tb in sl: thinking big about the very small
DESCRIPTION
Presentation for non-science audience on the educational use of the virtual world Second Life in the context of an ongoing pilot build themed on the bacterium Mycobacterium tuberculosis.TRANSCRIPT
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TBinSL:Thinking Big about the Very Small
Graham Mills
http://tidalblog.blogspot.com/http://bit.ly/listfaq
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Visualization: molecules, gene data, cells...
Max Chatnoir demonstrates her giant cellon Elucian Isles
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Context: TB (tuberculosis)
Downsides Bacterial infection Kills 4500 people daily Antibiotic-resistant strains Vaccines of limited use Rapidly lethal in HIV/AIDS Hard to do labwork
Upsides• Major research initiatives
aimed at developing new drugs and vaccines and eliminating TB by 2020
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Molecules
Small molecules (metabolites, drugs)• Hiro Sheridan: molecule rezzer (ACS), Orac [1]
o Incorporated into metabolic browser Large molecules: proteins, etc• Prim-intensive: Troy McLuhan [2]
o Added interactivity• Sculpted: Hiro Sheridan [3]
o Added interactivity• Also: animated [4] and static textures [5], particles
• SL Molecular Structures Group (Asorel Todriya)• Lang & Bradley (2009)
http://journal.chemistrycentral.com/content/3/1/14
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Molecules in Second Life
1 2
3
4
5
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Metabolic browser
Molecules by Hiro Sheridan’s Orac and stored inTroy McLuhan’s holoemitter
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Prim-intensive protein models (backbone only)
M. tuberculosiscellulase
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Student work on A2M in the E. coli cell wall (2008)
A2M
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Sculpted protein (+ particle)
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Student group work (2009)
Students work on different genesGroups work on different speciesLink by teleport to giant TB genome
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Datascape: Giant TB genome
Genes encode proteins>4000 TB genes, alltouch-sensitive
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Individual genes and their products
Associations withother proteins (STRING)Contextual sub-mapSLV 2.0 texture on marker
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Take your analytical tools with you: shared media dashboard
Follower is a mashup ofPuppeteer and Scratch4SL
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Cellscape: porins, alveolus, macrophage
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Cityscape: The Cure
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Robert Koch’s lab
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TB timeline maze (under construction)
TB started hereAnd is a major problem here
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Conclusions
Progress has been made so let’s share it!
It’s not content, it’s collaboration Reasons to be cheerful
Some students (not all) like this!! Groupwork works Shared media (meshes next?)