ted w. simon, ph.d., dabt - jurispro.com · ted simon, ph.d., dabt page 3 of 15 june, 2016 •...

June,2016

TedW.Simon,Ph.D.,DABT Contact4184JohnstonRoad email:[email protected] Winston,GAUSA30187 website:http://www.tedsimon-toxicology.commobile:(770)359-9807SummaryAwardwinningtoxicologistandscientist.10+years’experienceasatoxicologistemployedbytheEnvironmentalProtectionAgency(EPA).ServedasEPA’sseniortoxicologistinthewastemanagementdivisionworkingonriskandsoilcleanup.Expertiseintoxicology,riskassessment,mathematicalmodeling,statistics,neuroscience,andenvironmental/ecologicalhealthissues.Extensivenationalandinternationalpublicspeakingexperience.15+yearsteachingexperience.Wellpublished,includingauthoroftextbookontoxicologyandenvironmentalriskassessment.Experiencedexpertwitnessonissuesincludingenvironmentalrisk,drugandalcoholcases,DUI,accidentalpoisoning,andintellectualproperty.10+yearsconsultingexperience.Specialinterestandexpertiseindioxin-likechemicalsandpolychlorinatedbiphenyls(PCBs).ProfessionalCertification1994- DiplomateoftheAmericanBoardofToxicology(DABT) EmploymentHistory2004-present Principal,TedSimon,LLC,Winston,GA2006-present AdjunctProfessor,EnvironmentalHealthScience,CollegeofPublicHealth,UniversityofGeorgia,

Athens,GA1996-2006 Toxicologist,USEnvironmentalProtectionAgency,Region4,Atlanta,GA2003 Instructor,DepartmentofBiology,GeorgiaStateUniversity,Atlanta,GA2001-present Instructor,DepartmentofEnvironmentalHealthScience,UniversityofGeorgia,Athens,GA1996 EnvironmentalHealthScientist,AgencyforToxicSubstancesandDiseaseRegistry/Centersfor

DiseaseControl,Atlanta,GA1994-1996 Toxicologist,USEnvironmentalProtectionAgency,Region4,Atlanta,GA1993-1994 ProjectScientist,ManTechEnvironmentalInc.,USEPARegion4,Atlanta,GA1993 AssistantProfessorofBiology,LifeCollege,Marietta,GA1991-1993 GeorgiaStateUniversity,PostdoctoralResearchAssociate,Atlanta,GA1989-1991 EmoryUniversity,PostdoctoralResearchFellow,Atlanta,GA1982-1988 GeorgiaStateUniversity,Research/TeachingAssistant,Atlanta,GAPublicationsTEXTBOOK • SimonT.EnvironmentalRiskAssessment:AToxicologicalApproach.(2014)(ISBN978-1466598294)ATextbookfor

GraduateRiskAssessmentCourses,CRCPress,February2014.

PEER-REVIEWED JOURNAL ARTICLES • SimonTW,ZhuY,DoursonML,BeckN.(2016)BayesianMethodsforUncertaintyFactorApplicationforDerivationof

ReferenceValues.RegulToxicolPharmacol80:9-24.

• BeckNB,BeckerRA,ErraguntlaN,FarlandWH,GrantRL,GrayG,KirmanC,LakindJS,LewisRJ,NanceP,PottengerLH,SantosSL,ShirleyS,SimonT,DoursonML.(2016)Approachesfordescribingandcommunicatingoveralluncertaintyintoxicitycharacterizations:U.S.EnvironmentalProtectionAgency'sIntegratedRiskInformationSystem(IRIS)asacasestudy.EnvironInt89-90:110-128.

• BeckerRT,PatlewiczG,SimonTW,RowlandsJC,BudinskyRA(2015)Theadverseoutcomepathwayforrodentlivertumorpromotionbysustainedactivationofthearylhydrocarbonreceptor.RegulToxicolPharmacol73:172-90.

• SimonTW,BudinskyRA,RowlandsJC.(2015)AModelforArylHydrocarbonReceptor-ActivatedGeneExpressionShowsPotencyandEfficacyChangesandPredictsSquelchingduetoCompetitionforTranscriptionCo-activators.PLOSONE,10(6):e0127952

TedSimon,Ph.D.,DABT Page2of15

June,2016

• BeckerRA,FriedmanKP,SimonTW,MartyMS,PatlewiczG,RowlandsJC.(2014)Anexposure:activityprofilingmethodforinterpretinghigh-throughputscreeningdataforestrogenicactivity-Proofofconcept.RegulToxicolPharmacol71:398-408.

• PatlewiczG,SimonTW,RowlandsJC,BudinskyRA,BeckerRA.(2015)Proposingascientificconfidenceframeworktohelpsupporttheapplicationofadverseoutcomepathwaysforregulatorypurposes.RegulToxicolPharmacol71:463-477.

• SimonTW,SimonsSSJr.,PrestonRJ,BoobisAR,CohenSM,DoerrerNG,Fenner-CrispPA,McMullinT,McQueenCA,RowlandsJC(2014)TheUseofModeofActionInformationinRiskAssessment:QuantitativeKeyEvents/Dose-ResponseFramework(Q-KEDRF)forModelingtheDose-ResponseforKeyEvents.CritRevToxicol44Suppl3:17-43.

• Budinsky,RA,SchrenkD,SimonT,VandenBergM,ReichardJF,SilkworthJB,AylwardLL,BrixA,KaminskiN,PerdewG,StarrTB,WalkerNJ,RowlandsJC(2014)Modeofactionanddose-responseframeworkanalysisforreceptor-mediatedtoxicity:thearylhydrocarbonreceptorasacasestudy.CritRevToxicol44(1):83-119

• PatlewiczG,SimonT,GoyakK,PhillipsRD,RowlandsJC,SeidelSD,BeckerRA.(2013)UseandValidationofHT/HCAssaystosupport21stcenturytoxicityevaluations.RegulToxicolPharmacol65(2):259-68.

• StephensML,AndersenM,BeckerRA,BettsK,BoekleheideK,CarneyE,ChapinR,DevlinD,FitzpatrickS,FowleJR,HarlowP,HartungT,HoffmannS,HolsappleM,JacobsA,JudsonR,NaidenkoO,PastoorT,PatlewiczG,RowanA,SchererR,ShakihR,SimonT,WolfD,ZurloJ.(2013)WorkshopReport:Evidence-basedToxicologyforthe21stCentury:OpportunitiesandChallenges.ALTEX30:74-103.

• PatlewiczG,SimonT,GoyakK,PhillipsRD,Rowlands,JCR,SeidelSandBeckerRA(2013)UseandValidationofHT/HCAssaystoSupport21stCenturyToxicityEvaluations.RegulToxicolPharmacol5:1-7.

• KirmanC,Budinsky,RA,YostL,BakerBF,ZabikJM,RowlandsJC,LongTF,SimonT(2011)DerivationofSoilClean-UpLevelsfor2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD)ToxicityEquivalence(TEQD/F)inSoilThroughDeterministicandProbabilisticRiskAssessmentofExposureandToxicity.HumanandEcologicalRiskAssessment17(1):125-158.

• BudinskyRA,LeClyuseEL,FergusonSS,RowlandsJC,SimonT(2010)HumanandRatPrimaryHepatocyteCYP1A1and1A2Inductionwith2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD),2,3,7,8-Tetrachlorodibenzofuran(TCDF)and2,3,4,7,8-Pentachlorodibenzofuran(4-PeCDF).ToxicolSci118(1):224-235.

• SimonT(2010)JustWhoisatRisk?TheEthicsofEnvironmentalRegulation.HumExpToxicol30(8):795-819.

• SimonT,Kirman,CR,AylwardLL,BudinskyRA,RowlandsJC(2009)EstimatesofCancerPotencyof2,3,7,8-Tetrachlorodibenzo(p)dioxinusingLinearandNon-linearDose-ResponseModelingandToxicokinetics.ToxicolSci112(2):490-506.

• SimonT,Kirman,CR,AylwardLL,BudinskyRA,RowlandsJC,LongT(2008)EstimatesofCancerPotencyFor2,3,4,7,8-PentachlorodibenzofuranUsingBothNonlinearandLinearApproachs.ToxicolSci106(2):519-537.

• SimonT,BrittJK,JamesRC(2007)DevelopmentofaNeurotoxicEquivalenceSchemeofRelativePotencyforAssessingtheRiskofPCBMixtures.RegulToxicolPharmacol48:148-170.

• SimonTandManningR(2006)DevelopmentofaReferenceDoseforthePersistentCongenersofWeatheredToxaphenebasedoninvivoandinvitroeffectsRelatedtoTumorPromotion.RegulToxicolPharmacol44:268-281.

• SimonT(2000)InDefenseofRiskAssessment:aReplytotheEnvironmentalJusticeMovement’sCritique.HumanandEcologicalRiskAssessment6(4):556-560.

• EnglehardtJD,SimonT(1999)OrderAmidUncertainty.CivilEngineering,AmericanSocietyofCivilEngineers,69(6):8A-13A.

• SimonT(1999)TwoDimensionalMonteCarloSimulationandBeyond:AComparisonofSeveralProbabilisticRiskAssessmentMethodsappliedtoaSuperfundSite.HumanandEcologicalRiskAssessment5(4):823-843.

• SimonT(1997)CombiningPhysiologicallyBasedPharmacokineticModelingwithMonteCarloSimulationtoDeriveanAcuteInhalationGuidanceValueforTrichloroethylene.RegulToxicolPharmacol26:257-270.

• SimonT,BarnesK(1995)OlfactionandPreySearchinthecarnivorousleech,Haemopismarmorata.JExpBiol199:2041-2051.

• SimonT,DerbyCD(1995)MixtureSuppressionwithinhibitionforbinarymixturesfromwholecellpatchclampstudiesofinsituolfactoryreceptorneuronsofthespinylobster.BrainRes678(1-2):213-224.


June,2016

• SimonT,Schmidt,J,CalabreseRL(1994)ModulationofHighThresholdTransmissionBetweenHeartInterneuronsoftheMedicinalLeechbyFMRF-NH2.JNeurophysiol71:454-466.

• SimonT,OpdykeCA,CalabreseRL(1992)ModulatoryeffectsofFMRF-NH2ontheoutwardcurrentsandoscillatoryactivityinheartinterneuronsofthemedicinalleech.JNeurosci12(2):525-537.

• SimonT,EdwardsDH(1990)Light-evokedwalkingincrayfish:Behavioralandneuronalresponsestriggeredbythecaudalphotoreceptor.JCompPhysiolA166:745-755

• HersheySJ,SimonT,BasteC(1975)Histochemicallocalizationofcytochromeoxidaseingastricmucosa.JHistochemCytochem4:271-282.

ABSTRACTS • SimonTW,ZhuY,DoursonML,BeckNB.(2016)BayesianMethodsApplication:ProofofConceptandPitfalls.

SocietyofToxicologyAnnualMeeting,NewOrleans,LA

• SimonTW,BeckNB(2015)BayesianMethodsforUncertaintyFactor(UF)Application:ProofofConcept.SocietyofRiskAnalysisAnnualMeeting,T2-A.3,Arlington,VA

• CanadyRA,SimonTW.(2015)DisruptiveArrivalofBigDatatoFoodIntakeAssessment.SocietyofRiskAnalysisAnnualMeeting,M2-H.1,Arlington,VA

• RuizP,SimonT,MumtazM(2014)InterpretingNHANESBiomonitoringData:Dioxins.Abstract96d,TheToxicologist—AnofficialJournaloftheSocietyofToxicology,Volume138,Issue1,March

• BeckerR,SimonT,Patlewicz,G,KennedyS,FarhatA,BudinskyR.(2014)ImprovingTheDevelopmentOfAdverseOutcomePathways:LessonsLearnedFromTheAHRRodentLiverTumorandAHRAvianTeratogenicity/EmbryolethalityAOPs.Abstract2253TheToxicologist—AnofficialJournaloftheSocietyofToxicology,Volume138,Issue1,March

• SimonT.(2014)EvidentiaryStandardsforNeuroactiveandNeurotoxicDrugTesting(2014)Abstract723,TheToxicologist—AnofficialJournaloftheSocietyofToxicology,Volume138,Issue1,March

• BeckerR,PatlewiczG,SimonT,GoyakK,PhillipsR,RowlandsJC,SeidelS.(2013)ValidationofHigh-ThroughputandHigh-Content(HT/HC)AssaystoSupport21stCenturyToxicityEvaluations.Abstract2267.TheToxicologist—AnofficialJournaloftheSocietyofToxicology,Volume132,Issue1,March

• SimonT,StephensM,YangY,ManningR,RowlandsJC,BudinskyRA(2012)Applyingthe“ScienceandDecisions”ConceptualModels”toDioxin.Abstract133.TheToxicologistCD—AnofficialJournaloftheSocietyofToxicology,Volume126,Issue1,March

• Simon,T,RowlandsJC,BudinskyRA(2011)TheToxicEquivalenceFactorfor2,3,7,8-Tetrachlorodibenzofuran(TCDF):ToxicokineticandToxicodynamicConsiderations.OrganohalogenCompounds73:1003-1006.

• SimonT(2010)UsingHumanInVivoAHRActivationasaFunctionalDoseMetricforRiskAssessmentbasedonChloracne,EffectsinKeratinocytesandBackgroundCYPInduction.OrganohalogenCompounds62:582-585.

• SimonT,BudinskyRA,RowlandsJC,AbelTA(2010)Linearvs.NonlinearExtrapolationforDose-ResponseAssessmentofTCDD.OrganohalogenCompounds72:1418-1421.

• HawsL,TachovskyA,StaskalD,AylwardL,BurkhalterB,UrbanJ,SimonT,HarrisM(2010)AnEvaluationoftheInfluenceofDifferentSoilCleanupLevelsontheConcentrationofDioxin-LikeCompoundsinHumanSerum.OrganohalogenCompounds72:1448-1449.

• HarrisM,TachovskyA,StaskalD,AylwardL,BurkhalterB,SimonT(2010)SerumConcentrationsofDioxin-LikeCompoundsinaPopulationofMidlandMichigan:AnEvaluationoftheImpactofSoilExposures.OrganohalogenCompounds72:1442-1443.

• SimonT,GoodrumPE(2010)AComparisonofThreeDifferentMethodsofChildrens’SoilIngestion.TheToxicologist,#1916

• HawsL,TachovskyA,StaskalD,SimonT,BurkhalterK,HarrisMA(2010)EvaluationoftheImpactofSoilExposurestoDioxin-LikeCompoundsonBodyBurdeninaPopulationinMidland,Michigan.TheToxicologist,#1871

• HarrisMA,TachovskyA,StaskalD,SimonT,BurkhalterK,etal.(2010)AssessmentoftheImpactofVariousSoilCleanupLevelsonSerumConcentrationsofDioxin-LikeCompoundsinHumans.TheToxicologist,#1872


June,2016

• SimonT(2009)CancerPotencyEstimatesfor2,3,7,8-TCDDdevelopedfromtheNationalToxicologyProgramBioassayResults,TheToxicologist,Program#EA1-2251

• SimonT(2009)WhyHumansareLessSensitivetoPCBsthanRhesusMonkeys,TheToxicologist#EA4-2254

• KirmanC,BudinskyR,YostL,RowlandsC,LongT,SimonT(2008)DevelopmentofaDirectContactCriterion(DCC)for2,3,7,8-TCDDinSoilUsingDeterministicandProbabilisticMethods.OrganohalogenCompounds70:1204-1207.

• KirmanC.,CrouchE,AylwardL,SimonT,BudinskyR,LandenbergerB,LongT(2007)CancerPotencyEstimateFor2,3,4,7,8-Pentachlorodiobenzo(P)Dioxin(4-PeCDF)TheToxicologist,Program#1561,p323.

BOOK CHAPTER • SimonT,EdwardsDH(1990)TheCaudalPhotoreceptor:AMultifunctionalSensoryNeuronmayselectitsOutputsby

SpikeFrequency.InFrontiersinCrustaceanNeurobiology,WieseK,KrenzW-D,TautzJ,ReichertH,MulloneyB(eds.)Birkhauser-Verlag,Basel,Boston,Berlin

Grants,AwardsandHonors2012-15 GrantfromtheDowChemicalCompany.Developmentofamodeloftheeffectsoftheavailabilityof

coregulatorproteinsongenetranscription.2009 HonorableMention,RiskAssessmentSpecialtySectionoftheSocietyofToxicology,bestpaperoftheyear SimonT,Kirman,CR,AylwardLL,BudinskyRA,RowlandsJC(2009)EstimatesofCancerPotencyof2,3,7,8-

Tetrachlorodibenzo(p)dioxinusingLinearandNon-linearDose-ResponseModelingandToxicokinetics.ToxicologicalSciences112(2),490-506.

2005 RecognitionfromtheSouthWireCompanyforinnovativeapproachestoEnvironmentalCleanup2005 EPABronzeMedalforTestimonyintheNormanMayescaseinKnoxville,TNthatledtoadditionalUST

regulationsbeingpassedbytheStateofTennessee2005 EPABronzeMedalforDevelopingGuidanceonMonitoringLandUseControls2002 EPAScienceAchievementAwardforProbabilisticRiskAssessmentGuidance1995 EPABronzeMedalforCommendableService;Forleadershipinsettingtheexampleinself-directedworkteam

managementandinsettingtheexamplein"fast-track"multimediaenvironmentalinvestigationandcleanup1992 EnvironmentalEducationEnterprisesScholarshipinEnvironmentalScience,"PrinciplesofEnvironmental

DrillingandSampling,"AssociationofEngineeringGeologists,Atlanta,GA1992 SpecialAwardfromtheVicePresidentforResearch,GeorgiaStateUniversity,"Evolutionofdifferentprey

choiceandfeedingstrategyintworelatedspecies,"$10001989 NationalResearchServiceAwardF32NS08394-01A1fromNIH-NINCDS"ModulationofIonicChannelsinan

OscillatoryNetwork,EmoryUniversity,$41,0001989 HonorableMention,DonaldB.LindsleyPrizeinBehavioralNeuroscienceforPh.D.Thesis,HonorableMention

forPh.D.thesis,"TheNeuralBasisofLightEvokedWalkinginCrayfish,"SocietyforNeuroscience Education1989 Ph.D.Neurobiology&Behavior,GeorgiaStateUniversity,Atlanta,GA1971 B.A.Biology,MiddleburyCollege,Middlebury,VTProfessionalMemberships• 1995- SocietyofToxicology• 1997– SocietyforRiskAnalysis• 1984–1993 SocietyforNeuroscienceInvitedLectures• 2016 “BayesianMethodsforApplicationofUncertaintyFactors,”SocietyofToxicologyAnnualMeeting,New

Orleans,LA


June,2016

• 2016 “QuantitativePredictionofPhenotypicChangefromHighThroughputAssayResults,”EPAWorkshoponInVitrotoInVivoExtrapolation,February,ResearchTrianglePark,NC

• 2015 “BayesianMethodsforApplicationofUncertaintyFactors,”SocietyforRiskAnalysisAnnualMeeting,Arlington,VA

• 2015 “ANewLookatToxicityFactorsforToxaphenerelatedtoFishConsumptionintheGreatLakes,”PresentationtoTheGreatLakesConsortiumforFishAdvisories

• 2014 “QuantitativeKeyEventRelationshipsintheAdverseOutcomePathway(AOP)forAHR-MediatedRodentLiverTumorPromotionQuantitativeKeyEventRelationshipsintheAdverseOutcomePathway(AOP)forAHR-MediatedRodentLiverTumorPromotion,”InvitedSpeakeratameetingsponsoredbytheNationalInstituteofEnvironmentalHealthSciencesheldinBethesda,MD

• 2014 “EvidentiaryStandardsforNeuroactiveandNeurotoxicDrugTesting”InvitedSpeakerinaworkshopatthe2014meetingoftheSocietyofToxicology.

• 2013 “CurrentOutlookforImprovingUncertaintyandRiskCommunication.”InvitedSpeakeratUnderstandingandCommunicatingUncertaintyinHazardAssessment,aworkshopsponsoredbytheCenterforAdvancingRiskAssessmentScienceandPolicy(ARASP)oftheAmericanChemistryCouncil(ACC).

• 2013 FourLecturesinGraduateLevelEnvironmentalRiskAssessmentandRiskCommunication,UniversityofGeorgia,Athens,GA,Spring2013

• 2012 FourLecturesinGraduateLevelEnvironmentalRiskAssessmentandRiskCommunication,UniversityofGeorgia,Athens,GA,Spring2012

• 2011 “TheToxicEquivalenceFactorfor2,3,7,8-Tetrachlorodibenzofuran:Chemical-AdjustmentFactorsforAddressingTEFUncertainty.”Dioxin2011,Brussels,Belgium,August23,2011

• 2010 “Linearvs.NonlinearExtrapolationforDose-ResponseAssessmentofTCDD,”Dioxin2010,SanAntonio,TX,September15

• 2010 “UsingHumaninvivoAHRActivationasaFunctionalDoseMetricforRiskAssessmentBasedonChloracne,EffectsinKeratinocytesandBackgroundCYPInduction,”Dioxin2010,SanAntonio,TX,September13

• 2009 “DoseThresholdsinCancerRiskAssessment:Yes,theydoexist.”UniversityofGeorgia,DepartmentofEnvironmentalHealthScience,Athens,GA,October26

• 2008 "Toxaphene–HowBadisthisPesticide?"UniversityofGeorgia,DepartmentofEnvironmentalHealthScience,Athens,GA,October9

• 2008 "NaggingQuestionsaboutPCBs"UniversityofGeorgia,DepartmentofEnvironmentalHealthScience,Athens,GA,October7

• 2008 "ToxicologyofPolychlorinatedBiphenyls(PCBs),"GeorgiaPowerToxicSubstancesControlActTraining,GeorgiaPowerHeadquarters,Atlanta,GA,July24.

• 2008 “NeurotoxicModesofActionofPolychlorinatedBiphenylsandBrominatedFlameRetardants:ImplicationsforEnvironmentalRegulation”,NationalInstituteofEnvironmentalHealthScience5thPCBWorkshop:NewKnowledgegainedfromoldpollutants,May16-22,IowaCity,IA,invitedbyDr.P.R.S.Kodavanti

• 2007 “NeurotoxicEquivalenceSchemeofRelativePotencyforAssessingtheRiskofPCBMixtures,”Dioxin2007,Tokyo,Japan,invitedbyDr.P.R.S.KodavantiofEPA,September.

• 2007 “ProbabilisticRiskAssessmentandExposure,”UniversityofGeorgia,DepartmentofEnvironmentalHealthScience,Athens,GA

• 2006 “Toxaphene–theWorld’sMostMisunderstoodPesticide,”UniversityofGeorgiaDepartmentofEnvironmentalHealthScienceSeminarSeries,Athens,GA

• 2005 "RegulatoryPerspectivesonProbabilisticRiskAssessment.”SocietyforRiskAnalysisandInterstateRegulatoryCouncilWorkshop.MichiganStateUniversity,EastLansing,Michigan

• 2004 “NewDirectionsinEnvironmentalIssues:anEPAPerspective.”PanelDiscussionattheGeorgiaEnvironmentalLawSeminar,SaintSimonsIsland,GA

• 2003 "ProbabilisticApproachestoDose-ResponseAssessment."LecturetoEPA'sRiskAssessmentForum,


June,2016

Washington,DC

• 2000 “ProbabilisticRiskAssessment:StepbyStep,”SponsoredbyNIEHS,EPAandtheUniversityofFlorida,SafetyHarbor,FL

• 1999 “EPA’sNewGuidanceonCitizenInvolvementinSuperfundRiskAssessment–WhatLawyersandRiskProfessionalsNeedtoKnow.”PanelDiscussionattheSocietyofRiskAnalysisAnnualMeeting,Atlanta,GA

• 1999 “CalculatingCleanupLevelswithMonteCarlo:RegulatoryConcernsandPerspective.”WithinasymposiumorganizedbyScottFerson,SocietyforRiskAnalysisAnnualMeeting,Atlanta,GA

• 1999 “PracticalIssuesintheUseofProbabilisticRiskAssessmentandItsApplicationtoHazardousWasteSites,”sponsoredbyNIEHS,EPAandtheUniversityofFlorida,Sarasota,FL

• 1996 "EvaluatingtheRiskofLiverCancerfromOccupationalExposuretoTrichloroethylenewithPBPKModelingandMonteCarloSimulation.”ChemicalIndustryInstituteofToxicology,ResearchTrianglePark,NC

KeyExperienceLITIGATION SUPPORT / WORK FOR LEGAL APPLICATION 2015-16 ExpertReportontheToxicityofDioxin-likeChemicals Providedareportanddepositionondifferencesintoxicityofthevariousdioxin-likechemicals.2015 ConsultationwithaWaterUtilityregardingtheHealthEffectsofRadiuminDrinkingWater Workedwithahealthphysicisttodevelopajointopinionaboutthehealtheffectsofradiumandpotential

treatmenttechnologiestoenabletheutilityinanacquisition.2015 DepositiontoStateEnvironmentalRegulatorsabouttheEffectsofSeleniumonHumanHealth ProvideddepositionregardingthetoxicityofseleniumdischargedintostreamsnearAppalachiancoalmines.2015 ExpertReportontheLikelihoodofFungalEyeInfectionafterContactwithFertilizer Investigatedexposureofplaintifftoairbornefertilizerparticlesduringspreadingoperations.Thefertilizer

particlesenteredtheeyeandfungalinfectionofthecorneaensued.Wroteareportthatresultedinimmediatesettlementinfavoroftheplaintiff.

2015 ExpertOpinionontheToxicityandHealthEffectsofSyntheticCannabinoidsInJanuary,providedamemorandumtotheFairfaxCounty,VAPoliceDepartmentdetailingthehealtheffectsofsyntheticcannabinoidsusedintheillegaldrugsknownas“spice”or“K-2.”

2014-15DevelopmentofStatisticalBackgroundScreeningMethodsforUseataPotentialSuperfundSiteInDecember,providedacomparisontobackgroundforconcentrationsofarsenicandpolycyclicaromatichydrocarbonsatasitecurrentlygoingthroughtheHazardRankingSystem.

2008-14ExpertConsultationandDepositiononRegulatoryDecisionsataSuperfundSiteProvidedanexpertreporttoattorneysabouthowthepresenceofdioxin-likechemicalsandPCBsaffectedtheregulatoryactivities/decisionsataSuperfundsiteinNewEngland.In2014,providedadepositiontoaDept.ofJusticeattorneyinWashington,DC,

2014 ReportonTSCAComplianceStatusofRecentDataandPublicationsontheHealthEffectsofChromiumPreparedareportonthedeterminationsofwhetherthesedataandpublicationscouldbeconsidered“new”information.Thepurposewastoprovideattorneyswithriskinformationasindicatedinthe1978TSCASection8(e)PolicyStatementonSubstantialRiskNotificationstoEPA.

2010 RebuttalReportonHexavalentChromium Preparedareportrebuttingareportsubmittedbytheexpertworkingforopposingcounselregardingthehealth

andenvironmentaleffectsofhexavalentchromium.2008-10ExpertTestimonyregardingtheEffectsofInorganicMercury

Providedanexpertreporttoattorneysinachildcustodymatterregardingthelongtermneurologicalandpsychologicaleffectsofinorganicmercury.ProvidedexperttestimonyonthismatterinfamilycourtinFultonCounty,GAregardingthetoxicityofinorganicmercury.

2009 ExpertConsultationregardingUSEPA'snewArsenicToxicityCriterionProvidedamemorandumtoattorneysandpersonnelfromelectriccompaniesontheramificationsofEPA'sproposedchangeintheoralcancerslopefactorforArsenic.


June,2016

2008 RiskCommunicationandExpertConsultationregardingAerosolEmissionsRetainedasanexpertintoxicologybyattorneysforGeorgiaPowertoprovidescientificconsultationandriskcommunicationregardingemissionsofseveralinorganicchemicalsfrompowerplants.

2007 ProBonoEvaluationofExposuretopara-dichlorobenzene(PDB)ProvidedanexpertreportonexposureandpotentialliverdamageinanindividualworkinginabotanylaboratoryinwhichPDBwasusedasaninsectfumigantforplantspecimens.

2006 AssessmentofPossibleDrug/AlcoholImpairmentinforWorkman’sCompensationExaminedquickurinedrugscreenresultsshowingalcoholandmarijuanauseanddevelopedanassessmentofpossibleimpairment.

2006 ExpertConsultationontheRecentHistoryofArsenicRegulationbyEPAProvidedamemorandumdetailingthehistoryofarsenicregulationasasoilcontaminantbyEPAheadquartersandbyRegion4EPA(Southeast)since1988tosupporttheeffortsofattorneysregardingaSuperfundsite.

2006 ConsultingExpertregardingIndoorDampnessandMoldServedasaconsultingexpertregardingadverseeffectsofexposuretoindoordampness,associatedmoldandbacteriaandthedisinfectantchemicalsusedinthecleanup.

2003-4 ModelofChemicalReleasefromaRailroadTankCarDevelopedamathematicalmodelforthereleaseanddispersionofadensegas,ethylacrylate,fromarailroadtankcar.Thegasproducedorganolepticeffects,andathigherexposure,toxiceffects.Sourcecharacteristicswereobtainedusingbasicphysicalchemicalprinciples.Dispersionmodelingwasperformedfordensegasdispersionincomplexterrain.

2003 ExpertTestimonyinEPAvs.NormanC.MayesAsanEPAtoxicologist,providedtestimonytoAdministrativeLawJudgeBarbaraGunningregardingthehealtheffectsofbenzeneandotherfuelcomponentsandenvironmentalsamplingaroundundergroundstoragetanks.

2002-4 AirandExposureModelingandPBPKModelDevelopmentofCreosoteExposureataWoodTreatmentFacilityDevelopedacomprehensivedatabaseofchemicalsinwoodpreservativemadewithcoaltarcreosote,amathematicalmodeloftheairconcentrationsofthesechemicalsatawoodtreatmentfacility,andasecondmodelforhumaninternalexposuretothesechemicalsthatincludedingestion,inhalationanddermalpathways.

2001-2 ExpertTestimonyregardingCalibrationoftheIntoxilyzer5000DevelopedtestimonyregardingthecalibrationproceduresoftheIntoxilyzer5000,the"breathalyzer"usedinGeorgiaforDUItesting.ChargesinDUIcasesweredroppedinthethreecasesinwhichDr.Simonwasinvolvedpriortohistestimony.

2000 ChemicalReleasefromaRailroadTankCarDevelopedamodelofreleaseandtransportofacrylamidefromarailroadtankcarforuseinlitigation.

PRODUCT LIABILITY AND SAFETY EVALUATIONS 2013 PresentationtoaFrenchGovernmentAgencyonProductSafety

ProvidedareportwithestimatesofbothtoxicityandexposuretorailworkersontheuseofasyntheticdielectriccompoundmanufacturedbyacompanyintheUK.MetwithFrenchgovernmentpersonneltodiscussthereport.

2012 AssessmentofRiskfromMetalPlatingFlakingfromanAuxiliaryFaucetusedwithaWaterFilter Developedriskestimatesforwaterconsumersfromdissolvedmetalsandmetalflakesfromthefaucet.This

assessmentwasusedinternationallyandthereforeincorporatedWorldHealthOrganizationmethodology.

TEACHING 2014 Instructor,EnvironmentalRiskAssessmentandCommunication,EHSC8110,UniversityofGeorgia

TaughtagraduatelevelcourseIntheSchoolofPublicHealthusinghistextbook,“EnvironmentalRiskAssessment:AToxicologicalApproach.”

2008 LectureontheToxicologyofPCBsDevelopedandpresentedatrainingsegmentaspartoftheToxicSubstanceControlAct(TSCA)trainingforelectricpowercompanypersonnelattheGeorgiaPowerCompany.

2008 IntroductiontoRiskAssessment,atwodayclassfortheOntarioMinistryofEnvironmentWithanotherscientist,developedandtaughtaclassonriskassessmentfornewlyhiredpersonnelattheMinistry.


June,2016

2005 ProbabilisticRiskAssessmentandStatistics,ashortcoursetoMichiganDepartmentofEnvironmentalQualityWithanotherscientist,presenteda1½dayclassonprobabilisticriskassessmentandstatisticsaspartofaweeklongworkshopsponsoredbytheSocietyforRiskAnalysisandInterstateTechnologyRegulatoryCouncil.

2003 GraduateCourseinSimulationModeling,GeorgiaStateUniversityTaughtagraduatelevelcourseinSimulationModelingincludingstatistics,probabilisticmethodsandtime-dynamicdifferentialequationmodels.

2003 ShortCoursetoOntarioMinistryofEnvironmentonProbabilisticRiskAssessmentWithanotherscientist,developedandtaughtaclassonprobabilisticriskassessment,includingprobabilisticapproachestodose-responsetopersonnelattheOntarioMinistryofEnvironmentinToronto,Canada

2001-06UniversityofGeorgiaGraduateCourseinEnvironmentalRiskAssessmentOnthreeseparateoccasions,taughtagraduate-levelclassonEnvironmentalRiskAssessmentlasting15weeks,3hoursperweek.

2001 ShortCoursetoTexasNaturalResourcesConservationCommissiononProbabilityDistributionsWithanotherscientist,developedandtaughtaclassonstatisticsandprobabilitydistributionstodatatoTNRCCpersonnel.

2000 WorkshopsonProbabilisticRiskAssessmentPerformedasanEPAtoxicologist.In1999and2000,workedwithDr.SteveRobertsoftheUniversityofFloridatoorganizetwoworkshopsonPRAsponsoredbyEPA,NIEHSandtheUniversityofFlorida.

1999 ShortCoursetoTexasNaturalResourcesConservationCommissiononProbabilisticRiskAssessment Withanotherscientist,developedandtaughtaclassonprobabilisticriskassessmenttoTNRCCpersonnel.1997 ShortCoursetoNavyEnvironmentalHealthCenterpersonnelonProbabilisticRiskAssessment

Withanotherscientist,developedandtaughtaclassinprobabilisticriskassessmentNavypersonnelinNorfolk,VA.

REGULATORY TOXICOLOGY 2016 AnalysisofChemicalSimilarityforAbuseLiabilityofCandidateDrugMolecules ConductedastatisticalanalysisofchemicalsimilaritybetweentwocandidatedrugsandsubstancesontheDEA

ControlledSubstanceListtoaddresstheissueofpotentialabuseliability.2015-16WhitepaperonCausalAssociationsbetweenFlameRetardantExposureandFirefighters’Diseases

DevelopedfortheFlameRetardantsAlliance.2015 RevisionoftheToxicityFactorforthePesticideToxapheneforuseattheHerculessiteinBrunswick,GA Developedarevisedestimateofthetoxicitycriterion(ReferenceDose)forthepesticidetoxapheneforuseina

newriskassessmentfortheHerculessiteinBrunswick,Georgia.2015 AdverseOutcomeSummaryPathwaysforChemicalswithUncertaintyabouttheModeofAction Adverseoutcomepathways(AOPs)arebeingusedbyEPAandOECDtoformadatawikiforeventual

interpretationofhigh-throughputinvitrodata.DevelopedseparatesummariesofAOPsforfourchemicalscarcinogenicinanimalsusingtheassumptionofmutagenicityasmodeofactionandhyperplasia/cellproliferationasthemodeofaction.

2014-15ReportonBayesianStatisticalMethodsusedintheNRC(2014)ReviewofIRIS Developedareportexamining24toxicityfactorsfromEPA’sIntegratedRiskInformationSystemdatabase,the

subjectofarecentreviewbytheNationalResearchCouncil.ThereportcomparedEPA’smethodswiththoserecommendedintheNRCreport.

2014 PresentationonarsenicandchromiumatEPA’sIntegratedRiskInformationSystem(IRIS)BimonthlyMeeting InJune,presentedmodeofactioninformationforarsenicandhexavalentchromiumatEPA’sIRISmeeting.The

purposeofthesemeetingsistoseekinputfromstakeholdersfordevelopmentofIRISriskassessments.2013 PresentationonQuantitativeMethodsforModeofActionAnalysistoEPA’sBimonthlyIRISMeeting InDecember,presentedslidesanddiscussiontoEPAandotherstakeholdersbasedonthepaperwrittenwith

ILSI/HESItitled“TheUseofModeofActionInformationinRiskAssessment:QuantitativeKeyEvents/Dose-ResponseFramework(Q-KEDRF)forModelingtheDose-ResponseforKeyEvents.”


June,2016

2013-16DevelopmentofWikifilesontheAdverseOutcomePathwayfortheOrganisationforEconomicCooperationandDevelopment(OECD)

WroteandeditedwebpagesforuseinthenewAOPWikisponsoredbyOECD,EPAandothers.ThepurposeofthecollectionofAOPsandtheWikiistocontextualizeinvitrodataforuseinriskassessment.

2013 PreparationofaReportProvidingDerivedLD50ValuesforMetalsinFlyAsh DosesofflyashrepresentingtheLD50formetalsweredevelopedforflyashproducedbyanincinerator

operatedbyalargecountygovernmentinsouthernCalifornia.2013 DevelopmentofEvidenceTablesforEPA’sIntegratedRiskInformationSystem(IRIS)Assessments DevelopedtabularformatforpresentingmodeofactionandtoxicityinformationconsistentwiththeNational

AcademyofSciences’ReviewoftheEnvironmentalProtectionAgency'sDraftIRISAssessmentofFormaldehyde.PresentedthetablesandaccompanyingrationaletoEPAIRISstaffusinghexavalentchromiumasanexample.

2013 DevelopmentandPresentationofResponsestoChargeQuestionsforEPA’sFederalInsecticide,Fungicide,andRodenticideAct(FIFRA)ScientificAdvisoryPanel

Wroteresponsesonphysico-chemicalscreeningandtherainbowtroutExpertSystemforestrogeniceffects;presentedtheresponsesattheFIFRA/SAPmeetingatEPAHeadquarters.

2012 ReviewofEPA’sToxicologicalReviewofAmmonia ReviewedtheEPAdraftdocumentforammoniatodetermineconsistencywithrecommendationsfromthe

NationalAcademyofSciences.PresentedresultsatEPA’sIRISlisteningsessiononAmmonia.2012 Reviewof2012TexasCommissiononEnvironmentalQuality(TCEQ)“GuidelinestoDevelopToxicityFactors” TCEQdevelopsitsowntoxicitycriteriaanddoesnotdependonEPA’sIRISdatabase.Preparedcommentsonthe

guidanceforsubmissiontoTCEQ.2012 PreparationofaWhitePaperandmanuscriptforpublicationonValidationofEPA’sToxCast™SuiteofHigh

ThroughputInVitroAssays Wrotenarrativepaperandmanuscriptforachemicalindustrytradegrouponissueswithvalidationofthese

assaysforchemicalscreeningandprioritization.2011 DevelopmentofPhysiologically-basedPharmacokineticModelsforDioxin,PCBs,DDT,Hexachlorobenzeneand

OrganophosphatePesticidesforuseasteachingtoolsattheAgencyforToxicSubstancesandDiseaseRegistry(ATSDR)

DevelopedPBPKmodelsinBerkeleyMadonnasoftwareforuseasteachingaidsforpersonnelatATSDR.2011 ReviewofEPA’sPhysiologicallyBasedPharmacokineticModelforAcrylonitrileUsedintheIRISRisk

Assessment ReviewedtheMATLABcomputercodeandoutputforoptimizationofparametersusedinthismodel.

TOXICOLOGY AND REGULATORY ANALYSIS OF DIOXIN-LIKE CHEMICALS INCLUDING POLYCHLORINATED BIPHENYLS 2012-15ModelingofDioxin-inducedGeneExpressioninBreastCancerCells

Developedamodelofgeneexpressionusingstochasticsimulationmethodsthatreproducedseveralphenomenasuchasnon-monotonicdoseresponsecurves.TheresultsareinpressinPLOSONE.

2012 DevelopmentofaMarginofExposureforEnzymeInductionfromDioxinExposureforComparisonwithRecentEPAToxicityFactorsforaWeight-of-Analysis

Usingdatafrombothhumansandlaboratorytestspecies,determinedthedoseatwhichanincreaseinthyroidhormonemetabolismcouldbeexpectedandcomparedthisdosewiththecurrentEPAreferencedosebasedonthyroideffectsinnewborns.

2011 Inclusionof2009ReferenceDosefor2,3,7,8-Tetrachlorodibenzodioxin(TCDD)intheITERandTOXNETdatabases

Presentedconclusionsfroma2009publicationtoapeerreviewpanelconvenedbyToxicologyExcellenceinRiskAssessment(TERA)forplacementintheInternationalToxicityEstimatesforRiskAssessment(ITER)databaseandlinkedtotheTOXNETdatabaseattheNationalLibraryofMedicine.

2011 DevelopedaRevisedToxicEquivalenceFactor(TEF)for2,3,7,8-Tetrachlorodibenzofuran(TCDF) TCDFisadioxin-likechemicalthatismetabolizedandeliminatedwithinhoursincontrasttootherdioxin-like

chemicalsthatpersistinthebodyformanyyears;developedanestimateoftheTCDFTEFthatincorporatesthisrapidmetabolismforpresentationataninternationalconferenceinBrussels,Belgium.


June,2016

2011 AllianceforRiskAssessmentPresentationonDioxinusingScienceandDecisionsConceptualModels PresentedresultsfromtheapplicationofdoseresponsemethodsdescribedNationalResearchCouncil's2009Report

"ScienceandDecisions:AdvancingRiskAssessment"todioxin.TheaudiencewasanexpertpanelthatincludedseveraloftheauthorsoftheNRCreport.

2010 ReportonBiota-SedimentAccumulationFactor(BSAF)forAroclor1260,aCommercialPCBMixture ProvidedareviewandcommentaryonthedevelopmentofaBSAFforAroclor1260(PCBmixture)anditsgeneral

applicabilitytoPCBcontaminatedsites.2010 RapporteurataWorkshoponDose-ResponseApproachesforNuclearReceptor-MediatedModesofAction Ledpaneldiscussionandprovidedthepresentationofthereportforthepanelexaminingthemodeofactionof

thearylhydrocarbonreceptorthatmediatesgeneexpressionfromdioxin-likechemicals.2010 RiskAssessmentforDioxinbasedontheOccurrenceofChloracneinHumans Developedariskassessmentfor2,3,7,8-tetrachlorodibenzo-p-dioxinbasedsolelyondatafromhumansand

presentedtheworkattheDioxin2010meetinginSanAntonio,TX.2010 AnalysisofResponsesofHumanandRodentLiverCellstoDioxin-LikeChemicals Conductedstatisticalanalysisofgenomicandproteomicdatainresponsetothreedioxin-likechemicalsfrom

humanandrodenttissuesinvitro.2010 CancerSlopeFactorsandToxicityEquivalenceFactorsforDioxin-LikeChemicalsbasedonInternalDoses Developedacomparisonofthetoxicityoffourdioxin-likechemicalsbasedontissueconcentrationsfrom

NationalToxicologyProgrambioassaysusingphysiologically-basedpharmacokineticmodelinganddoseresponsemodels.

2009 EvaluationofToxicityEquivalenceFactorsforDioxin-likeChemicalsbasedonexternaldoses DevelopedacomparisonofmethodsusedtodevelopvaluesforTEFsusedinriskassessmentsofdioxin-like

chemicals.2009 EPAFederalAdvisoryCommitteeAct(FACA)WorkshoponDIoxin Attendedworkshopontheriskassessmentof2,3,7,8-tetrachlorodibenzodioxin(TCDD);providedpublic

commentaryonEPA'sproposedmethodsforrevisingthe2003dioxinreassessment.2008 ReviewofPCBEcotoxicologyInformationintheBaselineEcologicalRiskAssessmentfortheLCPChemical

SuperfundSite,Brunswick,GA ReviewedthetoxicityassessmentforPCBsfortheecologicalriskassessmentforthissitetoensureconsistency

withthevaluesandapproachusedinthehumanhealthriskassessment.2007 ComparisonbetweenBloodLevelsofDioxininresidentsofMidland,MIandthoseinratsassociatedwith

AdverseEffects Conductedacomparisonbetweenhumanbloodlevelsof2,3,7,8-TCDDand2,3,4,7,8-PeCDFmeasuredinhumans

intheUniversityofMichiganDioxinExposureStudyandestimatedbloodlevelsinratsfrombioassayspublishedbytheNationalToxicologyProgramin2006.

2007 DevelopmentofaRiskAssessmentMethodologyBasedonChangesinGeneExpression Withveryrecentinformationondioxin-relatedgeneexpressionchangesintheliver,developedamethodfor

usingthesechangesasabiomarkerfortheprogressiontotype2diabetes.2007 WhitepaperontheNon-cancereffectsonhumansofDioxin-likeChemicals Collectedscientificinformationrelatedtopotentialandactualhumanhealtheffectsfrompublishedstudiesof

theYu-Cheng/Yushopoisoning,theSevesoexposure,theBASFplantexposureandtheVietNamRanchhands(AgentOrangehandlers)andotherstoassessthelikelihoodofvarioushealthoutcomesfromdioxinexposure.

2007 SoilCleanupStandardsforDioxinrelatedtotheGeorgiaHazardousSubstancesResponseActforasecondarycoppersmelter

DevelopadioxincleanuplevelinsoilforconsiderationbytheGeorgiaEPDthatincludedanepidemiologicalstudyofdioxininthebloodofworkersatthesmelter.

2005 DevelopmentofSurrogateValuesforReportedDioxinConcentrationsBelowtheAnalyticalDetectionLimit PerformedasanEPAtoxicologist;theuseofcontract-specifiedreportinglimitsasnondetectsurrogatesfor

dioxinanalysisleadstolargeoverestimatesofsoilconcentrations;identifiedamoreaccuratenondetectsurrogatevaluebasedontheactualchemicalanalysis.


June,2016

2005 ReassessmentfortheNeedforPCBCongenerAnalysisattheAnniston/SolutiaPCBSite PerformedasanEPAtoxicologist;comparedresultsfromPCBcancerbioassaysofthecancerpotencyofdioxin-

likePCBs.2004-5 GeostatisticalmodelingofdioxinconcentrationsinsoilatSuperfundSitesinFlorida PerformedasanEPAtoxicologist;theseanalysesdemonstratedthatcleanupatthesesiteshadbeensuccessful

andappropriateforthepredictedlanduse;theanalysesalsoshowedthatdioxinoccurringoff-sitewasunrelatedtoon-sitecontamination.

HUMAN HEALTH AND ECOLOGICAL RISK ASSESSMENT AND RISK COMMUNICATION 2014 DevelopmentofaProbabilisticRiskAssessmentforNellisDunesRecreationArea,Nevada WorkedinconjunctionwithacademicscientistsattheUniversityofNevada,MontanaStateUniversityandthe

UniversityofSouthCarolinatousenewlydevelopedinformationofthegeologyofNellisDunesandsite-specifictoxicitybioassaysofdusttocompleteariskassessmentforexposuretodustatthisrecreationarea.

2012 ParticipationonaRiskAssessmentTeamdevelopingmethodologytoassessaSuperfundsiteconsistingofalargeareafloodplain

Evaluatedriskassessmentoptionsandlandusetosupportcleanupdecisionsatanimpactedareacomprisingseveralsquaremilesandmanyrivermiles.

2010 ScreeningLevelEcologicalRiskAssessment(SLERA)forasiteinFloweryBranchinHallCounty,Georgia Atanindustrialparknearaninterstatehighway,theareaofpotentialecologicalconcernconsistedofastorm-

waterretentionpondandastream.InvestigatedthesiteanddevelopedtheSLERAdocumentforsubmissiontotheGeorgiaEnvironmentalProtectionDivision.

2009 StreamlinedHumanHealthandEcologicalRiskAssessmentstosupportRemovalActionattheNabesnaMineSiteinNabesna,Alaska

ThissiteislocatedintheWrangell-St.EliasNationalParkandwasafunctioninggoldmineintheearly20thcenturywithhighconcentrationsofmetalsassociatedwithminetailingsandacidminedrainage;developedbothriskassessmentstosupportanon-time-criticalactionatthesite.

2009 DevelopmentofGeorgiaRiskReductionStandards(RRS)forDrexelChemicalCompanyinCordele,GAandanothersiteinNorthGeorgia

CalculatedGeorgiaRRSvaluesforthissite;negotiatedinpersonandbyteleconferencewithGeorgiaEnvironmentalProtectionDivisionpersonnelregardingtheappropriateuseoftoxicitycriteria.

2009 RiskCommunicationandRegulatoryReviewrelatedtotheTVACoalAshSpillinKingston,TN ProvidedriskcommunicationatpublicavailabilitysessionforboththeAmericanCoalAshAssociationandTVA;

reviewedsubmissionstoEPAdevelopedbyTVA.2008 EvaluationofSoilConcentrationsofArsenicwithanEmphasisonLocalBackgroundataPowerPlant DevelopedareportforsubmissiontotheGeorgiaEnvironmentalProtectionDivisionregardingareleaseofwaste

materialcontainingarsenicthatoccurredbystormwaterrunoff;thereportconsideredthegeologyandlocalbackgroundconcentrationandincludedastatisticalanalysis.

2008 StatisticalEvaluationofSolventDatainGroundwaterandCritiqueofATSDRHealthAssessmentofaSuperfundSite

ProvidedareportthatincludedsuggestionsandcommentsontheATSDRReport.PerformedastatisticalanalysistorefinetheconclusionsreachedandcritiquedthemethodologyfortheHealthAssessment.

2008 QualityAssuranceforFishConsumptionRiskAssessmentonthePassaicRiver Reviewedandprovidedcommentsonboththeaccuracyandconceptualizationoftheriskassessment.2008 DevelopmentofGeorgiaRiskReductionStandardsforTrivalentandHexavalentChromiumandseveral

VolatileOrganicChemicals CalculatednumericalstandardsunderGeorgia'sHazardousSiteResponseRule391-3-19asasubcontractorin

supportofapropertysaleandtransfer2008 InvestigationintotheScientificBasisofLandDisposalLimitof50partspermillionforPCBs Underthe1979ToxicSubstancesandControlAct(TSCA),EPAhasplacedanupperlimitof50ppmforland

disposalofPCBs.Investigatedthescientificbasisofthisvalueforapplicationataformerchlor-alkaliplantsiteinNorthCarolina.


June,2016

2008 ReviewofCleanupTargetLevelsofFloridaDepartmentofEnvironmentalProtection ProvidedareviewoftheCleanupTargetLevelsusedforregulationbyFloridaDepartmentofEnvironmental

Protection.2007 EvaluationofCalculationMethodsfortheGeorgiaRiskReductionStandardsoftheGeorgiaHSRAProgram ExaminedRRSvaluesforsoilandgroundwaterdevelopedforasiteinnorthGeorgiaandprovidedanexplanation

oftherationaleunderlyingdiscrepanciesinthecalculatedvalues.2007-9 RiskAssessmentfortheExposuretoMercuryandPCBsfromcontactwithMarshSedimentandConsumption

ofFishandGameBirdsattheLCPChemicalSuperfundSite,Brunswick,GA. Conductedariskevaluationforsedimentexposureand,fishconsumptionwithdevelopmentofsite-specificfish

consumptionestimatesandasite-specificsedimentexposureestimateforanupdatedRemedialInvestigationReportforsubmissiontotheUSEnvironmentalProtectionAgency.

2007 ProBonoEvaluationofGeorgiaDNRFishAdvisoriesforPCBsandMercury EvaluatedcurrentfishadvisoriesnearBrunswick,GAforDr.RandyManning,theGeorgiastatetoxicologist.2007 GeorgiaRiskReductionStandardsforPCBs,mercuryandotherchemicalsinSoilandGroundwaterattheLCP

ChemicalSuperfundSite Prepareddetailedcalculationsofsoilandgroundwaterscreeningvaluesbasedbothondirectexposureand

transferofchemicalsfromsoiltogroundwater.2006-10RiskAssessmentfortheResidentialExposureScenarioforPCBsandmercuryinUplandSoilsattheLCP

ChemicalSuperfundSite,Brunswick,GA. Conductedariskevaluationforresidentialexposure.TheoriginalriskassessmentfortheLCPsitedidnotinclude

anestimateofrisktoon-siteresidentsorotherhumanreceptorswithasmallexposureunit(ca.0.5acres).ThisriskevaluationwillbepartofanupdatedremedialinvestigationtosubmittoUSEPA.

2006-7 RiskAssessmentforConsumptionofEstuarineFishcontainingToxapheneResiduesbyCoastalGeorgiaResidentsrelatedtheHerculesChemicalSuperfundSiteinBrunswick,GA

DevelopedfishconsumptionestimatesforcoastalGeorgiaresidentsbasedontheprevioussurveysintheBrunswickareausedalongwithpublishedworkonthetoxicityoftoxaphenetosupportaprobabilisticriskassessmentforfishconsumptionpreparedforUSEPA.

2006 DevelopmentofaPhysiologically-basedPharmacokineticModelforCopperinMigratoryBirdsforEcologicalRiskAssessmentofMine-AssociatedTailingsPonds

Highcopperconcentrationsinwaterassociatedwithacidminedrainagemaybetoxictobirds;developedofaPBPKmodelofcopperabsorption,distribution,metabolismandexcretion(ADME)injuvenileducksandadultgeese;conductedafeasibilitystudyofincorporatingthephysiologicalchangesassociatedwithmigrationintothismodel.

2006 DevelopmentofaPreliminaryRiskAssessmentforSeleniumaspartofaProposaltoAddressOverallEffectsofSeleniuminaRiverSystem

Developedhumanhealthandecologicalriskestimatesforseleniummigratingfromcoalpilesintoariver.Theseestimatesincludedconsumptionoffishandwaterbyhumans.

2006 EvaluationofGeorgiaDNRFishAdvisoriesnearBrunswick,GA ConductedanevaluationoffishadvisoriesforToxapheneandPCBspublishedbytheGeorgiaDepartmentof

NaturalResources.2006 DevelopmentofawhitepaperpresentingthehistoryofProbabilisticRiskAssessment(PRA)atEPA ReviewedEPAguidancedocumentsandscientificliteratureandproducedadocumentthatdetailedthis

completehistoryofPRAatEPAandsuggestedlikelyusesofPRAinthefuture.2005 RiskCommunicationregardingsolventsingroundwateratAugusta,Georgia AsanEPAtoxicologist,providedinformationtocitizensatapublicmeetingregardingthepossiblehealtheffects

oftetrachloroethyleneandtrichloroethyleneingroundwaterrelatingtoaRCRAsite.2005 ReviewofProposedArsenicToxicityAssessmenttobeplacedonEPA’sIRISDatabase AsanEPAtoxicologistandconsensusreviewerforEPA’sIRISdatabase,reviewedandprovidedcommenton

proposedchangestothearsenictoxicityassessment.


June,2016

2004-5 RiskCommunicationtoCommunityAgainstPollution(CAP),acitizensgroupinAnniston,AL AsanEPAtoxicologist,developedarelationshipwithCAPandpresentedinformationonthehealtheffectsof

PCBsatseveralpublicandcommunitymeetings.2004 ProvidenceParkEcologicalRiskAssessment Conductedascreeninglevelecologicalriskassessment(SLERA)fortheProvidenceParksiteinAlpharetta,

Georgia.2004 RiskCommunicationregardingTrichloroethylene AsanEPAtoxicologist,providedinformationtotheCitizen'sAdvisoryGroup(CAG)atAnnistonArmyDepotanda

groupofconcernedcitizensaboutthehealtheffectsoftrichloroethylene.2003-5 DevelopmentofEPA'sGuidanceonSurfaceSoilCleanupatHazardousWasteSites:ImplementingCleanup

Levels AsanEPAtoxicologist,developedaguidancedocumentthatpresentedmethodsforapplyingrisk-basedcleanup

levelsasareaaveragesratherthannot-to-exceedlevels.2003 SoilCleanupStrategyforaSkeetRangeatNavalAirStationCecilFieldinJacksonville,FL. AsanEPAtoxicologist,usedbothgeostatisticsandexposureassessmenttorefinethesizeoftheareaneeding

remediation.2000 DiscussionofFlorida’sSecondaryDrinkingWaterStandardsbasedonOrganolepticEffects AsanEPAtoxicologist,investigatedthebiologicalbasisofFlorida’ssecondarydrinkingwatercriteriafor

aluminum,iron,manganeseandsilverforwhichsecondarystandardsbasedonesthetics(smellandtaste)werebelowhealth-basedcriteria

2000 MemorandumpresentingAmendedGuidanceonEcologicalRiskAssessmentatMilitaryBases:ProcessConsiderations,TimingofActivities,andInclusionofStakeholders

AsanEPAtoxicologist,authoredamemothatenabledecologicalriskassessmentsatDODfacilitiestobecompletedinatimelymannerandensuresthatriskassessmentactivitiesoccurattimesconsistentwithDODfundingschedules.

1996-9 DevelopmentofRiskAssessmentGuidanceforSuperfund,Part3.ProcessforConductingProbabilisticRiskAssessment

AsanEPAtoxicologist,madesignificantcontributionstothisguidance,whichreceivedEPA'sScienceAchievementAwardin2001.

1995 Region4Bulletins:RegionalRiskAssessmentGuidance AsanEPAtoxicologist,authoredRegion4riskbulletinsonToxicityAssessmentandonDevelopmentofRemedial

GoalOptions.

ADDITIONAL WORK IN TOXICOLOGY 2014-16DevelopmentofanAdverseOutcomePathwayDocumentforaMutagenicModeofActionforCancer Workedwithindividualsfrombothgovernmentandtheprivatesector,collaboratedonamanuscriptdetailing

themodeofaction/adverseoutcomepathwayforlivertumorigenesisinanimalsandhumansbyaflatoxinB1,atoxinproducedbyfungiandubiquitousingrainsandgroundnuts.

2009-16OngoingScientificConsultationontheHealthEffectsofHexavalentChromium Providesongoingsupportfortoxicologicalandriskassessmentinformationfortoxicologicalissuesrelatedto

hexavalentchromiumforaFortune100company.2010 StatisticalAnalysisofReproductiveEndpointsinRatsExposedtoFlameRetardantChemical PerformedstatisticalanalysisofdichotomousdataforreproductiveendpointstoinformaEuropeanconsortium

aboutthemostappropriatemethodsfordataanalysis.2009 ResponsestoEPAChargeQuestionsforReviewofthe2009ToxicologicalReviewof1,4-Dioxane WroteresponsestoEPA's"ChargetoExternalReviewersfortheToxicologicalReviewof1,4-Dioxane”relatedto

uncertaintyanalysis,physiologically-basedpharmacokinetic(PBPK)modelingandBenchmarkDosemodeling.2009 Physiologically-basedPharmacokineticModelsforMethylmercury,Arsenic,CadmiumandBisphenol-Aforuse

asteachingtools TranslatedexistingmodelsintotheBerkeleyMadonnacomputersoftwareforuseasteachingaidsforpersonnel

attheAgencyforToxicSubstancesandDiseaseRegistry.


June,2016

2008 WhitepaperontheEthicsofEnvironmentalRegulationandCompoundingConservatisminRiskAssessmentfortheOntarioMinistryoftheEnvironment

Usedhistoricalsources,philosophicalliteratureandmodernscientificpublicationstoprovideanunderstandingoftheextenttowhichenvironmentalregulationsandstandardsarebasedontheprecautionaryprinciple.

2008 AssessmentofConservatismofSoilandGroundwaterStandardsfortheOntarioMinistryoftheEnvironment Assessedthelevelofconservatismofproposedenvironmentalmediastandardsusingstatisticalmethods.2007 ExpertPanelDevelopingaProtocolforToxicityTestingofaLegacyPesticideMIxture Servedonapaneltorefineaprotocolfortoxicitytestingofsoilconsideringbothindividualpesticideisomersand

mixtures.2004 ConsultationwithEPARegion4MercuryStudyGroup AsanEPAtoxicologist,providedinformationtoagroupofRegion4personneltoaddressanewspapereditorial

regardinghumanhealthandmercury.

PeerReviewsandPeerConsultations2016 ScienceoftheTotalEnvironment,Dr.JayGan,Editor,“Occurrence,SourcesandEstimationofAir-SoilExchange

ofPolychlorinatedbiphenylsinIndiancities"2015 Structuredpeerreviewofacomparisonbetweentheeffectsoftobaccosmokeandnicotinevaporfrom

modifiedrisktobaccoproductsonthelungsofmice Answeredaseriesofchargequestionsandalsoprovidedsuggestionforfutureresearch.2015 EnvironmentalHealthPerspectives,Dr.MartinVandenBerg,Assoc.Editor,“Definingtheneurotoxicpotential

ofnon-dioxin-likePCBspresentinfishfromUSlakesusingaryanodinereceptor-basedequivalencyscheme.”2015 IUMBLife,Dr.AngeloAzzi,Editor,“Identificationofdifferentiallyexpressedthreenoveltranscriptvariantsof

mouseArntgene.”2015 EnvironmentalResearch,Dr.JoseL.Domingo,Editor,“Antioxidantactivityasapotentialmechanismexplaining

thenegativeinfluenceofleadandcadmiumonworkingmemoryduringaging.”2015 ToxicologicalandEnvironmentalChemistry,Dr.SamKacew,Editor,“Headspaceandsmallchamberstudiesof

airbornediacetylreleasefromselectedfoodflavoringmixtures:Activitycoefficientsandairmodelingimplications”

2015 EnvironmentalResearch,Dr.JoseL.Domingo,Editor,“Transcriptomicandvisualgene-networkanalysisofsilvernanoparticlespotentiallyinducedAlzheimer'sdiseaseprogressioninmousebrainneuralcells”

2015 EnvironmentalResearch,Dr.JoseL.Domingo,Editor,“IdentificationofFreePhthalateMetabolitesinHumanCerebrospinalFluid.”

2014 CriticalReviewsinToxicology,Dr.RogerO.McClellan,Editor,“Riskassessmentsforchronicexposureofchildrenandprospectiveparentstoethylbenzene(CASNo.100-41-4)"

2014 EnvironmentalResearch,Dr.JoseL.Domingo,Editor,“Impactofearly-lifebisphenolAexposureonprecorticaldopamineandserotoninsystemsinjuvenileandadultmalerats.”

2014 EnvironmentalResearch,Dr.JoseL.Domingo,Editor,“BisphenolAisassociatedwithinsulinresistanceandmodulatesadipokinesgeneexpressioninobesechildren.”

2014 HumanandExperimentalToxicology,Dr.KaiSavolainen,Assoc.Editor,“GlobalMethaemoglobinaemiaResearchOutput(1940–2013):ABibliometricAnalysisBasedonScopusDatabase."

2014 HumanandExperimentalToxicology,Dr.A.WallaceHayes,Assoc.Editor,“PharmacokineticStudyofOmeprazoleanditsMetabolitesinMalesandFemales,FemalesExposedtoHigherLevelsofOmeprazole.”

2013 ConsultationtoaWaterUtilityRegardingtheQualityofWaterProvidedtoaCommunity Providedinitialconsultationandcoordinatedapeerreviewofariskassessmentofthepesticidetoxaphene

occurringintraceamountsinthewater.2013 HumanandEcologicalRiskAssessment,Dr.BarryJohnson,Editor,“AssessmentofSoilScreeningLevelsdueto

AccidentalIngestionofChryseneandBenzo[k]fluorantheneatIran’sTORSite.”2012 HumanandExperimentalToxicology,Dr.A.WallaceHayes,Editor.“Effectofnicotinepre-treatmentonarsenic

inducedoxidativestressinWistarrats."


June,2016

2012 HumanandExperimentalToxicology,Dr.A.WallaceHayes,Editor,“ElementalimpuritiesinNigerianpediatricsyrups:Mercuryinviolationofstandardguidelines."

2011 JournalofToxicologyandEnvironmentalHealth,Dr.SamKacew,Editor,“ScreeningLevelRiskAssessmentforSANTrimerDetectedinSoilandGroundwater”

2011 HumanandEcologicalRiskAssessment,Dr.BarryJohnson,Ed.“MonteCarloSimulation-basedHealthRiskAssessmentofHeavyMetalPollution-ACaseStudyintheQixiaMiningArea,China”

2011 RiskAnalysis,Dr.TonyCox,Editor,“AGradientMarkovChainMonteCarloAlgorithmforComputingMultivariateMaximumLikelihoodEstimatesandPosteriorDistributions:MixtureDoseResponseAssessment”

2010 EnvironmentalResearch,EllenSilbergeld,Ed.“StructuralNeuroimagingEvaluationofAdultswithChildhoodLeadExposure”

2010 HumanandExperimentalToxicology,Prof.KaiSavolainen,EditorinChief.“TheWorldLibraryofToxicology,ChemicalSafetyandEnvironmentalHealth(WLT)”

2010 JournalofExposureScienceandEnvironmentalEpidemiology,Dr.NatalieFreeman,Assoc.Ed."Comparisonofatoxicokineticandaquestionnaire-basedapproachtoassessmethylmercuryintakeinexposedindividuals”

2010 EnvironmentalResearch,Dr.EllenSilbergeld,Ed.“VaryingcoefficientfunctionmodelstoexploreinteractionsbetweenmaternalnutritionalstatusandprenatalmethylmercurytoxicityintheSeychellesChildDevelopmentNutritionStudy”

2009 RegulatoryToxicologyandPharmacology,GioBattaGori,Ed."DerivedReferenceDoses(RfDs)fortheEnvironmentalDegradatesoftheHerbicidesAlachlorandAcetochlor:ResultsofanIndependentExpertPanelDeliberation"

2009 EnvironmentalResearch,EllenSilbergeld,Ed."EnvironmentalPolicyandChildren'sHealthinMexico"2009 ToxicologicalSciences,Dr.JohnLipscomb,Assoc.Editor,"Age-,Dose-andTime-DependencyofPlasmaand

TissueDistributionofDeltamethrininImmatureRats."2009 Chemosphere,HeideloreFiedler,Ed."Quantitativestructure-activityrelationship(QSAR)studiesforpredicting

activationoftheryanodinereceptortype1channelcomplex(RyR1)bypolychlorinatedbiphenyl(PCB)congeners"

2009 EnvironmentalResearch,EllenSilbergeld,Ed."DeterminationofbromadioloneresiduesinfoxfaecesbyLC/ESI-MSinrelationshipwithtoxicologicaldataandclinicalsignsafterrepeatedexposure.”

2008 Chemosphere,HeideloreFiedler,Ed."TissueDistributionofPolychlorinatedBiphenylsandEffectsonAlaskanNorthernFurSealsAssessedwithFiveCongenerClassificationSchemes"

2008 Chemosphere,HeideloreFiedler,Ed."LevelsofPolychlorinatedDibenzo-p-dioxins,Dibenzofurans,andBiphenylsinSouthernMississippiCatfishandEstimationofPotentialHealthRisks"

2007 CriticalReviewsinToxicology,RogerO.McClellan,Ed.“RiskAssessmentofToxapheneanditsBreakdownProducts:TimeforaChange”

2006 EnvironmentalForensics,IoanaPetrisor,Ed.“IdentifyingMetalsContaminationinGroundwaterUsingGeochemicalCorrelationEvaluation”

2002 EnvironmentalScienceandTechnology,MitchellJ.Small,Ed.“Whyandhowshouldweassessoccupationalhealthimpactsinintegratedproductpolicy?”

2001 OhioEnvironmentalProtectionAgency,“HumanHealthRiskAssessmentConceptPaper”2000 ToxicologyExcellenceinRiskAssessment,“LifetimeEstimateofSkinCancerRiskfromuseofCoalTarContaining

Shampoos”1999 EnvironmentalScienceandTechnology,MitchellJ.Small,Ed.“ChlordaneUptakeanditsTranslocationinFood

Crops”1997 AgencyforToxicSubstancesandDiseaseRegistry,“PublicHealthInterventionstoPreventorMitigatePossible

AdverseHealthEffectsRelatedtoMethylParathionPesticideExposure”1995 NationalResearchCouncil,“HumanHealthPreliminaryRiskEvaluationoftheJinkampoIncineratorComplex

ActivitiesintheNavalAirFacility,Atsugi,Japan”

ted w. simon, ph.d., dabt - jurispro.com · ted simon, ph.d., dabt page 3 of 15 june, 2016 •...

Documents