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TRANSCRIPT
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Thank you for viewing this presentation.
We would like to remind you that this
material is the property of the author.
It is provided to you by the ERS for your
personal use only, as submitted by the
author.
2016 by the author
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ASSESSMENT
OF
LUNG PARENCHYMAL ABNORMALITIES
Christian B. Laursen, MD, PhD, Clin Ass Prof
Department of Respiratory Medicine, Odense University Hospital, Denmark
Mail: [email protected]
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Conflict of interest disclosure
I have no real or perceived conflicts of interest that relate to this presentation.
This event is accredited for CME credits by EBAP and EACCME and speakers are required to disclose their potential conflict of interest. The intent of this disclosure is not to prevent a speaker with a conflict of interest (any significant financial relationship a speaker has with manufacturers or providers of any commercial products or services relevant to the talk) from making a presentation, but rather to provide listeners with information on which they can make their own judgments. It remains for audience members to determine whether the speaker’s interests, or relationships may influence the presentation. The ERS does not view the existence of these interests or commitments as necessarily implying bias or decreasing the value of the speaker’s presentation. Drug or device advertisement is forbidden.
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To do list
Interstitial Lung Diseases
Fluid overload/heart failure
Pneumonia
Lung tumours
Pulmonary emboli
- how to distinguish from infectious consolidation?
- does ultrasound have a role given the widespread availability of
CTPA?
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Lecture aims
Considerations prior to scanning
- Setting
- Preparation
- LUS protocol
Interstitial syndrome
- The B-line and interstitial syndrome
- Cardiogenic pulmonary edema
- Interstitial lung diseases
- Differentiation between IS causes
Lung parenchymal pathology
- Lung consolidation (e.g. pneumonia, PE, contusion)
- Lung atelectasis
- Lung tumor
- Differentiation between causes of lung parenchymal pathology
Clinical impact
- Does ultrasound have a role given the widespread availability of CTPA?
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CONSIDERATIONS PRIOR TO SCANNING
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CONSIDERATIONS PRIOR TO SCANNING
Setting
Preparation
- Appropriate transducer selection
- Appropriate preset selection
US protocol
- Focused examination
- Diagnostic examination
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SETTING MATTERS
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ACUTE RESPIRATORY SYMPTOMS IN THE ED
1. Decompensated HF
2. Pneumonia
3. COPD exacerbation
4. Thromboembolic disease (PE / DVT)
5. Other
Ray P et al. Acute respiratory failure in the elderly: Etiology, emergency diagnosis and prognosis. Critical care 2006;10:R82.
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“Chronic” Respiratory symptoms
1. Malignancy
2. Interstitial lung disease
3. COPD / Asthma
4. TB / chronic infection
5. Other
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PREPARATION OF THE US MACHINE
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APPROPRIATE TRANSDUCER SELECTION
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APPROPRIATE PRE-SET SELECTION
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US PROTOCOLS
Focused LUS
Diagnostic LUS
Advanced LUS
UL guided procedures
eFAST
FATE
FASH
RUSH
….
Volpicelli et al. International evidence-based recommendations for point-of-care lung ultrasound. Intensive Care Med. 2012;38:577-91
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DIAGNOSTIC VS. FOCUSED APPROACH
Diagnostic LUS Pulmonary edema
Lung parenchymal pathology
-Pulmonary embolism
-Pneumonia
-Atelectasis
-Lung contusion
Pleura effusion
-Simple effusion
-Complex effusion
Pneumothorax
Malignancy
Thickened parietal pleura
Trapped lung
Diaphragmatic paresis/ paralysis
Rib fracture
Interstitial lung disease
Chest wall pathology
Mediastinal pathology
Assessment of lymph nodes
………..
Focused LUS Pulmonary edema: yes/no?
Lung parenchymal pathology: yes/no?
-Pulmonary embolism
-Pneumonia
-Atelectasis
-Lung contusion
Pleura effusion: yes/no?
-Simple effusion
-Complex effusion
Pneumothorax: yes/no?
Malignancy
Thickened parietal pleura
Trapped lung
Diaphragmatic paresis/ paralysis
Rib fracture
Interstitial lung disease
Chest wall pathology
Mediastinal pathology
Assessment of lymph nodes
………..
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DIAGNOSTIC THORACIC / LUNG US
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FLUS EXAMINATION TECHNIQUE
Different approaches depending on clinical setting / tradition:
-1 zone assessed
-2 zones assessed
-4 zones assessed
-14 zones assessed
-…. zones assessed
Volpicelli et al. International evidence-based recommendations for point-of-care lung ultrasound. Intensive Care Med. 2012;38:577-91
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FLUS SCANNING ZONES
Laursen CB et al. Point-of-care ultrasonography in patients admitted with respiratory symptoms: a single-blind, randomised controlled trial. Lancet Respir Med 2014;2(8):638-46
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FLUS – how to do it
Focused questions:
- Signs of pneumothorax (yes / no)
- Pleural effusion present (yes / no)
- Signs of pulmonary edema present (yes/no)
- Signs of parenchymal pathology present (yes/no)
Noble VE, Nelson BP. Manual of Emergency and Critical Care Ultrasound: Cambridge University Press, 2011.
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FLUS – how to do it
Focused questions:
- Signs of pneumothorax (yes / no)
- Pleural effusion present (yes / no)
- Signs of pulmonary edema present (yes/no)
- Signs of parenchymal pathology present (yes/no)
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FLUS – how to do it
Focused questions:
- Signs of pneumothorax (yes / no)
- Pleural effusion present (yes / no)
- Signs of pulmonary edema present (yes/no)
- Signs of parenchymal pathology present (yes/no)
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FLUS – how to do it
Focused questions:
- Signs of pneumothorax (yes / no)
- Pleural effusion present (yes / no)
- Signs of pulmonary edema present (yes/no)
- Signs of parenchymal pathology present (yes/no)
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FLUS – how to do it
Focused questions:
- Signs of pneumothorax (yes / no)
- Pleural effusion present (yes / no)
- Signs of pulmonary edema present (yes/no)
- Signs of parenchymal pathology present (yes/no)
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INTERSTITIAL SYNDROME (IS)
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DEFINITION OF THE B-LINE
“B-lines are defined as discrete laser-like
vertical hyperechoic reverberation
artefacts that arise from the pleural line
(previously described as ‘‘comet tails’’),
extend to the bottom of the screen without
fading, and move synchronously with lung
sliding”
Volpicelli et al. International evidence-based recommendations for point-of-care lung ultrasound.
Intensive Care Med. 2012;38:577-91
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MULTIPLE B-LINE ARTEFACTS
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MULTIPLE B-LINE ARTEFACTS
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THE B-LINE ARTEFACT
Visible when the density
of the interstitial lung tissue
has been increased
(e.g. pulmonary edema, lung fibrosis)
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B-LINE PATTERNS
B-lines in pathology – 2 patterns:
- Focal / localized multiple B-lines
- Diffuse multiple B-lines: The interstitial syndrome
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INTERSTITIAL SYNDROME (IS)
Defined as:
- Multiple B-lines present (>2) in at
least 2 of the scanned anterior and
lateral zones on each side
- Posterior zones not included in
definition
Volpicelli et al. International evidence-based recommendations for point-of-care lung ultrasound. Intensive Care Med. 2012;38:577-91
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FOCAL B-LINES
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INTERSTITIAL SYNDROME
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INTERSTITIAL SYNDROME
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INTERSTITIAL SYNDROME
Causes in adults:
- Any disease causing diffuse
interstitial edema in the lungs
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INTERSTITIAL SYNDROME
Causes in adults:
- Cardiogenic pulmonary oedema
- Non-cardiogenic pulmonary oedema
- Interstitial lung diseases
- Viral pneumonia
- Bacterial pneumonia
- ARDS
- Acute Chest Syndrome
- Drowning / near-drowning
- Lung contusion
- ……
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INTERSTITIAL SYNDROME
Causes in adults:
- Cardiogenic pulmonary oedema
- Non-cardiogenic pulmonary oedema
- Interstitial lung diseases
- Viral pneumonia
- Bacterial pneumonia
- ARDS
- Acute Chest Syndrome
- Drowning / near-drowning
- Lung contusion
Not seen in:
- COPD Exacerbation
- Asthma Exacerbation
Pivetta E et al. Lung ultrasound-implemented diagnosis of acute decompensated heart failure in the Emergency Department - A SIMEU multicenter study. Chest 2015 Jul;148(1):202-10
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INTERSTITIAL SYNDROME
Causes in adults:
- Cardiogenic pulmonary oedema
- Non-cardiogenic pulmonary oedema
- Interstitial lung diseases
- Viral pneumonia
- Bacterial pneumonia
- ARDS
- Acute Chest Syndrome
- Drowning / near-drowning
- Lung contusion
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IS IN PATIENTS ADMITTED TO AN ED
Causes in adults:
- Cardiogenic pulmonary oedema
- Non-cardiogenic pulmonary oedema
- Interstitial lung diseases
- Viral pneumonia
- Bacterial pneumonia
- ARDS
- Acute Chest Syndrome
- Drowning / near-drowning
- Lung contusion
Pivetta E et al. Lung ultrasound-implemented diagnosis of acute decompensated heart failure in the Emergency Department - A SIMEU multicenter study. Chest 2015 Jul;148(1):202-10
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IS IN PATIENTS ADMITTED TO AN ICU
Causes in adults:
- Cardiogenic pulmonary oedema
- Non-cardiogenic pulmonary oedema
- Interstitial lung diseases
- Viral pneumonia
- Bacterial pneumonia
- ARDS
- Acute Chest Syndrome
- Drowning / near-drowning
- Lung contusion
Lichtenstein D et al. Relevance of lung ultrasound in the diagnosis of acute respiratory failure: the BLUE protocol. Chest. 2008 Jul;134(1):117-25.
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IS IN THE ICU WARD
Causes in adults:
- Cardiogenic pulmonary oedema
- Non-cardiogenic pulmonary oedema
- Interstitial lung diseases
- Viral pneumonia
- Bacterial pneumonia
- ARDS
- Acute Chest Syndrome
- Drowning / near-drowning
- Lung contusion
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IS IN THE OUH OUTPATIENT CLINIC
Causes in adults:
- Cardiogenic pulmonary oedema
- Non-cardiogenic pulmonary oedema
- Interstitial lung diseases
- Viral pneumonia
- Bacterial pneumonia
- ARDS
- Acute Chest Syndrome
- Drowning / near-drowning
- Lung contusion
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CARDIOGENIC PULMONARY EDEMA IN THE ED
Clinical examination
- Sens.: 85.3% (81.8-88.4%)
- Spec.: 90.0% (87.2-92.4%)
NT-pro-BNP
- Sens.: 85.0% (80.3-89.0%)
- Spec.: 61.7% (54.6-68.3%)
CXR
-Sens.: 69.5% (65.1-73.7%)
-Spec.: 82.1% (78.6-85.2%)
FLUS
-Sens.: 97.0% (95.0-98.3%)
-Spec.: 97.4% (95.7-98.6%)
Pivetta E et al. Lung ultrasound-implemented diagnosis of acute decompensated heart failure in the Emergency Department - A SIMEU multicenter study. Chest 2015 Jul;148(1):202-10
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CASE
68 year old female with severe COPD. Admitted with progressive dyspnoea and coughing. Symptoms had lasted 14 days. Possible fever.
Primary assessment: Auscultation: Prolonged expiration, wheezing. No murmurs. No edema or tenderness of the legs.
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CASE – FLUS patterns
Pattern 1 Pattern 2
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FLUS: IS PRESENT? YES/NO
Pattern 1 Pattern 2
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FLUS: IS PRESENT? YES/NO
Normal pattern IS pattern
Cardiogenic pulm. edema:
Excluded – COPD exa?
Cardiogenic pulm. edema:
Suspected
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INTERSTITIAL SYNDROME
How to differentiate between:
- Cardiogenic pulmonary oedema
- Non-cardiogenic pulmonary oedema
- Interstitial lung diseases
- Viral pneumonia
- Bacterial pneumonia
- ARDS
- Acute Chest Syndrome
- Drowning / near-drowning
- Lung contusion
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DIFFERENTIATION BETWEEN IS CAUSES
Zone pattern
Appearance of visceral pleura
Lung sliding
Pleural effusion
Consolidation
Lung pulse
Reassessment
Copetti R et al. Chest sonography: a useful tool to differentiate acute cardiogenic pulmonary edema from acute respiratory distress syndrome. Cardiovasc Ultrasound. 2008 Apr 29;6:16.
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DIFFERENTIATION BETWEEN IS CAUSES
Zone pattern:
- Gravidity dependent
- Spared areas
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DIFFERENTIATION BETWEEN IS CAUSES
Zone pattern:
- Gravidity dependent
- Spared areas
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DIFFERENTIATION BETWEEN IS CAUSES
Appearance of visceral pleura:
- Normal
- Abnormal
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DIFFERENTIATION BETWEEN IS CAUSES
Appearance of visceral pleura:
- Normal
- Abnormal
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DIFFERENTIATION BETWEEN IS CAUSES
Reassessment:
- Highly dynamic
- No change
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INTERSTITIAL LUNG DISEASES
ILD with ground glass opacity: B-lines in affected areas
ILD with honeycombing: Abnormal visceral pleura, +/- B-lines
Rare cystic lung diseases: Normal findings
Reissig A et al. Transthoracic Sonography of Diffuse Parenchymal Lung Disease. J Ultrasound Med. 2003;22:173-180 Sperandeo M et al. Transthoracic Ultrasound in the Evaluation of Pulmonary Fibrosis. Ultrasound Med Biol. 2009 May;35(5):723-9. Davidsen JR et al. Lung Ultrasound has Limited Value in Rare Cystic Lung Diseases. ATS 2016 Meeting abstract, C104
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LUNG PARENCHYMAL PATHOLOGY
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LUNG PARENCHYMAL PATHOLOGY
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FLUS VS. DIAGNOSTIC LUS
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FLUS VS. DIAGNOSTIC LUS
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LUNG PARENCHYMAL PATHOLOGY
LUS sonomorphology:
- Liver/organlike structure
- Hyperechoic
- Hypoechoic
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LUNG CONSOLIDATION: CXR VS. LUS
Chest X-ray:
Sensi.: 64.3% (95%CI: 51.9-75.4)
Speci.: 90.0% (95%CI: 83.2-94.7)
Lung ultrasound:
Sensi.: 81.4% (95%CI: 70.7-89.7)
Speci.: 94.2% (95%CI: 88.4-97.6)
Nazerian P et al. Accuracy of lung ultrasound for the diagnosis of consolidations when compared to chest computed tomography. Am J Emerg Med. 2015;33(6)620-5
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LUNG PARENCHYMAL PATHOLOGY
Characteristic US patterns:
Consolidations: Pneumonia, PE, contusion
Atelectasis: Compression, obstruction
Tumor: Malignant, benign
Uncharacteristic: -
Reissig A et al. Transthoracic Ultrasound of Lung and Pleura in the Diagnosis of Pulmomary Embolism: A Novel Non-Invasive Bedside Approach. Respiration 2003;70:441-452
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CASE
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PNEUMONIA
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PNEUMONIA
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PNEUMONIA
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PNEUMONIA DIAGNOSTIC ACCURACY
Lung ultrasound
- Sens.: 94% (92-96%)
- Spec.: 96% (94-97%)
- PLR: 16.8 (7.7-37.0)
- NLR: 0.07 (0.05-0.10)
Chavez et al. Lung ultrasound for the diagnosis of pneumonia in adults: a systematic review and meta-analysis. Respir Res 2014:23;15:50
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CASE
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COMPRESSION ATELECTASIS
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ATELECTASIS US PATTERN
Courtesy of Dr. Olav Petersen
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OBSTRUCTION ATELECTASIS
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OBSTRUCTION ATELECTASIS
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CASE
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FLUS FINDINGS IN ZONE L2
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PULMONARY EMBOLISM
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PULMONARY EMBOLISM
Joyner CR Jr et al. Reflected ultrasound in the detection of pulmonary embolism. Trans Assoc Am Physicians. 1966;79:262-77.
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PE DIAGNOSTIC CRITERIA
PE confirmed
Two or more typical lesions
Sensi.: 44.4%
Speci.: 98.7%
PPV: 97.4%
NPV: 62.1%
PE probable
One typical lesion and low grade
pleural effusion
Sensi.: 71.0%
Speci.: 94.9%
PPV: 93.8%
NPV: 75.1%
Mathis G et al. Thoracic Ultrasound for Diagnosing Pulmonary Embolism: A Prospective Multicenter Study of 352 Patients. Chest 2005;128:1531-1538
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PE DIAGNOSTIC ACCURACY
LUS for diagnosis of PE
Metaanalysis:
- Sens.: 80% (75-83%)
- Spec.: 93% (89-96%)
Niemann T et al. Transthoracic sonography for the detection of pulmonary embolism–a meta-analysis. Ultraschall Med 2009 30:150–156
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CASE
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LUNG CANCER
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LARGE LUNG CANCER IN UPPER LOBE
Laursen CB et al. Contrast Enhanced Ultrasound Guided Transthoracic Lung Biopsy. Am J Respir Crit Care Med. 2016 Jun 28. [Epub ahead of print]
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SARCOMA
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DIFFERENTIATION OF PARENCHYMAL PATHOLOGY
Reissig A et al. Transthoracic Ultrasound of Lung and Pleura in the Diagnosis of Pulmomary Embolism: A Novel Non-Invasive Bedside Approach. Respiration 2003;70:441-452
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SPOT THE CANCER(S)
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LUNG PARENCHYMAL PATHOLOGY
Pitfalls:
- Uncharacteristic pattern
- FLUS missing lesions
- LUS cannot “rule-out”
parenchymal pathology
- Malignancy
Help:
- Other forms of imaging
- Advanced lung ultrasound
- US-guided tissue sampling
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CLINICAL IMPACT
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PATIENTS WITH SUSPECTED PE
Need of additional of imaging?
- CT
- V/Q scintigrafi
- LUS
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PATIENTS WITH RESPIRATORY SYMPTOMS
Ultrasound
Need of additional of imaging?
- CT
- V/Q scintigrafi
- Advanced LUS
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WHOLE-BODY US APPROACH
Focused US assessment of:
- Lungs (FLUS)(PTX, IS, effusion, parenchymal path.)
- Heart (FCUS / FATE)(PE, HV strain, LV failure)
- Deep veins (LCU)(DVT)
Laursen CB et al. Focused sonography of the heart, lungs, and deep veins identifies missed life-threatening conditions in admitted patients with acute respiratory symptoms. Chest. 2013 Dec;144(6):1868-75
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CLINICAL IMPACT IN ED PATIENTS
Laursen CB et al. Point-of-care ultrasonography in patients admitted with respiratory symptoms: a single-blind, randomised controlled trial. Lancet Respir Med 2014;2(8):638-46
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IMPACT IN PATIENTS WITH SUSPECTED PE
Clinical assessment without US:
- Sensitivity 80.0%, specificity 96.7%
Whole-body US (deep veins, heart & lungs)
- Sensitivity 90.0%, specificity 86.2%
Clinical assessment with integrated US:
- Sensitivity 100%, specificity 95.3%
Nazerian et al. Accuracy of point-of-care multiorgan ultrasonography for the diagnosis of pulmonary embolism. Chest 2014 May;145(5):950-7 Laursen CB et al. Point-of-care ultrasonography in patients admitted with respiratory symptoms: a single-blind, randomised controlled trial. Lancet Respir Med 2014;2(8):638-46
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CLINICAL IMPACT IN CHILDREN
Substitution of CXR with LUS in children suspected of having
pneumonia:
-No cases of missed pneumonia
-No difference in adverse events
-38.8% reduction (95% CI, 30.0%-48.9%) in CXR use
Jones BP et al. Feasibility and Safety of Substituting Lung Ultrasonography for Chest Radiography When Diagnosing Pneumonia in Children: A Randomized Controlled Trial. Chest. 2016 Jul;150(1):131-8.
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Important “Side-effects”
Howard ZD et al. Bedside ultrasound maximizes patient satisfaction. J Emerg Med. 2014;46(1):46-53.
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Hope to see you in Odense for the ERS course in Thoracic Ultrasound!
Questions or comments?