Taha Ahmed TahaStudent At Biotechnology Program, Ain Shams UNIV. 2014

Founder Of: Biotechnology For All

Trainee At: The National Research Center

Team Member: AL Khwarizmi Center for Bioinformatics

RibosomesProtein Synthesis Machinery

The Amazing

Ribosomes at first: observed in 1950

by Romanian cell biologist “George

Emil Palade” using an electron

microscope.

Prokaryotic Ribosomes Eukaryotic Ribosomes

• Prokaryotic ribosomes arearound 20 nm (200 Å) indiameter and are composedof 65% rRNA and 35%ribosomal proteins.

Eukaryotic ribosomes arebetween 25 and 30 nm(250– 300 Å) in diameterwith an rRNA to proteinratio that is close to 1.

Also Found in Mitochondria.

What is The Ribosomes ?

It’s A Large Molecular Machine !!

Large Molecular MachineConsists of two subunits.

Small Subunit:

mRNA Reader

large subunit:

which joins amino acids to

form a polypeptide chain.

Site of Biological Protein

SynthesisMechanism Of Protein Synthesis

Location

References: - http://en.wikipedia.org/wiki/Ribosome

http://www.britannica.com/EBchecked/topic/502164/ribosome

http://www.biology4kids.com/files/cell_ribos.html

http://biology.about.com/od/cellanatomy/p/ribosomes.htm

- http://www.rcsb.org/pdb/101/motm.do?momID=121

http://www.rcsb.org/pdb/101/motm.do?momID=10

http://bscb.org/learning-resources/softcell-e-learning/ribosome/

- http://www.nature.com/scitable/definition/ribosome-194

http://www.bbc.co.uk/schools/gcsebitesize/science/add_ocr_gate

way/living_growing/moleculesrev1.shtml

External Links:

https://www.youtube.com/watch?v=1fiJupfbSpg

http://learn.genetics.utah.edu/content/molecules/centraldogma/

Protein folding

http://en.wikipedia.org/wiki/Protein_folding

https://www.youtube.com/watch?v=yZ2aY5lxEGE

https://www.youtube.com/watch?v=qBRFIMcxZNM

http://www.nature.com/horizon/proteinfolding/background/import

ance.html

Ribozyme

https://en.wikipedia.org/wiki/Ribozyme

https://www.youtube.com/watch?v=5KLajRMCLB4

Any Question ?!