the effect of atypical versus typical antipsychotics on ... leon2006).pdf¢  antipsychotic...

Eur Arch Psychialry Clin Neurosci (2006)

ORIGINAL PAPER

Jose de Leon

DOl 10.1007/s00406-006-0705-z

The effect of atypical versus typical antipsychotics on tardive dyskinesia Anaturalistic study

Recrived: 3t May 20061 ACupted: 18 October 20061 Published onli~ 5 Decembrr 2006

• Abstract Objective The aim was testing whether atypical antipsychotics (versus typicals) were associ- ated with less risk of tardive dyskinesia (TO) in 516 severely mentally ill patients. Methods The sample included 11% (57/516) with no exposure before current treatment wilh atypicals; 9% (48/516) with prior and current treatment with atypicals but no exposure to typicals; 18% (94/516) with lifetime exposure to typi- cals for

Table 1 Prevalen(es and 45 years, current antipsychotic and anticholinergic Ireatmenl and a polymorphic variation in the giutathione-S-transferase MI; 121 affecting the categorical variable measuring atypical exposure.

Results

The prevalence of TO was 5% in previously naive patients, 19% in those exposed only to atypicals, 19% in those with typical exposure of

When severe TD was examined in 162 patients with TD, the patients only on atypicals did not appear to have a better profile. The prevalence of severe TO was 0% (0/3) in those previously naive, 56% (5/9) in those with only atypical exposure, 28% (5118) in those with typical exposure for

those exposed only to atypicals, 6 years for those with typical exposure of