TEST TASKS ON PHARMACOLOGYTO «MODULE – 2».

1. At a patient, with chronic heart failure during process of digitalization such symptoms as fatigue, nausea, disturbances of colour vision are developed. What agent is used for reduction of symptoms of intoxication?А. Naloxone**В. UnithiolС. BemegridD. DipyroximЕ. Atropine sulfate

2. To the patient with congestive heart failure cardiac glycoside , which is characterized by high bioavailability, high plasma protein binding, hepatic biotransformation, significant biotransformation was appointed. Define preparation.**А. DigitoxinВ. AdonisidС. CorglyconD. Convallaria tinctureЕ. Strophantin

3. To the patient with cardiogenic shock was given a non-glycoside cardiotonic. Specify, what exactly preparation was entered to the patient.A. Caffeine **В. DobutamineС. CordiamineD. EthimisolЕ. Bemegride

4. To specify cardiac glycoside of rapid action, applied at acute cardiac insufficiency.А. AdonisidВ. Herba of Adonis vernalisС. DigitoxinD. Lantosid**Е. Strophantine

5. To the patient with chronic cordial disease prescribed digitoxin. However, in a week after taking the drug in the patient appeared symptoms of intoxication by this medicine. What phenomenon was it?A. IdiosyncrasyB. Functional cumulationC. ToleranceD. Tachyphylaxis**E. Material cumulation

6. To the patient an agent of Convallaria that characterized by quick and short cardiotonic action; used by intravenous injection only; doesn’t cumulate is prescribed. Define the drug.A. DigitoxinB. Infusion of Adonis herb**C. CorglyconD. CelanidE. Strophanthine

7. Point out the strategy of cardiac glycoside dosing after achievement of therapeutic concentration in blood and development of the effect.A. Single dose is increased in 2 timesB. Single dose is increased in 1.5 times

C. Single dose is not changedD. The highest therapeutic dose is given**E. The supporting dose is given

8. In the patient against a background of taking digitoxin appeared bigeminia, acute muscular weakness, diarrhea, retching, visual impairment. What drugs can weaken symptoms of intoxications?A. Preparations of Mg2+

B. Preparations of Ca2+

**C. Preparations of K+

D. Preparations of Fe3+

E. Preparations of Na+

9. What pharmacological effect does cardiac glycosides in therapeutic phase of action cause?A. Positive chronotropic effect**B. Positive inotropic effectC. Negative tonotropic effectD. Negative batmotropic effect

E. Positive dromotropic effect 10. To the patient with chronic cardiac insufficiency and edemata prescribed digoxin. What cause cardiotonic effect of cordial glycosides?A. Refectory influence on heartB. Stimulation of К+, Na+- АТP-ase**C. Increasing of Ca2+ content in cardiomyocytesD. Decreasing of Ca2+ content in cardiomyocytesE. Indirect activation of adrenoreceptors

11. Indications for prescribing cordial glycosides:A. Chronic cardiac insufficiencyB. Acute cardiac insufficiencyC. Atrial flutterD. Atrial fibrillation **E. All named

12. Show changes of hemodynamics after taking cardiac glycosides.A. Increasing of impact and minute volume**B. Decreasing of impact and minute volumeC. Increasing of impact and decreasing of minute volumeD. Increasing of minute and decreasing of impact volumeE. Impact and minute volumes do not change

13. To the patient with chronic cordial insufficiency prescribed digitoxin, but improvement came only in a weak. How to explain this latent period?A. Poor absorption of the drug in intestineB. Deficient dose of digitoxin**C. Strong link between digitoxin and blood proteinsD. Diuresis improvementE. Deficient quantity of carbohydrates in the food

14. The patient has acute cardiac insufficiency with concomitant vegetative neurosis. What medicine should be prescribed to the patient?

A. DigoxinB. Corglicon**C. AdonisidD. DigitoxinE. Cordigit

15. Absolute contraindication for prescribing cordial glycosides is:

A. Chronic cordial insufficiency ** B . Glycoside's intoxicationC. Acute cardial insufficiencyD. Atrial flutterE. Atrial fibrillation

16. To the patient with acute cardiac insufficiency with intolerance to cardial glycosides is prescribed. What mechanism of its action?**A. Blockade of К+, Na+- АТP-aseB. Complexation with membrane phospholipidsC. Stimulation of β1-adrenoreceptorsD. Inhibition of phosphodiesterase activityE. Rising tonus of n. vagus

17. To the patient with chronic cordial insufficiency prescribed cordial glycoside, which has lipophilic and hydrophilic abilities, medium cumulation, takes effect in 1-2 hours after taking the drug peroral. Name the drug.A. Strophanthine**B. DigoxinC. DigitoxinD. Cordigit E. Corglycon

18. What drug can be used for strophanthine substitution in patient with acute cardiac insufficiency?A. AdonosidB. Digitoxin**C. CorglyconD. AnaprilinE. Cardiovalen

19. In complex treatment of chronic cardiac insufficiency were used digoxin and furosemide. Soon appeared symptoms of glycosides intoxication. What may cause it?A. Hyperkalemia**B. HypokalemiaC. HypocalcemiaD. HypercalcemiaE. Hyponatremia

20. The patient has a ventricular arrhythmia. Cardiac rhythm has normalized after infusion of antiarrhythmic drug with local anaesthetic activity. What drug was used?**A. Lidocain

A. AnestesinB. VerapamilC. Panangin

E. Anaprilin

21. The patient has a bradyarrythmia and hypertensive disease. What drug should be prescribed?

A. ClophelinB. **Platyphylline hydrotartrateC. PapaverinD. ReserpinE. Methyldopa

.

22. During treatment of atrial flutter, in patient bronchospasm, dyspnoe has occurred. What antiarrhythmic drugs could cause this complication?

A. **AnaprilinB. AimalinC. NiphedipinD. VerapamilE. Novocainamid

23. To the patient with atrial flutter novocainamide (procainamide) was prescribed. What is the mechanism of this drug action?

A. Adrenoreceptors` blockadeB. Adrenoreceptors` stimulationC. **Membrane-stabilizingD. Blockade of K+-canalsE. Blockade of Ca2+-canals

24. Find out an antiarrhythmic drug with negative ino- and chronotropic effects.

A. AtropinB. **VerapamilC. IsadrinD. DobutaminE. Lidocain

25. In patient with hypertensive disease an attack of the atrial flutter has appeared. Name the medicine to stop the atrial flutter attack.

A. StrophantineB. Sustac-forteC. Potassium chlorideD. **AnaprilinE. Lidocain

26. Woman with toxic goiter complains of increasing of heart rate. What drug should be prescribed to normalize heart rate?

A. SalbutamolB. IsadrineC. **AnaprilinD. AdrenalineE. Pentamin

27. For the treatment of tachyarrhythmia verapamil was prescribed. What is the mechanism of antiarrhythmic effect of the medicine?

A. Activates β1-adrenoreceptorsB. Blocks M-cholinoreceptorsC. Direct membrane-stabilizing effectD. Blocks β-adrenoreceptorsE. **Blocks Ca2+-chanals

28. To the patient with atrial flutter an antiarrhythmic drug with antiepileptic effect was prescribed. Name the medicine.

A. Anaprilin (Propranolol)B. VerapamilC. NiphedipinD. Verapamil E. **Diphenin (Phenytoin)

29. Choose K+-containing antiarrhythmic drug.A. Diphenin (Phenytoin)B. MetoprololC. VerapamilD. NovocainamidE. **Panangin

30. In patient with myocardial infarction a tachycardia has occurred. Name the first aid drug.

A. **LidocainB. AnaprilinC. VerapamilD. NiphedipinE. Novocainamid

31. What drug should be prescribed in bradyarrhythmia?A. NovocainamidB. **AtropinC. VerapamilD. ChinidinE. Atenolol

32. What antiarrhythmic drug should be prescribed in case of digitalis intoxication?

A. DigoxinB. CorglyconC. StrophantinD. **PananginE. Celanid

33. Name the medicine, which corresponds to the next description: cinchona tree’s alkaloid, depress automatism, conductivity, excitability and contractility, has analgesic, febrifugal and anaesthetic activity.

A. LidocainB. AmiodaronC. NifedipineD. MetoprololE. **Qinidin

34. Choose cradioselective β-adrenergic antagonist, used for tachyarrhythmia.

A. AnaprilinB. VerapamilC. **MetoprololD. NovocainamidE. Amidaron

35. To the patient with diagnosed atrial tachycardia the doctor has prescribed a medicine that is a cardioselective blockers of the Ca2+-chanals. Name the medicine.

A. PananginB. AmiodaronC. NiphedipinD. **VerapamilE. Qinidin

36. In a 45-years-old atrial flutter and hypertensive disease were diagnosed. What drug should be prescribed to treat both dysfunctions?

A. StrophantinB. Sustak-forteC. Potassium chlorideD. **Anaprilin

E. Lidocain

37. To the patient with stenocardia attack the sustac-forte prescribed. At first the improvement was observed, but soon stenocardia attack has come back. What is the reason of the effect dropping?

A. IdiosyncrasyB. CumulationC. SensitizationD. ** ToleranceE. Dependence

38. In patient with stenocardia after taking of the antianginal drug bronchospasm appeared. What medicine may provoke one?

A. SustacB. Nitroglycerine (Glyceryl nitrate)C. ** Anaprilin (Propranolol)D. NiphedipinE. Dipyridamol

39. Tocopherol was used in complex therapy of ischemic heart disease. What effect of preparation is main in this situation?A. SpasmolyticB. HypotensiveC. **Antioxidant D. Increasing the delivery of oxygen to myocardiumE. Positive inotropic

40. To the patient with stenocardia a medicine as aerosol prescribed. After taking of the antianginal drug chest pain disappeared, but the patient complained on acute headache. What remedy the patient used?

A. **NitroglycerineB. AnaprilinC. MetoprololD. ValidolE. Verapamil

41. Patient suffers from ischemic heart disease and hypertension. Choose the medicine for ischemic heart disease treatment that will decrease blood pressure as well.

A. DipyridamolB. ** MetoprololC. CarbocromenD. ValidolE. Panangin

42. Patient addressed to the doctor because of strong headache, occurring after taking nitroglycerine. Rising of the intracranial pressure was revealed. What remedy do you recommend for the patient to remove stenocardia attack?

A. VerapamilB. SustacC. ** MolsidominD. EnalaprilE. Captopril

43. In the patient an acute stenocardia attack occurred. What drug should be used?

A. Isosorbide dinitrateB. Sustac

C. TrinitrolongD. Nitrosorbit**E. Nitroglycerine

44. To the patient with ischemic heart disease a nitrovasodilator trinitrolong was prescribed. Show the mechanism of the drug’s effect.

A. Blocks Ca2+-canalsB. Blocks β-adrenoreceptorsC. **Dilates veins and arteries, decreases pre- and afterload of the heartD. Blocks α- adrenoreceptorsE. Blocks α,β-adrenoreceptors

45. Patient with ischemic heart disease takes verapamil. What is the mechanism of action of this drug?

A. Blockade of β-adrenoreceptors

B. Blockade of α- adrenoreceptorsC. Blockade of Ca2+-canalsD. Blockade of K+-canalsE Activation of β-adrenoreceptors

46. In complex treatment for ischemic heart disease a medicine that increases oxygen delivery to the heart was prescribed. Name the drug.A. ** CarbocromenB. StrophantinC. NootropilD. Ascorbic acidE.Digitoxin

47. Name the drug, which is used for rapid relief of stenocardia attack with intolerance of nitrates.

A. TrinitrolongB. MolsidominC. **DipiridamolD. NitroglycerineE. Isosorbide mononitrate

48. Patient with stenocardia has concomitant bronchial asthma. What medicine needs to be prescribed for prophylaxis of stenocardia attack?A. Adrenaline hydrochloride **B. NitroglycerineC. Anaprilin D. Isadrine E. Ephedrine hydrochloride

49. Choose the drug with the next properties: irritates receptors of the mucosa of oral cavity, dilates coronary vessels and improve the bloodflow.A. AtenololB. NitroglycerineC. Anaprilin**D. ValidolE. Verapamil

50. To the patient with ischemic heart disease the drug that is also effective for hypertension and arrhythmia treatment prescribed. It’s adverse effects are following: hypotension, bradycardia, weakness, constipation. Name the medicine.A. Isosorbide mononitrateB. NitroglycerineC. MolsidominD. Validol**E. Verapamil

51. Point out the drug from the group of organic nitrates that is used for the prevention of stenocardia attack?A. Isosorbide dinitrateB. MetoprololC. VerapamilD. MolsidominE. Carbocromen

52. What antianginal drug causes reflective tachycardia?**A. Isosorbide mononitrateB. MetoprololC. VerapamilD. Anaprilin

E. Sotalol

53. To the patient with ischemic heart disease an antianginal drug, which blockades β1-adrenoreceptors, reduces frequency and strength of the cardiac contractions, decreases cardiac workload, was prescribed. Name the drug.A. NitroglycerineB. Molsidomin**C. AtenololD. NifedipinE. Verapamil

54. What antianginal drug diminishes cardiac oxygen demand, improves myocardial blood supply and belongs to the group of sidnonimins?A. Trinitrolong**B. MolsidominC. DipiridamolD. NifedipinE. Diltiazem

55. In patient at combined therapy of congestive heart failure by digitoxin and furosemide an acute muscular weakness developed. What electrolytic disturbances can be revealed in blood?A. HypercalcemiaB. HypokalemiaC. HypocalcemiaD. HypokalemiaE. None

56. In patient with congestive heart failure and peripheral oedema the increased level of aldosterone in blood is revealed. What diuretic is the most appropriate?A. HydrochlorothiazideB. TriamterenC. Diacarb**D. SpironolactoneE. Furosemide

57. To the patient with a burn shock diuretic, which increases osmotic pressure of the blood and acts along the whole nephron was administrated. Name the diuretic.A. Furosemide**B. MannitC. DichlothiazideD. DiacarbE. Spironolactone

58. Into admitting department the patient with alcoholic intoxication delivered. The doctor decided to conduct enforced diuresis for the patient. What diuretic should be used?**A. FurosemideB. SpironolactoneC. DiacarbD. EuphillineE. Amilorid

59. What diuretic among listed below should be prescribed for the treatment of cerebral edema?A. Cyclomethiazide**B. FurosemideC. OxodolinD. TriamterenE. Spironolactone

60. To the patient with open-angle glaucoma diacarb (acetazolamide) prescribed. Show the mechanism of decreasing of intraocular pressure.A. Blockade of Na+ reabsorption in canaliculus of nephronB. Increasing of Na+ reabsorption in canaliculus of nephronC. Increasing of the plasma osmotic pressure **D. Inhibition of carbonic anhydrase of the ciliary’s bodyE. Inhibition of aldosterone synthesis in adrenal glands

61. What of the listed diuretics will not show diuretic effect in patients with Addison’s disease?A. TriamterenB. FurosemideC. HypothiazideD. Etacrinic acid**E. Spironolactone

62. What diuretic should be prescribed for the patient, which is being treated with cardiac glycosides, to retain K+ in the organism?A. HypothiazideB. Furosemide**C. TriamterenD. DiacarbE. Clopamide

63. Choose uricosuric that inhibits synthesis of the uric acid.A. TriamterenB. UralitC. Hydrochlorothiazide**D. AllopurinolE. Amilorid

64. Which diuretics from listed below should be prescribed to the patient with primary aldosteronism?**A. SpironolactoneB. FurosemideC. HypothiazideD. TriamterenE. Mannitol

65. In patient the pulmonary edema has appeared. What diuretic should be used for the first aid?**A. Furosemide

B. TriamterenC. Verospiron (Spironolacton)D. AmiloridE. Euphilline

66. Patient with hypertension has been taken hydrochlorothiazide for a long time. Soon the gout attack has appeared. What could cause this disturbance?A. Hypochloremic alkalosis**B. HyperuricemiaC. HyponatremiaD. HypokalemiaE. Decreasing of the circulated blood volume

67. Point out K+-sparing diuretic.A. FurosemideB. Diacarb**C. TriamterenD. ClopamideE. Etacrine acid

68. Choose the diuretic that acts through the increasing of renal blood flow and glomerular filtration rate.A. HydrochlorothiazideB. FurosemideC. Clopamide**D. AminophillineE. Spironolactone

69. To diminish edemata the doctor prescribed a diuretic. After a while hypokalemia has appeared in patient. What medicine could cause hypokalemia?**A. Etacrinic acidB. SpironolactoneC. TriamterenD. TheophyllineE. All

70. To the patient in complex therapy of hypertension hydrochlorothiazide has been prescribed. What is the mechanism of its action?A. Blockade of Ca2+-chanalsB. Increasing of angiotensin II formation**C. Increasing of Na+-ions and water excretionD. Decreasing of Na+-ions and water excretionE. Carbonic anhydrase blockade

71. To a patient with the edema the preparation that does not act on electrolytes’ reabsorption is appointed. Specify the medication.A. Furosemide**B. MannitC. SpironolactoneD. TriamterenE. Diacarb (Acetazolamide)

72. At the patient with hypertension the increased level of renin in plasma is revealed. What hypotensive agent is wise to give for the treatment of patient?A. PapaverineB. Clophelin (Clonidine)C. Magnesium sulfate**D. EnalaprilE. Prazosin

73. To the patient with hypertensive emergency (crisis) clonidine intravenously was given. What mechanism underlies antihypertensive action of clonidine? A. Direct miotropic action on the blood vessels B. Blockage of the peripheral α-adrenoreceptors**C. Stimulation of the central presynaptic α2-adrenoreceptorsD. Blockage of N-cholinoreceptors of the sympathetic ganglia E. Blockage of β- adrenoreceptors

74. The patient suffers from atrial flutter and moderate hypertonic disease. Name the drug of choice for the treatment of both diseases. A. Sustak-forte **B. AnaprilinC. Potassium chloride D. Strophanthine E. Lidocaine

75. To the patient with arterial hypotension an adrenergic agonist is necessary to give. Find out the preparation.A. DoxazosinB. XylomethazolineC. Oxymethazoline (Sanorin)**D. Phenylephrine (Mesatone)E. Ergotamine

76. To the patient with hypertonic disease metoprolol is appointed. What mechanism of action of this preparation? A. Direct miotropic action on the blood vessels B. Blockage of the peripheral α-adrenoreceptorsC. Stimulation of the central постсинаптических α2-adrenoreceptors D. Blockage of N-cholinoreceptors of the autonomic ganglia**E. Blockage of β- adrenoreceptors

77. The patient experienced increasing of arterial blood pressure because of stress life style. Choose a medical agent that can decrease emotional excitation.A. CaffeineB. PapaverineC. Diltiazem**D. DiazepamE. Aminophylline

78. At the patient after intake of the antihypertensive drug in upright position became unconscious. It is known that this drug block N-cholinoreceptors of the vegetative ganglia. Point out this drug. A. Magnesium sulfateB. ResrpineC. Nifedipine **D. Benzohexonium E. Papaverine hydrochloride

79. To the patient with hypertonic illness the preparation – miotropic vasodilator, derivative of nicotinic acid is appointed. Name this medical agent. A. Papaverin B. No-spa C. Aminophylline**D. Xantinol nicotinate E. Dibazol

80. Because of hypertonic disease it was given an agent that possesses antihypertensive and anticonvulsant effects at intravenous administration and cholekinetic and laxative effects at oral. Specify the preparation.A. Anaprilin B. Nifedipine C. Reserpin **D. Magnesium sulfate E. Pentamine

81. The patient with hypertonic disease suffers from asthma attacks. What antihypertensive preparation is contra-indicated for him?A. Atenolol**B. AnaprilinC. VerapamilD. DilthiazemE. Metoprolol

82. Into admitting department the patient with hypertonic crisis has been delivered. What is necessary to appoint him? A. Strophantine**B. Sodium nitroprussideC. DobutamineD. DigoxinE. Spironolacton

83. At the patient after intake of the antihypertensive drug in upright position became unconscious. It is known that this drug is a sympatolytic. Point out this drug.**A. Reserpin B. PapaverinC. Dibasol D. FurosemideE. No-spa

84. Concerning hypertonic disease an agent - vasotropic Ca2+-channel blocker is appointed. Specify the medical agent. A. VerapamilB. Metoprolol C. Diltiazem D. Enalapril **E. Nifedipin

85. The patient with hypertonic disease takes enalapril. What is the mechanism of its action? **A. Inhibition of angiotensin - converting enzyme B. Blockage of angiontensin II receptors C. Inhibition of phosphodiesterase D. Inhibition of cyclooxygenase E. Blockage of Са2+-channels

86. To the patient with arterial hypotension a cardiotonic agent that stimulates dopamine, alpha and beta-adrenoreceptors. Find out the preparation.A. Noradrenalin hydrotartrateB. DobutamineC. Adrenalin hydrochloride**D. DopamineE. Mesaton (Phenylephrine)

87. For treatment of hypertension a non-selective β-blocker has been appointed. Cough, a bronchospasm after a while appeared. Specify this agent.A. AtenololB. Talinolol**C. PropranololD. AcebutalolE. Metoprolol

88. Increased level of arterial blood pressure is caused by peripheral vessels spasm. What agent from the group of adrenoblockers is wise to appoint to the patient?

**A. PrazosinB. CaptoprilC. DichlothiazideD. AnaprlinE. Clonidine

89. There is a hypercholesterolemia in the patient. What agent will lower concentration atherogenic lipoproteins due to suppression of the key enzyme of cholesterol synthesis? **A. Lovastatin B. Colestipol C. Cholestiramine D. Nicotinic acid E. Gemfibrosil

90. To the patient with atherosclerosis the drug that lowers level of triglycerides in blood has been appointed. Name the preparation.**A. Clofibrate B. ClonidinC. PilocarpineD. IsadrinE. Reserpine

91. To the patient with atherosclerosis lovastatin is appointed at bedtime. What is the reason of such schedule of prescription? A. It causes drowsiness **B. Synthesis of cholesterol occurs mainly at nighttime . C. The preparation is better absorbed at nighttime. D. The catabolism of cholesterol occurs mainly at night. E. Cholesterol is excreted mainly at night.

92. To the patient with chronic venous insufficiency, an agent that can strengthen venous wall is appointed. Specify the preparation.A. Cinnarizin **B. TroxevasinC. AminophyllinD. PapaverinE. Pentoxyphyllin

93. After application of miotropic spasmolytic (water-soluble vitamin) that was appointed to the patient with infringement of the peripheral bloodflow, the doctor has noticed occurrence of a “flushing syndrome”. Specify the preparation caused the specified adverse effect.A. Aminophyllin B. Troxevasin**C. Xantinol nicotinate

D. No-spaE. Dibazol

94. After uses of hypolipidemic agent the patient experienced muscular weakness, changes of liver function, increasing of transaminase level in blood, and diarrhea. Point this preparation.A. Tocoferol **B. LovastatinC. PentoxyphyllinD. HeparinE. Escusan

95. To the patient with migraine attack the preparation from the group of non-selective β-blockers is appointed. Name the preparation.A. Metoprolol B. AcebutalolC. Dihydroergotamine**D. AnaprilinE. None

96. For the prevention of migraine attack the patient was appointed an agent from the group of:**A. Ca2+-channels blockers B. AdrenomimeticsC. M-cholinomimetics D. N-cholinomimeticsE. Myorelaxants

97. In complex therapy of infringement of the cerebral bloodflow an antiaggregant have been appointed. Specify the preparation.A. Lovastatin **B. Acetylsalicylic acidC. ClofibratD. AtropineE. Adrenalin

98. To the patient with infringement of peripheral bloodflow the preparation – xantine (purine) derivative has been appointed. Name this agent.A. Lovastatin B. Dibazol**C. AminophyllinD. VerapamilE. Drotaverin

99. For treatment of the infringement of cerebral bloodflow the doctor has appointed a preparation that strengthen venous wall - an extract of chestnut fruits. Specify the preparation.A. Dihydroergotamine B. TroxevasinC. NifedipinD. Papaverin**E. Escusan

100. To the patient with infringement of the cerebral bloodflow the preparation improving metabolic processes in brain is appointed. Name the preparation. **A. Aminolon B. LinetolC. PapaverineD. DihydroergotamineE. Caffeine

101. To the patient with atherosclerosis a preparation clofibrate is appointed. What is the mechanism of its action?A. Antioxidant action B. Suppression of HMG-CoA reductase activity C. Increasing of bile acids and cholesterol excretion **D. Decreasing of triglycerides level E. Angioprotective action

102. To the patient with atherosclerosis a preparation cholestiramine is appointed. What is the mechanism of its action?A. Antioxidant action B. Suppression of HMG-CoA reductase activity **C. Suppression of cholesterol and lipids absorption in intestine D. Decreasing of triglycerides level E. Angioprotective action

103. To the patient with gastric peptic ulcer almagel is appointed. What pharmacological effect of the preparation is used for the treatment of this pathology? A. Local anesthetic action B. Blockade of Н2-histamine receptors **C. Neutralization of НClD. Blockade of M-cholinoreceptors E. Anti-inflammatory action

104. Explain to the patient why the long use of antacid agent as sodium bicarbonate is harmful at stomach hyperacidity?**A. Causes rebound increasing of acidity B. Has the significant latent period C. Tolerance is appeared D. Has low activity E. Cumulate

105. To the patient with hyperacidic gastritis the therapist has appointed bismuth agent. Define the preparation. A. AlmagelB. Apomorphine hydrochloride C. Dichlothiazide **D. De-nol E. Cyanocobalamine

106. To the patient with hypoacidity the doctor has appointed an agent for substitutive therapy. Name this agent. A. Tincture of wormwood**B. Natural gastric juice C. VikasolD. PhepranoneE. Aluminum hydroxide

107. To the patient concerning stomach ulcer the doctor has appointed famotidine. Explain, what mechanism underlies action of the given preparation? A. Blockade of Н2-histamine receptors**B. Blockade of Н2-histamine receptorsC. Blockade M-choline receptors D. Suppression of Н+К+АТPaze E. Blockade of choline receptors in sympathetic ganglia

108. The patient suffer from atony of gall-bladder complicated with bile stones. What agent should be used for strengthening of evacuation of bile in intestine? **A. Magnesium sulfate orally B. Magnesium sulfate parenterally C. Dehydrocholic acid D. LegalonE. No - spa

109. To the patient laxative drug - magnesium sulfate - is appointed. Name the mechanism of its laxative action.A. Strengthens of motor function basically of small intestineB. Strengthens of motor function basically of large intestines**C. Strengthens contractility and motor function of all intestine D. It is able to swell inside intestine and to increase its contentsE. Promotes softening of feces mass

110. To the patient with diaarhea the preparation regulating intestinal microflora is appointed. Define the preparation. A. LoperamidB. No-spa**C. OmeprazoleD. FamotidineE. Linex

111. To the patient with stomach ulcer omeprazole is appointed. What mechanism of action of this preparation? A. Blockade of Н2-histamine receptorsB. Blockade of M- choline receptors C. Neutralization of HCl **D. Suppression of Н+К+АТP-aze activity E. Stimulation of mucous formation

112. For the treatment of gastric peptic ulcer a M-cholinoblocker, possessing by the greatest selectivity for М1- choline receptors of gastric glands has been appointed. Specify this preparation. A. МеthаcineB. Scopolamine C. Platyphylline **D. Pirenzepine E. Ipratropium bromide

113. To the patient with bulimia the doctor has appointed anorexigenic agent. Specify this preparation. **A. PhepranoneB. Panzynorm C. Almagel D. Methacin E. De-nol

114. The old patient suffers from chronic constipation caused by bowel hypotonia. What preparation should be appointed to the patient? A. PhysostigmineB. Sodium sulfate C. Castor oil D. Atropine **E. Bisacodyl

115. For increasing of appetite and stimulation of digestion the doctor has appointed a centrally-acting agent. Define the preparation. A. Phepranone** B. Peritol C. Apomorphine hydrochloride D. Natural gastric juice E. De-nol

116. At fatty dystrophy of the liver the doctor has appointed to the patient vitamin-containing hepatoprotector. Specify this preparation.A. LegalonB. Silibor C. Heptral D. Hepobene **E. Essentiale

117. In surgical department the patient with acute pancreatitis was delivered. What preparation with anti-enzyme activity is necessary to give to the patient? A. Analginum**B. ContrycalC. Adrenaline D. Atropine sulfate E. Sodium bicarbonate

118. What drug is expedient for appointing at a chronic bronchitis with viscous sputum of purulent character? A. Salbutamol B. Codeine phosphateC. Ipratropium bromideD. Glaucine hydrochloride**E. Ambroxol

119. If fenoterol in inhalations is absent in a drugstore what preparation from the group of selective β2-adrenomimetics is necessary to prescribe? A. Isadrine**B. Salbutamol C. MethacineD. EphedrineE. Euphylline

120. The patient with acute bronchitis is recommended to take expectorant of plant-origin. What preparation can be offered the patient? **A. Mucaltin B. Sodium biocarbonateC. AcetylcysteineD. AmbroxolE. Sodium chloride

121. To the patient with bronchospasm atropine sulfate is appointed. What disease can serve as contra-indication for atropine? A. Renal colicB. Intestinal colic C. Sinus bradycardia **D. GlaucomaE. Stomach ulcer

122. To a 70-years-old man who suffers from chronic bronchitis, an anticough drug – codeine - has been prescribed. What mechanism does provide anticough effect?A. Local action**B. CentralC. ConcurrentD. ReflexE. Peripheral action

123. What antiallergic drug from the group of mast cells stabilizers is necessary to appoint to the patient with asthma for the prevention of attack? A. LoratidinB. Adrenaline**C. Cromolin-sodium D. Ipratropium bromideE. Salbutamol

124. The doctor diagnosed suppression of the respiratory center connected with hypnotic agent’s overdose. Specify a preparation stimulating the respiratory center. A.PiracetamB. AminazineC. Amitryptylline D. Euphylline**E. Bemegride

125. In complex treatment of bronchial asthma the doctor has appointed antiallergic agent - a preparation of hormones. Name the drug.**A. HydrocortisoneB. DimedrolC. Kеtotifen D. LoratidineE. Salbutamol

126. By what close drug acetylcystein can be replaced? **A. AmbroxolB. Libexin C. Codeine phosphate D. EuphyllineE. Glaucine

127. A mother has addressed to pediatrist with complaints on persistent cough in her 11-months-old infant, which disturb his sleep. What agent from the named drugs cannot be prescribed in this case? A. LibexinB. Glaucine**C. CodeineD. BromhexineE. Acetylcysteine

128. The patient has acute of bronchospasm. What preparation is wise to apply for removing of acute bronchospasm?**A. Salbutamol B. BromhexinC. Cromolyn-sodium D. MucaltinE. Libexin

129. A patient with bronchial asthma has been taking tablets which caused insomnia, headache, increased blood pressure. What medicine can cause such complications?**A. EphedrineB. Cromolyn sodiumC. AdrenalineD. Euphylline (Theophylline)E. Isadrinum

130. The doctor of an ambulance has established the diagnosis of pulmonary edema caused by acute left ventricular failure. Specify a cardiac glycoside of fast action for the first aid. A. Digitoxin **B. Strophanthin C. CorvalolD. Digoxin in tablets E. Triamteren 131. In complex therapy at chronic respiratory failure the analeptic, which also has direct cardiostimulating and expectorant action, has been prescribed. In addition, this medicinal agent can be applied externally to rub at arthritis. Specify this drug.A. Bemegride **B. Camphor C. Ethimizol D. CaffeineE. Cordiaminum

132. In connection with disturbances of contractility of myometrium in postpartum period, the parturient woman has uterine bleeding. What drug should be prescribed in the given situation? A. Sodium oxybutyrate**B. Ergometrine C. SalbutamolD. DinoprostE. Atropine

133. What medical drug is needed for prescribing to the parturient woman if her labor activity is in processes; and the uterus cervix is not opened? A. Partusisten**B. DinoprostoneC. OxytocinD. No-spa (Drotaverin)E. Magnesium sulfate

134. For the prevention of undesirable pregnancy the doctor - gynecologist has recommended to the young woman of 22 years an oral contraceptive drug, which should be applied immediately after the sexual intercourse. Specify this drug. A. RigevidonB. Triziston**C. PostinorD. EstradiolE. Proginova

135. The woman of 23 years who from time to time uses peroral contraceptives has addressed to the doctor with a question on composition of these agents. What steroid substances are included to postcoital peroral contraceptives?

**A. Progestins B. Mineralocorticoids C. Androgens D. Anabolic steroids E. Glucocorticoids

136. A 25-years-old young lady has addressed to a gynecologist for advice at a choice of a contraceptive agent. At application of the combined contraceptive agents there can be specified side effects, except: A. Mental depression B. Edema C. Nausea D. Development of migraine-like headache **E. Osteoporosis

137. The vitamin agent, deficiency of which can cause sterility in experimental animals, and can be applied to complex treatment of female infertility. Specify this vitamin.A. Vitamin AB. Vitamin KC. Vitamin В1

D. Vitamin D**E. Vitamin E

138. The doctor appointed a roral contraceptive that includes norgestrel. Name the most possible undesirable effect of this preparation. A. FeminizationB. Weight loss **C. Acne rash D. Katabolic effect E. General weakness

139. A doctor has prescribed a substitution therapy for the patient with hypotyreozis. Choose preparation which approaches in this case.**A. LevothyroxineB. ParathyreodineC. CalcitoninD. MercazolilE. Calcitrin

140. To the patient with diabetes mellitus the drug – insulin has been prescribed. What parameter from given actions is the basic for this agent? A. Transport of amino acids. B. Inhibition of gluconeogenesis. **C. Transport of glucose. D. Synthesis of triglycerides. E. Synthesis of glycogen.

141. A diabetic coma is diagnosed for a patient. What hypoglycemic preparation must be prescribes for this patient?

A. Long-acting insulinB. Intermediate-acting insulin**C. Short-acting insulinD. BiguanidesE. Derivatives of sulphonylureas

142. Endocrinologist prescribed glibenclamide to the patient with a diagnosis of diabetes melitus (II type). Specify the main mechanism of action of this preparation.

A. Supresses gluconeogenesis **B. Stimulates the secretion of insulin by the beta-cells of the

pancreasC. Strengthens metabolism of glucoseD. Strengthens the capture of glucose by peripheral tissuresE. Activates the transport of glucose into a cell

143. Specify contraindications to application of insulinA. Diabetic coma**B. FurunculezisC. Acute hepatitisD. HypoglycemiaE. Stenocardya

144. A doctor has prescribed pituitrinum to a parturient women of 32 years with weakness of labor activity. At presence of what concomitant disease introduction of this drug will be contraindicated? **A. HypertensionB. Bronchial asthmaC. Peptic ulcerD. Diabetes mellitusE. Diabetes insipidus

145. Indicate tablet forms of hypoglycemyc drugsA. Insulin semi-lenteB. Actrapid NM**C. Glibenclamide D. GlucoseE. Humulin NPK

146. A 52-years-old patient soon after removing of thyroid gland developed a numbness of extremities, paresthesia, and hypocalcemia. What hormonal drug should be prescribed? A. CalcitrineB. Thyreoidine **C. Parathyroidine D. Thyroxine E. Triiodothyronine

147. Mercazolil has been prescribed for the treatment of a patient with thyrotoxicosis. What underlies an antithyroid activity of the drug? A. Inhibition of metabolism B. Drop of thyrotropin production C. Drop of iodine absorption by thyroid gland D. Destruction of thyroid gland cells **E. Drop of production of thyroid Hormones

148. To the patient with diabetes mellitus, a nurse has entered by mistake almost double dose of insulin. In 2 hours patient experienced an intensive sweating, tachycardia, increasing of muscular tonus, cramps, and loss of consciousness. The diagnosis of a hypoglycemic coma is established. What is necessary to enter to the patient for retrieving from coma? A. InsulinB. Lydase C. Natrii bicarbonate **D. Glucose E. Noradrenaline

149. Pituitrinum was entered to a parturient women with weakness of labor activity. Specify hormones which contains in this preparation.А. Vasopressin and progesteroneB. Oxytocin and oestradiolC. Oxytocin and progesteroneD. Vasopressin and oestradiol**e. Oxytocin and vasopressin

150. Medical usages of adrenocorticotropic hormone.А. Renal insufficiencyB. Chronic cardiac insufficiencyC. Hyperproduction of ACTH by the hypophysis**D. Withdraw syndrome of glucocorticoids E. Overdose of glucocorticoids

151. A substitutive therapy was prescribed to the patient after the subtotal resection of thyroid gland. Choose the medicinal drug.A. Potassium iodideB. Corticotropinum**C. Thyroxine D. MercazolilE. Protirelin

152. Specify the pharmacological group of glibenclamide.A. Natural hormone of pancreasB. Thyroid hormonal preparationC. Parathyroid hormonal preparation**D. Synthetic hypoglicemic drug E. Mineralocorticoid

153. Specify the mechanism of action of mercazolilA. Increases a basic metabolism**B. Reduces the synthesis of thyroxin in thyroid glandC. Inhibits excretion of iodine from thyroid glandD. Increases iodine absorption from intestineE. Promote psychical and physical development

154. The patient of 45 years complains of constant thirst and expressed polyuria. The level of plasma glucose is 5 mM / L, in urine it is absent. The diagnosis of diabetes insipidus is established. What should be chosen from proposed agents for his treatment? A. HydrocortisoneB. Insulin **C. Adiurecrin D. Desoxycorticosterone (DOC)E. Prednisolone

155. Specify the hormonal drug of anterior hypophysis.**A. Corticotropin B. OxytocinC. MenotropinD. TriiodothyronineE. Pituitrinum

156. The patient with diabetes mellitus after routine insulin injection experienced an intensive sweating, tachycardia, increasing of muscular tonus, excitement. What is necessary to enter to the patient for retrieving from this condition?**A. AdrenalineB. Butamide

C. Sodium bicarbonateD. Noradrenaline E. Metformin

157. At the inspection at a patient hyperthyroidism is found. What from preparations need to appoint?А. Triiodothyronine B. L-thyroxine **C. Mercazolil D. Calcitonin E. Thyreoidine

158. What hormonal preparation doesn’t belong to pituitary hormones? A. CocticotropinB. Oxytocin**C. Thyreoidine D. DesmopressinE. Pituitrin

159. Specify the side effect(s) of sulfonurea derivativesA. Live dysfunction B. HypoglycemiaC. Inhibition of bone marrow D. Allergic reactions**E. All mentioned above

160. A 33-years-old woman that is received treatment because of chronic polyarthritis complains on increased blood pressure redistribution of fat tissues, disturbance of menstrual cycle. What preparation does the patient take? А. FlumethasoneB. Indomethacine C. Butadione **D. Prednisolone E. Beclomethasone

161. To the patient with allergic dermatitis and diabetes mellitus a doctor appointed fluor-containing hormonal preparation in the form of ointment. On the question of patient about advantages of the appointed preparation above ointment of hydrocortisone the doctor explained that the appointed preparation:А. Increases insulin synthesis **B. Practically does not have resorptive action C. Has short duration of actionD. More activeE. Is cheaper

162. A patient with neurodermatitis has been taken dexamethasone for a long time. At the inspection the increased glucose level in blood was found at him. What effect of glucocorticoids leads to this adverse effect?А. Increasing of glucose absorption in intestine B. Activation of glycogen synthesis **C. Activation of gluconeogenesis D. Suppression of glycogen synthesis E. Inactivation of insulin

163. The pregnant woman has history of habitual abortion. What hormonal preparation can be appointed for saving of present pregnancy?**А. Progesterone B. Testosterone propionate C. Methandrostenolone

D. Estrone E. Hydrocortisone

164. A patient with rheumatoid arthritis that has been taking glucocorticoid agent for a few weeks, abruptly stop their use. What complication can develop in this case?

А. HyperglycemiaB. Increasing of arterial blood pressure**C. Withdrawal syndrome D. Relapse of chronic infectious processes E. Erosive of mucous membrane of stomach and duodenum

165. A patient has been taken glucocorticoids for a long time. After abrupt drug’s cessation a withdrawal syndrome developed. What is shown for correction of this disturbance?А. MineralocorticoidsB. Progestines **C. ACTH D. AdrenalinE. Thyroxine

166. The patient has been taken a glucocorticoid agnet during two weeks. Improvement of the basic disease is observed, however he has signs of the relapse of chronic tonsillitis. What glucocorticoids’ effect causes this complication? А. AntiallergicB. Anti-inflammatoryc. Anti-shock**D. Immunodepressive E. Detoxicative

167. The boy of 15 years after car accident passed several operations on the inferior extremities. In the period of recovery an agent, which capable to stimulate synthesis of protein, has positive influence on calcium and nitrogen metabolism, improves appetite and promote weight gain, has been prescribed to the patient. What drug did the doctor prescribe? A. PrednisoloneB. Progesterone C. Dexamethasone **D. Retabolil E. Corticotropin

168. The patient was given an agent that caused following side effects: hyperglycemia, edema, osteoporosis, arterial hypertension. What group does this medication belong to?

A. EstrogensB. Mineralocorticoids**C. Glucocorticoids D. Non-steroid anti-inflammatory agentsЕ. Anticancer agents

169. A patient with the bronchial asthma was taken prednisolone. After stopping of the drug’s intake the asthma attacks become more frequent, arterial blood pressure decreases, weakness has developed. The reason of it can be:A. SensibilizationB. Tachyphylaxia**C. Withdraw syndrome D. Cumulation of the preparationЕ. Disturbance of elimination

170. A 54-years-old man with heavy polytrauma has weight loss, worsening of appetite and general weakness. An agent that stimulates protein synthesis is appointed to the patient. Define the preparation.A. Prednisolone**B. Retabolil C. DexametasoneD. ProgesteroneE. Mercaptopurine

171. A 45-years-old patient with acute adrenal cortex insufficiency was given an agent for substitutive therapy. Name the preparation.A. MercazolilB. Adrenaline**C. RetabolilD. CorticotropinE. Prednisolone

172. Into obstetric department a pregnant woman with risk of abortion is delivered. What hormonal preparation is wise to apply in this case?A. Estrone**B. ProgesteroneC. OxytocinD. PituitrinE. Prolactine

173. Many kinds of pathology (inflammation, pulmonary edema, shock of different origin) are accompanied by increasing of vascular permeability. What agent from the named drugs can be used for counteraction to this at any of the named kinds of pathology? A. Dimedrolum (Diphenhydramine)B. Acid acetylsalicylic C. Indomethacin**D. Prednisolone E. Beclomethasone

174. Consult a colleague, what pharmacological effect is absent in pharmacodynamics of glucocorticoids.A. Anti-inflammatory **B. Fibrinolytic C. ImmunodepressiveD. AntiallergicE. Anti-shock

175. To a 67-years-old patient after myocardial infarction retabolil was appointed. Administration of the preparation led to the improvement of the patient’s condition. What is the mechanism of this positive action?A. Adinylate cyclase activation B. Stimulation of the Са2+ channels **C. Stimulation of proteins synthesis in heart D. Blockade of acetylcholinesteraseE. Inhibition of Na+ К+-АTP-аze

176. A 35-years-old woman that have been treated for a long time because of chronic polyarthritis is complaining on raising of blood pressure, redistribution of fat tissues, disturbances of menstrual cycle. With what drug administration these complains are related to?A. Phenylbutazone (Butadion)B. Indomethacine

**C. PrednisoloneD. SynaflanE. Beclomethasone

177. A 46-years-old woman has breast cancer. What hormonal preparation is necessary to appoint for therapy of the patient?A. NerobolB. SynestrolC. PhenobolineD. Progesterone**E. Testosterone propionate

178. After prolong use of a preparation the patient developed osteoporosis, erosions of stomach mucous, hypokaliemia, sodium and water retention, reduction of corticotropic hormone level in blood. What preparation was applied?A. HypothiazideB. PhenobolineC. Methylandrostenolone**D. Prednisolone E. Reserpine

179. A patient with chronic alcoholism have the symptoms of polyneuritis and cardiac insufficiency. What vitamin preparation needs to be used to the patient? А. PhylloquinoneB. ErgocalciferolC. RetinolD. Rutin**E. Thiamine

180. A patient with the diagnosis of tuberculosis gets isoniazid. After while a patient began to grumble about a muscle weakness, lowering of sensitiveness of skin, violation of sight, coordination of movements. What vitamin preparation needs to be used for the removal of these phenomena?А. Vitamin C**В. Vitamin В6 С. Vitamin AD. Vitamin D Е. Vitamin В12

181. A doctor appointed to the patient 65 years nicotine acid as part of complex therapy. What are the contraindications for nicotine acid?А. PellagraВ. Blood vessels spasms**С. Hypotension D. AtherosclerosisЕ. Hepatitis

182. In city О is epidemic of flu. A doctor recommended to the patient 34 years to take ascorbic acid with the purpose of prophylaxis of viral infection. What is not typical for pharmacological action of ascorbic acid:**А. Increasing of vascular permeabilityВ. Increasing adaptation possibilities of organismС. Increasing of glucocorticoids synthesisD. Desintoxication actionЕ. Increasing of immunity

183. A doctor has prescribed vitamin preparation in an injection for the removal of peripheral angiospasm. The redness and itching of skin of the body top appeared through 20 minutes.

These symptoms independently got through 40 minutes. What preparation was prescribed?**A. Nicotine acid B. Ascorbic acidC. Thiamine bromideD. PyridoxineE. Riboflavin

184. A doctor has prescribed vitamin preparation intravenously. The symptoms of anaphylactic shock developed in a few minutes. What preparation caused it ?A. RiboflavinB. Ascorbic acidC. Nicotine acidD. Pyridoxine**E. Thiamine

185. A patient has dementia, diarrhea, dermatitis. Pellagra is diagnosed. What vitamin preparation you shall use for medical treatment?А. Tocopherol acetateB. Thiamine bromide**C. Nicotinic acid D. CocarboxylaseE. Riboflavin

186. Radial therapy is appointed to the patient. What vitamin preparation with antioxidant properties needs to be prescribed for promotion of vessels firmness?А. PyridoxineB. Thiamine chloride**C. Ascorutin D. CyanocobalaminE. Folic acid

187. The megaloblastic anaemia is diagnosed for a patient. What vitamin preparation must be prescribed to the patient?**A. Vitamin В12 B. Vitamin В1

C. Vitamin В3

D. Vitamin В6 E. Ascorbic acid

188. A vitamin preparation with expressed vasodilative action was used in complex medical treatment of periodontosis. Specify this preparation.A. Pyridoxine hydrochlorideB. Ascorbic acidC. Thiamine chloride**D. Nicotinic acid E. Retinol acetate

189. This vitamin acts important part in maintenance of normal visual function of eye and in the synthesis of haemoglobin. Define this vitamin.A. Pyridoxine hydrochlorideB. Ascorbic acidC. Thiamine chlorideD. Nicotinic acid**E. Riboflavin

190. Vitamin C hypovitaminosis is diagnosed at a patient. A doctor prescribed for him this vitamin in a dose, proper day's necessity. Define the type of vitaminotherapy.A. AdaptationB. Braking**C. Substitutive D. PharmacodynamicE. Prophylactic

191. This vitamin deficiency leads to increased pyruvic and lactic acids concentrations in the blood (acidosis), decreasing of acetylcholine concentration and fluorine utilisation. The Beriberi disease develops. Define this vitamin.A. Pyridoxine hydrochlorideB. Ascorbic acid**C. Thiamine chloride D. Nicotinic acidE. Riboflavin

192. The treatment of tuberculosis with preparations from the group of hydrazides of isonicotinic acid leads to vitamin B6 deficiency. Specify the mechanism of this hypovitaminosis.A. Inhibition of vitamin absorption in GI tractB. A vitamin destroys by hydrazides in an intestine**C. Hydrazides oppresses pyridoxalphosphate synthesis D. Hydrazides stimulates pyridoxalphosphate synthesisE. Hydrazides oppresses decarboxylation of the vitamin in a liver

193. Preparations of this vitamin are widely used in ophthalmology practice, for treatment of different hypoxias, acute and chronic hepatitis. Define this vitamin.A. Pyridoxine hydrochlorideB. Ascorbic acidC. Thiamine chlorideD. Folic acid**E. Riboflavin

194. This vitamin is the activator of the hematopoetic system, regeneration processes and growth. Megaloblastic (malignant) anaemia can develops at its deficiency. Define this vitamin.A. Pyridoxine hydrochlorideB. Ascorbic acidC. Thiamine chloride**D. Cyanocobalamin E. Riboflavin

195. This vitamin participates in the synthesis of macroergic compounds, purines and pyrimidines. It initiates the DNA synthesis and hemopoiesis. Define this vitamin.**A. Folic acid B. Ascorbic acidC. Thiamine chlorideD. Pyridoxine hydrochlorideE. Riboflavin

196. A doctor has prescribed vitamin preparation for treatment of hemeralopia. What from these vitamins will you give a preference?A. Lipoic acid**B. Retinol C. Ascorbic acidD. Nicotinic acidE. Ergocalciferol

197. The mother of child (10 months) appealed to the doctor with complaints that a child sleeps badly and strongly sweats. A doctor diagnosed rachitis. What vitamin is needed in this situation?A. Retinol acetateB. Tocopherol acetate**C. Ergocalciferol D. RiboflavinE. Ascorbic acid

198. For the man 39 years old diagnosed: hyperkeratosis, hemeralopia and promoted risk of infectious diseases. What vitamin preparation must be prescribed?A. RiboflavinB. Pyridoxine hydrochloride**C. Retinol acetate D. ErgocalciferolE. Tocopherol acetate

199. A patient appealed to the doctor with in a number of complaints. Vitamin D hypervitaminosis was diagnosed after the examination of the patient. What is not characteristically for vitamin D hypervitaminosis?A. General weaknessB. Worsening of kidneys functionC. Metallic taste in the mouth**D. Damage of teeth enamel E. Calcification of internal organs and vessels

200. Preparation from the aminoacids group was prescribed for treatment of viral hepatitis. Choose him.**A. Methionine B. Pantothenic acidC. PancreatinD. Glutamine acidE. Arginine

201. A patient with the diagnosis of acute pancreatitis (vomiting, diarrhea, acute pain in a stomach, fever) is delivered to surgical department of hospital. What preparation with antienzyme activity is necessary to prescribe?A. AdrenalineB. Analginum**C. Contrykal D. Atropine sulfateE. Sodium hydrocarbonate

202. Enzymes and other active compounds which regulate closeness and permeability of connecting tissure are produced into cells of this tissure. What enzyme preparation is used with the purpose of making light and increasing of permeability of connecting tissure?**A. Lydase B. AmylaseC. LipaseD. CocarboxylaseE. Cholinesterase

203. Chronic pancreatitis was diagnosed for the patient after an examination. What preparation must be prescribed to him?A. TrypsinB. Pepsin**C. Mezym-forte D. Methionine

E. Urokinase

203. Chronic pancreatitis was diagnosed for the patient after an examination. What preparation must be prescribed to him?A. TrypsinB. Pepsin**C. Mezym-forte D. MethionineE.Urokinase

204. Preparation of acetaldehydeoxydase inhibitor is prescribed for a patient with chronic alcoholism. Specify this preparation.A. Diacarb (Acetazolamide)B. Allopurinol**C. Teturamum (Disulfiram) D. GordoxE. Nialamide

205. A disease of skin (hyperkeratosis) is diagnosed at patient. Prescribe a vitamin which stimulates epithelization and protects the surplus cornification of epithelium.A. Vitamin CB. Vitamin РРC. Vitamin D**D. Vitamin A E. Ascorutin

206. What from these preparations is connected with all of these 4 determinations: vitamin of growth, antiinfectious, epithelium and antixerophthalmic vitamin?A. ErgocalciferolB. Riboflavin**C. Retinol acetate D. Tocopherol acetateE. Vicasol

207. It is necessary to clean wounds from necrotic tissues in the patient 45 years old with the numerous burns. Name enzymic preparation, used in this case.A. AsparaginaseB. Mezym-forteC. Streptokinase**D. Trypsin E. Panzynorm

208. One of vitamins can be used for complex treatment of infertility. The deficit of this vitamin for experimental animals causes sterility. Specify this preparation.A. Retinol acetateB. Vicasol**C. Tocopherol acetate D. Thiamin chlorideE. Cyanocobalaminum

209. A patient with chronic gastroenterocolitis and cholecystopancreatitis must takes a preparation for the digestive processes improvement. What preparation is necessary to prescribe?A. TrypsinB. Pepsin**C. Festal D. Natural gastric juiceE. Hydrochloric acid

210. The apathy, somnolence, headache, diffuse bulge and pains in bones, vomiting, itching, fall of hairs, painting of skin in yellow colors take place in case of hypervitaminosis of this vitamin. Specify this vitamin.A. Ergocalciferol**B. Retinol acetate C. VicasolD. Tocopherol acetateE. Cholecalciferol

211. Tocopherol was used in complex therapy of ischemic heart disease. What effect of preparation is main in this situation?A. SpasmolyticB. Hypotensive**C. Antioxidant D. Increasing the delivery of oxygen to myocardiumE. Positive inotropic

212. At patient which appealed to the doctor diagnosed anacid gastritis. The pills of pepsin were prescribed to a patient for the improvement of stomach work. What type of treatment was prescribed for a patient?A. Causal therapyB. Symptomatic therapyC. Prophylactic applicationD. Etiotropic therapy**E. Substitutive therapy

213. The patient with an anemia is treated by oral forms iron-containing agents. With the help of substance it is possible to increase iron absorption?A. Sodium bicarbonateB. TrypsinC. FestalD. Gastrozepine**E. Ascorbic acid

214. At the pregnant woman megaloblasts and increased color index are found in blood. The diagnosis of megaloblastic anemia is established. What agent is necessary to appoint to the patient?**A. CyanocobalaminB. PyridoxinC. Ascorbic acidD. Nicotinic acidE. Coamide

215. For the treatment of hypochromic anemia the doctor has appointed ferrum lactate in capsules orally. With what purpose iron is appointed in capsules?

A. For the prevention of vomittingB. For the prevention of constipation**C. For the prevention of interaction in an oral cavity with

hydrogen sulphide D. For elimination of bitter taste of the preparationE. For improvement of the drug’s intestinal absorption

216. A patient has iron deficiency anemia. Together with iron preparations, vitamin C has been prescribed. What role does ascorbic acid carry out in this case? **A. Promotes absorption of iron due to reduction trivalent iron

(ferric form) into divalent iron (ferrous form) B. Promotes iron absorption due to its ionization C. Improves epithelization of the gastrointestinal tract D. Promotes meal digestion

E. Improves transport of iron to blood

217. To the patient who is a permanent blood donor for prevention of iron-deficient anemia ferrous sulfate is appointed. What is the mechanism of action of the preparation?A. Increases formation of erythropoietin **B. Stimulates synthesis of hemoglobin C. Stimulates synthesis of nucleic acidsD. Hasten maturation of megaloblastsE. Actives methionine formation

218. For the patient with diabetes mellitus complicated by hyperglycemic coma it is necessary to correct ketoacidosis. Solution of what preparation is wise to give? A. Ammonium chloride**B. Sodium bicarbonateC. Sodium lactate D. NeohemodesE. Ringer’s solution

219. The 37-years-old patient concerning hypochromic anemia had been treated for a long time. Three years later he started to feel worse and monocomponent iron-containing agent didn’t bring improvement. Offer a preparation which can be effective at iron-resistant anemias.A. Ferrous sulfate**B. CoamideC. FerbitolD. Vitamin B12

E. Festal

220. After assignment of iron-containing preparation the doctor has warned the patient about an opportunity of side effects. Find out them.A. Calcification of internal organsB. ConstipationC. Black discoloration of stool D. A and B**E. B and C

221. The megaloblastic anemia is diagnosed at the patient. The doctor has explained to him that it can be due to insufficiency of external Castle’s factor and substitutive therapy has appointed. Choose the preparation most suitable to it.A. Ferrous sulfate**B. CyanocobalamineC. Folic acidD. Vitamin AE. All mentioned above

222. The patient has signs of iron overdose. Choose the preparation for elimination of this condition.A. FestalB. Vitamin B12

C. Acid folic**D. DeferoxamineE. Fercoven

223. The patient that has been taken loop diuretics for a long time has developed ionic imbalance. Choose the preparation for correction of this condition.A. Potassium chlorideB. Sodium bicarbonateC. Sodium chloride

D. Panagin**E. A and D

224. To the patient in the postoperative period the doctor has appointed parenteral nutrition. Choose the preparation(s) that can be used for it.A. AminocrovineB. NeohemodesC. Polyamine**D. A and CE. None

225. A doctor recommended acetylsalicylic acid to the patient after an acute myocardial infarction for 0,25 1 times a day during 3-4 months. What action of aspirin is preferable in this situation?А. AnalgesicB. AntiinflammatoryC. Antipyretic**D. Antiaggregative E. Vasodilative

226. A patient has been taking levomycetin during long time. After the laboratory examination leukopenia is diagnosed. What preparation must be prescribed for correction of leucopoiesis?А. MercaptopurineB. Methotrexate**C. Pentoxil D. CyanocobalaminE. Prednisolone

227. The double dose of heparin was entered to the patient by mistake. What from these drugs is heparin’s antidote?A. Sodium citrateB. VicasolC. Calcium chloride**. Protamine sulfate E. Sodium bicarbonate

228. The frequent and strong hypodermic hemorrhages has diagnosed at a 6-month-old child. Prescribing of synthetic analogue of vitamin K (Vicasol) gave a positive effect. With synthesis of what protein is connected this vitamin?**А. Prothrombin В. Antihemophilic globulin AС. Hagemann factorD. FibrinogenЕ. Rozental factor

229. A preparation with anticoagulant action must be prescribed for the patient after the carried out myocardial infarction. The latent period of what from them is most long?A. HeparinB. Acetylsalicylic acidC. FibrinolysinD. Reopolyglucin**E. Neodicumarin

230. The heparin is prescribed to the 56 years old patient in postoperative period for the thromboembolism prophylaxis. Specify, what is typically for heparin:А. Effective at the peroral pathway**В. Inhibit blood coagulation in vitro (in a test tube) and in vivo (in vessels) С. Onset of action – 18-24 h. and duration – few days

D. Strong cumulantЕ. Strong coagulant

231. The massive uterine fibrinolytic bleeding began at a woman during births. What preparation must be prescribed?**A. Aminocaproic acid B. VicasolC. FibrinogenD. Calcium chlorideE. Hemostatic sponge

232. Expressed leukopenia is diagnosed at a patient after the course of antiinflammatory therapy with the usage of butadion. Choose preparation for the removal of leukopenia.A. FtoruracilB. Methotrexate**C. Pentoxil D. BleomycinE. B and C

233. The nose-bleeds became more frequent at a patient which uses neodicumarin in connection with thrombophlebitis. What preparation must be prescribed for this patient?A. HydrochlorthiazideB. Protamine sulfateC. Acetylsalicylic acidD. Trental **E. Vicasol

234. The methotrexate is used for a treatment of leukosis. The antagonist of what vitamin is it? A. Cyanocobalamin**B. Folic acid C. PhylloquinoneD. PyridoxineE. Routine

235. A preparation influencing on all stages of thrombus formation is prescribed to the patient with thrombophlebitis. Specify this preparation.A. Acetylsalicylic acidB. FibrinolysinC. NeodicumarinD. Dipyridamole**E. Heparin

236. A patient has symptoms of heparin overdosage. What preparation is the antidote of heparin?A. Sodium citrate**B. Protamine sulfate C. Calcium chlorideD. VicasolE. Rutin

237. T-cell immunity became worse at a patient after the chemotherapy of cancer. What preparation needs to be prescribed?А. PrednisoloneB. CyanocobalaminC. Preparations of iron**D. Thymalinum E. Acetylsalicylic acid

238. A patient with allergic rhinitis took antihistaminic

preparation in pills. After some time a patient felt dryness of the mouth, sedation, somnolence. What preparation took a patient?А. DiazolinB. Phenobarbital**C. Dimedrolum D. DiazepamE. Paracetamol

239. A doctor prescribed Н1-histamine blocker to the patient with allergic dermatitis. Specify this preparation.А. HydrocortisoneB. Cromolyn sodiumC. PrednisoloneD. Adrenalin**E. Diprazin

240. doctor prescribed cromolyn sodium to the patient for prophylaxis of bronchial asthma attacks. Specify the mechanism of action of this preparation.А. Blockage of histaminic receptorsВ. Decreasing of immunoglobulins concentrationsС. Binding of free D. Stabilization of macrophages membranes Е. Inactivation of histamine

241. A doctor must prescribe antihistaminic preparation which does not oppress CNS to the woman working by a driver. Specify this preparation.**A. Diazolin B. DimedrolumC. DiprazinD. SuprastinE. Tavegil

242. The dimedrolum is prescribed to the patient for the complex therapy of dermatitis. What mechanism provides efficiency of the dimedrolum in this case?A. Oppression of histamine releaseB. Oppression of histamine synthesisC. Independent antagonism with histamineD. Acceleration of histamine destruction**E. Concurrent blockade of Н1-receptors

243. What preparation needs to be prescribed to the patient at which insomnia appears from allergic dermatitis with the inflammation and itching?A. Sodium oxybutyrateB. Phenobarbital**C. Dimedrolum D. DiazolinE. Loratadine

244. The immunodepressive preparation from the group of antimetabolites is prescribed to the patient for treatment of systemic scleroderma. What preparation is prescribed to the patient?**A. Azathioprine B. PrednisoloneC. DexamethasoneD. CycloserineE. Chlorbutin

245. A doctor has prescribe immunostimulator to the patient. Specify the medical usages of immunostimulators.

A. Immediate hypersensitivity**B. Chronic infections C. Delayed hypersensitivityD. After organs transplantationE. All mentioned about

246. The anaphylactic shock developed at a patient in a few minutes after a skin test on a sensitiveness to penicillin. What preparation is prescribed in this case?A. AtropineB. MesatonumC. Noradrenaline**D. Adrenalin E. Salbutamol

247. A patient with allergic conjunctivitis has treated by dimedrolum. What from the effects on pathogenesis of allergy is most characterized for dimedrolum?

A. Synthesis of immunoglobulinsB. Histamine releaseC. Formation of antigen-antibody complex**D. Influencing of histamine with organ’s receptors E. The B-lymphocytes activating

248. There is the epidemic of flu in city. What from indicated preparations (as drops in a nose) must be prescribe to the child for the prophylaxis of disease?**A. Interferon B. RemantadinumC. AmpicillinD. AcyclovirE. Paracetamol

249. For the prevention of attack of bronchial asthma, the doctor has prescribed to the patient cromolyn sodium. What mechanism from given ones is characteristic for this agent?A. Blockage of histaminic receptorsB. Decreasing of immunoglobulin concentration C. Binding of free histamine**D. Stabilization of membranes of mast cellsE. Inactivation of histamine

250. The increased sensitiveness to the cold diseases is developed at a patient after the prolonged application of one of medical preparations. What from medications could be stimulate the decline of immunity?A. Prednisolone B. Claritin**C. MethyluracilD. DibazolumE. Cromolyn sodium