tear-film stability in patients with obstructive sleep apnea syndrome masaki sato, md tetsuro...
TRANSCRIPT
![Page 1: Tear-film Stability in Patients with Obstructive Sleep Apnea Syndrome Masaki Sato, MD Tetsuro Oshika, MD Department of Ophthalmology University of Tsukuba](https://reader035.vdocuments.site/reader035/viewer/2022062719/56649ef25503460f94c044f7/html5/thumbnails/1.jpg)
Tear-film Stability in Patients with Obstructive Sleep Apnea Syndrome
Masaki Sato, MD Tetsuro Oshika, MD
Department of Ophthalmology
University of Tsukuba
Japan
The authors have no commercial or proprietary interest in any of the companies, products, or methods described in this presentation.
![Page 2: Tear-film Stability in Patients with Obstructive Sleep Apnea Syndrome Masaki Sato, MD Tetsuro Oshika, MD Department of Ophthalmology University of Tsukuba](https://reader035.vdocuments.site/reader035/viewer/2022062719/56649ef25503460f94c044f7/html5/thumbnails/2.jpg)
Epidemiology : About 20 million patients in the world
Classification : Obstructive ・ Central
Symptoms : Snore ・ Daytime somnolence ( The risk of the traffic accident : seven times )
Risk factors : Obesity ・ Respiratory diseases ・ Alcohol
Systemic complications : Hypertension ・ Diabetes etc…
Diagnosis : Polysonography Apnea/Hypopnea Index (AHI) ≧ 5 times / hr
Therapy : nasal CPAP (nasal Continuous Positive Airway Pressure)
Sleep Apnea Syndrome : SAS
Introduction
![Page 3: Tear-film Stability in Patients with Obstructive Sleep Apnea Syndrome Masaki Sato, MD Tetsuro Oshika, MD Department of Ophthalmology University of Tsukuba](https://reader035.vdocuments.site/reader035/viewer/2022062719/56649ef25503460f94c044f7/html5/thumbnails/3.jpg)
Ocular manifestations Glaucoma : 2 ~ 27 %
The retinal nerve fiber layer thickness correlates nagatively the SAS severity (Eye 2005, J Glaucoma 2007)
Keratoconus
Filamentary keratitis
Reccurent corneal erosion
Tear abnormality
Floppy eye lid : 52% Corneal lesion
The SLE-BUT correlates nagatively the SAS severity ? (Ophthalmology 1999)
n= ?
Objective quantitative analysis !!
![Page 4: Tear-film Stability in Patients with Obstructive Sleep Apnea Syndrome Masaki Sato, MD Tetsuro Oshika, MD Department of Ophthalmology University of Tsukuba](https://reader035.vdocuments.site/reader035/viewer/2022062719/56649ef25503460f94c044f7/html5/thumbnails/4.jpg)
To evaluate the tear-film stability in
patients with obstructive sleep apnea
syndrome (OSAS) using the tear-film
stability analysis system (TSAS).
Purpose
![Page 5: Tear-film Stability in Patients with Obstructive Sleep Apnea Syndrome Masaki Sato, MD Tetsuro Oshika, MD Department of Ophthalmology University of Tsukuba](https://reader035.vdocuments.site/reader035/viewer/2022062719/56649ef25503460f94c044f7/html5/thumbnails/5.jpg)
Subjects & Methods
Design : cross-sectional study.
Participants : Consecutive 116 left eyes of 116 cases
on nCPAP therapy.
Exclusion criteria : Contact lens wearing, post-
intraocular surgery, other ocular disease, diabetes,
and collagen disease.
Subjects : 86 eyes of 86 cases ( M:F = 74:12 )
Age : 55 ± 12 years ( range: 37-71 )
![Page 6: Tear-film Stability in Patients with Obstructive Sleep Apnea Syndrome Masaki Sato, MD Tetsuro Oshika, MD Department of Ophthalmology University of Tsukuba](https://reader035.vdocuments.site/reader035/viewer/2022062719/56649ef25503460f94c044f7/html5/thumbnails/6.jpg)
RT-7000® ( Tomey ) Corneal topographic maps each second for 10 seconds BUI (Breakup Index ; 0 〜 100) RBUT (Ring Breakup Time ; 0 〜 10)
TSAS (Tear Stability Analysis System)
Main Outcome Measures AHI ( at diagnosis / present ) BMI ( Body Mass Index ) Period of nCPAP therapy BUI RBUT
![Page 7: Tear-film Stability in Patients with Obstructive Sleep Apnea Syndrome Masaki Sato, MD Tetsuro Oshika, MD Department of Ophthalmology University of Tsukuba](https://reader035.vdocuments.site/reader035/viewer/2022062719/56649ef25503460f94c044f7/html5/thumbnails/7.jpg)
BUI RBUT
r P r P
Age
AHI ( at diagnosis )
AHI ( at present )
BMI
Period of nCPAP therapy
0.123
-0.273
0.004
-0.254
0.073
0.261
0.011
0.973
0.026
0.517
0.102
-0.265
-0.021
-0.067
0.052
0.349
0.014
0.854
0.570
0.647
(Pearson’s correlation coefficient)
Results
![Page 8: Tear-film Stability in Patients with Obstructive Sleep Apnea Syndrome Masaki Sato, MD Tetsuro Oshika, MD Department of Ophthalmology University of Tsukuba](https://reader035.vdocuments.site/reader035/viewer/2022062719/56649ef25503460f94c044f7/html5/thumbnails/8.jpg)
r = -0.273p = 0.0108
r = 0.004p = 0.973
AHI (at diagnosis)
BUI BUI
AHI (at present)
Correlation between AHI and BUI
(Pearson’s correlation coeffient)
![Page 9: Tear-film Stability in Patients with Obstructive Sleep Apnea Syndrome Masaki Sato, MD Tetsuro Oshika, MD Department of Ophthalmology University of Tsukuba](https://reader035.vdocuments.site/reader035/viewer/2022062719/56649ef25503460f94c044f7/html5/thumbnails/9.jpg)
r = -0.265p = 0.0135
r = -0.021p = 0.854
RBUT RBUT
(Pearson’s correlation coeffient)
Correlation between AHI and RBUT
AHI (at diagnosis) AHI (at present)
![Page 10: Tear-film Stability in Patients with Obstructive Sleep Apnea Syndrome Masaki Sato, MD Tetsuro Oshika, MD Department of Ophthalmology University of Tsukuba](https://reader035.vdocuments.site/reader035/viewer/2022062719/56649ef25503460f94c044f7/html5/thumbnails/10.jpg)
1) Exacerbation of OSAS
A long period before nCPAP therapy is started.
2) Influence of nCPAP (Optometry 2007)
Ocular complications by nCPAP in 3 OSAS cases.
HCL wear for keratoconus → Keratoconjunctivitis
Injury for fellow eye → Keratoconjunctivitis
HCL wear for Pellucid cornea → Keratoconjunctivitis
Inappropriate fitting of CPAP mask → leaking air
Inappropriate fitting of CPAP mask → leaking air
DiscussionThe origin of the deteriorated tear-film stability…
![Page 11: Tear-film Stability in Patients with Obstructive Sleep Apnea Syndrome Masaki Sato, MD Tetsuro Oshika, MD Department of Ophthalmology University of Tsukuba](https://reader035.vdocuments.site/reader035/viewer/2022062719/56649ef25503460f94c044f7/html5/thumbnails/11.jpg)
Tear-film instability
Keratoconjunctivitis
Concept in Dry Eye
MGDMGD
ConjunctivochalasisConjunctivochalasis
クリアランス低 下
クリアランス低 下
Moisture ↓Moisture ↓
StressStress
CLwearCLwear
Eye dropsEye drops
MedicineMedicine
DMDMTrichiasisTrichiasisInjuryInjury
Limbal function ↓
Limbal function ↓
SurgerySurgery
LagophthalmosLagophthalmos
Sensation ↓Sensation ↓
Nictation ↓ Nictation ↓
InflammationInflammation
Tear secretion ↓
Tear secretion ↓
Lid abnormality
Lid abnormality
SASSAS
![Page 12: Tear-film Stability in Patients with Obstructive Sleep Apnea Syndrome Masaki Sato, MD Tetsuro Oshika, MD Department of Ophthalmology University of Tsukuba](https://reader035.vdocuments.site/reader035/viewer/2022062719/56649ef25503460f94c044f7/html5/thumbnails/12.jpg)
The tear-film stability in OSAS patients
correlates negatively with the AHI at diagnosis.
From the point of view of preventive medicine,
it is very important for the OSAS patients to
have the ophthalmic examinations.
This research was partially supported by the Grant-in-Aid for Young Scientists (B) No.20791244 from MEXT Japan.
Conclusions