Environmental data* (19)

Product and Indoor Air data (3)

20

19

3 3

HBM ENV INDOOR FOOD

DATA/METADATA INTEGRATED IN IPCHEM

MID. 2018

* The Environmental Specimen Bank of Germany stores both HBM and ENV data

Blood-whole blood Blood -plasma Blood -serum Cord blood: whole blood/plasma/serum Urine: spot/24h/morning urine Saliva/sputum Semen Hair Breast milk Adipose Tissue/Fat

Surface water Ground water Industrial water Drinking water Atmospheric water Suspended particulate matter (SPM) Sediment in water Biowaste Sewage sludge Refuse derived fuels (RDF) Demolition waste Ashes Other city waste Topsoil Subsoil Underwater/subaqueous soil Plants Animals Bacteria

Outdoor air

Indoor air

Personal Sampling

Under refinement

Food and Feed data (3)

Spatial coverage and resolution 0,

4083

61

0,53

3102

0,02

2

0,03

3978

0,05

375

0,80

5368

0,24

2615

0,02

9009

0,25

9096

17,4

4397

4

2,49

7328

0,05

2052

0,12

0412

0,18

6369

3,08

306

0,02

8615

0,06

2246

0,02

2303

0,01

1042

2,19

5094

0,19

8299

0,19

081

0,08

0868

0,25

3218

0,09

2046

0,76

5873

0,26

7517

2,75

5498

0

5

10

15

20

Mill

ione

n

Measurements records per Country (EU28), end of 2017

0 0 2

10 5 3

6 7 3

15

5 4

05

101520

Level of coverage of IPCHEM data, mid 2018

IPCHEM Data

IPCHEM-HBM data

Level of detail and accessibility in IPCHEM

6

11

2 0

5

0 1

13

1 0 2

0 0 0 3

0 02468

101214

Aggregated Singlemeasurement

Singlemeasurements

filtered orgeneralised

Metadata only(temporal)

IPCHEM-Level of Data granularity-end 2017

Environment Human Biomonitoring Products&Indoor Air Food&Feed

8 8

3 5

1 2 2 1 1 3

0 0 0

5

10

Public Restricted to EC and EUAgencies

Under integration

IPCHEM-Level of Data accessibility-mid 2018

Environment Human Biomonitoring Products&Indoor Air Food&Feed

IPCHEM – Main tools and functionalities

Interoperability With relevant international Information Systems/web services for establishing a more comprehensive knowledge framework on chemical exposure

Data comparability Spatial and temporal comparative analysis across chemicals/media

Data quality To properly understand, use/re-use the data that are accessible and retrievable through IPCHEM

IPCHEM - as Improver

IPCHEM OBJECTIVES

Search page

Metadata info page

Database Console

Basket tool

Map viewer

IPCHEM: Main Tools & Funtionalities

Links with relevant information systems and services

Definition and implementation of Central IPCHEM Quality Control Rules Rules are ingested into the IPCHEM ETL process service and launched IPCHEM ETL creates the “IPCHEM Quality and Harmonisation Report” shared with the data providers Any remaining quality issues are flagged and displayed into the IPCHEM DB console

IPCHEM: Salient Features DATA QUALITY IPCHEM Data Quality Control Rules

IPCHEM: Salient Features DATA COMPARABILITY

IPCHEM internal Data Model

“Chemical Monitoring data” definition and data templates

Definition of the IPCHEM internal data model

Internal IPCHEM ETL mechanism for data mapping, transformation and integration

IPCHEM Data Visualisation options

Direct link for each chemical searchable via IPCHEM from the “structural information and properties” window

Built on CAS registry number (exceptionally on chemical name)

IPCHEM: Salient Features INTEROPERABILITY

Linking external Information Systems by chemical ID

Solved case by case, via: • Web services with

third party repository (ChemAgora)

• Provision of links (eChemPortal), on regular basis

• Scheduled download and update of links (ECHA info card)

IPCHEM: Salient Features INTEROPERABILITY

Linking database’s web application by record ID

Use of the ID sampling record to link IPCHEM with an external database web application (e.g. the ESB of UBA) to trace each record from IPCHEM to the source database and vice-versa

The web application of the

external database might provide additional information (e.g. further attributes not provided to IPCHEM)

IPCHEM: new Tools & Functionalities

IPCHEM Advanced Search Tool

Module-based filter criteria (the first one is for HBM data)

Extended to search multiple chemicals, groups and relations (e.g. parent compounds and their metabolites, HBM4EU group of priority substances)

Quality control and chemical names, synonyms, IDs, groups and relations are managed into the IPCHEM Chemical Nomenclature Registry

The new IPCHEM version will be released by end of October 2018

IPCHEM: new Tools & Functionalities

IPCHEM Advanced Viewer

Search/view/download multiple chemicals by location: typing a city or drawing an area

The new IPCHEM version will be released by end of October 2018

IPCHEM – Module 4 ‘Products & Indoor Air Data’

AIRMEX - European Indoor Air Monitoring and Exposure Assessment Project • 27 chemicals • 9 EU Countries • 8.487 SINGLE concentration measurements OFFICAIR - Indoor air pollution in modern office buildings • 33 chemicals • 7 EU Countries • 11.156 SINGLE concentration measurements SINPHONIE - Schools Indoor Pollution and Health Observatory Network in Europe database on chemical and biological pollutants • 11 chemicals • 22 EU Countries • 2165 SINGLE concentration measurements

• Links to BUMA and BUMAC, providing product emissions and health relevant thresholds

IPCHEM Module 4 ‘Products & Indoor Air Monitoring Data’

IPCHEM Module 4 ‘Products & Indoor Air Monitoring Data’

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European Energy Efficiency Platform E3P

Workshop on IPCHEM-Module 4 ‘Indoor Air Monitoring Data’ (2-3 October 2017, Ispra)

• Enhancing and expanding the scope of the IPCHEM-Module 4 metadata and data model so that existing and future data collections on Indoor Environment Data can serve policies cross cutting the chemical policy (e.g. on health and energy performing buildings).

• Integrating IPCHEM-M4 data into the DG ENER’s EU Building Stock Observatory & JRC’s European Energy Efficiency Platform – E3P

• The further enhancement will rely on and benefit from on-going and former relevant harmonisation efforts undertaken by European Commission and other international organisations;

• Engage potential data providers

IPCHEM Module 4: improving data and metadata model and increasing indoor air monitoring data collections

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n Data Collection Providers Level of detail Accessibility Media Spatial Coverage Temporal coverage

1 National monitoring programs on IAQ in Belgium

VITO, BBIEM

Aggregated data

Public Indoor air Belgium -

2 The OQAI French Indoor Air Quality Observatory

French Authorities

Aggregated data later single measurements, filtered or generalised data

Public Indoor air France From 2001

3 IAQ data of the German Environmental Survey (GerES)

UBA-Germany

Aggregated data Public Indoor air Germany Several years, to be decided

4 Indoor air quality study - CO2 concentration in preschools/schools in Estonia

Health Board-Estonia

Single measurements, filtered or generalised data

Public Indoor air Estonia 2007-2008

Indoor Air Monitoring Data Integration Plan 2018-2019 (1/3)

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5 GENASIS Database RECETOX, Masaryk University

Aggregated data


Public Indoor air World 2005-2016

6 Survey of indoor air quality in insulated and not insulated school buildings in Tallinn

Health Board-Estonia


Public Indoor air in insulated and not insulated schools

Estonia 2015

7 Emerging contaminants dataset, EMERTOX, Toxicology dataset

RECETOX, Masaryk University

Aggregated data


Public Indoor air

Outdoor air

World 2005-2008


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8 INSULAtE project National Institute for Health and Welfare, Finland


Public Indoor air Finland 2011-2015

9 Indoor environmental data (pollutants and comfort) in Greece from various types of spaces – Personal Exposure

National and Kapodistrian University of Athens

Single measurements data

Public Indoor air Greece 2012-2017

10 IAQ in Lithuanian low energy buildings

Kaunas University of Technology, Lithuania


Restricted to EC and EU Agencies;

Restricted to EU MS

Indoor air Lithuania 2014


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IPCHEM - salient collaborations

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IPCHEM – HBM MODULE EXTENSION

IPCHEM is the official platform (long-term HBM data repository) for accessing and sharing existing and new human biomonitoring data collected during the HBM4EU project (2017-2022).

Agreement for integrating OECD HBM db into IPCHEM (OECD Working Party Exposure Assessment - June 2017)

The European Human Biomonitoring Initiative (HBM4EU) is a joint effort of 26 countries and the European Commission which aims to coordinate and advance human biomonitoring in Europe.

Using IPCHEM as the platform for searching, retreiving, accessing HBM metadata and data on global scale

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84 HBM4EU metadata was compiled in 2018 by HBM4EU partners sharing data and metadata via IPCHEM and stored into the IPCHEM-HBM4EU Data Repository (IPCHEM share).

Once quality checked by IPCHEM team, the metadata is published in IPCHEM and approved by

the data providers

Once approved the metadata page is indexed and available on line from the IPCHEM search tool

So far 14 metadata are published in IPCHEM, the remaining 70 will be published by the HBM

Conference “Human Biomonitoring in Europe –science and policy for healthy citizens”, September 28, 2018 in Vienna (Austrian Presidency of the Council of the European Union)

2 HBM4EU data collections has been integrated into IPCHEM (both of Israel), still under final

quality control by IPCHEM team

HBM4EU data collections/metadata integrated into IPCHEM (mid 2018)

IPCHEM – HBM MODULE EXTENSION

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IPCHEM – EFSA DATAWAREHOUSE data sharing

Centralised data

(S-DWH) Implemented

data flows Matrix

(data from applications)

Self-service data

(Zenodo)

Data sharing supported by

EFSA

External data

sources Access/retrieve data from EFSA Data Lake

IPCHEM

Access/retrieve IPCHEM data & metadata

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IPCHEM as potential platform to track chemical of concern in products/articles within the EU Circular Economy context

Chemicals in

Products

Prioritisation

Assessment

Criteria

Tracking

How can IPCHEM support the tracking, prioritisation and assessment of chemicals of concern in products/articles (e.g. toys, electronics, textiles, construction materials/products), the environment, the food-web, indoor environments and humans?

According to the EU Circular Economy Action Plan (from production, consumption, waste and recycling)

SAICM - Chemicals in Products Program (CiP) Synergistically with relevant developments on global scale (e.g. UNEP-

SETAC, USEtox, Tox21, ConsExpo, OECD WPEA, ECHA REACH, SubsPort, etc.)

Kick-off discussions, Workshop IPCHEM-M4 ‘PRODUCTS DATA’, 26-27 October 2017, Ispra

Experts from DGs ENV, JRC, ECHA, EEA, US EPA, HEALTH CANADA, OECD and experts from EU MS

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IPCHEM supporting the assessment of chemical mixtures

Workshop ‘IPCHEM Supporting the assessment of chemical mixtures, 11-12 December 2017, JRC-Ispra

Purpose: • How can IPCHEM be used for mixture risk assessment (MRA)?

• What data collections, data elements and templates should IPCHEM integrate to support MRA practices

• What functionalities IPCHEM is currently featuring and which should be developed additionally in the future to support exposure and risk assessment of mixtures?

• Which other tools, e.g. databases and information systems developed in H2020 funded projects on chemical mixtures should become interoperable with IPCHEM?

Joint H2020 Workshop (29-30 May 2018, JRC-Ispra)

Purpose: to create a joint forum for researchers and policy-makers to discuss and identify gaps in risk assessment and governance of chemical mixtures. It has addressed how the state-of-the-art knowledge can be used to prioritise new initiatives and strategies to limit unwanted impact on human health and the environment from combined exposure to multiple chemicals.

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IPCHEM – our partners’ view

• Established in the 1980s

• Annual collection of aquatic, terrestrial, and human samples which reflect a broad cross-section of environmental conditions in Germany.

• Samples are cryo-preserved for retrospective analyses

• Annual quantification of a fixed set of pollutants

1) The German Environmental Specimen Bank (ESB) German Environment Agency (UBA): IPCheM Experiences

39 August 29th 2018 | ISES-ISEE (Ottawa, Canada)

2) The German POP-Dioxin Database German Environment Agency (UBA): IPCheM Experiences


• Since 1991: compile, document, and evaluate data from monitoring programs at Government and Federal State level

• Data on dioxins and other POPs managed in a harmonized way including specific metadata (reason of investigation, location, sampling, analysis, and administrative aspects)

• Analytical data is stored as congeners. Calculation of toxicity equivalents (TEQ) can be updated or compared between different approaches.

3) Database on Pharmaceuticals in the Environment German Environment Agency (UBA): IPCheM Experiences


Sour

ce: d

jaha

n / F

otol

ia.c

om

• Result of comprehensive literature review (1981-2013): 1,016 original publications and 150 reviews

• Data on observed environmental concentrations of human and veterinary pharmaceuticals worldwide

• Systematic database on substances in surface water, groundwater, drinking water, manure, soil, and other environmental matrices

Conclusions and Outlook German Environment Agency (UBA): IPCheM Experiences


• IPCHEM participation helps in fully tapping the value of data for science and policy-making by putting them into a broader context and making them widely accessible.

• Timely access for policy makers and regulatory agencies to sound monitoring data

• Increasing international visibility of own activities is a key benefit.

DB on Pharmaceuticals in the Environment updated in 2018 (approx. 20.000 new entries)

Future contributions to IPCHEM are i. a. indoor air monitoring data of the German

Environmental Survey (GerES) and from HBM4EU.

IPCHEM: The reference platform for chemical monitoring data in Europe

A unique and reference access point for searching, accessing, retreiving chemical occurence data in different media EU and beyond

Developed as distributed infrastructure Strategy, user requirements, Data Policy and governance defined in collaboration with IPCHEM partners Providing hosting facilities for orphan data and research data Improving quality, comparability, standardisation of chemical data and metadata Handling heterogeneity of data sources, formats and accessibility regimes Promoting and, where possible, implementing, the overarching principles of free, full, open and timely access to

chemical monitoring data and interoperability with other existing relevant information systems and web services Facilitating assessments Streamlining data reporting

https://ipchem.jrc.ec.europa.eu/

IPCHEM – Driving Data & Knowledge Sharing

Enables Risk assessment of combination effects; Early warning system; Alert system between environment and food; Correlation of assessments

Improves Risk assessment; Prioritisation of chemicals; Validation of exposure and

deposition models; Policy effectiveness evaluation; State of environment evaluation

Saves Resources for data collections and data

storing; Burden for reporting;

The benefits of using IPCHEM

IPCHEM – Driving Data & Knowledge Sharing

Scientific coordinator:

• Stelios Kephalopoulos (F.7)

Technical coordinator:

• Silvia Dalla Costa (B.6)

Developing and support team:

• Alberto Cusinato (B.6)

• Roberto Sgnaolin (B.6)

• Vittorio Reina (F.2)

• Dorelia Lipsa (F.2)

• Otmar Geiss (F.2)

• Mariana Valerio (F.2)

The JRC’s IPCHEM Team Supervisors:

• Guy Van Den Eede (HoU F.7)

• Arnd Hoeveler (HoU F.2)

• Maurice Whelan (HoU F.3)

• Alessandro Annoni (HoU B.6)

Other contributing JRC Units:

• Nick Nicholson (F.1)

• Clemens Wittwehr (F.3)

• Stephanie Bopp (F.3)

• A. Pistocchi (D.2)

Please contact us:

[email protected]

mailto:[email protected]




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