The Contact Allergen The Contact Allergen Replacement DatabaseReplacement Database

James A. Yiannias MDJames A. Yiannias MDAssociate Professor of Associate Professor of

DermatologyDermatology

Mayo Clinic ScottsdaleMayo Clinic Scottsdale

Purpose

To facilitate antigen avoidance Database generates list of skin care

products free of patient’s known allergens > 1,500 U.S. skin care products

Utility of Database

Consider a patient who is patch test sensitive to fragrance mixfragrance mix

Patient has been educated how to avoid fragrance, yet...

Eczema persists since patient didn’t realize – Cinnamic alc. & Balsam of PeruCinnamic alc. & Balsam of Peru = Fragrance– Unscented & fragrance free products don’t

assure elimination of fragrance cross-reactors

How CARD Helps…

CARD recognizes cross-reactions & synonyms and – generates a comprehensive list of skin

care products free of all fragrance like antigens!

Another eg: Utility of CARD

Patient is imid urea & quat-15 sensitive Allergen avoidance reviewed Patient’s eczema persists--

Pt didn’t realize that DMDM-Hydantoin should be avoided

Database recognizes cross-reactions & deletes all products containing formaldehyde releasers

Products in Database

Soaps, Shampoos, Conditioners Moisturizers Sunscreens Make-ups All prescription topicals in PDR All OTC topicals in OTC PDR

How Products Were Chosen

Hypoallergenic skin care product lines (eg. Aveeno, Almay, many others)

Large companies with widely available products

Database Maintenance

All product formulations are updated continuously

Products with formulas > 1 year are deleted

Database Clinical Usage

In use clinically at Mayo Clinic for 6 years and by American Contact Dermatitis Society Members for more than 3 years

Broad patient and physician acceptance / endorsement

How to use CARD …next 7 slides

www.contactderm.orgwww.contactderm.org

CARDCARD