the central nervous system central nervous system – the brain and spinal cord directional terms...
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The Central Nervous System
• Central nervous system – the brain and spinal cord
• Directional terms unique to the CNS• Rostral – toward the nose
• Caudal – toward the tail
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Embryonic Development of the Brain
Figure 13.2a-e
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Embryonic Development of the Brain
Figure 13.2a-e
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Embryonic Development of the Brain
Figure 13.2a-e
QuickTime™ and aTIFF (LZW) decompressor
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Embryonic Development of the Brain
Figure 13.2a-e
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Embryonic Development of the Brain
• Brain arises from the rostral part of the neural tube
• Three primary brain vesicles in 4-week embryo• Prosencephalon – the forebrain
• Mesencephalon – the midbrain
• Rhombencephalon – the hindbrain
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Embryonic Development of the Brain
• Secondary brain vesicles• Prosencephalon
• Divides into telencephalon and diencephalon
• Mesencephalon – remains undivided
• Rhombencephalon • Divides into metencephalon and myelencephalon
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Embryonic Development of the Brain
• Structures of the adult brain• Develop from secondary brain vesicles
• Telencephalon the cerebral hemispheres
• Diencephalon thalamus, hypothalamus, and epithalamus
• Metencephalon pons and cerebellum
• Myelencephalon medulla oblongata
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Embryonic Development of the Brain
• Brain stem includes:• The midbrain, pons, and medulla oblongata
• Ventricles • Central cavity of the neural tube enlarges
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Embryonic Development of the Brain
• Brain grows rapidly, and changes occur in the relative position of its parts• Cerebral hemispheres envelop the diencephalon
and midbrain
• Wrinkling of the cerebral hemispheres • More neurons fit within limited space
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Brain Development from Week 5 to Birth
Figure 13.3a-d
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Basic Parts and Organization of the Brain
• Divided into four regions• Cerebral hemispheres
• Diencephalon
• Brain stem: midbrain, pons, and medulla
• Cerebellum
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Basic Parts and Organization of the Brain
Figure 13.4
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Basic Parts and Organization of the Brain
• Organization • Centrally located gray matter• Externally located white matter• Additional layer of gray matter external to white
matter• Due to groups of neurons migrating externally
• Cortex – outer layer of gray matter• Formed from neuronal cell bodies• Located in cerebrum and cerebellum
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Basic Parts and Organization of the Brain
Figure 13.5
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Ventricles of the Brain
• Expansions of the brain’s central cavity
• Filled with cerebrospinal fluid
• Lined with ependymal cells
• Continuous with each other
• Continuous with the central canal of the spinal cord
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Ventricles of the Brain
• Lateral ventricles – located in cerebral hemispheres• Horseshoe-shaped from bending of the cerebral
hemispheres
• Third ventricle – lies in diencephalon • Connected with lateral ventricles by
interventricular foramen
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Ventricles of the Brain
• Cerebral aqueduct – connects 3rd and 4th ventricles
• Fourth ventricle – lies in hindbrain• Connects to the central canal of the spinal cord
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Ventricles of the Brain
Figure 13.6a, b
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Protection of the Brain – Cerebrospinal Fluid (CSF)
• Provides a liquid cushion for the brain and spinal cord
• The brain “floats” in CSF
• Formed in choroid plexuses in the brain ventricles
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Protection of the Brain – Cerebrospinal Fluid (CSF)
Figure 13.27a
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Protection of the Brain – Cerebrospinal Fluid (CSF)
Figure 13.27b
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Protection of the Brain – Blood-Brain Barrier
• Prevents most blood-borne toxins from entering the brain• Impermeable capillaries
• Not an absolute barrier• Nutrients such as oxygen pass through
• Allows alcohol, nicotine, and anesthetics through