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No similarity vs no homology If two (complex) sequences show significant similarity in their primary sequence, they have shared ancestry, and probably
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Chapter 6 How Cells Read the Genome: From DNA to Protein –RNA –Transcription –RNA processing –Translation
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Why Manual Genome Annotation? Even the best gene predictors and genome annotation pipelines rarely exceed accuracies of 80% at the exon level, meaning
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Discovery of Alternative Splicing First discovered with an Immunoglobulin heavy chain gene (D. Baltimore et al.) Alternative splicing gives two forms of
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Introns and Exons Introns--Untranslated intervening sequences in mRNA Introns--Untranslated intervening sequences in mRNA Exons– Translated sequences Exons–
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HEPATIC ENCEPHALOPATHY Ashwini Gandhe History of Present Illness 63yr old white man presents with change in mental status.Patient has become increasingly
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