8TH SANTORINI Conference SYSTEMS MEDICINE & PERSONALISED HEALTH & THERAPY3-5 October 2016Thira-Santorini / Greece

Nomikos Conference Centerwww.santoriniconference.org

FINAL PROGRAM

The symbol of the 8th Santorini Conference is the poppy, a symbol in memory of Gérard Siest.A suffering took place this year on our Life’s path. It came and stays deep inside our heart. The suffering for a very significant person… Gérard SIEST passed away just one month before his 80th birthday and he never received his Birthday gift: 8 Poppies…Day after day the poppies invited me to enjoy reading a small book of Rosette Poletti called La voie du coquelicot, The poppy’s path. I found there some sentences, which accompany me and that I wanted to share with you on the first day of this conference, October 3rd, the Name Day of Gérard…I quote:“To continue on the path of the poppy is like walking and taking the step forward… It’s by walking that the path can be created...” In line with this, twenty years ago, Gérard SIEST visited Santorini for the first time. I can’t say that I remember much or that it enchanted him. I remember a magical view of the caldera and a unique, breathless, extremely serene and dreamy smile on Gérard’s face while losing his gaze on the horizon. The island had bewitched him! It became his small paradise…

And in 2002, the story begins…The 1st Santorini Conference “From Genetic Variations to Risk Prediction and Pharmacogenomics” was organised on 25-28 September 2002!In some outstanding cases, inspiration confirms the talent and resulting work speaks for itself. And Gérard SIEST was one of those cases, whose ideas have taken the “Santorini Conferences” by storm.Throughout the 14 years, 8 Santorini Conferences welcomed each time, about 150 registered participants coming from more than 30 different countries, 50 invited speakers and 20 selected oral presentations, 50 posters and exhibitions to a world of passion for science with specific Personalised Medicine sessions on Genetics and Pharmacogenomics of risks and chronic diseases.From innovative projects, such as the creation of the European Society of Pharmacogenomics and Personalised Therapy (ESPT) in 2010 and upcoming research to the quintessence of per-sonalised medicine with “hidden” and famous researchers, the Santorini Conferences had many faces and like a chameleon had the capacity to enchant academic and industry research in many ways.Over the years, the Santorini Conferences became one of the most important conferences on genetic predisposition to health, disease, response to drugs and environment, in harmony with the island creative spirit, attracting scientists from all over the planet. None can dispute the unique vision of Gerard!After 14 years, we are here again to follow the path along the caldera of the 8th Santorini Conference “Systems medicine and Personalised Health and Therapy” that Gérard had already initiated before passing away. The time has come to honour the memory of Gérard and our scientific guests and sponsors!You will never get bored of this conference, that’s for sure!Just follow the 9 sessions, the oral communications, the 5 satellite meetings organised in colla- boration with ESPT and the MAST4HEALTH EU Project, the round table and see the posters and the website (www.santoriniconference.org)…

Sofia SiestPresident of the 8th Santorini Conference

WELCOME LETTER

8TH SANTORINI Conference

ORGANIZING COMMITTEEUMR INSERM U1122; IGE-PCV“Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire”, Nancy, France

ALDASORO ARGUIÑANO Alex-Ander

CHATELIN Jérôme

HIEGEL Brigitte

KLEIN Marc

MASSON Christine

PETRELIS Alexandros

RANCIER Marc

SIEST Gérard †

SIEST Sofia

STATHOPOULOU Maria

ULMER Patricia

VERMION Catherine

WERYHA Georges Richard

XIE Ting

SCIENTIFIC COMMITTEEANSARI Marc (Geneva, Switzerland)

BAROUKI Robert (Paris, France)

BÜHLMANN Roland P. (Schönenbuch, Switzerland)

DAGHER Georges (Paris, France)

DEDOUSSIS George (Athens, Greece)

DELOUKAS Panos (Cambridge, United Kingdom)

FITZGERALD Peter (Crumlin, Co-Antrim, United Kingdom)

FROGUEL Philippe (Lille, France)

INGELMAN-SUNDBERG Magnus (Stockholm, Sweden)

JACOBS Peter (Gent, Belgium)

LAMONT John (Co-Antrim, United Kingdom)

LINDPAINTNER Klaus (Waltham, USA)

LLERENA Adrian (Badajoz, Spain)

MANOLOPOULOS Vangelis G. (Alexandroupolis, Greece)

MÄRZ Winfried (Mannheim, Germany)

MEIER-ABT Peter (Basel, Switzerland)

MEYER Urs A. (Basel, Switzerland)

NOYER-WEIDNER Mario (Berlin, Germany)

ROSES Allen (Durham, USA)

SIEST Gérard (Nancy, France) †

SIEST Sofia (Nancy, France)

VAN SCHAIK Ron (Rotterdam, The Netherlands)

ORGANIZING & SCIENTIFIC COMMITTEES

CONGRESS VENUENomikos Conference CenterPetros M. Nomikos A.E.Santorini, GreeceTel.: +30210 7241516Email: info@thera-conferences.grcom

CONTACT ORGANIZATIONCom&Co, Etienne Jarry15, Bd Grawitz - 13016 Marseille, FranceTel.: +33 (0)4 91 09 70 53Fax: +33 (0)4 96 15 33 08Email: ejarry@comnco.com

INFORMATION

www.santoriniconference.org

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REGISTRATION

OPENING RECEPTION

Coffee break & first poster visit

Coffee break & poster visit

Coffee break

Coffee break & poster visit

Lunch break

Poster visit

Lunch break & poster visit Lunch break

SESSION I FROM SYSTEMS BIOLOGY TO SYSTEMS MEDICINE

SESSION V OMICS STUDIES

OF HUMAN PHENOTYPES AND ENVIRONMENT

SESSION VII PHARMACOGENOMICS AND PERSONALISED / STRATIFIED THERAPY

SESSION II SYSTEMS PHARMACOGENOMICS

AND MECHANISMS OF DRUG ACTION

SESSION VI NUTRITION

AND METABOLIC HEALTH SESSION VIII GENOMIC BIOMARKERS

AND MANAGEMENT OF METABOLIC

AND INFLAMMATORY DISEASES

SESSION IX NEW BIOMARKERS

AND COMPANION DIAGNOSTICS

ROUND TABLE The future of personalised medicine, systems medicine and systems pharmacology: how to translate the big

data for the clinicians and personalised therapy

VEGF CONSORTIUM MEETING

SESSION III PHARMACOGENOMICS,

IMMUNOTHERAPY AND ONCO-HEMATOLOGY

SELECTED ORAL PRESENTATIONS

SESSION IV GENOMICS AND PROTEOMICS OF ALZHEIMER’S DISEASE

GALA DINNER Special keynote addresses in honor of Gérard Siest

POSTER AWARDS CEREMONY

MONDAY OCTOBER 3RD TUESDAY OCTOBER 4TH WEDNESDAY OCTOBER 5TH

Coffee break

H2020 MSCA-

RISE-2015 (MAST4HEALTH

PROJECT)

ESPT WORKING GROUPS

SATE

LLIT

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MEE

TIN

GS

08:00 REGISTRATION

08:30 SESSION I

FROM SYSTEMS BIOLOGY TO SYSTEMS MEDICINE

Chairs: Philippe Froguel, Lille, France / Sofia Siest, Nancy, France

08:30 • From the 1st to the 8th Colloquium Sofia Siest, Nancy, France

09:10 • Population ressources: shifting requirements for advancing health care Klaus Lindpaintner, Waltham, USA

09:30 • Epigenetic signatures of brain aging Andreas Papassotiropoulos, Basel, Switzerland

10:00 • Mechanistic bioprofiles and pharmacophenomics for precision medicine of heart failure Faiez Zannad, Nancy, France

10:30 Coffee break and first poster visit

11:00 SESSION II

SYSTEMS PHARMACOGENOMICS AND MECHANISMS OF DRUG ACTION

Chairs: Peter Meier-Abt, Bern, Switzerland / Urs Meyer, Basel, Switzerland

11:00 • Metabolomics and its role in precision medicine: From patient to drug John Ryals, Raleigh, USA

11:30 • Prediction of combination therapy based on perturbation modeling of the immune system signaling network in patients with multiple sclerosis Pablo Villoslada, Barcelona, Spain

12:00 • Genomic precision to be achieved in the use of VEGF- inhibitors in cancer patients Federico Innocenti, Chapel Hill, USA

12:30 Poster visit

12:30 Lunch break

14:00 SESSION III

PHARMACOGENOMICS, IMMUNOTHERAPY AND ONCO-HEMATOLOGY Chairs: Marc Ansari, Geneva, Switzerland / Maja Krajinovic, Montreal, Canada 14:00 • Stem cell transplantation and pharmacogenomics

Marc Ansari, Geneva, Switzerland 14:30 • Tumor immunity and immunotherapy:

past, present, future Pierre-Yves Dietrich, Geneva, Switzerland

15:00 • The myeloma targets Aurore Perrot, Nancy, France

15:30 • Leukemia pharmacogenomics Maja Krajinovic, Montreal, Canada

16:00 Coffee break and poster visit

16:30 SESSION IV

GENOMICS AND PROTEOMICS OF ALZHEIMER’S DISEASE

Chairs: Andreas Papassotiropoulos, Basel, Switzerland / Allen Roses, Chapel Hill, USA

16:30 • African-American TOMM40 ’523-APOE haplotypes are admixture of West African and Caucasian alleles, not present in other ethnic groups Allen Roses, Chapel Hill, USA

17:00 • Functional analysis of the APOE/TOMM40 locus implicates a complex regulatory structure Lynn Bekris, Cleveland, USA

17:30 • Proteomics, identification of new small molecules and prediction of Alzheimer‘s disease Erich Wanker, Berlin, Germany

18:00 • Careful neuropsychological testing reveals a novel genetic marker, GSTO1*C, linked to mild cognitive impairment and late-onset Alzheimer’s disease Ellen Umlauf, Vienna, Austria

19:00 OPENING RECEPTION Suites of the Gods on the Caldera

MONDAY OCTOBER 3RDFINAL PROGRAM AT A GLANCE

FINAL PROGRAM8TH SANTORINI Conference

Most of the abstracts will be published in CCLM & DMPT, issue DOI:

DOI: 10.1515/cclm-2016-0831

DOI: 10.1515/dmpt-2016-0030

Group photo

WEDNESDAY OCTOBER 5THTUESDAY OCTOBER 4TH

FINAL PROGRAM8TH SANTORINI Conference

08:30 SESSION VII

PHARMACOGENOMICS AND PERSONALISED / STRATIFIED THERAPY

Chairs: Pierre-Yves Dietrich, Geneva, Switzerland / Ron Van Schaik, Rotterdam, The Netherlands

08:30 • A novel predictive tool for 5-Fluorouracil toxicity and efficacy Maurizio Simmaco, Roma, Italy

09:00 • The PGx implementation challenge: lessons learned in Austria Markus Paulmichl, Salzburg, Austria

09:30 • The use of pharmacogenomic methodologies in the pharmacovigilance evaluation of medicinal products Michael Marschler, Mannheim, Germany

10:00 • High throughput ADME PGx genotyping for clinical trial stratification Robin Everts, San Diego, USA

10:30 • GSTA1 genetic variants: a missing key factor in Busulfan first dose prediction models in conditioning before hematopoietic stem cell transplant in children Tiago Nava, Montreal, Canada

10:45 Coffee break

11:15 SESSION VIII

GENOMIC BIOMARKERS AND MANAGEMENT OF METABOLIC AND INFLAMMATORY DISEASES

Chairs: Federico Innocenti, Chapel Hill, USA / Winfried März, Augsburg, Germany

11:15 • Causality versus predictive ability in personalised medicine: C-Reactive Protein Behrooz Z. Alizadeh, Gröningen, The Netherlands

11:45 • Interplay between epigenetic mechanisms in rheumatic disorders Steffen Gay, Zurich, Switzerland

12:15 • The gut microbiome and metabolic health Pilar Francino, Valencia, Spain

12:45 • Contribution of an integrative multi-omic approach in the metabolic syndrome prediction: a nested case-control study Blandine Comte, Saint-Genès-Champanelle, France

13:00 • The association of ATP binding cassette gene B1 (ABCB1) C3435T polymorphism with apixaban peak concentration in patients with acute cardioembolic stroke and atrial fibrillation Alexander Kryukov, Moscow, Russia

13:15 Lunch break

14:30 SESSION IX

NEW BIOMARKERS AND COMPANION DIAGNOSTICS

Chairs: Lynn Bekris, Cleveland, USA / Panos Deloukas, London, United Kingdom

14:30 • Cell-Free DNA: the search of prognostic biomarkers in prostate cancer Tomris Özben, Antalya, Turkey

15:00 • PCSK9 and Pharmacogenomics Winfried März, Augsburg, Germany

15:30 • Osteoporosis in the age of biotherapies with anti-sclerostin Georges Weryha, Nancy, France

16:00 • OneOmics in the cloud: integrating multi-omics data for quantitative system biology Jean-Baptiste Vincendet, Paris, France

16:30 ROUND TABLE The future of personalised medicine,

systems medicine and systems pharmacology: how to translate the big data for the clinicians and personalised therapy

Discussion leaders: Sofia Siest, Nancy, France / Maurizio Simmaco, Roma, Italy

Panel discussion • Georges Dagher, Paris, France • Denis Horgan, EAPM, Brussels, Belgium • Klaus Lindpaintner, Waltham, USA • Markus Paulmichl, Salzburg, Austria • Adrian Llerena, Badajoz, Spain (Skype) • Magnus Ingelmann Sundberg, Stockholm, Sweden (Skype)

17:30 VEGF CONSORTIUM MEETING Moderator: Sofia Siest, Nancy, France

18:30 End of the conference

08:30 SESSION V

OMICS STUDIES OF HUMAN PHENOTYPES AND ENVIRONMENT

Chairs: Georges Dedoussis, Athens, Greece / Baishen Pan, Shanghai, China

08:30 • Insights to coronary artery disease genetics through UK Biobank Panos Deloukas, London, United Kingdom

09:00 • Update on the exposome in Europe and in The States Robert Barouki, Paris, France

09:30 • Non alcoholic fatty liver disease (NAFLD): interaction between phenotype and environment Amalia Gastaldelli, Pisa, Italy

09:50 • The human plasma-metabolome: reference values in 800 healthy volunteers; impact of cholesterol, gender and age Laurent Becquemont, Paris, France

10:10 Coffee break and poster visit

10:20 Group photo

10:30 SESSION VI

NUTRITION AND METABOLIC HEALTH Chairs: Roland P. Bühlmann, Basel, Switzerland /

Mario Noyer-Weidner, Berlin, Germany 10:30 • Genetics of nutrition and of metabolic diseases

Philippe Froguel, Lille, France 11:00 • Gene-nutrient interaction data stemmed

from nutritional interventions. The paradigm of the MAST4HEALTH EU program Georges Dedoussis, Athens, Greece

11:30 • Xenohormetic nutrient signals that modulate aging and healthspan: a complex regulatory network for nutrigenomics research Giovanni Scapagnini, Molise, Italy

12:00 ESPT GENERAL ASSEMBLY 13:30 Lunch break and poster visit

14:30 SELECTED ORAL PRESENTATIONS Chairs: Tomris Ozben, Antalya, Turkey /

Georges Weryha, Nancy, France 14:30 • Clinical Development of Tanibirumab and its next

generation bispecific antibodies for cancer treatment Jin-San Yoo, Daejeon, South Korea

14:45 • Unbiased mass-spectrometry-based metabolomics profiling in over 1,000 patients reveals specific abnormalities in biochemical pathways in patients with atherosclerosis, as defined by cardiovascular CT-based precision phenotyping in the multi-center GLOBAL Clinical study Szilard Voros, Atlanta, USA

15:00 • Single nucleotide polymorphisms in dopaminergic pathways genes are associated with bruxism Gonzalo H Oporto V, Temuco, Chile

15:15 • The “antioxidogram”: a biomarker of clinical interest for personalized medicine in blood diseases Olivier Herault, Tours, France

15:30 Coffee break

16:00 SATELLITE MEETINGS (simultaneous sessions) 16:00-17:30 ESPT WORKING GROUPS ON: Pediatric individualised treatment in oncology hematology Moderator: Marc Ansari, Geneva, Switzerland Curriculae and education

for pharmacogenomics and personalised medicine Moderator: Janja Marc, Ljubljana, Slovenia Endiobiotic and drug interactions Moderator: Adrian Llerena, Badajoz, Spain 16:00 • Pharmacogenetic and pharmacological bases

of drud-drug interactions: examples on pain treatment Ana Peiró, Alicante, Spain

16:20 • Pharmacogenetics of endogenous metabolism: CYP2D6 and its relevance for psychopatology and suicide Adrián LLerena, ESPT Board

16:40 • Discussion of clinical cases in pain treatment Ana Peiró, Alicante, Spain

17:00 • Proposals for the ESPT Working Group Adrián LLerena, ESPT Board & WP Members

Transporter of drugs and metabolites Moderator: Ingolf Cascorbi, Kiel, Germany 16:00 • Drug transporters in cancer resistance

Ingolf Cascorbi, Kiel, Germany 16:20 • Pharmacogenetics of drug transporters: clinically relevance

Mauricio Simmaco, Roma, Italy 16:40 • General discussion 17:25 • Final remarks - Ingolf Cascorbi, Kiel, Germany

16:00-18:00 H2020 MSCA-RISE-2015 (MAST4HEALTH PROJECT) Practical issues in NAFLD/NASH

diagnosis and management Moderator: Milica Medic-Stojanoska, Novi Sad, Serbia 16:00 • An interventional study with a natural

product to implement safety and efficacy Andriana Kaliora, Athens, Greece

16:30 • General discussion 17:55 • Final remarks - George Dedoussis, Athens, Greece

21:00 GALA DINNER – Pyrgos restaurant Special keynote addresses in honor of Gérard Siest A lifetime work dedicated to the promotion

of personalised medicine and the visionary man behind the Santorini Conferences.

With the participation of: • The Director of the Research Unit, UMR INSERM U1122;

IGE-PCV - Sofia Siest, Nancy, France • The President of the University of Lorraine

Pierre Mutzenhardt, Nancy, France • The President of the European Society

of Pharmacogenomics and Personalised Therapy Ron H. Van Schaik, Rotterdam, The Netherlands

• The President of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) - On behalf of the President, Maurizio Ferrari: Tomris Ozben, Antalya, Turkey

POSTER AWARDS CEREMONY 2 ‘Gérard Siest’ awards of 850 euros each one granted one

by the University of Lorraine and one by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC).

GOLD SPONSORS

Under the auspices of:

BRONZE SPONSORS

SILVER SPONSORS

Diagnostics

ACKNOWLEDGEMENTS

OTHERS